Digital Commons Network^™

Optimizing Virtual Machine I/O Performance In Cloud Environments, Tao Lu

Theses and Dissertations

Maintaining closeness between data sources and data consumers is crucial for workload I/O performance. In cloud environments, this kind of closeness can be violated by system administrative events and storage architecture barriers. VM migration events are frequent in cloud environments. VM migration changes VM runtime inter-connection or cache contexts, significantly degrading VM I/O performance. Virtualization is the backbone of cloud platforms. I/O virtualization adds additional hops to workload data access path, prolonging I/O latencies. I/O virtualization overheads cap the throughput of high-speed storage devices and imposes high CPU utilizations and energy consumptions to cloud infrastructures. To maintain the closeness between …

Nostalgia And Iphone Camera Apps: An Ethnographic Visual Approach To Iphoneography, Maria L. De Panbehchi

Theses and Dissertations

The iPhone is the most popular smartphone and camera on social media. iPhoneography, the photography taken or edited with the iPhone, has set the trend of nostalgic photography on social media during the 2010s; thus, the iPhone, a high-tech camera, produces low-tech-looking images. This dissertation attempts to find out why iPhone photographers (iPhoneographers) take, edit, and share images that mimic photographs taken with analog photographic equipment. I argue that nostalgia allows iPhoneographers to use the iPhone as a creative tool and to belong to a community. Based on the arguments of Vilém Flusser—who suggested that photographers are more interested in …

Beyond The Single Story: How Analog Hypertext Facilitates Representation Of Multiple Critical Perspectives In An Art Museum Object Study Gallery, Aimee D. Hunt

Theses and Dissertations

This project utilized a form of arts based educational research described as analog hypertext to develop interpretative material representing multiple critical, theoretical, and disciplinary perspectives on objects in a university art museum’s object study gallery. Drawing on scholars’ recommendations for postcolonial interpretation of non-Western art, the project created a web of information, which simultaneously revealed and critiqued the underlying ideologies and power structures shaping the museum’s display in an effort to change existing interpretive practice. The project developed five color-coded thematic self-guided tours—art as commodity, spiritual practice, technology and cultural evolutionism, mortuary rituals, and postcolonial perspectives—presented to the public as …

Valuing Natural Space And Landscape Fragmentation In Richmond, Va, Lee Wyatt Carpenter

Theses and Dissertations

Hedonic pricing methods and GIS (Geographic Information Systems) were used to evaluate relationships between sale price of single family homes and landscape fragmentation and natural land cover. Spatial regression analyses found that sale prices increase as landscapes become less fragmented and the amount of natural land cover around a home increases. The projected growth in population and employment in the Richmond, Virginia region and subsequent increases in land development and landscape fragmentation presents a challenge to sustaining intact healthy ecosystems in the Richmond region. Spatial regression analyses helped illuminate how land cover patterns influence sale prices and landscape patterns that …

Improved Capability Of A Computational Foot/Ankle Model Using Artificial Neural Networks, Ruchi D. Chande

Theses and Dissertations

Computational joint models provide insight into the biomechanical function of human joints. Through both deformable and rigid body modeling, the structure-function relationship governing joint behavior is better understood, and subsequently, knowledge regarding normal, diseased, and/or injured function is garnered. Given the utility of these computational models, it is imperative to supply them with appropriate inputs such that model function is representative of true joint function. In these models, Magnetic Resonance Imaging (MRI) or Computerized Tomography (CT) scans and literature inform the bony anatomy and mechanical properties of muscle and ligamentous tissues, respectively. In the case of the latter, literature reports …

Eeg Interictal Spike Detection Using Artificial Neural Networks, Howard J. Carey Iii

Theses and Dissertations

Epilepsy is a neurological disease causing seizures in its victims and affects approximately 50 million people worldwide. Successful treatment is dependent upon correct identification of the origin of the seizures within the brain. To achieve this, electroencephalograms (EEGs) are used to measure a patient’s brainwaves. This EEG data must be manually analyzed to identify interictal spikes that emanate from the afflicted region of the brain. This process can take a neurologist more than a week and a half per patient. This thesis presents a method to extract and process the interictal spikes in a patient, and use them to reduce …

The Role Of Matrix Metalloproteinase 9 And Osteopontin In Synaptogenesis And Reinnervation Of The Olfactory Bulb Following Brain Injury, Melissa A. Powell

Theses and Dissertations

Traumatic brain injury (TBI) is a serious health concern, causing cognitive, motor, and sensory deficits, including olfactory dysfunction. This dissertation explores the effects of TBI on synaptic plasticity within the olfactory system, seeking to define mechanisms guiding postinjury sensory reinnervation. Physical forces induced by TBI can axotomize olfactory receptor neurons (ORNs), which innervate olfactory bulb (OB). These axons regenerate OB projections after injury, a process involving growth through a complex extracellular matrix (ECM). As such, we investigated a potential molecular mechanism capable of modifying local OB ECM to support postinjury synaptogenesis. Since matrix metalloproteinases (MMPs) and their ECM substrates are …

Characterization Of Poly(Dimethylsiloxane) Blends And Fabrication Of Soft Micropillar Arrays For Force Detection, Thomas J. Petet Jr

Theses and Dissertations

Diseases involving fibrosis cause tens of thousands of deaths per year in the US alone. These diseases are characterized by a large amount of extracellular matrix, causing stiff abnormal tissues that may not function correctly. To take steps towards curing these diseases, a fundamental understanding of how cells interact with their substrate and how mechanical forces alter signaling pathways is vital. Studying the mechanobiology of cells and the interaction between a cell and its extracellular matrix can help explain the mechanisms behind stem cell differentiation, cell migration, and metastasis. Due to the correlation between force, extracellular matrix assembly, and substrate …

The Care Factor: The Importance Of Using Domain Identification Measures To Identify Stereotype Threat Vulnerability In High School Females, Kimberly Y. Randolph

Theses and Dissertations

Abstract

THE CARE FACTOR: THE IMPORTANCE OF USING DOMAIN IDENTIFICATION MEASURES TO IDENTIFY STEREOTYPE THREAT VULNERABILITY IN HIGH SCHOOL FEMALES.

By Kimberly Y. Randolph, PhD

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2016.

Major Director: Dr. Charol Shakeshaft, PhD. Professor Department of Educational Leadership

There is a gap that persists in math achievement between high school males and females. Although the NAEP 2015 longitudinal report shows a narrowing in math achievement between males and females there still remains a gap. More importantly, females are …

Forest Stand Structure And Primary Production In Relation To Ecosystem Development, Disturbance, And Canopy Composition, Cynthia M. Scheuermann

Theses and Dissertations

Temperate forests are complex ecosystems that sequester carbon (C) in biomass. C storage is related to ecosystem-scale forest structure, changing over succession, disturbance, and with community composition. We quantified ecosystem biological and physical structure in two forest chronosequences varying in disturbance intensity, and three late successional functional types to examine how multiple structural expressions relate to ecosystem C cycling. We quantified C cycling as wood net primary production (NPP), ecosystem structure as Simpson’s Index, and physical structure as leaf quantity (LAI) and arrangement (rugosity), examining how wood NPP-structure relates to light distribution and use-efficiency. Relationships between structural attributes of biodiversity, …

Design And Development Of A High-Temperature High-Pressure Rolling Ball Viscometer/Densimeter And Evaluation Of Star Polymer-Solvent Mixtures, Matthew Stanton Newkirk

Theses and Dissertations

Modern automotive applications such as transmission clutch plates, combustion chambers, diesel fuel injector tips, and axle gears and friction plates operate at temperatures that can exceed 250°C and pressures of 40,000 psia. Industrial practice is to add homopolymers and copolymers to base oils to modify bulk fluid viscosity and frictional properties for these demanding applications. However, designing polymeric additives for lubricants and predicting their performance is limited by the lack of available high-temperature high-pressure (HTHP) viscosity and density data needed to test contemporary lubricity models. Thus, a major objective of this thesis is the design, development, and commissioning of a …

Longitudinal Relations Between Parental Messages Supporting Fighting And Aggressive Behavior In Early Adolescence: The Moderating Role Of Positive Parenting Practices, Megan M. Carlson

Theses and Dissertations

The prevalence of physical aggression increases during adolescence and is associated with negative health outcomes. It is important to identify risk and protective processes for adolescent aggression in the context of the parent-adolescent relationship. The current study examined the potential moderating role of positive parenting at Wave 1 on relations between perceived parental messages supporting fighting at Wave 1 and adolescent aggression based on parent- and student-report at Wave 2. Participants included a sample of 537 adolescents and their primary caregivers, recruited from four sites in the U.S. No significant moderating effects were found. However, parental messages supporting fighting were …

Adjustment Profiles Among Youth In Diverse Cultural Contexts: Individual, Family, And Contextual Influences, Alicia Borre

Theses and Dissertations

Recent literature has noted that not all youth who experience adverse circumstances (e.g. poverty, exposure to violence, maltreatment) end up displaying expected unfavorable outcomes (e.g. academic failure, depression, drug dependence); in fact, some youth display “resilience,” broadly understood as adaptive functioning in the face of adversity (Luthar, Cicchetti, & Becker, 2000). Overall, research on resilience has offered a new approach to the study of at-risk populations, emphasizing the study of strengths, processes, and mechanisms among individuals and communities that may favor positive adaptation, rather than emphasizing deficits among those experiencing adversity (Schoon, 2012). Although resilience research has come a long …

The Role Of Enteric Glia In Opioid-Induced Constipation, Sukhada Bhave

Theses and Dissertations

Morphine is one of the most widely used drugs for the treatment of pain but its clinical efficacy is limited by adverse effects including persistent constipation and colonic inflammation. Morphine-induced colonic inflammation is facilitated by microbial dysbiosis and bacterial translocation. In this study, we demonstrate that secondary inflammation and persistent constipation are modulated by enteric glia. In chronic morphine treated mice (75 mg morphine pellet/5 days), ATP-induced currents were significantly enhanced in enteric glia isolated from the mouse colon myenteric plexus. Chronic morphine resulted in significant disruption of the colonic epithelium and increased Il-1β in the myenteric plexus. The increase …

An Investigation Of Kinetic Visual Biofeedback On Dynamic Stance Symmetry, Trisha J. Massenzo

Theses and Dissertations

The intent of the following research is to utilize task-specific, constraint-induced therapies and apply towards dynamic training for symmetrical balance. Modifications to an elliptical trainer were made to both measure weight distributions during dynamic stance as well as provide kinetic biofeedback through a man-machine interface. Following a review of the background, which includes research from several decades that are seminal to current studies, a design review is discussed to cover the design of the modified elliptical (Chapter 2).

An initial study was conducted in a healthy sample population in order to determine the best visual biofeedback representation by comparing different …

Exploring Predictors Of Teamwork Performance In An Interprofessional Education Setting, Danah Alsane, Patricia Slattum W. Slattum

Theses and Dissertations

Abstract

EXPLORING PREDICTORS OF TEAMWORK PERFORMANCE IN AN INTERPROFESSIONAL EDUCATION SETTING

By Danah M. Alsane, MS.

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Pharmaceutical Science at Virginia Commonwealth University

Virginia Commonwealth University, 2016

Advisor: Patricia Slattum, Pharm.D., Ph.D.

Professor and Director of the Geriatric Pharmacotherapy Program

Department of Pharmacotherapy and Outcomes Science

Objectives: The primary objective of this study was to explain how individual characteristics influence teamwork development. In addition, it evaluated how teamwork development, in conjunction with content knowledge, impact students’ performance on a team-based project in an Interprofessional Quality Improvement …

Joint Detection-State Estimation And Secure Signal Processing, Mengqi Ren

Theses and Dissertations

In this dissertation, joint detection-state estimation and secure signal processing are studied. Detection and state estimation are two important research topics in surveillance systems. The detection problems investigated in this dissertation include object detection and fault detection. The goal of object detection is to determine the presence or absence of an object under measurement uncertainty. The aim of fault detection is to determine whether or not the measurements are provided by faulty sensors. State estimation is to estimate the states of moving objects from measurements with random measurement noise or disturbance, which typically consist of their positions and velocities over …

Investigating The Role Of The Nucleosome Remodeling Factor Ino80 In Development And Nurf In Anti-Tumor Immunity, Zeinab Abdallah Elsayed Ms

Theses and Dissertations

Understanding how an epigenetic regulator such as ATP-dependent chromatin-remodeling complexes modulate processes such as development and/or immune response is essential for our comprehension of cell biology. Deletion of the ATP-dependent chromatin remodeling factor INO80 is known to be embryonically lethal, however, the mechanism is not known. To identify roles for INO80 in mouse early development we generated Ino80 KO mice. Ino80 KO ESCs (Embryonic stem cells) were viable when maintained at ground state pluripotency but fail to differentiate in vitro and in vivo. Gene expression analysis of Ino80 KO early embryos by in situ hybridization showed elevated Bmp4 expression …

Wreading, Performing, And Reflecting: The Application Of Narrative Hypertext And Virtual World Experiences To Social Work Education, Linda Ayscue Gupta Phd

Theses and Dissertations

In this dissertation I propose the use of a new media composition of narrative hypertext, performances in a virtual world, and a dialogic process of writing to provide a continuum of learning opportunities in social work education. I suggest that the structure of the hypertext narrative, embedded with hypermedia, mirrors the dissociative aspects of traumatic memory. I argue that work with the multivocality and multisequentiality of narrative hypertext emulates the process of discovery in the clinical interview. The immersive component of work in a virtual world deepens the realism and affective impact of simulations and creates opportunities to practice and …

Understanding And Design Of An Arduino-Based Pid Controller, Dinesh Bista

Theses and Dissertations

This thesis presents research and design of a Proportional, Integral, and Derivative (PID) controller that uses a microcontroller (Arduino) platform. The research part discusses the structure of a PID algorithm with some motivating work already performed with the Arduino-based PID controller from various fields. An inexpensive Arduino-based PID controller designed in the laboratory to control the temperature, consists of hardware parts: Arduino UNO, thermoelectric cooler, and electronic components while the software portion includes C/C++ programming. The PID parameters for a particular controller are found manually. The role of different PID parameters is discussed with the subsequent comparison between different modes …

The Family Affective Attitude Rating Scale In Children With Asthma: The Association Between Relational Schemas And Emotional Security, Jessica L. Greenlee

Theses and Dissertations

The Five Minute Speech sample is a cost effective, efficient means of data collection in developmental research, but recent criticism of traditional coding methods associated with the methodology has spurred the creation of more developmentally appropriate coding systems. The purpose of this study is to examine the reliability and validity of a new coding system, The Family Affective Attitudes Rating Scale (FAARS), for use in children with chronic illness. Results did not support the use of this coding system, at least in its current form, in a pediatric asthma population. Discussion focuses on whether the FAARS may be of use …

Development Of A Two-Factor Self-Forgiveness Scale, Brandon J. Griffin

Theses and Dissertations

Notwithstanding progress made in description, prediction, and manipulation of self-forgiveness, the extant literature continues to be wrought with theoretical and empirical quandaries. In the current dissertation, I conceptualize self-forgiveness within the framework of Social Cognitive Theory and develop a two-factor scale to assess distinct decisional and emotional aspects of self-forgiveness among perpetrators of interpersonal transgressions. In Study One, I test the hypothesized two-factor structure in a new measure of state self-forgiveness and provide preliminary evidence supporting construct validity via associations of that measure with perceived responsibility, guilt, and shame. In Study Two, I replicate the factor structure and provide preliminary …

Examining Ptsd Symptoms And The Effectiveness Of Group Therapy Among African American And Caucasian Veterans, Jennifer A. Coleman

Theses and Dissertations

Millions of Americans have served in the military, and improved survival rates in wars have increased the percentage of those who return home. Posttraumatic stress disorder (PTSD) is one of the most prevalent mental health diagnoses for veterans. Although few studies have examined the link, previous research as well as the minority stress model and transgenerational trauma theories, suggest that race may be associated with PTSD, particularly in military samples. The current study examined whether there were differences in PTSD symptomology (global and symptom cluster-specific) based on veterans’ race and whether group therapy effectively reduced symptoms of PTSD. Data were …

Internal And External Validity Of Sluggish Cognitive Tempo In Young Adolescents With Adhd, Zoe Smith

Theses and Dissertations

Adolescents with Sluggish Cognitive Tempo (SCT) show symptoms of slowness, mental confusion, excessive daydreaming, low motivation, and drowsiness/sleepiness. Although many symptoms of SCT reflect internalizing states, no study has evaluated the utility of self-report of SCT in an ADHD sample. Further, it remains unclear whether SCT is best conceptualized as a unidimensional or multidimensional construct. In a sample of 262 adolescents comprehensively diagnosed with ADHD, the present study evaluated the dimensionality of a SCT scale and compared CFA and bifactor model fits for parent- and self-report versions. Analyses revealed the three-factor bifactor model to be the best fitting model. In …

Atm Phosphorylates Subunit A Of Pp2a Resulting In Its Nuclear Export And Spatiotemporal Regulation Of The Dna Damage Response, Amrita D. Sule

Theses and Dissertations

Ataxia telangiectasia mutated (ATM) is a serine-threonine protein kinase and major regulator of the DNA damage response (DDR). One critical ATM target is protein phosphatase 2A (PP2A) known to regulate diverse cellular processes such as mitosis and cell growth as well as dephosphorylation of many proteins during the recovery from the DDR while returning the cell to normalcy. Interestingly, ATM and PP2A are known to form an auto-regulatory yin-yang kinase-phosphatase relationship. Herein, we show that the phosphorylation of the PP2A-Aα structural subunit at S401 by ATM results in nuclear export, which regulates the DDR at multiple levels and affects genomic …

A Reused Distance Based Analysis And Optimization For Gpu Cache, Dongwei Wang

Theses and Dissertations

As a throughput-oriented device, Graphics Processing Unit(GPU) has already integrated with cache, which is similar to CPU cores. However, the applications in GPGPU computing exhibit distinct memory access patterns. Normally, the cache, in GPU cores, suffers from threads contention and resources over-utilization, whereas few detailed works excavate the root of this phenomenon. In this work, we adequately analyze the memory accesses from twenty benchmarks based on reuse distance theory and quantify their patterns. Additionally, we discuss the optimization suggestions, and implement a Bypassing Aware(BA) Cache which could intellectually bypass the thrashing-prone candidates.

BA cache is a cost efficient cache design …

2016-01-00 Concerns, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress concerns for January of 2016.

A Flipped Classroom Redesign In General Chemistry, Scott A. Reid

Chemistry Faculty Research and Publications

The flipped classroom continues to attract significant attention in higher education. Building upon our recent parallel controlled study of the flipped classroom in a second-term general chemistry course (J. Chem. Educ., 2016, 93, 13–23), here we report on a redesign of the flipped course aimed at scaling up total enrollment while keeping discussion sizes small (i.e.,students), and maintaining equivalent contact hour load for faculty and workload for students. To that end, the course format featured lecture contact pushed outside of the classroom in the form of video lectures (mean duration 13 minutes) paired with online …

Reactivity Of (3-Methylpentadienyl)Iron(1+) Cation: Late-Stage Introduction Of A (3-Methyl-2z,4-Pentadien-1-Yl) Side Chain, Subhabrata Chaudhury, Shukun Li, William A. Donaldson

Chemistry Faculty Research and Publications

The 3-methyl-2Z,4-pentadien-1-yl sidechain is found in various sesquiterpenes and diterpenes. A route for the late stage introduction of this functionality was developed which relies on nucleophilic attack on the (3-methylpentadienyl)iron(1+) cation, followed by oxidative decomplexation. This methodology was applied to the synthesis of the proposed structure of heteroscyphic acid A methyl ester. Realization of this synthesis led to a correction of the proposed structure.

Does Koopmans’ Paradigm For 1-Electron Oxidation Always Hold? Breakdown Of Ip/EOx Relationship For P-Hydroquinone Ethers And The Role Of Methoxy Group Rotation, Marat R. Talipov, Anitha Boddeda, Sergey V. Lindeman, Rajendra Rathore

Chemistry Faculty Research and Publications

Koopmans’ paradigm states that electron loss occurs from HOMO, thus forming the basis for the observed linear relationships between HOMO/IP, HOMO/Eox, and IP/E_ox. In cases where a molecule undergoes dramatic structural reorganization upon 1-electron oxidation, the IP/E_oxrelationship does not hold, and the origin of which is not understood. For example, X-ray crystallography of the neutral and cation radicals of bicyclo[2.2.1]heptane-annulated p-hydroquinone ethers (^THE and ^MHE) showed that they undergo electron-transfer-induced conformational reorganization and show breakdown of the IP/E_ox relationship. DFT calculations revealed that Koopmans’ paradigm …