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Tip-Enhanced Laser Ablation Sample Transfer For Mass Spectrometry, Chinthaka Aravinda Seneviratne
Tip-Enhanced Laser Ablation Sample Transfer For Mass Spectrometry, Chinthaka Aravinda Seneviratne
LSU Doctoral Dissertations
In this research, atomic force microscope tip-enhanced laser ablation mass spectrometry (AFM TELA-MS), an ambient sub-micrometer scale sampling method for offline MS was developed. AFM TELA was used to transfer molecules from thin films to a suspended silver wire for off-line mass spectrometry using laser desorption ionization (LDI) and matrix-assisted laser desorption ionization (MALDI). An AFM with a 30 nm radius gold-coated silicon tip was used to image the sample and to hold the tip 15 nm from the surface for material removal using a pulsed Nd:YAG laser, which provides output at wavelengths of 532 nm in the visible, 1064 …
Understanding Chemical Reactions In Novel Materials: From Metal Organic Frameworks To Oxyallyl Cations, Kiara Taylor-Edinbyrd
Understanding Chemical Reactions In Novel Materials: From Metal Organic Frameworks To Oxyallyl Cations, Kiara Taylor-Edinbyrd
LSU Doctoral Dissertations
The work of this dissertation investigates the chemical processes of novel materials through quantum mechanical calculations and molecular dynamics simulations. The first section of this work focuses on probing copper based metal organic frameworks (MOFs) for their ability to catalytically release nitric oxide from s-nitrosothiol (RSNO) precursors in a slow, controlled and sustained manner and compares these findings to a free copper ion/ethanol solution. Through the use of electronic structure calculations and molecular dynamics simulations, studies are carried out to better understand how the barriers of RSNOs approach to the catalytic copper center changes with modifications to the R-group (of …
Structure And Functional Potential Of Microbial Communities In Subglacial Lake Whillans And At The Ross Ice Shelf Grounding Zone, West Antarctica, Amanda Marie Achberger
Structure And Functional Potential Of Microbial Communities In Subglacial Lake Whillans And At The Ross Ice Shelf Grounding Zone, West Antarctica, Amanda Marie Achberger
LSU Doctoral Dissertations
The abundance of liquid water found beneath the Antarctic Ice Sheet (AIS) is thought to provide a suitable habitat for microbial life. However, the thick ice sheet has posed a significant obstacle to accessing this isolated system and as a consequence, little data exists to infer ecosystem processes occurring beneath ice sheets. To address this deficit, data generated through 16S rRNA (genes and molecules) and metagenomic sequencing was used to evaluate the diversity and potential metabolic function of communities inhabiting Subglacial Lake Whillans (SLW) and the ocean basin into which it discharges (Whillans Ice Stream grounding zone; WIS-GZ). The analysis …
Does Enhanced Nitrogen Input Affect The Structure And Composition Of Forest Vegetation? Results From Long-Term Experiments At The Fernow Experimental Forest, Christopher Alan Walter
Does Enhanced Nitrogen Input Affect The Structure And Composition Of Forest Vegetation? Results From Long-Term Experiments At The Fernow Experimental Forest, Christopher Alan Walter
Graduate Theses, Dissertations, and Problem Reports (ETD)
The effects of nitrogen (N) deposition have been studied in many ecosystems, and one general pattern of response that has emerged from these studies is a decline in species richness. Globally, anthropogenic deposition of N has more than doubled the ambient input of N in terrestrial ecosystems, and the rate at which humans produce reactive N continues to increase annually. As a result of both the current and projected future rates of N input, N deposition is a threat to biodiversity worldwide and is projected to contribute, along with other global change factors, to species extinction. To prevent the loss …
Biology, Ecology And Efficacy Of Lecanicillium Muscarium As A Potential Fungal Biocontrol Of The Invasive Hemlock Woolly Adelgid (Adelges Tsugae) On Eastern Hemlock (Tsuga Canadensis), Kristen L. Wickert
Graduate Theses, Dissertations, and Problem Reports (ETD)
Hemlock woolly adelgid (HWA) is an exotic insect pest of eastern hemlock. The entomopathogen Lecanicillium muscarium, including the commercially available strain MycotalRTM, is a potential candidate for fungal biocontrol. There are many factors to consider when using a fungal biocontrol such as ecology and genetic variation of candidate strains and interactions with other fungi and life stages of the target insect pest. Efforts of this study focused on: 1) sampling for reservoirs for L. muscarium and other Lecanicillium spp., 2) elucidating interactions between Lecanicillium and other fungi present in hemlock tissues and 3) characterizing genetic diversity of Lecanicillium and subsequent …
Detection And Alleviation Of Pesticide Residue In Food And Water, Olubode James Adeniyi
Detection And Alleviation Of Pesticide Residue In Food And Water, Olubode James Adeniyi
LSU Doctoral Dissertations
Use of pesticide has become part of modern day agricultural practice. Some pesticides can remain in the environment for decades and contaminate surface water that is used for irrigation of produce. Two studies were conducted- first to examine possible pesticide residue in surface water and some fruits, vegetables and cereals in Louisiana; and second was to alleviate possible pesticide residues in the water using zeolite filtration. Samples of 8 foods (tomato, corn, rice, blueberry, cucumber, cabbage, wheat and melon) and 35 surface waters were studied using a QuEChERS extraction method for food samples and an EPA method for the water …
Molecularly Imprinted Polymers For Enantiomer Separations And Biomolecular Sensors, Britney Lyn Hebert
Molecularly Imprinted Polymers For Enantiomer Separations And Biomolecular Sensors, Britney Lyn Hebert
LSU Doctoral Dissertations
Molecularly Imprinted Polymers (MIPs) encompass a wide range of applications by changing the different components, e.g. the template, crosslinker or functional monomers. Of interest among these different applications are separations and sensors. Separations by MIPs traditionally use a chiral pure template but in some cases that chiral pure template may not be available for imprinting. Using chiral (N-α-bismethacyloyl-L-alanine) and achiral (N,O-bisacrylamide ethanolamine) crosslinkers we investigated imprinting of scalemic and racemic template mixtures of Boc-tyrosine enantiomers. The achiral and chiral crosslinkers yielded similar results for the partial separation of enantiomers by scalemic imprinted polymers because separation and recognition are not dependent …
Prickly Sida (Sida Spinosa L.): Biology And In-Crop And Post-Harvest Management Programs, Josh Thomas Copes
Prickly Sida (Sida Spinosa L.): Biology And In-Crop And Post-Harvest Management Programs, Josh Thomas Copes
LSU Doctoral Dissertations
Prickly sida (Sida spinosa L.) is widely distributed in the southern U.S. and is a troublesome weed in many agronomic crops. In northeastern Louisiana on silty clay loam and clay soils, prickly sida seedling emergence began in early March when soil temperature reached 13.8 C and ceased in mid-October. Seasonal peaks in emergence were associated with rainfall events and variability in prickly sida emergence was observed between soil types and years. Total emergence was as high as 3,000 prickly sida plants m-2. In shade studies, prickly sida was able to emerge and persist under a heavy shade environment and to …
The Vulnerability Of Louisiana To Hurricane Damage And The Value Of Wetlands For Hurricane Risk Reduction, James Luke Boutwell
The Vulnerability Of Louisiana To Hurricane Damage And The Value Of Wetlands For Hurricane Risk Reduction, James Luke Boutwell
LSU Doctoral Dissertations
Coastal Louisiana is annually threatened by coastal storms. Population grown, wetland loss, and potentially increasing storm frequency are likely to increase coastal vulnerability to these events. Increasingly, coastal management entities are managing land resources to reduce the economic impact of natural disasters with the use of natural infrastructure. This is true in Louisiana where the Louisiana Coastal Master Plan allocates billions of dollars to coastal restoration projects, many of which are intended to mitigate economic damages from tropical storms and hurricanes. Despite this significant proposed investment, the risk reduction value provided by these projects is not well known. This analysis …
Studies Of The Properties Of Designed Nanoparticles Using Atomic Force Microscopy, Steve Matthew Deese
Studies Of The Properties Of Designed Nanoparticles Using Atomic Force Microscopy, Steve Matthew Deese
LSU Doctoral Dissertations
The purpose of the research in this dissertation was to elucidate the intrinsic properties of how nanoparticles are different from bulk materials. This was done by mechanical and electronic studies of the properties of designed nanoparticles using advanced modes of atomic force microscopy. Information relating to the work functions, contact potential difference, Young’s Moduli, elasticity, and viscoelasticity can be investigated using state-of-the-art atomic force microscope (AFM) experiments. Subsurface imaging of polystyrene encapsulated cobalt nanoparticles was achieved for the first time using Force Modulation Microscopy (FMM) in conjunction with contact mode AFM. Previously prepared sample of polystyrene coated cobalt nanoparticles were …
Psychological And Environmental Predictors Of Test Anxiety: A Structural Equation Model, Meredith Taylor Harris
Psychological And Environmental Predictors Of Test Anxiety: A Structural Equation Model, Meredith Taylor Harris
LSU Doctoral Dissertations
Test anxiety is a construct that includes cognitive, physiological, and behavioral symptoms occurring in response to anxiety prior to, during, or following examinations. The current literature on test anxiety has evaluated a number of possible predictors, including demographic variables, academic indicators, and self-perceptions. The movement toward school accountability and higher academic expectations of students has increased the severity of consequences occurring as a result of poor academic achievement. Thus, test anxiety is a critical concern that may impact student academic success. The current study evaluated a structural equation model to determine the strength of associations between trait anxiety, academic achievement, …
East Meets West: A Musical Analysis Of Chinese Sights And Sounds, By Yuankai Bao, Jiazi Shi
East Meets West: A Musical Analysis Of Chinese Sights And Sounds, By Yuankai Bao, Jiazi Shi
LSU Doctoral Dissertations
In the wake of the Chinese Cultural Revolution (1966-76) and with China’s new “Open Door” policy toward Western culture and Western music, Chinese composers have adapted Western compositional techniques. The new generation of Chinese composers have expressed in various ways of their research to the heritage of Western composers. Yuankai Bao is one of the new generations of Chinese composers. The topic of this paper is the integration of Chinese and Western compositional techniques in Chinese folk songs. The purpose of this research is to find out how Yuankai Bao connects Chinese pentatonic scale to Western harmony, and how he …
Two Complete Mitochondrial Genomes From Praticolella Mexicana Perez, 2011 (Polygyridae) And Gene Order Evolution In Helicoidea (Mollusca, Gastropoda), Russell L. Minton, Marco A. Martinez Cruz, Mark L. Farman, Kathryn E. Perez
Two Complete Mitochondrial Genomes From Praticolella Mexicana Perez, 2011 (Polygyridae) And Gene Order Evolution In Helicoidea (Mollusca, Gastropoda), Russell L. Minton, Marco A. Martinez Cruz, Mark L. Farman, Kathryn E. Perez
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Helicoidea is a diverse group of land snails with a global distribution. While much is known regarding the relationships of helicoid taxa, comparatively little is known about the evolution of the mitochondrial genome in the superfamily. We sequenced two complete mitochondrial genomes from Praticolella mexicana Perez, 2011 representing the first such data from the helicoid family Polygyridae, and used them in an evolutionary analysis of mitogenomic gene order. We found the mitochondrial genome of P. mexicana to be 14,008 bp in size, possessing the typical 37 metazoan genes. Multiple alternate stop codons are used, as are incomplete stop codons. Mitogenome …
Modeled Inflow Validation & Nutrient Loading Estimation In Two Subwatersheds Of The Lower Laguna Madre, Hudson R. Deyoe, Warren Pulich, Nelun Fernando
Modeled Inflow Validation & Nutrient Loading Estimation In Two Subwatersheds Of The Lower Laguna Madre, Hudson R. Deyoe, Warren Pulich, Nelun Fernando
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
University of Texas Rio Grande Valley will characterize nutrient loading rates into the Lower Laguna Madre for subwatersheds by monitoring stream flow and water quality (particularly total nitrogen and phosphorus). This information will be used to evaluate Texas Rainfall-Runoff model performance in estimating ungaged inflows and to establish a relationship between ungaged inflows and nutrient loading regimes to the Lower Laguna Madre. View on Map
Optimization Of Rgd Containing Cyclic Peptides Against Αvβ3 Integrin, Yan Wang, Wenwu Xiao, Yonghong Zhang, Leah Meza, Harry Tseng, Yoshikazu Takada, James B. Ames, Kit S. Lam
Optimization Of Rgd Containing Cyclic Peptides Against Αvβ3 Integrin, Yan Wang, Wenwu Xiao, Yonghong Zhang, Leah Meza, Harry Tseng, Yoshikazu Takada, James B. Ames, Kit S. Lam
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)
We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity (Mol Cancer Ther, 9:2714–23, 2010). αvβ3 integrin is known to be over-expressed in many cancers and in tumor vasculature, and it has been established as a cancer therapeutic target. To further optimize LXW7, we have performed systematic structure activity relationship (SAR) studies. Based on the results, two highly focused OBOC peptide libraries were designed, synthesized and screened against αvβ3 integrin transfected K562 cells. One of the best …
The Inclusion Of Culture In Canadian Social Psychology Textbooks: A Content Analysis Of Introductory Texts, Colin Scott, Saba Safdar
The Inclusion Of Culture In Canadian Social Psychology Textbooks: A Content Analysis Of Introductory Texts, Colin Scott, Saba Safdar
Online Readings in Psychology and Culture
Cultural diversity features prominently in Canadian social and political life. Canadian social psychologists, for their part, have led a rich tradition of research on intercultural relations. We identified the undergraduate social psychology textbooks used to introduce students of psychology in Canada to the field and examined the extent that culture is incorporated into the teaching of introductory social psychology. Through a content analysis of Canadian-published introductory social psychology texts, we found that these textbooks are inclusive of cultural diversity, although not all textbooks covered culture with the same depth. Across textbooks, cultural coverage was broad, with many hits across textbooks, …
"Miss" Communication: Women Navigating The Crossroads Of The Journalism And Mass Communication Industry And Academia, Aariel Roxanne Charbonnet
"Miss" Communication: Women Navigating The Crossroads Of The Journalism And Mass Communication Industry And Academia, Aariel Roxanne Charbonnet
LSU Doctoral Dissertations
This qualitative study explores the career transitions of women from the mass communication industry to academia using Schlossberg’s (1984) theory of transition. In addition to the job demands as academics and administrators, mass communication leaders must satisfy the demands of the professional communities their schools serve. This calls for a more practical curriculum with media and communication professionals serving as faculty members. For women, the demands appear to have another layer, as women are leaving the journalism industry earlier than men (Willnat & Weaver, 2014). This begs the following questions: Why are women leaving the industry? What are the experiences …
Caregiver Choice In Autism Intervention: Selections And Influential Factors, Hilary Lynn Adams
Caregiver Choice In Autism Intervention: Selections And Influential Factors, Hilary Lynn Adams
LSU Doctoral Dissertations
Although research on Autism Spectrum Disorder (ASD) continues to increase, there is not yet a “cure” for the disorder. There is a lack of consensus regarding most effective treatments, much less an accepted treatment plan or course. Families may feel alone and lost in the treatment decision process. In order to best assist caregivers, psychologists must understand the selections caregivers make, their sources of information, and what influences them in their decision-making process. With this knowledge, clinicians may best effect change in caregiver choice by encouraging informed decision-making and use of empirically-based interventions. Thus, the purpose of the current study …
Roles Of Members Of The Conserved Deda/Tvp38 Membrane Protein Family In Escherichia Coli Drug Resistance And Alkaline Ph Tolerance, Sujeet Kumar
LSU Doctoral Dissertations
The objective of this dissertation is to understand the functions of Escherichia coli YqjA and YghB, which are members of the conserved DedA/Tvp38 membrane protein family. YqjA and YghB are inner membrane (IM) proteins with multiple predicted membrane–spanning domain, sharing 62% amino acid identity and partly overlapping functions. Simultaneous in-frame deletions of these two genes in a strain named BC202 results in various phenotypes including cell division defects, temperature sensitivity, and sensitivity to drugs and alkaline pH. The cell division defect of BC202 is due to the inefficient secretion of periplasmic amidases by the twin arginine transport (Tat) pathway into …
The Relationship Between Secondary Schools' Plc Characteristics And Literacy Achievement, Jennifer C. Topper
The Relationship Between Secondary Schools' Plc Characteristics And Literacy Achievement, Jennifer C. Topper
College of Graduate Studies: Theses & Dissertations
This quantitative, non-experimental, correlational study examined the relationship between secondary school staff perceptions of their school’s effectiveness and the change in student literacy over a one year period. The staff perception data was elicited through an anonymous, electronically administered survey, the SEDL’s School Professional Staff as Learning Community Questionnaire (SPSLCQ) (Hord, 1996). Perceptions were gathered and measured based on the responses to descriptors in the five PLC domains of shared and supportive leadership; shared vision and values; collective learning and application of learning; supportive conditions; and shared personal practice. The populations whose perceptions were measured were the staffs of middle …
Effects Of Continuous Exposure To Bisphenol A On Male And Female Mice From Prenatally To Adulthood, Kannikar Chatsantiprapa, Tip-Arpa Sophon, Jintana Sattayasai
Effects Of Continuous Exposure To Bisphenol A On Male And Female Mice From Prenatally To Adulthood, Kannikar Chatsantiprapa, Tip-Arpa Sophon, Jintana Sattayasai
The Thai Journal of Pharmaceutical Sciences
BisphenolA (BPA), a monomer estrogenic chemical of many plastic products has controversial biological effects. This study assessed the effects at 0.05 mg/kg BW/day (Tolerable Daily Intake, TDI) and 0.5 mg/kg BW/day (10TDI), in male and female mice contin...
Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain, Amit Kumar, Kundan Singh Bora, Amteshwar Singh Jaggi, Richa Shri
Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain, Amit Kumar, Kundan Singh Bora, Amteshwar Singh Jaggi, Richa Shri
The Thai Journal of Pharmaceutical Sciences
Objectives: Allium cepa has been used extensively for culinary purposes as well as in traditional system of medicine. A number of varieties of A. cepa are available commercially with varietal differences in phytoconstituents and biological activities. Ho...
Targeting Voltage Gated Sodium Channels For Prevention Of Breast Cancer Metastasis, Shilpa Dutta
Targeting Voltage Gated Sodium Channels For Prevention Of Breast Cancer Metastasis, Shilpa Dutta
All ETDs from UAB
Voltage gated sodium channels (VGSC) are a recently identified drug target involved in the breast cancer invasion mechanism. VGSCs participate in the acidification of the perimembrane, activating the cysteine proteases, cathepsin B and S, thereby triggering the proteolysis of the extracellular matrix and the basement membrane, thereby promoting cell invasion. Highly aggressive, invasive breast cancer cells dramatically overexpress one subtype of VGSC, nNav1.5. Described here are the design, synthesis and in vitro evaluation of drug-like, small molecule blockers of nNav1.5 that are potential therapeutic agents for the prevention of breast cancer metastasis. Initially, five compounds were designed and synthesized based …
Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia
Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia
All ETDs from UAB
program pilot study randomly assigned 100 women, aged 19 to 25 to two groups. One
Serum Vitamin D And C-Reactive Protein: Predictors Of Glucose Control In African-Americans With Type 2 Diabetes?, Mary Luree Garvin-Surpris
Serum Vitamin D And C-Reactive Protein: Predictors Of Glucose Control In African-Americans With Type 2 Diabetes?, Mary Luree Garvin-Surpris
All ETDs from UAB
Introduction African-Americans experience more years of life lost as a result of complications from type 2 diabetes mellitus (T2DM) than any other racial or ethnic group. Evidence suggests that serum 25(OH)D (serum vitamin D), generally low in African-Americans, may play a role in glucose control. In addition, elevated levels of chronic low-grade inflammation, measured by C-reactive protein (CRP), may also relate to glucose control. The purposes of this study were to determine whether serum 25(OH)D and CRP are independent predictors of glucose control in adult African-Americans with T2DM, after controlling for other factors associated with glucose control, and to examine …
Neurobiological Consequences Of Perinatal Ssri Exposure, Matthew Edward Glover
Neurobiological Consequences Of Perinatal Ssri Exposure, Matthew Edward Glover
All ETDs from UAB
Selective serotonin reuptake inhibitors (SSRIs) have been a mainstay pharmacological treatment for women experiencing depression during pregnancy and postpartum for nearly three decades. Recently, though, growing evidence indicates that early-life SSRI exposure triggers long-lasting behavioral abnormalities. Clinically, children exposed to SSRIs in early life exhibit increased internalizing behavior, reduced social behavior, and increased risk for depression in adolescence. Similarly, in rodents, perinatal SSRI exposure leads to increased traits of anxiety- and depression-like behavior. Interestingly, certain individuals are more susceptible to early-life SSRI exposure than others, suggesting that perinatal SSRI exposure poses greater risks for negative outcome within certain populations; however, …
The (Non)Tragic Passing Of Rena Walden: Black Female Agency In Charles Chesnutt's The House Behind The Cedars, Sarah Emily Goggans
The (Non)Tragic Passing Of Rena Walden: Black Female Agency In Charles Chesnutt's The House Behind The Cedars, Sarah Emily Goggans
All ETDs from UAB
This project analyzes Charles W. Chesnutt’s The House Behind the Cedars in an attempt to accredit Chesnutt as a forerunner of Critical Race Theory (CRT). Secondly, this project argues that Rena gains agency solely through her black ancestry in her ability to read and write both cultural and written texts. I will also argue in that creating a metanarrative form for his novel, Chesnutt is able to provide a radically feminist text through his representation of the power of Rena’s literacy, and furthermore, that Chesnutt is able to critique the laws and customs of normative white society. Lastly, this project …
Conceptualizations Of Health And Health Communication By Clergy In Jefferson County, Alabama: A Qualitative Exploration, Anthony David Campbell
Conceptualizations Of Health And Health Communication By Clergy In Jefferson County, Alabama: A Qualitative Exploration, Anthony David Campbell
All ETDs from UAB
The purpose of this dissertation is to examine how clergy define health and how they communicate health messages to their congregations and communities. Clergy are influential figures who fulfill a variety of roles outside of their unique pastoral responsibilities, including serving as a source of health-related information and resources. Little is known about how clergy perceive the role of churches and their own role in health and health ministry. In-depth qualitative interviews were conducted with 32 African American and white clergy members from a variety of religious denominations in Jefferson County, Alabama between January 2015 and February 2016. Data were …
Social Worker Experiences Serving At-Risk Youth With Emotional And Behavioral Disabilities, Sherriese S. Anderson
Social Worker Experiences Serving At-Risk Youth With Emotional And Behavioral Disabilities, Sherriese S. Anderson
Theses and Dissertations
This dissertation was a qualitative study of school social workers who worked with special needs adolescent youth with emotional and behavioral disabilities in a public high school. This study centered on the experiences of 10 social workers in a public high school in New Jersey. All 10 school social workers were interviewed individually to uncover (a) how they perceived the school social worker's role within the public school setting, (b) the lived experiences of school social workers who worked with special needs youth with emotional and behavioral disabilities, and (c) why they desired to continue working with at-risk special needs …
Parental Acculturation And Adolescent Depression, Serra Sevde Aydogan
Parental Acculturation And Adolescent Depression, Serra Sevde Aydogan
All ETDs from UAB
This study investigates whether or not parental acculturation is associated with depression levels among youth in US-based immigrant families. Previous research has shown that even though individual acculturation is negatively correlated with adolescents’ good mental health, parental acculturation is associated with higher levels of mental health among youth. This study elaborates on these prior findings by using a large national sample of immigrant children ages 13-14 and considering the mediating role of social ties and social support. Data for the study are derived from the Children of Immigrant Longitudinal Study to examine the relationship between parental acculturation and youth depression. …