Digital Commons Network^™

1995 The Log Of Beaver College

University Yearbooks

No abstract provided.

1996 The Log Of Beaver College

University Yearbooks

No abstract provided.

1997 The Log Of Beaver College

University Yearbooks

No abstract provided.

1998 The Log Of Beaver College

University Yearbooks

No abstract provided.

1999 The Log Of Beaver College

University Yearbooks

No abstract provided.

2000 The Log Of Beaver College

University Yearbooks

No abstract provided.

2001 The Log Of Beaver College

University Yearbooks

No abstract provided.

2003 Arcadia University Enthymion

University Yearbooks

No abstract provided.

2004 Arcadia University Enthymion

University Yearbooks

No abstract provided.

2005 Arcadia University Enthymion

University Yearbooks

No abstract provided.

2006 Arcadia University Enthymion

University Yearbooks

No abstract provided.

2007 Arcadia University Enthymion

University Yearbooks

No abstract provided.

2008 Arcadia University Enthymion

University Yearbooks

No abstract provided.

2009 Arcadia University Enthymion

University Yearbooks

No abstract provided.

Development, Manufacturing, And Supply Of Msd’S Ebola Vaccine, Jeffrey T. Blue

Vaccine Technology VI

Ebola was first discovered in 1976 and is a member of the filoviridae family of viruses. There are multiple strains of Ebola and infection can lead to hemorrhagic fever and death. In March 2014, a historic Ebola outbreak occurred in three Western African countries, Guinea, Liberia, and Sierra Leone. Over 28,000 cases were reported and led to more than 11,000 deaths, more than ten times the amount of cases compared to all past outbreaks combined. On August 8^th 2014, the World Health Organization declared a Public Health Emergency of International Concern (PHEIC). Merck Sharp & Dohme (MSD) partnering with …

Description Of Mesocriconema Ericaceum N. Sp. (Nematoda: Criconematidae) And Notes On Other Nematode Species Discovered In An Ericaceous Heath Bald Community In Great Smoky Mountains National Park, Usa, Thomas O. Powers, Peter Mullin, Rebecca Higgins, Timothy Harris, Kirsten S. Powers

Department of Plant Pathology: Faculty Publications

A new species of Mesocriconema and a unique assemblage of plant-parasitic nematodes was discovered in a heath bald atop Brushy Mountain in Great Smoky Mountains National Park. Mesocriconema ericaceum n. sp., a species with males, superficially resembles M. xenoplax. DNA barcoding with the mitochondrial COI gene provided evidence of the new species as a distinct lineage. SEM revealed significant variability in arrangement of labial submedian lobes, plates, and anterior and posterior annuli. Three other nematodes in the family Criconematidae were characterized from the heath bald. Ogma seymouri, when analyzed by statistical parsimony, established connections with isolates from north-eastern Atlantic …

Improving Global Human Health Through Norovirus Virus-Like Particle Manufacturing, Scot Shepard

Vaccine Technology VI

Norovirus infection is the most common cause of acute gastroenteritis in the U.S., estimated to afflict 21 million people per year. For scale-up manufacturing of a norovirus vaccine candidate, the baculovirus expression system has been used in 1000 L working volume stirred-tank bioreactors for production of two distinct norovirus virus-like particles (VLP). Downstream processing using methods for enveloped virus inactivation and a series of orthogonal chromatography steps results in norovirus VLP that contain low residual levels of host-cell protein, host cell and baculovirus DNA, and are free of replicating baculovirus. Emphasis has been placed on employing single-use technologies including disposable …

Research Experience Leads Alumna To Residency Program, Sarah Gardner, Dave Albee

Press Releases

Motivated by the learning environment at Dominican, Natalie Aquino ’12 earned her doctorate of pharmacy last month at the University of California San Francisco. Now she is matched to the UC Davis Medical Center (PGY-1) acute care pharmacy residency program that will start this summer.

Session V: Getting Vaccines To The Market: Case Studies, Rebecca Sheets, Grimalkin Partners, Danilo Casimiro

Vaccine Technology VI

This is a presentation of Session V.

(No Abstract)

We Are...Marshall, June 15, 2016, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Selective Phenotyping Traits Related To Multiple Stress And Drought Response In Dry Bean, Jennifer J. Trapp, Carlos A. Urrea, Jianfeng Zhou, Lav R. Khot, Sindhu Sankaran, Phillip N. Miklas

Panhandle Research and Extension Center

Abiotic stress tolerance in dry bean (Phaseolus vulgaris L.) is complex. Increased population sizes are contributing to finding QTL conditioning stress response but phenotyping has not kept pace with high throughput genotyping for such studies. Our objectives were to determine effectiveness of 20 most tolerant and 20 most susceptible lines representing phenotypic extremes from a RIL population (‘Buster’ x 'Roza’ [BR]) to facilitate examination of 19 traits for relevance to stress response and to validate existing QTL conditioning stress response. Using phenotypic extremes tested across multiple trials, eight of the 19 traits were clearly associated with drought stress. Pod …

Nfat5/Stat3 Interaction Mediates Synergism Of High Salt With Il-17 Towards Induction Of Vegf-A Expression In Breast Cancer Cells, Suneetha Amara, Dalal Alotaibi, Venkataswarup Tiriveedhi

Biology Faculty Research

Chronic inflammation has been considered an important player in cancer proliferation and progression. High salt (sodium chloride) levels have been considered a potent inducer of chronic inflammation. In the present study, the synergistic role of high salt with interleukin (IL)‑17 towards induction of the inflammatory and angiogenic stress factor vascular endothelial growth factor (VEGF)‑A was investigated. Stimulation of MCF-7 breast cancer cells with high salt (0.2 M NaCl) and sub‑minimal IL‑17 (1 ng/ml) enhanced the expression of VEGF-A (2.9 and 2.6-fold, respectively, P<0.05) compared with untreated cells. Furthermore, co‑treatment with both high salt and sub‑minimal IL‑17 led to a 5.9‑fold increase in VEGF‑A expression (P<0.01), thus suggesting a synergistic role of these factors. VEGF‑A promoter analysis and specific small interfering RNA knock‑down of transcription factors revealed that high salt induced VEGF‑A expression through nuclear factor of activated T‑cells (NFAT)5, while IL‑17 induced VEGF‑A expression via signal transducer and activator of transcription (STAT)3 signaling mechanisms. Treatment of normal human aortic endothelial cells with the supernatant of activated MCF‑7 cells enhanced cell migration and induced expression of migration‑specific factors, including vascular cell adhesion protein, β1 integrin and cluster of differentiation 31. These data suggest that high salt levels synergize with pro‑inflammatory IL‑17 to potentially induce cancer progression and metastasis through VEGF‑A expression. Therefore, low‑salt diet, anti‑NFAT5 and anti‑STAT3 therapies may provide novel avenues for enhanced efficiency of the current cancer therapy.

A Generalized Computer Vision Approach To Mapping Crop Fields In Heterogeneous Agricultural Landscapes, Stephanie R. Debats, Dee Luo, Lyndon Estes, Thomas J. Fuchs, Kelly K. Caylor

Geography

Smallholder farms dominate in many parts of the world, particularly Sub-Saharan Africa. These systems are characterized by small, heterogeneous, and often indistinct field patterns, requiring a specialized methodology to map agricultural land cover. Using a variety of sites in South Africa, we present a new approach to mapping agricultural fields, based on efficient extraction of a vast set of simple, highly correlated, and interdependent features, followed by a random forest classifier. We achieved similar high performance across agricultural types, including the spectrally indistinct smallholder fields as well as the more easily distinguishable commercial fields, and demonstrated the ability to generalize …

Temperature-Dependent Pathogenicity Of Grouper Iridovirus Of Taiwan (Tgiv), Hsin-I Liu, Ying-Chu Lin, Pinwen Peter Chiou, Hsin-Yiu Chou

Journal of Marine Science and Technology–Taiwan

Grouper iridovirus of Taiwan (TGIV) is one of the most devastating infectious pathogens of grouper fry in Taiwan. As environmental temperature often plays an important role in the outbreak of diseases, we assayed the impact of different temperatures (18, 25 and 32℃) on TGIV infection both in vitro and in vivo. Cytopathic effect (CPE) characterized as cell rounding and lysis were observed in TGIV-infected grouper SB (swim bladder) cells at 25℃ and 32℃, but was absent at 18℃. With temperature rising to 32℃, the presence of pycnotic nuclei and chromatin margination became prominent in the infected cells, indicating an apoptotic …

Holy Cross Magazine, Vol. 50, No. 3, Summer 2016, College Of The Holy Cross

Holy Cross Magazine

Syllabus: Corporation Finance
with Nancy Baldiga, professor of accounting
By Maura Sullivan Hill

Staging “Hamlet,” on Campus and in the Community
The theatre department’s spring production of Shakespeare’s “Hamlet,” set in the present day and in modern dress, explores the anxiety of youth.
By Katharine Whittemore

His Brother’s Keeper
Broderick Johnson ’78 made the journey from The Hill to Capitol Hill, and then to the Obama White House. Along the way, his priority has always been to give back to others.
By Debra Steilen

Going the Way of the Dodo
Professor Leon Claessens studies the bird that other scientists—and society …

Facilitating The Release Of Bionutrients From Morinda Citrifolia (Noni) By Cellulase Hydrolysis And Lactic Acid Bacteria Fermentation And Their Effects On Α-Amylase And Α-Glucosidase Activities, Hui-Hung Lee, Li-Jung Yin, Hsueh-Ming Tai, Shann-Tzong Jiang

Journal of Marine Science and Technology–Taiwan

For facilitating the release of bionutrients from noni, 6 h of hydrolysis with 100 U/mL cellulase at 50℃ and an additional 48 h of fermentation with Pediococcus pentosaceus BCRC 14053 at 37℃ were performed. Increases in the extraction yields (87.8-607.8 mg/g) and the total phenolic content (2.02-7.45 mg/g) of various extracts were obtained, suggesting that bionutrients were released from noni during hydrolysis or fermentation. In hydrolyzed and/or additionally fermented samples, significant decreases in the half maximal inhibitory concentration (IC50) against α-amylase (10.28-1.61 mg/mL) and α-glucosidase (46.47-3.73 mg/mL) were observed. Gas chromatography–mass spectrometry results revealed that the major components with these …

A Cross-Species Bi-Clustering Approach To Identifying Conserved Co-Regulated Genes, Jiangwen Sun, Zongliang Jiang, Xiuchun Tian, Jinbo Bi

Faculty Publications

© 2016 The Author 2016. Published by Oxford University Press. Motivation: A growing number of studies have explored the process of pre-implantation embryonic development of multiple mammalian species. However, the conservation and variation among different species in their developmental programming are poorly defined due to the lack of effective computational methods for detecting co-regularized genes that are conserved across species. The most sophisticated method to date for identifying conserved co-regulated genes is a two-step approach. This approach first identifies gene clusters for each species by a cluster analysis of gene expression data, and subsequently computes the overlaps of clusters identified …

Performance And Cross-Crop Resistance Of Cry1f-Maize Selected Spodoptera Frugiperda On Transgenic Bt Cotton: Implications For Resistance Management, Fei Yang, David L. Kerns, Sebe Brown, Ryan Kurtz, Tim Dennehy, Bo Braxton, Graham Head, Fangneng Huang

Faculty Publications

Transgenic crops producing Bacillus thuringiensis (Bt) proteins have become a primary tool in pest management. Due to the intensive use of Bt crops, resistance of the fall armyworm, Spodoptera frugiperda, to Cry1F maize has occurred in Puerto Rico, Brazil, and some areas of the southeastern U.S. The sustainability of Bt crops faces a great challenge because the Cry1F-maize resistant S. frugiperda may also infest other Bt crops in multiple cropping ecosystems. Here we examined the survival and plant injury of a S. frugiperda population selected with Cry1F maize on three single-gene and five pyramided Bt cotton products. Larvae of Cry1F-susceptible …

Volume 53, Number 44: June 15, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Potential Roles Of Amiloride-Sensitive Sodium Channels In Cancer Development, Siguang Xu, Cui Liu, Yana Ma, Hong-Long Ji, Xiumin Li

Cellular and Molecular Biology Faculty Publications and Presentations

The ENaC/degenerin ion channel superfamily includes the amiloride-sensitive epithelial sodium channel (ENaC) and acid sensitive ionic channel (ASIC). ENaC is a multimeric ion channel formed by heteromultimeric membrane glycoproteins, which participate in a multitude of biological processes by mediating the transport of sodium (Na+) across epithelial tissues such as the kidney, lungs, bladder, and gut. Aberrant ENaC functions contribute to several human disease states including pseudohypoaldosteronism, Liddle syndrome, cystic fibrosis, and salt-sensitive hypertension. Increasing evidence suggests that ion channels not only regulate ion homeostasis and electric signaling in excitable cells but also play important roles in cancer cell behaviors such …