Digital Commons Network^™

Developmental Transcription Factors In Age-Related Cns Disease: A Phoenix Rising From The Ashes?, Robert White, Meghan Thomas

Research outputs 2014 to 2021

Few would doubt that understanding the developmental landscape from which a mature neuron is derived is essential to understand its biology. The temporal and spatial position of a cell from the very earliest stages of development predicts the unique combinations of growth factors it will subsequently be exposed to. This combination of factors determines the transcriptional platform set within the cell by its specific combination of transcription factors, who direct the show. This, in turn, determines what cell type it will differentiate into, and what connections it will make. How this developmental platform translates to maintenance of a differentiated neuron …

Omics' Biomarkers Associated With Chronic Low Back Pain: Protocol Of A Retrospective Longitudinal Study, M. Allegri, Manuela De Gregori, Cristina E. Minella, Catherine Klersy, Wei Wang, Moira G. Sim, Christian Gieger, Judith Manz, Iain K. Pemberton, Jane Macdougall, Frances M. Williams, Jan Van Zundert, Klaas Buyse, Gordan Lauc, Ivan Gudelj, Dragan Primorac, Andrea Skelin, Yurii S. Aulchenko, Lennart C. Karssen, Leonardo Kapural, Richard L. Rauck, Guido Fanelli

Research outputs 2014 to 2021

Introduction

Chronic low back pain (CLBP) produces considerable direct costs as well as indirect burdens for society, industry and health systems. CLBP is characterised by heterogeneity, inclusion of several pain syndromes, different underlying molecular pathologies and interaction with psychosocial factors that leads to a range of clinical manifestations. There is still much to understand in the underlying pathological processes and the non-psychosocial factors which account for differences in outcomes. Biomarkers that may be objectively used for diagnosis and personalised, targeted and cost-effective treatment are still lacking. Therefore, any data that may be obtained at the-omics' level (glycomics, Activomics and genome-wide …

Periodization Strategies In Older Adults: Impact On Physical Function And Health, Jennifer Conlon, Greg Haff, James J. Tufano, Robert Newton

Research outputs 2014 to 2021

Purpose

This study compared the effect of periodized versus nonperiodized (NP) resistance training (RT) on physical function and health outcomes in older adults.

Methods

Forty-one apparently healthy untrained older adults (women = 21, men = 20; 70.9 ± 5.1 yr; 166.3 ± 8.2 cm; 72.9 ± 13.4 kg) were recruited and randomly stratified to a NP, block periodized, or daily undulating periodized training group. Outcome measures were assessed at baseline and after a 22-wk × 3 d·wk⁻¹ RT intervention, including; anthropometrics, body composition, blood pressure and biomarkers, maximal strength, functional capacity, balance confidence, and quality of life.

Results

Thirty-three …

Ultra-Sustainable Fe78si9b13 Metallic Glass As A Catalyst For Activation Of Persulfate On Methylene Blue Degradation Under Uv-Vis Light, Zhe Jia, Xiaoguang Duan, Wenchang Zhang, Weimin Wang, Hongqi Sun, Shaobin Wang, Laichang Zhang

Research outputs 2014 to 2021

Stability and reusability are important characteristics of advanced catalysts for wastewater treatment. In this work, for the first time, sulfate radicals (SO4∙−) with a high oxidative potential (Eo = 2.5–3.1 V) were successfully activated from persulfate by a Fe78Si9B13 metallic glass. This alloy exhibited a superior surface stability and reusability while activating persulfate as indicated by it being used for 30 times while maintaining an acceptable methylene blue (MB) degradation rate. The produced SiO2 layer on the ribbon surface expanded strongly from the fresh use to the 20th use, providing stable protection of the buried Fe. MB degradation and kinetic …

An Introduction To The Australian And New Zealand Flux Tower Network – Ozflux, Jason Beringe, Lindsay B. Hutley, Ian Mchugh, Stefan K. Arndt, David Campbell, Helen A. Cleugh, James Cleverly, Víctor R. De Dios, Derek Eamus, Bradley Evans, Cacilia Ewenz, Peter Grace, Anne Griebel, Vanessa Haverd, Nina Hinko-Najera, Alfredo Huete, Peter Isaac, Kasturi Kanniah, Ray Leuning, Michael J. Liddell, Craig Macfarlane, Wayne Meyer, Caitlin Moore, Elise Pendall, Alison Phillips, Rebecca L. Phillips, Suzanne M. Prober, Natalia Restrepo-Coupe, Susanna Rutledge, Ivan Schroder, Richard Silberstein, Patricia Southall, Mei S. Yee, Nigel Tapper, Eva Van Gorsel, Camilla Vote, Jeff Walker, Tim Wardlaw

Research outputs 2014 to 2021

OzFlux is the regional Australian and New Zealand flux tower network that aims to provide a continental-scale national research facility to monitor and assess trends, and improve predictions, of Australia's terrestrial biosphere and climate. This paper describes the evolution, design, and current status of OzFlux as well as provides an overview of data processing. We analyse measurements from all sites within the Australian portion of the OzFlux network and two sites from New Zealand. The response of the Australian biomes to climate was largely consistent with global studies except that Australian systems had a lower ecosystem water-use efficiency. Australian semi-arid/arid …

Incorporating Field Studies Into Species Distribution And Climate Change Modelling: A Case Study Of The Koomal Trichosurus Vulpecula Hypoleucus (Phalangeridae), Shaun Molloy, Robert Davis, Eddie Van Etten

Research outputs 2014 to 2021

Species distribution models (SDMs) are an effective way of predicting the potential distribution of species and their response to environmental change. Most SDMs apply presence data to a relatively generic set of predictive variables such as climate. However, this weakens the modelling process by overlooking the responses to more cryptic predictive variables. In this paper we demonstrate a means by which data gathered from an intensive animal trapping study can be used to enhance SDMs by combining field data with bioclimatic modelling techniques to determine the future potential distribution for the koomal (Trichosurus vulpecula hypoleucus). The koomal is a geographically …

Regular Fat And Reduced Fat Dairy Products Show Similar Associations With Markers Of Adolescent Cardiometabolic Health, Theresa A. O'Sullivan, Alexandra P. Bremmer, Trevor A. Mori, Lawrence J. Beilin, Charlotte Wilson, Katherine Hafekost, Gina L. Ambrosini, Rae Chi Huang, Wendy H. Oddy

Research outputs 2014 to 2021

Reduced fat dairy products are generally recommended for adults and children over the age of two years. However, emerging evidence suggests that dairy fat may not have detrimental health effects. We aimed to investigate prospective associations between consumption of regular versus reduced fat dairy products and cardiometabolic risk factors from early to late adolescence. In the West Australian Raine Study, dairy intake was assessed using semi-quantitative food frequency questionnaires in 860 adolescents at 14 and 17-year follow-ups; 582 of these also had blood biochemistry at both points. Using generalized estimating equations, we examined associations with cardiometabolic risk factors. Models incorporated …

Decriminalizing Polygamy, Casey E. Faucon

Utah Law Review

Polygamous families are our national outlaws. Despite the expansion of sexual rights and marriage equality in the U.S., polygamy remains a crime. Challenging that stigma is the Brown family, who star in the reality TV show “Sister Wives” and who practice polygamous marriageas a tenet of their religion. The Browns filed suit against multiple Utah state actors in federal district court, challenging Utah’s polygamy statute as unconstitutional in violation of their Free Exercise of Religion, substantive Due Process, and Equal Protection rights. The district court agreed and decriminalized informal polygamy in Utah. On appeal, the Tenth Circuit reversed the district …

Metabolomics Enables Precision Medicine: “A White Paper, Community Perspective”, Richard D. Beger, Warwick B. Dunn, Michael A. Schmidt, Steven S. Cross, Jennifer A. Kirwan, Marta S. Cascante, Lorraine Brennan, David S. Wishart, Matej Orešič, Thomas Hankemeier, David Broadhurst, Andrew N. Lane, Karsten Suhre, Gabi Kastenmüller, Susan J. Sumner, Ines Thiele, Oliver E. Fiehn, Rima Kaddurah- Daouk

Research outputs 2014 to 2021

Introduction:Background to metabolomics:

Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or “-omics” level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person’s metabolic state provides a close representation of that individual’s overall health status. This metabolic state reflects what has been encoded by the genome, and modified by diet, environmental factors, and the gut microbiome. The metabolic profile provides …

Combined Effects Of Ocean Acidification, Ocean Warming And Oil Spill On Aspects Of Development Of Marine Invertebrates, Maj Arnberg

School of Biological and Marine Sciences Theses

For decades, humans have impacted marine ecosystems in a variety of ways including contamination by pollution, fishing, and physical destruction of habitats. Global change has, and will, lead to alterations in in a number of abiotic factors of our ocean in particular reduced oxygen saturation, salinity changes, elevated temperature (ocean warming or OW) and elevated carbon dioxide (ocean acidification or OA). Now and in the future, OA and OW will operate together with local anthropogenic drivers such as oil pollution. And yet, at present, very little is known about their potential combined interactive effects on physiological performance and tolerance of …

The Effects Of Ocean Acidification On Zooplankton: Using Natural Co2 Seeps As Windows Into The Future, Joy Smith

School of Biological and Marine Sciences Theses

Since the beginning of the Industrial Revolution, carbon dioxide (CO2) has been emitted into the atmosphere at rates unprecedented to Earth’s history. Nearly 30% of the anthropogenic CO2 in the atmosphere has been absorbed in surface waters of the ocean, pushing carbonate chemistry towards increased bicarbonate ions and hydrogen protons and decreased carbonate ions. Consequently, seawater pH has decreased from pre-Industrial Revolution levels of 8.2 to current levels of 8.1, and it is expected to continue to drop to 7.8 by the year 2100 if carbon emissions continue as predicted. The combination of these effects is referred to as ocean …

Impacts Of Waterborne Copper And Silver On The Early Life Stage (Els) Of Zebrafish (Danio Rerio): Physiological, Biochemical And Molecular Responses, Sahib Mohammadbakir

School of Biological and Marine Sciences Theses

Toxic metals are major pollutants of the aquatic environment and are able to cause survival impairment of the early life stage of the aquatic organisms. They can affect the osmoregulatory system and electrolyte balance in fishes as well as the expression of genes which are essential in the formation and development of the organs at the early embryonic stages of development. There are a lack of studies concerning the toxic effects of waterborne copper and silver on the osmoregulation, electrolytes balance and expression the genes which are responsible for the formation and development of heart and metal binding proteins in …

The Role Of Physical Oceanography On The Distributions And Foraging Behaviours Of Marine Mammals And Seabirds In Shelf-Seas, Samantha Lucy Cox

School of Biological and Marine Sciences Theses

Mid-latitude shelf-seas are highly productive regions that host a rich diversity of animals including large numbers of marine mammals and seabirds. These large vertebrate predators play a crucial role in the functioning of shelf-sea ecosystems. However, the combined effects of multiple anthropogenic stressors are driving unprecedented declines in many of their populations. Mitigating this depends upon effective conservation and integrated ecosystem based approaches to management, which require a comprehensive understanding of the habitat needs of marine predators. The foraging efficiencies of marine predators are closely tied to the availability of a number of oceanographic features. As such, these physical habitats …

The Effects Of Selected Bio-Active Feed Additives On Nile Tilapia (Oreochromis Niloticus) Production And Health, Ayodeji Adeoye

School of Biological and Marine Sciences Theses

Three investigations were conducted to assess the effects of selected bio-active feed additives on tilapia (Oreochromis niloticus) growth performance, feed utilisation, haemato-immunological status, intestinal morphology and microbiology. The first experiment was conducted to evaluate the effects of feeding tilapia semi-practical diets supplemented with exogenous enzymes (phytase, protease or carbohydrase). After six weeks of the dietary supplementation, tilapia fed diets supplemented with exogenous enzymes (phytase and carbohydrase) showed enhanced growth performance and higher microvilli density when compared to the control group. Additionally, the intestinal bacterial community profile of tilapia fed the carbohydrase supplemented diet was significantly altered in contrast to those …

Assessment Of A Solid-State Fermentation Product In Contemporary And Lupin-Containing Diets For Commercial Finfish, Peter Hervé A. Bowyer

School of Biological and Marine Sciences Theses

This body of research explores the dietary application of a bioactive, solid-state fermentation (SSF) product in contemporary and lupin-containing diets of Nile tilapia (Oreochromis niltoticus) and rainbow trout (Oncorhynchus mykiss). Consequently, the work provides holistic assessment of the influences of SSF products on animal health and performance; depending upon rearing temperature, nutritional physiologies, feed formulations and extrusion conditions; alongside information on the performance of lupins in aquafeeds. The SSF product (at 0.1 % inclusion) improved growth performance of Nile tilapia fed diets containing lupins. Phosphorous retention appeared higher when the SSF product was included in a yellow lupin (Lupinus luteus) …

Technological Benefits And Potential Of Incorporation Of Probiotic Bacteria And Inulin In Soft Cheese, Emad Jawad

School of Biological and Marine Sciences Theses

There is an increasing consumer demand for dairy products which are safe and free from additives. Microbial starter strains, in combination with other factors, were studied for their contribution to the control of unwanted microbes, and maintaining the quality of soft cheese. The technological and functional characteristics of the starter culture strains Lactococcus lactis subsp. lactis and Lactococcus lactis subsp. cremoris, and probiotic bacterial strains Bifidobacterium animalis subsp. lactis BB12, Lactobacillus acidophilus LA-5 and Lactobacillus casei Shirota were investigated. The tests included the milk fermentation, resistance to salt and heat, bile and acid resistance, and growth at a range of …

Maine Law Magazine - Issue No. 91, University Of Maine School Of Law

Maine Law Magazine

FEATURES

• Justice for Women
  Momentum is growing for the lecture series
• Meet the Dean
  Dean Danielle Conway on her vision for Maine Law
• Bankruptcy law
  Graduates are making their mark
• Hands-on Learning
  Students volunteer to aid detained immigrants
• Student Spotlight
  Chris Poulos makes the most of a second chance
• Celebrating Legacy
  A look at honoring six retiring professors

Robotics In The Classroom: The Effectiveness Of Robotics Based Curriculum In Stem Education, Mark Nall

Graduate Research Papers

Students learn best when they are engaged and are able to interact with their environment. They can build their own definition of concepts and themes, which are more meaningful because they are related to their own experiences and memories (Kolb, 1984). Simply put it all comes down to constructivism, which means a person builds knowledge and meaning from interactions between their experiences and ideas (the environment they work/play in and the people and objects they interact with). The purpose of this study is to find out how a middle school and high school constructivist robotics curriculum impacts students’ conceptual understanding …

Fogging Practices Of Iowa Counties For Mosquito Abatement, Alex Jay Davey

Graduate Research Papers

Global warming has been associated with an increase of mosquito-borne diseases. Mosquito-borne diseases currently have no prescription remedies. The counties across the state of Iowa will increase their fogging procedure, to supplement the increase in mosquitos and mosquito-borne diseases. This study examined which chemicals each county uses for mosquito abatement, the patterns and frequency of spraying, and what patterns of human exposure may be occurring. The county auditor was identified and recruited via email. The county auditors across the state forwarded the email message to the Environmental Health Director, in each county. At county level, they are not in control …

Racial Disparities Among African Americans Primarily In The Criminal Justice System And Other Areas In Society, Juana D. Hollingsworth

Graduate Research Papers

African Americans are overrepresented in the criminal justice system and known to experience disadvantages in society because of their race/ethnicity. In an effort to understand the barriers that hinder African Americans from equal opportunity; this study explores the possible factors that account for the disparities against the African American population in the criminal justice system and other areas in society. The current studies that exist utilize qualitative and quantitative interviews to collect the perceptions and experiences of African Americans with law enforcement. Findings revealed disparities particularly in the criminal justice system; the disparities are present in traffic tops, arrest, and …

Homocysteine And Csrp-3 Protein In Migrating Neural Crest Cells: A Quantitative And Qualitative Confocal Microscopy Study, Allysan R. White

Dissertations and Theses @ UNI

Congenital heart defects are one of the leading causes of infant death. High maternal blood serum levels of the amino acid homocysteine and the frequency of heart defects are correlated, but the immediate cause is unknown. During early embryonic development, a distinctive population of cells arises dorsally as the neural tube closes, forming the brain and spinal cord. These are the neural crest cells, which play a crucial role in the development of the nervous system, head skeletal, certain endocrine and connective tissues, and, notably, the heart’s outflow region. These migratory cells will follow specific pathways and respond to signals …

Comparison Between Natural Radioactivity Levels Andgeochemistry Of Some Granitoids In Western Turkey, Si̇bel Tatar Erkül, Süleyman Fati̇h Özmen, Fuat Erkül, İsmai̇l Boztosun

Turkish Journal of Earth Sciences

Granitoids commonly include K-feldspar, biotite and zircon, apatite, titanite, allanite, and xenotime crystals, which are known to contain common radioactive elements. Radioactive isotopes of 40K, 238U, and 232Th can be harmful to human health with increasing dosage and their quantification should be well defined to assess the suitability of wall-rock granitoids for indoor and outdoor purposes. In this study, it is aimed to correlate the possible relationship between concentrations of natural radionuclides and SiO2, Na2O, K2O, and CaO together with elements U, Th, Zr, Y, Ba, Rb, and Sr to provide a basic approach to the compatibility of geochemical data …

Synthetic Protocols On 6$H$-Benzo[$C$]Chromen-6-Ones: A Review, Ofentse Mazimba

Turkish Journal of Chemistry

6$H$-Benzo[$c$]chromen-6-ones serve as core structures of secondary metabolites and are of considerable pharmacological importance. Natural sources produce limited quantities, hence the need for synthetic procedures for 6$H$-benzo[$c$]chromen-6-ones, which are herein reviewed. The literature describes protocols such as the Suzuki coupling reactions for the synthesis of biaryl, which then undergoes lactonization, reactions of 3-formylcoumarin (chromenones) with 1,3-bis(silylenol ethers), radical mediated cyclization of arylbenzoates, metal or base catalyzed cyclization of phenyl-2-halobenzoates and 2-halobenzyloxyphenols, and benzoic acid coupling with benzoquinone using electrophilic metal-based catalyst. The efficient and simple procedures are those involving the reactions of Michael acceptor (chromenones and chalcones) with 1,3- and …

Square Wave Voltammetric Determination Of Valproic Acid In Pharmaceutical Preparations, Ebru Türköz Acar, Ati̇ye Nur Onar

Turkish Journal of Chemistry

The electrochemical behavior of valproic acid (VAL) was investigated using square wave voltammetry, cyclic voltammetry, and sampled direct current polarography and a new square wave voltammetric method was developed for determination of VAL in pharmaceutical preparations. VAL showed two reduction peaks at about --0.2 V and --0.8 V vs. Ag/AgCl 3 M KCl with a hanging mercury drop electrode in 0.05 M pH 3.3 Britton--Robinson (BR) buffer. These peaks were named peak I and peak II, respectively. The types of limiting current of both peaks were determined as diffusion controlled based on cyclic voltammetry studies. A linear calibration graph was …

Wittig--Horner Reagents: Powerful Tools In The Synthesis Of 5-And 6-Heterocyclic Compounds; Shedding Light On Their Application In Pharmaceutical Chemistry, Rizk Elsayed Khidre, Wafaa Mahmoud Abdou

Turkish Journal of Chemistry

This paper reviews literature over 25 years' activity on phosphoryl carbanion reagents and shows that these compounds are powerful tools in organic chemistry. The main target of this review is to outline some of the reactive peculiarities that make this class of compounds powerful tools in the synthesis of 5- and 6-heterocyclic compounds and/or substituted heterocycle phosphor esters. The importance of these latter compounds in pharmacology is also discussed.

Polybrominated Methoxy- And Hydroxynaphthalenes, Kiymet Berki̇l Akar, Osman Çakmak, Tuncay Tunç

Turkish Journal of Chemistry

Regio- and stereoselective synthesis are described for convenient preparation of hydroxy- and methoxynaphthalenes starting from naphthalene (\textbf{1}). \textit{cis,cis,trans}-2,3,5,8-Tetrabromo-4-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol (\textbf{6}), \textit{cis,cis,trans}-2,3,5,8-tetrabromo-1,4-dimethoxy-1,2,3,4-tetrahydronaphthalene (\textbf{7}), and \textit{cis,cis,cis}-2,3,5,8-tetrabromo-1,4-dimethoxy-1,2,3,4-tetrahydronaphthalene (\textbf{8}) were obtained with silver-induced substitution of \textit{trans,cis,trans}-1,2,3,4, 5,8-hexabromo-1,2,3,4-tetrahydronaphthalene (\textbf{3}). Base-promoted aromatization of dimethoxides \textbf{7} and \textbf{8} afforded 3,5,8-tribromo-1-methoxynaphthalene (\textbf{9}) and 2,5,8-tribromo-1-methoxynaphthalene (\textbf{10}). The reaction of \textbf{6 }with sodium methoxide formed compounds \textbf{10 }and 3,5,8-tribromonaphthalen-1-ol (\textbf{16}). Bromination of \textbf{9} and\textbf{ 16} with Br$_{2}$ in dichloromethane at room temperature produced 2,3,5,8-tetrabromo-1-methoxynaphthalene (\textbf{14}) and 2,3,4,5,8-pentabromonaphthalen-1-ol (\textbf{18}), respectively, while compound \textbf{10} did not react in the same conditions. Pyridine-induced elimination of hexabromide \textbf{3} afforded 1,4,6\textbf{-}tribromnaphthalene (\textbf{21}) in 99{\%} yield and …

Synthesis And Application Of Polyvinylimidazole-Based Bronsted Acidic Ionic Liquid Grafted Silica As An Efficient Heterogeneous Catalyst In The Preparation Of Quinoxaline Derivatives, Bahman Tamami, Alireza Sardarian, Elaheh Ataollahi

Turkish Journal of Chemistry

Two types of polymer-grafted silica based on polyvinylimidazole Bronsted acidic ionic liquids were prepared and used as new heterogeneous catalysts for the preparation of pharmaceutically important quinoxaline derivatives. These catalysts were characterized by thermogravimetric analysis, FT-IR spectroscopy, and titration. They could be recycled without considerable loss in their catalytic activity. High efficiency of the catalysts along with short reaction times, high yields, easy purification, recyclability, and simple procedure are among the advantages of these catalytic systems.

Visible Light Photocatalysis Of A Textile Dye Over Zno Nanostructures Covered On Natural Diatomite, Reza Darvishi Cheshmeh Soltani, Zohreh Haghighat

Turkish Journal of Chemistry

In the present study, ZnO nanostructures were ultrasonically synthesized and immobilized on the surface of diatomite and used for visible light photocatalysis of Acid Red 88 (AR88) in the aqueous phase. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses were employed for characterization of the samples. The process was optimized via response surface methodology (RSM) on the basis of central composite design (CCD). Based on numerical optimization, for the maximized color removal of 96% the initial dye concentration, the catalyst dosage, the reaction time, and the initial pH were 13 mg/L, 1.5 g/L, 85 min, and 4, respectively. The …

Ecofriendly One-Pot Synthesis And Antiviral Evaluation Of Novel Pyrazolyl Pyrazolines Of Medicinal Interest, Sobhi Gomha, Magda Abdalla, Mohamad Abd El-Aziz, Nany Serag

Turkish Journal of Chemistry

Ethyl 3-acetyl-1,5-diphenyl-1$H$-pyrazole-4-carboxylate reacts with a variety of arylaldehydes by grinding method in the presence of a catalytic amount of sodium hydroxide at ambient temperature to give the respective chalcones. The latter compounds react also by grinding method with nitrogen nucleophiles such as hydrazine hydrate, phenylhydrazine, and thiosemicarbazide to afford the corresponding pyrazol-3-yl pyrazolines. A series of 6-pyrazolylpyrimidine-2-thione derivatives were prepared by reaction of the above chalcones with thiourea by grinding method in the presence of a catalytic amount of sodium hydroxide at room temperature. In addition, 7-pyrazolylpyridopyrimidine-3-thione was prepared by reaction of chalcone with 6-aminothiouracil. All the newly synthesized compounds …

Comparative Density Functional Study Of Antioxidative Activity Of The Hydroxybenzoic Acids And Their Anions, Zoran Markovic, Jelena Djorovic, Jasmina M. Dimitric Markovic, Radomir Biocanin, Dragan Amic

Turkish Journal of Chemistry

Hydroxybenzoic acids (HBAs) and their anions play an important role in the food and pharmaceutical industries because of their antioxidant activity. In this study, we examined the mechanisms of the free radical scavenging action of HBAs and their anions using density functional theory (DFT) methods. Reaction enthalpies related to the mechanisms of free radical scavenging by the investigated species were calculated by DFT methods in water, DMSO, pentylethanoate, and benzene. Hydrogen atom transfer (HAT) is a preferred reaction pathway in benzene, while sequential proton loss electron transfer (SPLET) is a predominant reaction pathway in polar solvents, water, and DMSO for …