Digital Commons Network^™

Resource Utilization And Costs Associated With Off-Label Use Of Atypical Antipsychotics In An Adult Population, Della Varghese

Theses and Dissertations

Introduction: Atypical Antipsychotics (AAPs) are approved by the Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder. AAPs are commonly used off-label to treat depression, post-traumatic stress disorder and neuropsychiatric symptoms in dementia due to lack of alternative treatment options and treatment resistance. Concerns for off-label use arise since AAPs increase the risk of cardiovascular events and death. The objectives were 1) describe patterns of RU and costs among off-label AAPs users in a nationally representative population 2) identify prevalence of off-label use in the Medicare population 3) compare RU and costs between off-label AAPs …

Interactomics-Based Functional Analysis: Using Interaction Conservation To Probe Bacterial Protein Functions, J. Harry Caufield

Theses and Dissertations

The emergence of genomics as a discrete field of biology has changed humanity’s understanding of our relationship with bacteria. Sequencing the genome of each newly-discovered bacterial species can reveal novel gene sequences, though the genome may contain genes coding for hundreds or thousands of proteins of unknown function (PUFs). In some cases, these coding sequences appear to be conserved across nearly all bacteria. Exploring the functional roles of these cases ideally requires an integrative, cross-species approach involving not only gene sequences but knowledge of interactions among their products. Protein interactions, studied at genome scale, extend genomics into the field of …

Methods For Predicting An Ordinal Response With High-Throughput Genomic Data, Kyle L. Ferber

Theses and Dissertations

Multigenic diagnostic and prognostic tools can be derived for ordinal clinical outcomes using data from high-throughput genomic experiments. A challenge in this setting is that the number of predictors is much greater than the sample size, so traditional ordinal response modeling techniques must be exchanged for more specialized approaches. Existing methods perform well on some datasets, but there is room for improvement in terms of variable selection and predictive accuracy. Therefore, we extended an impressive binary response modeling technique, Feature Augmentation via Nonparametrics and Selection, to the ordinal response setting. Through simulation studies and analyses of high-throughput genomic datasets, we …

Curcumin/Melatonin Hybrids As Neuroprotective Agents For Alzheimer's Disease, John Saathoff

Theses and Dissertations

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting ~5.2 million Americans. Current FDA approved medications provide mainly symptomatic relief and there are no agents available to delay or cure this disease. Multiple factors such as amyloid-β aggregates, dyshomeostasis of biometals, oxidative stress, and neuroinflammation have been implicated in the development of AD. Even though significant advances have been made in understanding the mechanisms leading to AD, the exact etiology still remains elusive. Given AD’s multifactorial nature, a multifunctional strategy of small molecule design would help to identify novel chemical templates. Recently our lab …

A Qualitative Study Of Woodland County Public Schools’ Social Media Policy For Employees: Its Development, Interpretation, And Significance, Greenlee B. Naughton

Theses and Dissertations

The popularity of social networking sites on the World Wide Web has exploded during the past two decades. As more and more K-12 public school teachers choose to actively participate on social networking sites, school leaders and school boards face the increasingly difficult decision about whether or not to enact policies which will enable them to discipline teachers for their online behavior. The purpose of this qualitative case study was to explore the development, interpretation, and significance of one such policy.

The Instructional Technology Resource Teacher: A Descriptive Case Study Of Deployment, Use, And Perceptions, Mary Sepelyak

Theses and Dissertations

This case study describes one professional development approach to support technology integration at all public schools in one large county in central Virginia. Using data obtained from daily time logs, the frequency of Instructional Technology Resource Teacher (ITRT) use by classroom teachers was analyzed. Descriptive statistics were used to describe overall percentage of ITRT use, the various types of professional development requested by teachers, the consistency of those activities over time, and if the frequencies of activities varied as a function of school level, Title I status at the elementary level, or subject area taught by teachers at the secondary …

Representativeness Of Patients Enrolled In A Primary Care Clinical Trial For Substance Use Disorders, Sydney S. Kelpin

Theses and Dissertations

Understanding the characteristics of research participants is crucial to ensuring sample representativeness and generalizability of findings to broader patient groups with substance use disorders. Using anonymous computer-administered health survey data, the present study had a unique opportunity to compare patients who chose to participate in an RCT for heavy/problem drinking or drug use (N=713; consenters) with those that chose not to participate (N=625; non-consenters). The sample was 40% male, 76% African American, and had a mean age of 45.2 years. Using multivariate regression, the most parsimonious model found older age, unemployment, prescription misuse, positive screen for drug problems (CAGE), having …

Women At The Crossroads, Women At The Forefront, American Women In Letterpress Printing In The Nineteenth Century, Dianne L. Roman Ms

Theses and Dissertations

The significant role of the female printer in the American home-based print shops during the colonial and early republic periods has been documented in print history, socioeconomic, labor, and women studies, yet with the industrialization of the printing trade, women’s presence is thought to have disappeared. Contrary to the belief that industrialization of the print shop eradicated women’s involvement in skilled employments such as typesetting, the creation of the Women’s Cooperative Printing Union in California and the creation and chartering of the Women’s Typographical Union in New York, both in the late 1860s, clearly indicate that women continued to work …

“‘It’S A Cu’Ous Thing Ter Me, Suh’: The Distinctive Narrative Innovation Of Literary Dialect In Late-Nineteenth Century American Literature”, Kym M. Goering

Theses and Dissertations

American literature and verse advanced in dialectal writing during the late-nineteenth century. Charles Chesnutt’s “The Goophered Grapevine” (1887), “Po’ Sandy” (1888), and “Hot-Foot Hannibal” (1899); Joel Chandler Harris’ Uncle Remus: His Songs and His Sayings (1881); Thomas Nelson Page’s “Marse Chan” (1884); and Mark Twain’s “Sociable Jimmy” (1874) and “A True Story, Repeated Word for Word as I Heard It” (1874) provided diverse dialect representations. Dialect expanded into poetry with

James Whitcomb Riley’s “She ‘Displains’ It” (1888), “When the Frost is on the Punkin” (1882), and “My Philosofy” (1882) and Paul Laurence Dunbar’s “The Spellin’ Bee” (1895), “An Ante-Bellum Sermon” …

The New Gatekeepers: How Blogs Subverted Mainstream Book Reviews, Rebecca E. Johnson

Theses and Dissertations

Book reviewing has a fraught history in the United States. Reviewers have long been accused of not being analytical enough. It should be no wonder then with the emergence of social media that online book reviewing has become increasingly popular. Online reviewers, especially book bloggers, are no literary gatekeepers in their own right, shaping the tastes of readers across the world. Book blogs in particular pay special attention to titles which have long been derided by institutions such as libraries, academia, publishers, and bookstores. These literary gatekeepers typically ignore romance, fantasy, mystery, science fiction, young adult fiction, comic books, and …

Write To Work: The Use And Importance Of Writing As Perceived By Business Leaders, Clay Aschliman

Theses and Dissertations

The relation of English Language Arts (ELA) to the economy has played a historic role in educational policy, persisting to today’s corporate reform movement. It is, however, an area that remains under-researched. This study builds upon the limited existing literature base with a systematic replication of the College Board’s National Commission on Writing for America’s Families, Schools, and Colleges’ (NCW) 2004 report, “Writing: A Ticket to Work…Or a Ticket Out.” The guiding research questions for this study are 1) How important is writing in the workplace? 2) Is writing an important hiring consideration? 3) What kind of writing is expected …

Electrochemical Studies Of Cerium And Uranium In Licl-Kcl Eutectic For Fundamentals Of Pyroprocessing Technology, Dalsung Yoon

Theses and Dissertations

Understanding the characteristics of special nuclear materials in LiCl-KCl eutectic salt is extremely important in terms of effective system operation and material accountability for safeguarding pyroprocessing technology. By considering that uranium (U) is the most abundant and important element in the used nuclear fuel, measurements and analyses of U properties were performed in LiCl-KCl eutectic salt. Therefore, the electrochemical techniques such as cyclic voltammetry (CV), open circuit potential (OCP), Tafel, linear polarization (LP), and electrochemical impedance spectroscopy (EIS) were conducted under different experimental conditions to explore the electrochemical, thermodynamic, and kinetic properties of U in LiCl-KCl eutectic. The ultimate goal …

Positivity Ratio: Predicting Sleep Outcomes Across The Adult Lifespan, Janna L. Imel

Theses and Dissertations

Although sleep has been linked to changes in positive and negative affect across the lifespan, the prediction of sleep from affect has not been explored completely. As such, the main objective of this study was to examine the association between affect and sleep across the adult lifespan, using a novel gauge of affect, the positivity ratio. Both subjective and objective assessments of sleep were used in analyses. This study was an archival analysis of data collected as a part of the Midlife in the United States Study (MIDUS-II), with participants ranging from 34 to 83 years of age. Results revealed …

The Role Of Procedural Justice Within Police-Citizen Contacts In Explaining Citizen Behaviors And Other Outcomes, Shana M. Mell

Theses and Dissertations

American policing is shaped by an array of challenges. Police are expected to address crime and engage the community, yet police are held to higher expectations of accountability, effectiveness, and efficiency than ever before. Police legitimacy is the ability of the police to exercise their authority in the course of maintaining order, resolving conflicts, and solving problems (PERF, 2014). The procedural justice and police legitimacy literature suggest that by exhibiting procedurally just behaviors within police-citizen encounters, officers are considered legitimate by the public (PERF, 2014; Tyler, 2004, Tyler & Jackson, 2012).

This study examines procedural justice through systematic observations of …

The Implementation And Emulation Of Cult Movie Marketing, Rebekah W. Mckendry

Theses and Dissertations

Cult media is often an area of media studies that is difficult to define. Cult media branches through numerous time periods, genres, and fandom patterns. Cult trends are also constantly evolving over time, changing from word-of-mouth and point-of-sale advertising to social networks and Internet culture. But have the rudimentary basics of how media cults develop and spread their message changed along with the progressing marketing presentation? This dissertation explores the definition of media cults, their history, and marketing styles over time, ultimately exploring the tools utilized to market cult media and examine how these tools are now synthetically applied to …

On Workaholism: Do Parental Work Behaviors Predict The Work Behaviors Of Undergraduates?, Jesse A. Wingate

Theses and Dissertations

This cross-sectional study examined the associations among perceived parental behavior and personality on work behaviors of undergraduate students from a large Southeastern university. Past research suggests that children who perceive their parents to be workaholics are more likely to exhibit workaholic behavior themselves (Chamberlin & Zhang, 2009). Moreover, personality factors including conscientiousness and neuroticism, have been categorized as antecedents of workaholic behavior in previous studies (Andreassen, Hetland, & Pallesen, 2010; Aziz & Tronzo, 2011; Burke, Matthiesen, & Pallesen, 2006). Students (N = 209) completed questionnaires assessing Big Five personality factors, dispositional optimism, and perceptions of parental work drive, parental …

Exploring The Concept Of Human Oct3 Inhibitors As A Novel Class Of Antidepressants, Kavita A. Iyer

Theses and Dissertations

The Dukat laboratory developed 2-amino-6-chloro-3,4-dihydroquinazoline (A6CDQ) as a 5-HT₃ receptor ligand. A6CDQ and one of its positional isomers, the 7-chloro analog A7CDQ, produced antidepressant-like effects in the mouse tail suspension test (TST). We investigated and systematically ruled out a solely 5-HT₃ receptor or hSERT mediated mechanism of antidepressant-like effect for both A6CDQ and A7CDQ.

The role of organic cation transporter 3 (OCT3) as an alternative mechanism in the regulation of neurotransmitters including serotonin (5-HT) and the therapeutic potential of targeting hOCT3 to achieve antidepressant effects has been established. By virtue of possessing protonatable nitrogen atoms, 2-aminodihyroquinazolines could potentially …

Exploring The Role Of Intersectionality On Cardiovascular Disease Risk In Sexual Minorities, Leia Harper

Theses and Dissertations

Background: Previous research has shown that sexual minority individuals (SM) are twice as likely to smoke, twice as likely to be overweight or obese, and less likely to be physically active than heterosexual persons; all of which place SMs at an increased risk for cardiovascular disease (CVD). While information on CVD risk by race/ethnicity and socioeconomic status is well documented, there is scant literature examining race, gender, and the potential CVD risk in SMs. The purpose of this study was to examine CVD risk in sexual minorities.

Method: The current study used data from the National Longitudinal Study of Adolescent …

Is Your Student Fit For That College? A Study Of The Factors That Contribute To Students’ Academic Performance In College, Abdulaziz A. Alotaibi

Theses and Dissertations

The purpose of this study was to expand the extent of available literature in regard to the factors that contribute to students’ academic performance in college. It focused on a neglected segment of the student population, which is Saudi Arabian students studying in the United States. This study utilized a nonexperimental quantitative research design in order to investigate the relationship between the independent variables (the characteristics of the student, the characteristics of the program, and the academic and social integration between the student and the program) and the dependent variables (degree GPA, ability to graduate within academic program time frame, …

Dietary Adaptations And Intra- And Interspecific Variation In Dental Occlusal Shape In Hominin And Non-Hominin Primates, Kelsey O'Neill

Theses and Dissertations

Dental morphology and tooth shape have been used to recreate the

dietary adaptations for extinct species, and thus dental variation can provide

information on the relationship between fossil species and their

paleoenvironments. Variation in living species with known behaviors can provide

a baseline for interpreting morphology, and behavior, in the fossil record.

Tooth occlusal surface outlines in hominins and non-hominin primates, and other

mammals, have been used for assessments of taxonomic significance, with

variability often considered as being primarily phylogenetic. Few studies have

attempted to assess how diet might influence the pattern of variability in closely

related species. Here the …

Role Of Vav2 In Podocyte Inflammasome Activation And Glomerular Injury During Hyperhomocysteinemia, Sabena Conley

Theses and Dissertations

Hyperhomocysteinemia (hHcys) is a widely known pathogenic factor in the progression of end-stage renal disease (ESRD) and it is also associated with an increased risk for injurious cardiovascular pathologies during ESRD. HHcys is linked to the formation and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, characterized as a critical early mechanism initiating the inflammatory response. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) mediate the activation of the NLRP3 inflammasome in podocytes in response to elevated levels of homocysteine (Hcys) in vitro and in vivo. However, it remains unknown how NLRP3 inflammasome activation is triggered by NOX. The …

The Effects Of Tidal Forcing On Nutrient Fluxes In The Tidal, Freshwater James River Estuary, Va, Dana L. Devore

Theses and Dissertations

A 12-month study (January to December 2015) focused on the effects of tidal forcing on nutrient fluxes in the tidal, freshwater segment of the James River Estuary (JRE). Discrete sampling of nutrient chemistry and continuous monitoring of tidal discharge were used to determine the volume and timing of the tides, and differences in nutrient concentrations between incoming and outgoing tides. The goal of this study was to improve understanding of tidal influence on nutrient fluxes and their role in nutrient transport to the lower estuary. Results suggested that differences in nutrient concentrations between incoming and outgoing tides were small throughout …

Dimension Reduction And Variable Selection, Hossein Moradi Rekabdarkolaee

Theses and Dissertations

High-dimensional data are becoming increasingly available as data collection technology advances. Over the last decade, significant developments have been taking place in high-dimensional data analysis, driven primarily by a wide range of applications in many fields such as genomics, signal processing, and environmental studies. Statistical techniques such as dimension reduction and variable selection play important roles in high dimensional data analysis. Sufficient dimension reduction provides a way to find the reduced space of the original space without a parametric model. This method has been widely applied in many scientific fields such as genetics, brain imaging analysis, econometrics, environmental sciences, etc. …

Measurement Of Rare Earth And Uranium Elements Using Laser-Induced Breakdown Spectroscopy (Libs) In An Aerosol System For Nuclear Safeguards Applications, Ammon N. Williams

Theses and Dissertations

The primary objective of this research is to develop an applied technology and provide an assessment for remotely measuring and analyzing the real time or near real time concentrations of used nuclear fuel (UNF) elements in electrorefiners (ER). Here, Laser-Induced Breakdown Spectroscopy (LIBS) in UNF pyroprocessing facilities was investigated. LIBS is an elemental analysis method, which is based on the emission from plasma generated by focusing a laser beam into the medium. This technology has been reported to be applicable in solids, liquids (includes molten metals), and gases for detecting elements of special nuclear materials. The advantages of applying the …

Laser Vaporization Controlled Condensation And Laser Irradiation In Solution For The Synthesis Of Supported Nanoparticle Catalysts, Vitaly Kisurin Mr.

Theses and Dissertations

Solid catalyst supports of SiOx-RGO (Reduced Graphene Oxide) and UiO-67 (Universitet i Oslo) have been successfully synthesized and were loaded with palladium nanoparticles to test for a series of heterogeneous reactions. The SiOx/RGO catalysts were synthesized through laser ablation of silicon and graphite oxide micron powder and UiO-67 metal-organic framework (MOF) was synthesized through mixing of precursors with DMF/HCl solution and washing the resultant powder from impurities. The SiOx/RGO supports were later impregnated with palladium precursors which were then subject to Microwave Irradiation (MWI). The UiO-67 framework was impregnated with palladium precursors and was irradiated with pulsed Nd:YAG 532 nm …

What’S Real? What’S Not? : Reality Tv’S Effect On Relational Aggression Among Black College Women, Ashley N. Hill

Theses and Dissertations

Relational aggression, behaviors that manipulate social relationships, is a pressing issue among Black college women (Dahlen, Czar, Prather, & Dyess, 2013). As a result of experiencing and using relational aggression, Black women may experience diminished interpersonal interactions and poorer overall psychological well-being (Gomes, Davis, Baker, & Servonsky, 2009). The present study examined how Black reality television (BRTV) models relationally aggressive behaviors for viewers. According to Cultivation theory, television has the power to influence the social reality (i.e. attitudes and perceptions) of individuals who consume high amounts of television (Gerbner et al, 2002), while Identification theory suggests that deep cognitive and …

Optimizing Virtual Machine I/O Performance In Cloud Environments, Tao Lu

Theses and Dissertations

Maintaining closeness between data sources and data consumers is crucial for workload I/O performance. In cloud environments, this kind of closeness can be violated by system administrative events and storage architecture barriers. VM migration events are frequent in cloud environments. VM migration changes VM runtime inter-connection or cache contexts, significantly degrading VM I/O performance. Virtualization is the backbone of cloud platforms. I/O virtualization adds additional hops to workload data access path, prolonging I/O latencies. I/O virtualization overheads cap the throughput of high-speed storage devices and imposes high CPU utilizations and energy consumptions to cloud infrastructures. To maintain the closeness between …

Nostalgia And Iphone Camera Apps: An Ethnographic Visual Approach To Iphoneography, Maria L. De Panbehchi

Theses and Dissertations

The iPhone is the most popular smartphone and camera on social media. iPhoneography, the photography taken or edited with the iPhone, has set the trend of nostalgic photography on social media during the 2010s; thus, the iPhone, a high-tech camera, produces low-tech-looking images. This dissertation attempts to find out why iPhone photographers (iPhoneographers) take, edit, and share images that mimic photographs taken with analog photographic equipment. I argue that nostalgia allows iPhoneographers to use the iPhone as a creative tool and to belong to a community. Based on the arguments of Vilém Flusser—who suggested that photographers are more interested in …

Beyond The Single Story: How Analog Hypertext Facilitates Representation Of Multiple Critical Perspectives In An Art Museum Object Study Gallery, Aimee D. Hunt

Theses and Dissertations

This project utilized a form of arts based educational research described as analog hypertext to develop interpretative material representing multiple critical, theoretical, and disciplinary perspectives on objects in a university art museum’s object study gallery. Drawing on scholars’ recommendations for postcolonial interpretation of non-Western art, the project created a web of information, which simultaneously revealed and critiqued the underlying ideologies and power structures shaping the museum’s display in an effort to change existing interpretive practice. The project developed five color-coded thematic self-guided tours—art as commodity, spiritual practice, technology and cultural evolutionism, mortuary rituals, and postcolonial perspectives—presented to the public as …

Valuing Natural Space And Landscape Fragmentation In Richmond, Va, Lee Wyatt Carpenter

Theses and Dissertations

Hedonic pricing methods and GIS (Geographic Information Systems) were used to evaluate relationships between sale price of single family homes and landscape fragmentation and natural land cover. Spatial regression analyses found that sale prices increase as landscapes become less fragmented and the amount of natural land cover around a home increases. The projected growth in population and employment in the Richmond, Virginia region and subsequent increases in land development and landscape fragmentation presents a challenge to sustaining intact healthy ecosystems in the Richmond region. Spatial regression analyses helped illuminate how land cover patterns influence sale prices and landscape patterns that …