Digital Commons Network^™

September 14, 2016 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Student Profile: Meg Maloney, Dawnn Fann

College of Arts and Sciences Newsroom

University of Dayton junior Meg Maloney had an adventurous, eventful summer in the U.S. and abroad. The Chicago native - an environmental biology major with a minor in sustainability, energy and environment - traveled to Sikkim, India, on a study abroad experience through the Students for International Training program. She also conducted research in Dayton with Ryan McEwan, associate professor of biology and the environmental biology program coordinator.

2016-September-14-Ashley Hayes, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Curriculum Minutes 09/14/2016, Curriculum Committee

Curriculum Committee Minutes

In these minutes: Revisit of EDP priorities; Science and Mathematics catalog course changes; and Education catalog course changes

Whalesong 2016-09-14, N/A N/A

Whalesong

No abstract provided.

Comparative Analysis Of Linker Histone H1, Mecp2, And Hmgd1 On Nucleosome Stability And Target Site Accessibility, Caitlyn Riedmann, Yvonne N. Fondufe-Mittendorf

Molecular and Cellular Biochemistry Faculty Publications

Chromatin architectural proteins (CAPs) bind the entry/exit DNA of nucleosomes and linker DNA to form higher order chromatin structures with distinct transcriptional outcomes. How CAPs mediate nucleosome dynamics is not well understood. We hypothesize that CAPs regulate DNA target site accessibility through alteration of the rate of spontaneous dissociation of DNA from nucleosomes. We investigated the effects of histone H1, high mobility group D1 (HMGD1), and methyl CpG binding protein 2 (MeCP2), on the biophysical properties of nucleosomes and chromatin. We show that MeCP2, like the repressive histone H1, traps the nucleosome in a more compact mononucleosome structure. Furthermore, histone …

Condition Of Larval Red Snapper (Lutjanus Campechanus) Relative To Environmental Variability And The Deepwater Horizon Oil Spill, Frank J. Hernandez Jr., J.E. Filbrun, J. Fang, John Timothy Ransom

Faculty Publications

The Deepwater Horizon oil spill(DWHOS)spatially and temporally overlapped with the spawning of many fish species, including Red Snapper, one of the most economically important reef fish in the Gulf of Mexico. To investigate potential impacts of the DWHOS on larval Red Snapper, data from a long-term ichthyoplankton survey off the coast of Alabama were used to examine: (1)larval abundances among pre-impact (2007–2009), impact(2010), and post-impact (2011, 2013) periods; (2) proxies for larval condition (size-adjusted morphometric relationships and dry weight) among the same periods; and (3) the effects of background environmental variation on larval condition. We found that larval Red Snapper …

Isoacceptor Specific Characterization Of Trna Aminoacylation And Misacylation In Vivo, Kyle Mohler, Rebecca Mann, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Amino acid misincorporation during protein synthesis occurs due to misacylation of tRNAs or defects in decoding at the ribosome. While misincorporation of amino acids has been observed in a variety of contexts, less work has been done to directly assess the extent to which specific tRNAs are misacylated in vivo, and the identity of the misacylated amino acid moiety. Here we describe tRNA isoacceptor specific aminoacylation profiling (ISAP), a method to identify and quantify the amino acids attached to a tRNA species in vivo. ISAP allows compilation of aminoacylation profiles for specific isoacceptors tRNAs. To demonstrate the efficacy and …

The Diamond, September 14, 2016, Dordt College

Dordt Diamond

• Front Page: Dordt Football with Historic Perfect Start; New $30 Fee for Computer Services; Dordt no Longer a Solely Four-Year Liberal Arts College
• News: Where Do All the Nursing Majors Go?; Will the Dakota Access Pipeline Access the Bakken Oil Fields?; Four New Faces Grace Dordt Classrooms; Iowa Grants Utility's Push for 100% Renewable Energy; Lingering Effects of Zika Continue; Dead Reindeer Spark Scientific Hypothesis; Dordt Featured on Shame List, But What are the Facts?; A New Adoption Story: Visscher and China; "A Dollar Worth Death"; The More You Listen, The More You Hear... ; An Introduction to Study Abroad …

The Assessment Of A Nano-Delivery System For Increasing The Bioavailability And Efficacy Of Lutein In Preventing Hepatic Steatosis And Systemic Inflammation In Guinea Pigs, Ana G. Murillo

Doctoral Dissertations

Lutein is a xanthophyll synthesized by plants. In biological systems, lutein has antioxidant and anti-inflammatory properties, which could protect against chronic diseases. Despite its potential as a bioactive food component, lutein intake is low among Americans. In addition, lutein has low bioavailability, making it difficult to achieve biological effects. One approach to overcome these challenges is the use of nanotechnology.

This project evaluated the effects of a lutein nanoemulsion (NANO) on hepatic steatosis and systemic inflammation in guinea pigs. Our hypothesis was that NANO lutein would be more bioavailable and, therefore, more effective than powdered lutein (PL) in protecting against …

Temporal Regularity Increases With Repertoire Complexity In The Australian Pied Butcherbird’S Song, Eathan Janney, Hollis Taylor, Constance Scharff, David Rothenberg, Lucas C. Parra, Ofer Tchernichovski

Publications and Research

Music maintains a characteristic balance between repetition and novelty. Here, we report a similar balance in singing performances of free-living Australian pied butcherbirds. Their songs include many phrase types. The more phrase types in a bird’s repertoire, the more diverse the singing performance can be. However, without sufficient temporal organization, avian listeners may find diverse singing performances difficult to perceive and memorize. We tested for a correlation between the complexity of song repertoire and the temporal regularity of singing performance. We found that different phrase types often share motifs (notes or stereotyped groups of notes). These shared motifs reappeared in …

Fecal Metabolome Of The Hadza Hunter-Gatherers: A Host-Microbiome Integrative View, S. Turroni, J Fiori, S Rampelli, S. L. Schnorr, C. Consolandi, M. Barone, E. Biagi, F. Fanelli, M. Mezzullo, Alyssa Crittenden, A. G. Henry, P. Brigidi, M. Candela

Anthropology Faculty Research

The recent characterization of the gut microbiome of traditional rural and foraging societies allowed us to appreciate the essential co-adaptive role of the microbiome in complementing our physiology, opening up significant questions on how the microbiota changes that have occurred in industrialized urban populations may have altered the microbiota-host co-metabolic network, contributing to the growing list of Western diseases. Here, we applied a targeted metabolomics approach to profile the fecal metabolome of the Hadza of Tanzania, one of the world's few remaining foraging populations, and compared them to the profiles of urban living Italians, as representative of people in the …

Convergence In Nitrogen Deposition And Cryptic Isotopic Variation Across Urban And Agricultural Valleys In Northern Utah, Steven J. Hall, E. M. Ogata, Samantha R. Weintraub, Michelle A. Baker, James R. Ehleringer, C I. Czimczik, David R. Bowling

Biology Faculty Publications

The extent to which atmospheric nitrogen (N) deposition reflects land use differences and biogenic versus fossil fuel reactive N sources remains unclear yet represents a critical uncertainty in ecosystem N budgets. We compared N concentrations and isotopes in precipitation-event bulk (wet + dry) deposition across nearby valleys in northern Utah with contrasting land use (highly urban versus intensive agriculture/low-density urban). We predicted greater nitrate (NO3−) versus ammonium (NH4+) and higher δ15N of NO3− and NH4+ in urban valley sites. Contrary to expectations, annual N deposition (3.5–5.1 kg N ha−1 yr−1) and inorganic N concentrations were similar within and between valleys. …

Secondary Structure Adopted By The Gly-Gly-X Repetitive Regions Of Dragline Spider Silk, Geoffrey M. Gray, Arjan Van Der Vaart, Chengchen Guo, Justin A. Jones, David Onofrei, Brian R. Cherry, Randolph V. Lewis, Jeffery L. Yarger, Gregory P. Holland

Biology Faculty Publications

Solid-state NMR and molecular dynamics (MD) simulations are presented to help elucidate the molecular secondary structure of poly(Gly-Gly-X), which is one of the most common structural repetitive motifs found in orb-weaving dragline spider silk proteins. The combination of NMR and computational experiments provides insight into the molecular secondary structure of poly(Gly-Gly-X) segments and provides further support that these regions are disordered and primarily non-β-sheet. Furthermore, the combination of NMR and MD simulations illustrate the possibility for several secondary structural elements in the poly(Gly-Gly-X) regions of dragline silks, including β-turns, 310-helicies, and coil structures with a negligible population of α-helix observed.

Impulsive Behavior In Competition: Testing Theories Of Overbidding In Rent-Seeking Contests, Roman M. Sheremeta

ESI Working Papers

Researchers have proposed various theories to explain overbidding in rent-seeking contents, including mistakes, systematic biases, the utility of winning, and relative payoff maximization. Through an eight-part experiment, we test and find significant support for the existing theories. Also, we discover some new explanations based on cognitive ability and impulsive behavior. Out of all explanations examined, we find that impulsivity is the most important factor explaining overbidding in contests.

Toward A Multi-Agent System For Marine Observation, R Polvara, S Sharma, R Sutton, J Wan, A Manning

School of Engineering, Computing and Mathematics

No abstract provided.

Another New Species Of Euscorpius Thorell, 1876 From The Taurus Mountains In Antalya Province, Southern Turkey (Scorpiones: Euscorpiidae), Gioele Tropea, Ersen Aydın Yağmur, Aristeidis Parmakelis, Kadir Boğaç Kunt

Euscorpius

A new scorpion species, Euscorpius alanyaensis sp. n., is described based on specimens collected from the Taurus Mountains in Antalya Province (Alanya District) in southern Turkey. It is a sibling species of the recently described E. gocmeni Tropea et al., 2014, and similarly, the new species is also characterized by a high trichobothrial count (Pv = 9–11, et = 7, em = 4, and eb = 4), a high pectinal teeth count (Dp = 9–11 in males, 8 in females), medium-small size, and light to medium brown-reddish colour. In addition, for the first time a phylogenetic …

Activation Of Nqo1 In Nqo1*2 Polymorphic Human Leukemic Hl-60 Cells By Diet-Derived Sulforaphane, Joseph M. Wu, Ardalan Oraee, Barbara B. Doonan, John T. Pinto, Tze-Chen Hsieh

NYMC Faculty Publications

BACKGROUND: The NAD(P)H: quinone oxidoreductase (NQO1) confers protection against semiquinones and also elicits oxidative stress. The C609T polymorphism of the NQO1 gene, designated NQO1*2, significantly reduces its enzymatic activity due to rapid degradation of protein. Since down regulation of NQO1 mRNA expression correlates with increased susceptibility for developing different types of cancers, we investigated the link between leukemia and the NQO1*2 genotype by mining a web-based microarray dataset, ONCOMINE. Phytochemicals prevent DNA damage through activation of phase II detoxification enzymes including NQO1. Whether NQO1 expression/activity in leukemia cells that carry the labile NQO1*2 genotype can be induced by broccoli-derived phytochemical …

Impact Of An Invasive Insect And Plant Defense On A Native Forest Defoliator, Claire M. Wilson, Justin F. Vendettuoli, David A. Orwig, Evan L. Preisser

Biological Sciences Faculty Publications

Eastern hemlock (Tsuga canadensis [L.] Carriére) in the United States is threatened by the invasive hemlock woolly adelgid (Adelges tsugae Annand). The native hemlock looper (Lambdina fiscellaria Guenée) also appears to have played a role in previous population declines of this conifer. Although these two insects co-occur in much of the adelgid’s invaded range, their interactions remain unstudied. We assessed looper performance and preference on both uninfested and adelgid-infested foliage from adelgid-susceptible hemlocks, as well as on uninfested foliage from an eastern hemlock that is naturally adelgid-resistant. Larvae reared on uninfested foliage from adelgid-susceptible hemlocks experienced 60% mortality within the …

Impact Of Platelet-Rich Plasma On Arthroscopic Repair Of Small- To Medium-Sized Rotator Cuff Tears: A Randomized Controlled Trial, Richard Holtby, Monique Christakis, Eran Maman, Joy C. Macdermid, Tim Dwyer, George S. Athwal, Kenneth Faber, John Theodoropoulos, Linda J. Woodhouse, Helen Razmjou

Bone and Joint Institute

© 2016, © The Author(s) 2016. Background: Increased interest in using platelet-rich plasma (PRP) as an augment to rotator cuff repair warrants further investigation, particularly in smaller rotator cuff tears. Purpose: To examine the effectiveness of PRP application in improving perioperative pain and function and promoting healing at 6 months after arthroscopic repair of small- or medium-sized rotator cuff tears. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This was a double-blinded randomized controlled trial of patients undergoing arthroscopic repair of partial- or full-thickness rotator cuff tears of up to 3 cm who were observed for 6 months. …

In Re: Modafinil Antitrust

2016 Decisions

USDC for the Eastern District of Pennsylvania

A Microrna/Runx1/Runx2 Network Regulates Prostate Tumor Progression From Onset To Adenocarcinoma In Tramp Mice., Nicholas H Farina, Areg Zingiryan, Jacqueline A Akech, Cody J Callahan, Huimin Lu, Janet L Stein, Lucia R Languino, Gary S Stein, Jane B Lian

Department of Cancer Biology Faculty Papers

While decades of research have identified molecular pathways inducing and promoting stages of prostate cancer malignancy, studies addressing dynamic changes of cancer-related regulatory factors in a prostate tumor progression model are limited. Using the TRAMP mouse model of human prostate cancer, we address mechanisms of deregulation for the cancer-associated transcription factors, Runx1 and Runx2 by identifying microRNAs with reciprocal expression changes at six time points during 33 weeks of tumorigenesis. We molecularly define transition stages from PIN lesions to hyperplasia/neoplasia and progression to adenocarcinoma by temporal changes in expression of human prostate cancer markers, including the androgen receptor and tumor …

Analysis Of Chondron Deformation During Physiologic And Hyper-Physiologic Compression Of Growth Plate Cartilage, Bhavya Vendra

Electronic Theses and Dissertations Archive

The physis, or growth plate, is a layer of cartilage responsible for long bone growth. It is organized into reserve, proliferative and hypertrophic zones. Unlike the reserve zone, where chondrocytes are arranged randomly, either singly or in pairs, the proliferative and hypertrophic chondrosytes are organized within a tubular structure called a chondron. Strain gradients within the growth plate have been found to be heterogenous with an apparent random pattern. No study to date has examined how chondrons deform when the physis is compressed. This thesis reports on a method to measure structural deformations along the entire lengths of chondrons when …

Computational And Experimental Tools To Explore Autotaxin Inhibition By Novel Small Molecules, Lauren Elizabeth Ragle

Electronic Theses and Dissertations Archive

Autotaxin (ATX) is a ubiquitous ectoenzyme that hydrolyzes lysophosphatidylcholine (LPC) to form the bioactive lipid mediator lysophosphatidic acid (LPA). LPA activates specific G-protein coupled receptors (GPCR) to elicit downstream effects leading to cellular motility, survival, and invasion. Through these downstream effects, autotaxin is involved in many diseases including cancer, heart disease, chronic pain, asthma, and other inflammatory diseases. Inhibition of autotaxin activity is therefore a therapeutically attractive goal. Initial ATX inhibitors included L-histidine and analogs which acted as metal chelators. Subsequently, LPA and sphingosine-1-phosphate were identified as ATX inhibitors, leading to extensive structure-activity relationship (SAR) studies on phospholipid analogs. Later, …

The Sun Star Vol 36 No 3 (September 13th, 2016), N/A N/A

Sun Star

No abstract provided.

Maintenance Of Transcription-Translation Coupling By Elongation Factor P, Sara Elgamal, Irina Artsimovitch, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Under conditions of tight coupling between translation and transcription, the ribosome enables synthesis of full-length mRNAs by preventing both formation of intrinsic terminator hairpins and loading of the transcription termination factor Rho. While previous studies have focused on transcription factors, we investigated the role of Escherichia coli elongation factor P (EF-P), an elongation factor required for efficient translation of mRNAs containing consecutive proline codons, in maintaining coupled translation and transcription. In the absence of EF-P, the presence of Rho utilization (rut) sites led to an ~30-fold decrease in translation of polyproline-encoding mRNAs. Coexpression of the Rho inhibitor Psu …

The Guardian, September 13, 2016, Wright State University Student Body

The Guardian Student Newspaper

Eight page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

The Current Volume 27 : Issue 4, Nova Southeastern University

Student Newspapers

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

• Opinions
• Features
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De Novo Sequencing, Assembly And Analysis Of Eight Different Transcriptomes From The Malayan Pangolin, Aini Mohamed Yusoff, Tze King Tan, Ranjeev Hari, Klaus-Peter Koepfli, Wei Yee Wee, Agostinho Antunes, Frankie Thomas Sitam, Jeffrine Japning Rovie-Ryan, Kayal Vizi Karuppannan, Guat Jah Wong, Leonard Lipovich, Wesley C. Warren, Stephen J. O'Brien, Siew Woh Choo

Biology Faculty Articles

Pangolins are scale-covered mammals, containing eight endangered species. Maintaining pangolins in captivity is a significant challenge, in part because little is known about their genetics. Here we provide the first large-scale sequencing of the critically endangered Manis javanica transcriptomes from eight different organs using Illumina HiSeq technology, yielding ~75 Giga bases and 89,754 unigenes. We found some unigenes involved in the insect hormone biosynthesis pathway and also 747 lipids metabolism-related unigenes that may be insightful to understand the lipid metabolism system in pangolins. Comparative analysis between M. javanica and other mammals revealed many pangolin-specific genes significantly over-represented in stress-related processes, …