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Transcriptional And Post-Transcriptional Regulation Of Nrf2 In The Heart By The Deubiquitinase Cyld, Bryan J. Mathis

Theses and Dissertations

The cylindromatosis (CYLD) is a K63-linked deubiquitinase (DUB) that has been linked to the regulation of multiple physiological or pathological processes, such as neural development, inflammation and fibrosis. However, a novel paradigm for CYLD has been recently postulated; namely that of CYLD as a mediator of cardiac disease. Nuclear factor, erythroid-2 related factor 2 (Nrf2), a master antioxidant transcription factor, has been shown to suppress cardiac pathological remodeling and dysfunction via downregulation of reactive oxygen species formation (ROS). It is normally regulated by Kelch-like ECH associated protein 1 (Keap1). However, the regulatory link between CYLD and Nrf2 in the diseased …

The Undiagnosed Patient And The Diagnostic Odyssey: Current Genetic Counseling Practices And Perspectives, Amelia Cordell Wardyn

Theses and Dissertations

Patients seen in genetics clinics often endure a diagnostic odyssey in their search for answers for their medical symptoms. This time is not only challenging for patients and their families, but also for the genetic counselors who are trying to help the patients. Previous research has shown that parents of children with undiagnosed medical disorders have specific goals and reasons for wanting to find a diagnosis, and there are many difficulties faced by these parents. Genetic counselors often serve as a prominent figure during the diagnostic odyssey, but little known research has assessed the current practices of and impact that …

An Investigation Of The Succination Of The Selenoproteins Thioredoxin Reductase And Glutathione Peroxidase, Scott Lanci

Theses and Dissertations

We have identified the irreversible protein modification S-(2-succino)cysteine, a product of the Kreb’s cycle intermediate fumarate reacting with the thiol group of cysteine (Cys) residues, also termed succination. Succination is increased in adipose tissue of diabetic mice in vivo and in adipocytes matured in high glucose medium (25 mM) in vitro. Selenocysteine (Sec) is a less common but highly conserved amino acid that has major functions in redox chemistry. Sec possesses a lower pKa (~5.4) and is much more reactive in comparison to Cys. This project aimed to determine if succination occurred on Sec residues in two selenoproteins that play …

Novel Methods For Analyzing Longitudinal Data With Measurement Error In The Time Variable, Caroline Munindi Mulatya

Theses and Dissertations

In some longitudinal studies, the observed time points are often confounded with measurement error due to the sampling conditions, resulting into data with measurement error in the time variable. This type of data occurs mainly in observational studies when the onset of a longitudinal process is unknown or in clinical trials when individual visits do not take place as specified by the study protocol, but are often rounded to coincide with the study protocol. Methodological and inferential implications of error in time varying covariates for both linear and nonlinear models have been studied widely. In this dissertation, we shift attention …

Assessing The Effects Of The Mud Snail, Ilyanassa Obsoleta, On The Benthic Microalgal Community In A Pristine Saltmarsh, Miranda Gore

Theses and Dissertations

Saltmarshes are among the most productive ecosystems globally. At North Inlet estuary, South Carolina, about one third of the primary production comes from benthic microalgae. During the tidal cycle, mobile microalgae vertically migrate through the upper 3 mm of sediment. At low tide, algae are vulnerable to a variety of grazers, including the mud snail, Ilyanassa obsoleta, which is abundant in tidal creeks. Many species of intertidal snails have been shown to significantly alter the community structure and density of microalgae within the sediment. The purpose of this study was to determine how I. obsoleta affects the benthic microalgae community …

Editorial: Linking Ecosystem Function To Microbial Diversity, Anne E. Bernhard, John J. Kelly

Biology: Faculty Publications and Other Works

No abstract provided.

Conversations About Sexuality On A Public University Campus: Exploring Perspectives From Campus Ministry Leaders And Students, Charis Rebecca Davidson

Theses and Dissertations

Since the 1800s, religious organizations have been a presence on public universities. However, there is limited research on the influence these organizations may have on student health communication and behaviors. Prior research on campus ministries has focused primarily on the culture of individual organizations. In this study, researchers explored the goals and experiences of USC leaders related to communication around sexuality with their students, as well as student perceptions of these messages, and how students incorporate religious messages about sexuality into their lives. The present study had four aims:

1. Assess whether students participating in campus ministries at USC differ …

The Influence Of Motivational Salience On Attention Selection: An Erp Investigation, Constanza De Dios

USF Tampa Graduate Theses and Dissertations

The current study used event-related potentials (ERPs) to investigate how motivational salience in the form of expectation violation influences spatial attention. The medial frontal negativity (MFN) ERP indexes expected value, being negative to unexpected punishments and positive to unexpected rewards. The P1 and N1 ERPs index spatial attention, being larger to stimuli in attended locations. This design attached motivational value to locations by making one visual hemifield economically rewarding (greater probability of a rewarding outcome) and the other punishing (greater probability of a punishing outcome). Keypresses to a dot probe following a reward-signifying stimulus were awarded money if correct, and …

Hexamethylene Diisocyanate Homopolymer And Monomer Exposure Assessment And Characterization At An Automobile Manufacturer In The United States, Karthik Reguram Sivaraman

USF Tampa Graduate Theses and Dissertations

A variety of paint products are used for their aesthetic and anti-corrosive properties. Isocyanates are consistently found in automobile paint products, particularly in clear coat polyurethane products. Clear coat is typically sprayed via pressurized air by means of an auto-spray robot. In clear coat repair situations, manual, air-powered spray guns are used, and manual spray Operators administer the clear coat material. The isocyanates are a primary anti-corrosive agent in polyurethane products. The Occupational Safety and Health Administration (OSHA) has not established a Permissible Exposure Limit (PEL). The National Institute for Occupational Safety and Health (NIOSH) and American Conference of Governmental …

The Effects Of Personal And Family History Of Cancer On The Development Of Dementia In Japanese Americans: The Kame Project, Adam Lee Slotnick

USF Tampa Graduate Theses and Dissertations

An increasing number of studies have shown an inverse association between a personal history of cancer (PHC) and dementia/Alzheimer’s disease (AD), both in those using dementia/AD as the outcome or cancer as the outcome. This is the first study to examine this potential association in Japanese Americans; and to examine family history of cancer and its association with incident dementia. Also, the association between these two diseases in the parents of participants were analyzed.

The Kame Project, conducted from 1992 through 2001 in King County, Washington was a population-based, prospective cohort study of older Japanese Americans. Conversion to incident dementia …

A‌ ‌Study‌ ‌Of‌ ‌The‌ ‌Factors‌ ‌That‌ ‌Lead‌ ‌To‌ Burnout‌ ‌In‌ ‌The‌ ‌Accounting‌ ‌Profession‌, Stephen N. Kervin

Theses and Dissertations

This applied dissertation was designed to provide information on the causes of burnout to employees in the accounting profession. A review of the literature revealed research on many different industries, but a lack on research within the accounting profession. The purpose of this research study was to examine what demographic variables increase the likelihood of an employee suffering from burnout.

In order to identify the causes of burnout for accountants, this study used a descriptive research design. The research utilized the Maslach Burnout Inventory-General Survey and a demographic questionnaire.

Quantitative analysis was applied to the interpretation of the descriptive data …

Indigenous Movements In Southeast Asia: An Analysis Based On The Concept Of ‘Resonance’, Isabel Inguanzo, Claire Wright

Asia-Pacific Social Science Review

This paper analyses the different indigenous movements that have been active in Southeast Asia over the past 30 years. For that purpose, the concept of “resonance” is used, due to its versatility as a perspective for the study of social movements. The analysis is descriptive and longitudinal given that the resonance of indigenous mobilization is analyzed in each one of the seven Southeast Asian territories, from 1980 until 2010. It is worth highlighting that the information used in the analysis comes mainly from in-depth interviews with members of organizations advocating the rights of indigenous peoples in the region. Consequently, this …

Research Agenda On History And Culture In Relation To Peace And Development In Mindanao Focus On The Homeland, Rolando C. Esteban

Asia-Pacific Social Science Review

No abstract provided.

Engaruh Model Pembelajaran Problem-Based Field Investigation (Pbfi) Terhadap Kemampuan Bertanya, Agung Wibowo, Hadi Sowono, Dwi Listyorini

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The purpose of this study was to determine the effect of learning model Problem-Based Field Investigation toward questioning skill of biology students of the State University of Malang (UM). This research quasi experimental elaborated One Group Time-Series Design. The study was conducted on 26 students who take a Limnology course. Data were collected from the observation and questionnaire before and after the application of the model. Based on the results of Analysis of Variance (ANOVA) with significance level of 0.05 (P value<0.05) showed that questioning skill increased significantly over time (P = 0.000).

Pembelajaran Berbasis Proyek Berbantuan Modul Program Krpl Untuk Mengembangkan Sikap Peduli Lingkungan Dan Keterampilan Proses Sains Siswa Sd Islam Moh. Hatta Malang, Bonny Timutiasari, Mimien Henie Irawati, Suhadi Suhadi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The results of observations in November 2015 in SD Islam Moh. Hatta Malang shows that activities related to science learning done using more discussion. This thing makes science learning activities becomes less meaningful. One solution that can be done is to provide differentiated learning. Learning that used is the project-based learning (PjBL) assisted module of KRPL program. Some aspects that can be measured during PjBL learning activities is the science process skills and attitude of care for the environment. The average yield environmental gains caring attitude of students before and after PjBL are respectively 85.20% and 95.04%. The average yield …

Pembelajaran Role Playing Dipadu Group Investigation Berbantuan Komik Program Krpl Sebagai Upaya Untuk Mengembangkan Kemampuan Kognitif Dan Sikap Sosial, Vindri Catur Putri Wulandari, Mimien Henie Irawati, Suhadi Suhadi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Lack of attention from the teacher to the learning process because it is more focused on students results. Need a way to develop students' cognitive ability. Students' understanding of the material is not enough, social attitudes must be developed. Students are required to have an attitudes such as honest, responsibilities, polite and caring. This research aims were to know combined of Role Playing (RP) and Group Investigation (GI) assisted comic of KRPL program can develop cognitive ability and society attitudes. This research subject is a fourth grade student at SDI Moh. Hatta Malang. This research is a qualitative descriptive study. …

Mir-217 Regulates Heme Oxygenase-1 Expression In ‘Humanized’ Renal Proximal Tubular Cells, Ravindra Boddu, Travis D. Hull, Reny Joseph, Amie M. Traylor, Anupam Agarwal

Manipal Journal of Medical Sciences

Background: Heme oxygenase-1 (HO-1) is an inducible enzyme that affords cytoprotection in reaction to cellular stress and tissue damage. To study the in vivo regulation of human HO-1 gene expression at the molecular level, our laboratory previously generated HO-1 transgenic (hBAC mice) mice that lack murine HO-1 gene and overexpress a human HO-1 transgene on a BAC or bacterial artificial chromosome. The human HO-1 levels in the basal state in various tissues including the kidneys were significantly elevated in hBAC mice compared to HO-1 wild type (WT) mice. Previously, microRNAs or miRNAs have been reported to be involved in the …

Significance Of Serum Uric Acid Levels In Non-Arthritic Psoriasis With Special Reference To Metabolic Syndrome, Chetana Shenoy, Manjunath Shenoy M, Manjula Shantaram, Soumya Shetty, Nitin B. Nair, Arjun Ajay Shankar

Manipal Journal of Medical Sciences

Background: Psoriasis has been considered of late as dermatological disorder with systemic inflammation that could contribute to various systemic events. There are studies that have demonstrated increased Serum uric acid levels in patients with psoriasis and psoriatic arthritis. There have been no studies so far on Uric acid levels in relation to psoriasis and metabolic syndrome (MetS). Objectives: The purpose of this study was to investigate the possible presence of hyperuricemia in non-arthritic psoriasis and to analyze serum uric acid levels in psoriasis patients with and without MetS and in controls with and without MetS. Uric acid levels were also …

A New Method For Ecoacoustics? Toward The Extraction And Evaluation Of Ecologically-Meaningful Soundscape Components Using Sparse Coding Methods, Alice Eldridge, Michael Casey, Paola Moscoso, Mika Peck

Dartmouth Scholarship

Passive acoustic monitoring is emerging as a promising non-invasive proxy for ecological complexity with potential as a tool for remote assessment and monitoring (Sueur & Farina, 2015). Rather than attempting to recognise species-specific calls, either manually or automatically, there is a growing interest in evaluating the global acoustic environment. Positioned within the conceptual framework of ecoacoustics, a growing number of indices have been proposed which aim to capture community- level dynamics by (e.g., Pieretti, Farina & Morri, 2011; Farina, 2014; Sueur et al.,2008b) by providing statistical summaries of the frequency or time domain signal. Although promising, the ecological relevance and …

Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity Via Interferon-Beta And Indoleamine-2,3-Dioxygenase, Michael B. Cheung

USF Tampa Graduate Theses and Dissertations

Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infection in young children worldwide, accounting for an estimated 33.8 million cases of respiratory disease, over 3 million of which require hospitalization, and between 66,000 and 199,000 deaths in this susceptible population. Additionally, severe RSV infection early in life is associated with an increased risk of wheeze and other airway disorders later in life. Despite this, there is currently no vaccine or economically reasonable prophylactic regimen to prevent infection. While disease is typically more severe in infancy RSV can infect throughout the lifespan repeatedly as the …

Assessment Of Prolonged Occupational Exposure To Heat Stress, Ximena Garzon-Villalba Garzon-Villalba

USF Tampa Graduate Theses and Dissertations

Heat stress is a recognized occupational hazard present in many work environments. Its effects increase with increasing environmental heat loads. There is good evidence that exertional heat illness is associated with ambient thermal conditions in outdoor environments. Further, there is reason to believe that risk of acute injury may also increase with the ambient environment. For these reasons, the assessment of heat stress, which can be done through the characterization of the wet bulb globe temperature (WBGT), is designed to limit exposures to those that could be sustained for an 8-h day. The ACGIH Threshold Limit Value (TLV) for heat …

Polymer Characteristics Of Polyelectrolyte Polypeptides, Jorge Monreal

USF Tampa Graduate Theses and Dissertations

Polypeptides are polymerized chains of amino acids linked covalently through peptide bonds. Polyelectrolyte polypeptides are polypeptides with electrolyte repeating groups. Several amino acids contain ionizable side chains which result in charge distributions when dissolved in aqueous solutions. This dissertation is motivated by a desire to gain knowledge of polyelectrolyte polypeptides as recent advances in chemical synthesis of polypeptides have made possible the fabrication of designed polypeptides that do not naturally occur in nature. Potential applications of newly designed polypeptides span the range from medical to clothing and energy even to robotics.

In this dissertation we compare the characteristic behavior of …

Applications Of Molecular Modelling And Structure Based Drug Design In Drug Discovery, Sreya Mukherjee

USF Tampa Graduate Theses and Dissertations

Calcium ions have important roles in cellular processes including intracellular signaling, protein folding, enzyme activation and initiation of programmed cell death. Cells maintain low levels of calcium in their cytosol in order to regulate these processes. When activation of calcium-dependent processes is needed, cells can release calcium stored in the endoplasmic reticulum (ER) into the cytosol to initiate the processes. This can also initiate formation of plasma membrane channels that allow entry of additional calcium from the extracellular milieu. The change in calcium levels is referred to as calcium flux. A key protein involved in initiation of calcium flux is …

Cell Cycle Arrest By Tgfß1 Is Dependent On The Inhibition Of Cmg Helicase Assembly And Activation, Brook Samuel Nepon-Sixt

USF Tampa Graduate Theses and Dissertations

Tumorigenesis is a multifaceted set of events consisting of the deregulation of several cell-autonomous and tissue microenvironmental processes that ultimately leads to the acquisition of malignant disease. Transforming growth factor beta (TGFß) and its family members are regulatory cytokines that function to ensure proper organismal development and the maintenance of homeostasis by controlling cellular differentiation, proliferation, adhesion, and survival, as well as by modulating components of the cellular microenvironment and immune system. The pleiotropic control by TGFß of these cell intrinsic and extrinsic factors is intimately linked to the prevention of tumor formation, the specifics of which are dependent on …

Relationship Between Teacher Characteristics And Accuracy In Identifying Middle School Students With Symptoms Of Anxiety And Depression, Elizabeth Storey

USF Tampa Graduate Theses and Dissertations

As a universal screening method, teacher nominations have been found to both miss and misidentify a substantial proportion of students with internalizing disorders such as anxiety and depression (Cunningham & Suldo, 2014; Gelley, 2014; Moor et al., 2007). Although some research has explored the accuracy of teacher nominations when used to identify students with anxiety and depression, no research examined the teacher characteristics that are potentially related to accuracy. The current study conducted a secondary analysis of an archival dataset (Gelley, 2014) to determine which characteristics of teachers (N= 19) are more closely related to accuracy in identifying …

Moderating The Impact Of Climate Change One University At A Time, Elmer Soriano

Journal of Management for Global Sustainability

A sufficient response to the threats posed by climate change presents a leadership challenge proportional in scale with the urgency and complexity of wartime mobilization. The world’s 190 million students may be enlisted to respond to such threats through action-research focused on building resiliency. Concepts such as social labs, institutional empathy, and scholarship help reframe the mandates of universities as they respond to climate change, making them platforms for developing leaders and changemakers who will increase the resilience of communities and ecosystems.

Pengembangan Perangkat Pembelajaran Berbasis Model Learning Cycle-7e Pada Materi Trigonometri Untuk Meningkatkan Kemampuan Koneksi Matematis Siswa, Natalia Rosalina Rawa, Akbar Sutawidjaja, Sudirman Sudirman

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The aim of this research is producing learning instrument based on the model of learning cycle 7E in trigonometry which are valid, practical and effective. This research refers to the developmental model of Plomp which consists of three phases that are pleminary research, prototyping phase, and assessment phase. The quality of learning instrument based on the test of validity, practicality and effectiveness. Based on data analysis, the results are: the score validity of lesson plan and the students worksheet are 3,54 and 3,44 respectively, the score practicality of lesson plan and the students worksheet are 3,53 and 3,21 respectively, the …

Pengaruh Pembelajaran Berbasis Masalah Penyakit Tropis Terhadap Kecakapan Hidup Siswa Sma, Tutut Indria Permana, Hadi Suwono, Dwi Listyorini

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Indonesia is tropical country with high risk of tropical disease. Students need to develop life skills to cope that challenges. Therefore research to determine the effect of tropical diseases in problem-based learning on students' life skills need to be established. This experimental research was used nonrandomized control group pretest-posttest design. The subjects were 66 high school students in Malang, 35 students as an experimental group and 31 students as a control group. Students' life skill was measured using test and data were analyzed using Anacova. The results showed that tropical disease problem-based learning significantly enhance students' life skills (p < 0.05).

Pengembangan Buku Ajar Bioteknologi Berbasis Penelitian Bioremidiasi Logam Berat Kadmium Untuk Mahasiswa S1 Biologi Universitas Negeri Malang, Agung Pambudiono, Endang Suarsini, Mohamad Amin

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The purpose of this research is to produce research based textbook on bioremediation of heavy metals. This study adapted the Dick & Carey development model. Feasibility of the textbook is based on the results of product testing by experts and small groups. Types of data collected is quantitative data and qualitative data. The collected data have analyzed by quantitative and qualitative descriptive. The tests conducted by subject matter experts gave validity percentage of 91.6 %, an expert assessment of the media at 90.81 %, while a small group votes for 85.56 %. Based on the validation results, the textbook that …

Pengaruh Scientific Inquiry Based Learning Terhadap Keterampilan Proses Siswa Kelas Xi Sma, Ndzani Latifatur Rofi’Ah, Hadi Suwono, Dwi Listyorini

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This purpose of this research was to determine the influence of scientific inquiry based learning on science process skills. This experimental research was used nonrandomized control group pretest-posttest design. Population was all students of class XI SMAN 7 Malang. Samples in this study consists of two classes, XI MIPA 1 as experimental group and XI MIPA 2 as the control group. The independent variable was scientific inquiry based learning. The dependent variable was science processes skills. The research result show that scientific inquiry based learning significantly increase the student’s science process skills (p<0,05).