Digital Commons Network^™

Orchestrated Architecture Dismantling: Borrelia Burgdorferi’S Coordinated Destruction Of Adaptive Immune Responses, Craig A. Land

Electronic Theses and Dissertations

Borrelia burgdorferi represents the most prevalent vector-borne bacteria in North America, affecting ~476,000 Americans annually yet persisting despite robust immune responses. This project reveals spirochetes target adaptive immunity through coordinated lymphatic colonization and precision immune dysregulation.

Using comparative host models (C57BL/6 vs. reservoir Peromyscus leucopus), we demonstrate lymph node colonization within 48-hours, with spirochetes exploiting LYVE-1-positive lymphatic structures as dissemination highways while avoiding the interior of follicular regions. Critically, we identify targeted CD4+ T-cell elimination in germinal center border zones at 21-DPI, precisely when these cells should be coordinating protective immunity. Concurrent upregulation of inhibitory receptor CD32b creates molecular …

The Impact Of Estrogen Loss On Caveolin Expression And Cardiac Myocyte Remodeling In Ovariectomized Mice Following Chronic Sympathetic Stimulation, Juliana Barnie

Electronic Theses and Dissertations

Cardiovascular disease (CVDs) remains the top cause of death globally, with postmenopausal women at higher risk due to estrogen decline. Beta-Adrenergic (β-AR) signaling is a major regulator of heart function. Caveolins, structural proteins of caveolae, coordinate cell signaling activities in the heart by co-localizing with estrogen receptors and β-AR and contribute to maintaining healthy cardiac function. The caveolin scaffolding domain (CSD), a binding component of caveolin, has shown therapeutic potential in animal models of heart disease. However, most studies on CSD have been completed in male mice. This thesis evaluates the therapeutic potential of CSD in female mouse models and …

Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan

Surgery Faculty Publications

Background: Mutational landscape is prognostic in colorectal cancer (CRC). Rat sarcoma (RAS) oncogenes, such as KRAS and NRAS, with driver mutations, portend poor survival outcomes, whereas pathologic mutations in HRAS are extremely rare, and their prognostic value remains uncertain. Methods: This retrospective study analyzed the Oncology Research Information Exchange Network (ORIEN) alliance tumor RNA-Seq data in Stages II and III CRC to investigate the association between RAS gene expression and survival outcomes. Results: High transcript levels of HRAS were associated with superior overall survival (OS). The high HRAS-associated OS benefit was most pronounced in patients with right-sided primary expressing low …

Molecular And Clinical Insights Into Role Of Gper In Hepatocellular Carcinoma (Hcc), Hossain Ahmed

Theses and Dissertations

Metabolic dysfunction–associated steatotic liver disease (MASLD), encompassing stages from steatosis (MASLD) to steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma (HCC), is the most prevalent chronic liver disease worldwide, yet molecular markers of progression remain limited. The G protein–coupled estrogen receptor (GPER), a non-genomic estrogen receptor with metabolic and anti-inflammatory roles, emerges as a candidate regulator in hepatic pathophysiology. In this Dissertation thesis, we have delineated for the first time clinicopathological assessment of liver biopsies across MASLD stages revealing a robust inverse correlation between GPER expression and disease severity. Higher GPER levels in early MASLD associated with favorable metabolic and biochemical profiles, …

Principles And Practice In Pediatric Vascular Trauma: Part 1: Scope Of Problem, Team Structure, Multidisciplinary Dynamics, And Solutions, Matthew T Harting, Natalie A Drucker, Mary T Austin, Matthew R Greives, Bryan A Cotton, S Keisin Wang, Derrick P Williams, Joseph J Dubose, Charles S Cox

The Brown Foundation: Institute of Molecular Medicine

As of 2020, penetrating injuries became the leading cause of death among children and adolescents ages 1-19 in the United States. For the patients who initially survive and receive advanced medical care, vascular injuries are a significant cause of morbidity and additionally trigger notable trauma team angst. Moreover, penetrating injuries can lead to life-threatening hemorrhage and/or limb-threatening ischemia if not addressed promptly. Vascular injury management demands timely and unique expertise, particularly for pediatric patients. As the frequency of vascular injuries requiring operative management increases, it becomes clear that an ad hoc approach is not ideal. An integrated team would provide …

Enigmatic Roles Of Complement Anaphylatoxin Signaling In Health And Disease, Anthony Shadid, Kathryn D Hok, Aleksey Y Domozhirov, Tingting Weng-Mills, Marie-Françoise Doursout, Nirmal K Banda, Marcos I Restrepo, Pooja Shivshankar

The Brown Foundation: Institute of Molecular Medicine

Complement anaphylatoxins C3a and C5a are potent immunomodulators whose impact extends well beyond their traditional roles in innate immunity. Acting through G protein-coupled receptors C3aR, C5aR1, and C5aR2, these peptides take part in coordinating immune cell recruitment, vascular tone, and tissue remodeling. Yet their functions are deeply context-dependent: while they play essential roles in microbial clearance and immune coordination, their overactivation contributes to immunopathology in a wide range of diseases. The anaphylatoxins play key roles in early pathogen containment but can also drive cytokine storm and tissue damage, as in coronavirus disease 2019 (COVID-19) and bacterial sepsis. In autoimmune conditions, …

Synergistic Enhancement Of Tribological Behavior And Colloidal Stability In Cuo Nanolubricants Via Ligand Tuning, Sherif Elsoudy, Sayed Akl Akl Dr, Sayed Akl A. Akl Dr, Esm Lane, Abas Hadawey, Philip D. Howes

Mechanical Engineering

Nanoparticle-based lubricants, or nanolubricants, can exhibit superior tribological properties compared to unmodified base oils. However, these performance gains are highly dependent on the nanoparticle surface chemistry, particularly in maintaining stable colloidal dispersions. This study explores the influence of oleic acid (OA) and oleylamine (OAm) functionalization on the tribological and colloidal properties of CuO nanoparticles dispersed in an SAE 20W50 base oil. We present a hybrid optimization framework combining Response Surface Methodology (RSM) with Bayesian Optimization (BO) to identify the optimal OA to OAm ratio (OA–OAm) for CuO nanolubricants. Unlike prior studies that employed either RSM alone or trial-and-error approaches, this …

2025 August, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for August of 2025.

The Pharmacology Of Gpr171 Ligands In The Treatment Of Pain: An In Vitro And In Vivo Preclinical Characterization, Max V. Mcdermott

All Graduate Theses and Dissertations, Fall 2023 to Present

Opioids are addictive, ineffective for long-term treatment, readily produce withdrawal and tolerance, and can cause overdose and death. These properties have contributed to an epidemic of addiction and overdose, which continues unabated in the United States. Therefore, new drugs to treat acute and chronic pain are needed. Opioids bind to receptors belonging to a superfamily of proteins called G protein-coupled receptors (GPCRs). GPCRs are the most commonly targeted proteins among FDA-approved drugs. As such, under-researched GPCRs are a viable source of new targets in the field of drug development. One such underexplored GPCR is GPR171. Studies have demonstrated that a …

The Global Neurodegeneration Proteomics Consortium: Biomarker And Drug Target Discovery For Common Neurodegenerative Diseases And Aging, Farhad Imam, Rowan Saloner, Jacob W Vogel, Varsha Krish, Gamal Abdel-Azim, Muhammad Ali, Lijun An, Federica Anastasi, David Bennett, Alexa Pichet Binette, Adam L Boxer, Martin Bringmann, Jeffrey M Burns, Carlos Cruchaga, Jeff L Dage, Amelia Farinas, Luigi Ferrucci, Caitlin A Finney, Mark Frasier, Oskar Hansson, Timothy J Hohman, Erik C B Johnson, Mika Kivimaki, Roxanna Korologou-Linden, Agustin Ruiz Laza, Allan I Levey, Inga Liepelt-Scarfone, Lina Lu, Niklas Mattsson-Carlgren, Lefkos T Middleton, Kwangsik Nho, Hamilton Se-Hwee Oh, Ronald C Petersen, Eric M Reiman, Oliver Robinson, Jeffrey D Rothstein, Andrew J Saykin, Artur Shvetcov, Chad Slawson, Bart Smets, Marc Suárez-Calvet, Betty M Tijms, Maarten Timmers, Fernando Vieira, Natalia Vilor-Tejedor, Pieter Jelle Visser, Keenan A Walker, Laura M Winchester, Tony Wyss-Coray, Chengran Yang, Niranjan Bose, Simon Lovestone, The Global Neurodegeneration Proteomics Consortium (Gnpc)

Faculty, Staff and Student Publications

More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due to disease heterogeneity, prolonged preclinical and prodromal phases, poor understanding of disease mechanisms, and diagnostic challenges. Identifying novel biomarkers is crucial for improving early detection, prognosis, staging and subtyping of these conditions. High-dimensional molecular studies in biofluids ('omics') offer promise for scalable biomarker discovery, but challenges in assembling large, diverse datasets hinder progress. To address this, the Global Neurodegeneration Proteomics Consortium (GNPC)-a public-private partnership-established one of the …

A Large-Scale Genome-Wide Study Of Gene-Sleep Duration Interactions For Blood Pressure In 811,405 Individuals From Diverse Populations, Pavithra Nagarajan, Thomas W Winkler, Amy R Bentley, Clint L Miller, Aldi T Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R Brown, John L Morrison, Ayush Giri, Jeffrey R O'Connell, Traci M Bartz, Lisa De Las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E Harris, Zhijie Huang, Mart Kals, Minjung Kho, Christophe Lefevre, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan Van Der Graaf, Peter J Van Der Most, Yujie Wang, Stefan Weiss, Kenneth E Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna D Argoty-Pantoja, Michael Arzt, Hugues Aschard, John R Attia, Lydia Bazzanno, Max A Breyer, Jennifer A Brody, Brian E Cade, Hung-Hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul S De Vries, Latchezar M Dimitrov, Anh Do, Jiawen Du, Charles T Dupont, Todd L Edwards, Michele K Evans, Tariq Faquih, Stephan B Felix, Susan P Fisher-Hoch, James S Floyd, Mariaelisa Graff, Charles Gu, Dongfeng Gu, Kristen G Hairston, Anthony J Hanley, Iris M Heid, Sami Heikkinen, Heather M Highland, Michelle M Hood, Mika Kähönen, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Tanika N Kelly, Pirjo Komulainen, Daniel Levy, Henry J Lin, Peter Y Liu, Pedro Marques-Vidal, Joseph B Mccormick, Hao Mei, James B Meigs, Cristina Menni, Kisung Nam, Ilja M Nolte, Natasha L Pacheco, Lauren E Petty, Hannah G Polikowsky, Michael A Province, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Stephen S Rich, Renata L Riha, Lorenz Risch, Martin Risch, Edward A Ruiz-Narvaez, Rodney J Scott, Colleen M Sitlani, Jennifer A Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko Willems Van Dijk, Otis D Wilson, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer E Below, Carsten A Böger, David Conen, Simon R Cox, Marcus Dörr, Mary F Feitosa, Ervin R Fox, Nora Franceschini, Sina A Gharib, Vilmundur Gudnason, Sioban D Harlow, Jiang He, Elizabeth G Holliday, Zoltan Kutalik, Timo A Lakka, Deborah A Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna C Morrison, Brenda Wjh Penninx, Patricia A Peyser, Jerome I Rotter, Harold Snieder, Tim D Spector, Lynne E Wagenknecht, Nicholas J Wareham, Alan B Zonderman, Kari E North, Myriam Fornage, Million Veteran Program, Adriana M Hung, Alisa K Manning, James Gauderman, Han Chen, Patricia B Munroe, Dabeeru C Rao, Diana Van Heemst, Susan Redline, Raymond Noordam, Heming Wang

Faculty, Staff and Student Publications

Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health …

Accelerometer-Measured Chronoactivity And Type 2 Diabetes Risk: A Prospective Study In Uk Biobank Participants, Qiuyu Feng, Gali Albalak, Ko Willems Van Dijk, Jeroen H P M Van Der Velde, Qian Xiao, Raymond Noordam, Diana Van Heemst

Faculty, Staff and Student Publications

Objective: We assessed whether timing of physical activity, independent from the total activity amount, - which we refer to as chronoactivity - is associated with type 2 diabetes (T2D) risk.

Methods: We included UK Biobank participants with valid accelerometry data (UK, exposure measurement: 2013-2015, follow-up till November 2023) and without diabetes mellitus at baseline (N = 89,439; mean age: 61.7 [SD:7.9] years). Relative hourly physical activity was calculated by dividing the average hourly clock time physical activity by the average hourly physical activity in a week. Participants were categorized into different chronoactivity clusters using k-means cluster analysis on relative hourly …

Temporal Disparities In Diagnosis: The Critical Impact Of Laboratory Workflow Inefficiencies On Outcomes In Metabolic And Cardiovascular Disorders, Evans Dzreke, Celene Dzreke, Ramseyer Adekorang Asamoah, David Kanze

Health & Biomedical Sciences Faculty Publications

Diagnostic delays and laboratory process inefficiencies constitute a common but unaddressed dilemma in contemporary healthcare, quietly undermining patient outcomes in metabolic and cardiovascular illnesses where immediate intervention is critical. This seminal work goes beyond traditional operational viewpoints to demonstrate diagnostic inefficiency as an independent, adjustable risk factor with far-reaching implications. We rigorously quantified the impact of delayed test processing and reporting on clinical outcomes using a comprehensive mixed-methods approach that included multi-center retrospective cohort analysis (N=128,743 patients), real-time workflow mapping across 37 laboratories, in-depth case reviews, and economic modeling. Our findings challenged conventional wisdom by indicating that each 24-hour increase …

Exploring Transgender And Gender Expansive Youth's Experiences With Vicarious Minority Stress, Erin T. Pereida

Graduate Doctoral Dissertations

In the United States (U.S.), transgender and gender expansive (TGE) youth experience elevated rates of depressive symptoms, self-harm behaviors, and suicidality compared to cisgender peers. Mental health professionals and researchers often use the gender minority stress model to explain these elevated rates, positing that stressors related to minority identity experienced above and beyond normative daily stress contribute to adverse mental health outcomes. One emerging component of the model requiring further investigation is vicarious minority stress; stress experienced indirectly through witnessing or learning of gender minority stressors affecting other TGD individuals or the community more broadly. The present study explored this …

Antibacterial Effect Of Ethanol Extracts Of Murraya Paniculata Leaves, Smallanthus Sonchifolius Leaves, Apis Trigona Honey, And Their Combination Against Staphylococcus Epidermidis, Sri Agung Fitri Kusuma, Irma Erika Herawati, Felika Nugrahaningtiyas

Chimica et Natura Acta

Several studies have reported that combining plant extracts may enhance their efficacy against specific bacterial infections. This study aimed to analyze the antibacterial interaction of ethanol extracts of Murraya paniculata leaves, Smallanthus sonchifolius leaves, Apis trigona honey, and their combinations against Staphylococcus epidermidis ATCC 12228, as each component has shown individual antibacterial activity against this bacterium. The antibacterial interactions of the test materials, both individually and in combination, were evaluated using the agar diffusion method with clindamycin phosphate as the standard antibiotic. The minimum inhibitory concentration (MIC) of the most potent extract was determined through the microdilution method according to …

Effect Of Fermentation On The Phsyco And Functional Properties Of Red Sorghum Flour (Sorghum Bicolor L.), Elazmanawati Lembong, Endah Wulandari, Putri Widyanti Harlina, Syifa Tsalitsu

Chimica et Natura Acta

Modification of red sorghum flour by fermentation method can improve the physical, chemical, and functional properties of the resulting sorghum flour. The purpose of this study was to determine the fermentation time that can affect the physical and functional characteristics of red sorghum flour fermented spontaneous (TSS) and non-spontaneous (TTS). Results indicated that the best treatment was red sorghum flour fermented at 24 hours both spontaneous and non-spontaneous. TSS at 24 hours had a water absorption capacity of 1.04%, oil binding capacity of 1.04%, swelling volume of 7.47%, solubility of 7.57%, initial gelatinization temperature of 76.56oC, peak viscosity of 2855 …

In-Silico Of Vascular Endothelial Growth Factor Receptor-2 (Vegfr-2) Inhibitors Of Seven Bioactive Compounds From Sonneratia Alba, Madyawati Latief, Fitria Melani, Yusnaidar Yusnaidar, Indra Lasmana Tarigan

Chimica et Natura Acta

Cancer is a disorder resulting from genetic changes, abnormal growth, and spread to other parts of the body. Cancer treatment is commonly administered through chemotherapy, which often results in adverse side effects. Therefore, research is essential to identify safer alternative cancer therapies. This study aims to identify potential bioactive compound ligand receptor targets from Sonneratia alba as anticancer candidates in silico by identifying VEGFR target proteins based on their pharmacophores and studying their interactions through the reverse docking method. Docking simulations between the native ligand (Tivozanib) and the receptor yielded promising results, with a free energy value of -12.76 kcal/mol …

Maggot As A Bioconversion Agent Of Cow Blood Waste And Date Pulp Into Feed Raw Materials: A Chemical Profile Study, Imra Atun Helmi, Hidayati Nufus, Ikrima Ahdavia, Muhamad Farid, Ahmad Sjahriza

Chimica et Natura Acta

Cow blood waste and date residue become environmental problems if not appropriately managed. So far, there has yet to be any special management to handle the waste. On the other hand, cow blood waste and date pulp can be efficiently decomposed by maggots. This research was carried out to utilize organic waste as maggot cultivation by producing animal feed materials high in protein and fat, and to determine the best composition in the feed medium. Maggot feed treatment consisted of household organic waste as P0, mixed feed as P1, the ratio of cow blood waste to date pulp P2 (1:1), …

Synthesis Of 1,2-Di(Phenyl)Ethan-1,2-Dione Through Oxidation Of 2-Hydroxy-1,2-Dipheniletanone By Using Copper(Ii) Citrate, Winda Seviani, Arif Fadlan, Vania Wirastuti

Chimica et Natura Acta

1,2-Di(phenyl)-1,2-dione widely used in chemical and pharmaceutical industries and found as a framework in secondary metabolites can be obtained through oxidation of 2-hydroxy-1,2-diphenylethanone using strong acids, homogeneous, heterogeneous, and metal catalysts. However, these oxidation methods exhibit various drawbacks. This study reported the oxidation of 2-hydroxy-1,2-diphenylethanone by using copper(II) citrate to produce 1,2-di(phenyl)-1,2-dione. The oxidation performed with copper(II) citrate and ammonium nitrate in glacial acetic acid as solvent yielded 1,2-di(phenyl)-1,2-dione in 88% yield higher than the nitric acid method (79% yield). The FTIR, NMR spectriscopies, and mass analysis confirmed the structure of 1,2-di(phenyl)ethane-1,2-dione. The oxidation of 2-hydroxy-1,2-diphenylethanone using copper(II) citrate is …

Cytotoxicity Of Chromanone Acid From The Steam Bark Of Calophyllum Incrassatum Against P-388 Leukemia Murine Cells, Ulfatun Hasanah, Robi’Atul Andawiyah, Barrotut Taqiyah, Ratih Dewi Saputri, Tjitjik Srie Tjahtjandarie

Chimica et Natura Acta

Calophyllum incrassatum is one of the plant species of the Calophylloceae family and is found endemic in Kalimantan and Sumatra. This study aims to isolate chromanone acid compounds from the stem bark of C. incrassatum and determine the relationship between structure and activity against murine Leukemia P-388 cells. The extraction method used was maceration using methanol solvent, partitioned with n-hexane and ethyl acetate solvents. Separation and purification of n-hexane and ethyl acetate extracts by vacuum liquid chromatography, pressed column, and radial. Two chromanone acids derivatives, isoapetalic acid (1), and methyl isoapetalic (2), have been successfully isolated from the stem bark …

Antioxidant Potential And Active Compound Identification Of Hylocereus Costaricensis And Hylocereus Undatus Peel Extracts Using Lc-Ms/Ms, Ade Heri Mulyati, Reni Nurmayani, Diana Widiastuti, Siti Warnasih, Siska Elisahbet Sinaga

Chimica et Natura Acta

The object of this research was to determine the antioxidant potential and identify active compounds in the peel extracts of red dragon fruit (Hylocereus costaricensis) and white dragon fruit (Hylocereus undatus). Phytochemical tests were conducted to identify flavonoids, alkaloids, tannins, coumarins, and saponins. The antioxidant activity was assessed using the DPPH assay, while vitamin C content was quantified using UV-Vis spectrophotometry, and bioactive antioxidant compounds were identified through LC-MS/MS spectrophotometry. The results demonstrated that phytochemical screening revealed the presence of flavonoids and alkaloids in both extracts. Antioxidant activity assays indicated that the red dragon fruit peel extract exhibited an IC50 …

Identification Of Secondary Metabolites In Ethyl Acetate Extract Of Ki Encok Plant Roots (Plumbago Zeylanica Linn) And In Silico Cytotoxicity Activity, Mitayani Purwoko, Trisnawati Mundijo, Yesi Astri, Siti Rohani

Chimica et Natura Acta

The Ki Encok plant (Plumbago zeylanica Linn) has been extensively studied and is known to have cytotoxic activity. However, no research has yet investigated the compound content of the ethyl acetate extract from that plant. This study aims to identify the secondary metabolite content in the ethyl acetate extract of Plumbago zeylanica L. roots and to determine the potential of these secondary metabolites to bind with the Caspase-3 protein in silico. The ethyl acetate extract of Plumbago zeylanica roots was tested for its phytochemical properties and examined using GC-MS. The compounds found were then searched for their structures in Pubchem, …

Child Abuse In Colonial America, Brian Allen

Graduate Masters Theses

Child Abuse in Colonial America is an investigation of the extent to which colonial societies were aware of child abuse and how they responded. Historians often assert that awareness of the problem did not exist in America until the mid-nineteenth century; however, the evidence uncovered suggests that cases of child abuse were recognized during the colonial period and that the societal responses differed widely. Historians of childhood document myriad social, economic, political, religious, and other cultural influences that dictate how children were treated at different times and locations, and this framework is used to interpret why the responses to child …

Lesbian, Gay, Bisexual, Transgender, Gender Expansive, And Queer+ Client Experiences Discussing Consensual Nonmonogamy In Therapy: An Interpretive Phenomenological Analysis, Evan Wendell Engle-Newman

Dissertations

This dissertation presents the findings from an Interpretive Phenomenological Analysis (IPA) study on how lesbian, gay, bisexual, transgender, gender expansive, and queer+ (LGBTGEQ+) clients experience discussing consensual nonmonogamy (CNM) in therapy. This study explored how five individuals made meaning of their experiences discussing CNM with current or prior therapists. The meaning they made of these experiences were situated in the context of social and cultural factors that influenced their discussions of CNM in therapy.

There were three research questions for this study including one primary question and two guiding sub-questions. The primary question was: what are the experiences of LGBTGEQ+ …

From Foster Care To College Graduation: A Qualitative Study Of The Experiences Of College Graduates Who Aged Out Of Foster Care, Antonia Irene Thomas

Dissertations

Students who have spent time in the foster care system encounter a myriad of barriers and challenges to academic success. Among these challenges is attending post-secondary school and completing a college degree. High school academic performance, knowledge of the college application process, and lack of financial support are some factors that act as barriers to post-secondary attendance. Lack of support and difficulty navigating the college experience can negatively impact the ability to complete college. Even in instances of desire and academic ability to attend college, many of these students never attend, or do not complete and obtain a degree. Between …

Beliefs Of California And Colorado Parents, School Professionals, And School Administrators Around Providing Comprehensive Sexuality Education To School-Aged Youth With Intellectual And Developmental Disabilities, Michelle Aleen Kalos

Dissertations

People with intellectual and developmental disabilities (IDD) are victims of sexual assault at a rate seven times higher than people without IDD (Shapiro, 2018a). “One of the best ways to stop sexual assault is to give people with intellectual disabilities the ability to identify abuse and to know how to develop the healthy relationships they want” (Shapiro, 2018b, p. 1). Comprehensive sexuality education (CSE) could be a scientifically accurate, evidence-based, age-appropriate, culturally relevant, and inclusive educational experience for youth with IDD (Koch et al., 2024). However, only around 16% of students with IDD were likely to receive sex education in …

Students’ Ability To Transfer Organic Chemistry Concepts To Metabolic Reactions, Timothy Jones

Dissertations

Bridging foundational knowledge learned in prerequisite courses like organic chemistry to higher-level courses like biochemistry represents a significant challenge in science education, often hindering deeper student understanding and future knowledge application. The purpose of this dissertation was to investigate students’ ability to transfer and apply their understanding of organic chemistry when reasoning through metabolic reaction problems often seen in biochemistry courses. The research questions guiding the project were two-fold:

Q1 What are the organic chemistry reaction concepts deemed foundational to understanding metabolism by experts in the field?

Q2 What is the student’s ability to transfer knowledge of organic chemistry reactions …

Microstructural Investigation Of Graphene Reinforced Nickel Aluminum Bronze Prepared Via Laser Powder Bed Fusion, Wen Qian, Maxwyll Mcconnell, Jazmin Ley, Luke Schwaninger, Xin Chen, Bai Cui, Joseph A. Turner

Mechanical Engineering Faculty Publications

Nickel aluminum bronze (NAB) powders coated with reduced graphene oxide (RGO) were successfully fabricated using additive manufacturing (AM) via laser powder bed fusion. The resulting samples were characterized using a suite of complementary techniques, including x-ray diffraction, scanning electron microscopy, energy-dispersive x-ray spectroscopy, nanoindentation, x-ray computed tomography, and electron backscatter diffraction. These methods were employed to reveal the micro- and nanoscale features within the fine dendritic microstructure. The as-fabricated microstructures were observed to deviate significantly from typical as-cast configurations. In the AM RGO-coated NAB specimens, the formation of the κ_I phase was notably suppressed and is attributed to the …

Teacher Leadership In Social Studies: The Search For Meaning And Identity, Zachary F. Lawson

Dissertations

This qualitative research study brings together social studies education and teacher leadership. Social studies lacks study in the teacher leader literature. This study aimed to understand whether the disciplinary nature of social studies education influenced the enactment of teacher leadership. This study sought an answer to the central research question: What does it mean to be a social studies teacher leader? Using a hermeneutic phenomenology research design, data were collected through semi-structured interviews across two groups of participants. Seven social studies teacher leaders made up one group, and five social studies teachers without leadership roles comprised the other. Findings indicated …

Cotton Yield And Tissue-Potassium Response To Potassium Fertilization, Maria Paula Ramos Do Prado

Graduate Theses and Dissertations

Potassium (K) deficiency is a common yield-limiting factor in cotton (Gossypium hirsu tum L.) production across the U.S. Cotton Belt. Adequate fertilizer-K management is paramount to ensure optimum plant growth and development, minimizing yield losses. Currently, fertilizer K recommendations for cotton in Arkansas are derived from expected yield responses of other crops, with no calibrated fertilizer-K rates or critical tissue-K concentrations defined to maxim ize crop yield. Our research objectives were i) to investigate cotton yield response and fiber qual ity to K fertilization on soils with different K availability; ii) to correlate relative yield with tis sue-K concentrations at …