Digital Commons Network^™

In Vivo Assessment Of Antioxidant And Wound Healing Improvement Of A New Schiff Base Derived Co (Ii) Complex In Rats, R.M. El-Ferjani, M. Ahmad, S.M. Dhiyaaldeen, F.W. Harun, M.Y. Ibrahim, H. Adam, B. Mohd. Yamin, M.M.J. Al-Obaidi, R.A. Batran

Research Publications (2016 to 2020)

Co (II) complex (CMLA) was investigated to evaluate the rate of wound healing in rats. Animals were placed into four groups: gum acacia, Intrasite gel, 10 and 20 mg/ml of CMLA. Wounds were made on the dorsal neck area, then treated with Intrasite gel or CMLA; both of these treatments led to faster healing than with gum acacia. Histology of the wounds dressed with CMLA or Intrasite gel displayed a smaller scar width, required less time to heal and showed more collagen staining and fewer inflammatory cells in comparison to wounds dressed with the vehicle. Immunohistochemistry for Hsp70 and TGF-β …

Influence Of Immunology Knowledge On Healthcare And Healthy Lifestyle, N.L. Abu Kassim, A. Saleh Huddin, J.I. Daoud, M.T. Rahman

Research Publications (2016 to 2020)

Completing a course in Immunology is expected to improve health care knowledge (HCK), which in turn is anticipated to influence a healthy lifestyle (HLS), controlled use of health care services (HCS) and an awareness of emerging health care concerns (HCC). This cross-sectional study was designed to determine whether these interrelationships are empirically supported. Participants involved in this study were government servants from two ministries in Malaysia (n = 356) and university students from a local university (n = 147). Participants were selected using the non-random purposive sampling method. Data were collected using a self-developed questionnaire, which had been validated in …

In Silico, In Vitro And Cytotoxicity Investigations Of Biphenyl Alanine And Its Derivatives As Potentia) Hiv-1 Gp 120 Attachment Inhibitors, C.T. Teow, A.R. Hunin, I. Mohammed Rizman, H. Md Arman

Research Publications (2016 to 2020)

No abstract provided.

Melayu Dalam Perubahan, M.H.S.A. Murad, M.Z. Mamat, H. Maisarah

Research Publications (2016 to 2020)

Kertas kerja ini akan membincangkan persoalan perubahan yang dialami oleh masyarakat Melayu Islam dari sudut modenisasi masyarakat Melayu, khususnya dari segi ekonomi dan keagamaan. Aspek ini akan dilihat di dalam dua institusi utama, iaitu institusi ekonomi dan institusi keagamaan. Bagi institusi ekonomi, FELDA diambil sebagai kajian kes, dan bagi institusi keagamaan pula, proses modenisasi dilihat telah membawa cabaran baru kepada asas ilmu dan pandangan alam Islam, dan bagaimana cendekiawan Melayu- Muslim tempatan menyahut cabaran tersebut dengan usaha-usaha seperti pengIslaman Ilmu dan pengIslaman sains. Hasil dapatan daripada perubahan kedua-dua aspek perubahan ekonomi dan keagamaan membawa kepada kesimpulan bahawa masyarakat Melayu mempunyai …

Molecular Characterization Of Leptospira Species Isolated From Urban Rats In Peninsular Malaysia, M.Z. Siti Nursheena

Research Publications (2016 to 2020)

No abstract provided.

Nanowires Nickel Oxide And Nanospherical Manganese Oxide Synthesized Via Low Temperature Hydrothermal Technique For Hydrogen Peroxide Sensor, S. Ibrahim, T. Charinpanitkul, E. Kobatake, M. Sriyudthsak

Research Publications (2016 to 2020)

Binary catalyst nickel oxides (NiO) and manganese oxides (MnO) were prepared individually via hydrothermal route. The catalysts were characterized by scanning electron microscope (SEM), Brunauer-Emmett-Teller (BET) analysis, cyclic voltammetry (CV), and amperometry. Morphology studies revealed physical structure of nanowires nickel oxide and spherical manganese oxide with estimated length of 0.3–2.3 μm and diameter of 0.2–0.8 μm, respectively. Surface areas obtained for nickel oxide and manganese oxide were 68.9 m2 g−1 and 45.2 m2 g−1, respectively. Cyclic voltammetry exhibits electrochemical responses corresponding to the electrode surfaces. The linear responses of the binary catalyst modified gold electrodes with NiO-MnO were observed in …

Organogenesis And Ultrastructural Features Ofin Vitrogrowncanna Indical., Sharifah Nurashikin Wafa, Rosna Mat Taha, Sadegh Mohajer, Noraini Mahmad, Bakrudeen Ali Ahmed

Research Publications (2016 to 2020)

An efficient protocol for micropropagation of Canna indica L., an economically and pharmaceutically important plant, was standardized using rhizome explants, excised from two-month-old aseptic seedlings. Complete plant regeneration was induced on MS medium supplemented with 3.0 mg/L BAP plus 1.5 mg/L NAA, which produced the highest number of shoots (73.3 ± 0.5%) and roots (86.7 ± 0.4%) after 2 weeks. Furthermore, the optimum media for multiple shoots regeneration were recorded on MS enriched with 7.0 mg/L BAP (33.0 ± 0.5%). Plantlets obtained were transplanted to pots after two months and acclimatized in the greenhouse, with 75% survival. In addition, ultrastructural …

Phosphorylated And Nonphosphorylated Pfmap2 Are Localized In The Nucleus, Dependent On The Stage Ofplasmodium Falciparumasexual Maturation, F.A. Dahalan, H.M. Sidek, M.D. Murtey, M.N. Embi, J. Ibrahim, L. Fei Tieng, N.A. Zakaria, N.M. Abdul-Aziz

Research Publications (2016 to 2020)

Plasmodium falciparum mitogen-activated protein (MAP) kinases, a family of enzymes central to signal transduction processes including inflammatory responses, are a promising target for antimalarial drug development. Our study shows for the first time that the P. falciparum specific MAP kinase 2 (PfMAP2) is colocalized in the nucleus of all of the asexual erythrocytic stages of P. falciparum and is particularly elevated in its phosphorylated form. It was also discovered that PfMAP2 is expressed in its highest quantity during the early trophozoite (ring form) stage and significantly reduced in the mature trophozoite and schizont stages. Although the phosphorylated form of the …

Preliminary Screening Of Antioxidant And Antibacterial Activities And Establishment Of An Efficient Callus Induction Incurculigo Latifoliadryand (Lemba), R. Farzinebrahimi, Rosna Mat Taha, K.A. Rashid, B.A. Ahmed, Mahmoud Danaee, S.E. Rozali

Research Publications (2016 to 2020)

Leaf, seed, and tuber explants of C. latifolia were inoculated on MS medium supplemented with various concentrations of BAP and IBA, alone or in combinations, to achieve in vitro plant regeneration. Subsequently, antioxidant and antibacterial activities were determined from in vitro and in vivo plant developed. No response was observed from seed culture on MS media with various concentrations of PGRs. The highest percentage of callus was observed on tuber explants (94%) and leaf explants (89%) when cultured on MS media supplemented with IBA in combination with BAP. A maximum of 88% shoots per tuber explant, with a mean number …

Preliminary Taxonomic Survey And Molecular Documentation Of Jellyfish Species (Cnidaria: Scyphozoa And Cubozoa) In Malaysia, I. Mohammed Rizman, A.B. Farah Azwa, V.C. Chong

Research Publications (2016 to 2020)

Scientific enqumes into jellyfish blooms and associated problems in Malaysia are often deterred by the lack of taxonomical and ecological studies. To date, only two scyphozoan jellyfish species have been documented from field surveysin Malaysian waters, whereas other four Malaysian scyphozoan and two cubozoan jellyfish species have been mentioned in toxicological studies, all of which their species identity were not verified. Thus,this study aimed to document and to resolve the identification of jellyfish in Malaysia using morphology and molecular DNA sequencing of COl, 16Sand ITS1 regions. Jellyfish specimens were collected from 2008 to 2010 in the Straits of Malacca, South-China …

Renin-Angiotensin System Gene Variants And Type 2 Diabetes Mellitus: Influence Of Angiotensinogen, S.M. Joyce-Tan, Shamsul Mohd Zain, M.Z.A. Sattar, Nor Azizan Abdullah

Research Publications (2016 to 2020)

Genome-wide association studies (GWAS) have been successfully used to call for variants associated with diseases including type 2 diabetes mellitus (T2DM). However, some variants are not included in the GWAS to avoid penalty in multiple hypothetic testing. Thus, candidate gene approach is still useful even at GWAS era. This study attempted to assess whether genetic variations in the renin-angiotensin system (RAS) and their gene interactions are associated with T2DM risk. We genotyped 290 T2DM patients and 267 controls using three genes of the RAS, namely, angiotensin converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AGTR1). There were …

Seroprevalence Of Toxoplasmosis And Associated Risk Factors Among Migrant Workers In Malaysia, M.Z. Siti Nursheena

Research Publications (2016 to 2020)

No abstract provided.

Study On The Afm Force Curve Common Errors And Their Effects On The Calculated Nanomechanical Properties Of Materials, D. Almasi, R. Sharifi, M.R.A. Kadir, G. Krishnamurithy, Tunku Kamarul

Research Publications (2016 to 2020)

The atomic force microscope (AFM) force curve has been widely used for determining the mechanical properties of materials due to its high resolution, whereby very low (piconewton) forces and distances as small as nanometers can be measured. However, sometimes the resultant force curve obtained from AFM is slightly different from those obtained from a more typical nanoindentation force curve due to the AFM piezo’s hysteresis. In this study the nanomechanical properties of either a sulfonated polyether ether ketone (SPEEK) treated layer or bare polyether ether ketone (PEEK) were evaluated via AFM nanoindentation and a nanomechanical test system to probe the …

The Discrepancies Of Wing Hamuli Numbers In Indo-Malayan Stingless Bees Observed Under Scanning Electron Microscope (Sem), A.H. Zubaidah, B. Shamsul

Research Publications (2016 to 2020)

Wing hamuli in stingless bee are considered as one of the unique characteristics and could be used as the features in taxonomy and identification of species. The number of wing hamuli differs from species to species. Wing hamuli can be found on the hind wing, which link the fore wing of the stingless bee for a distant foraging. In this experiment, nine Indo-Malayan stingless bee species were collected from a specialized collection center in Sekayu, Terengganu, Malaysia (Indo- Malayan Meliponine Respository Sekayu) and stingless bee farm in Jalan Kebun, Selangor. Uncoated fresh samples were introduced into the low-vacuum chamber of …

The Role Of Nigella Sativa And Its Active Constituents In Learning And Memory, M.K.A. Sahak, N. Kabir, G. Abbas, S. Draman, N.H. Hashim, D.S.H. Adli

Research Publications (2016 to 2020)

The loss of the ability for learning and memory is a prominent feature of dementia, which affects millions of individuals all over the world, due to either neurodegenerative diseases or brain injury. Although a lot of information is known about the pathology involved, treatment remains elusive at best. The Black Seed of Nigella sativa has been historically and religiously used for thousands of years for preventing and treating many different kinds of diseases. This review article looks at Nigella sativa and its potential role in facilitating learning and memory. The possible use of this seed’s extract or compounds isolated from …

What A Wonderful Fauna Of Black Flies (Diptera: Simuliidae) In The Oriental Region, H. Takaoka

Research Publications (2016 to 2020)

Owing to the recent increasing interest and activity in research of black flies, the fauna of black flies in the Oriental Region, which was poorly studied before 1970, and once ranked last among the six zoogeographical regions in number of species, has dramatically emerged as the second largest in the number of the constituent species following that of Palaearctic Region. A yearly progress in taxonomic research of black flies is summarized in an e-article "World blackflies (Diptera: Simuliidae): A comprehensive revision of the Taxonomic and Geographical Inventory" annually revised and issued by P. H. Adler & R. W. Crosskey, which …

The Effect Of Therapeutic Horseback Riding On Balance And Self-Efficacy In Children With Developmental Disabilities, Alexandra Smola, Lauren Hurley

Williams Honors College, Honors Research Projects

Therapeutic horseback riding (THR) has positive health related outcomes in children with developmental disabilities. The purpose of this study was to determine the effect of a 10-week THR intervention on balance and task-specific self-efficacy in children with developmental disabilities. Bandura’s social cognitive theory and the physical stress theory guided the quasi-experimental study. A pre-test post-test design (N=20) was implemented with a 10-week THR class at a riding center in Midwest United States. The first research question was: In children with developmental disabilities ages 5 to 18, does one 10-week session of THR affect balance? With time 1 balance mean at …

Mec-10 And Mec-19 Reduce The Neurotoxicity Of The Mec-4(D) Deg/Enac Channel In Caenorhabditis Elegans, Yushu Chen, Shashank Bharill, Robert O'Hagan, Ehud Y. Isacoff, Martin Chalfie

Department of Biology Faculty Scholarship and Creative Works

The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 and mec-4(d) result in a hyperactive channel and neurodegeneration in vivo. Loss of MEC-6, a putative DEG/ENaC-specific chaperone, and of the similar protein POML-1 suppresses the neurodegeneration caused by a mec-4(d) mutation. We find that mutation of two genes, mec-10 and a new gene mec-19 (previously named C49G9.1), prevents this action of POML-1, allowing the touch receptor neurons to die in poml-1 mec-4(d) animals. The proteins encoded by these genes normally inhibit mec-4(d) neurotoxicity through different mechanisms. MEC-10, …

University Of Texas Health Science Center At Tyler Catalog, 2016 - 2018, University Of Texas Health Science Center At Tyler

Catalogs

No abstract provided.

Vitamin B2 As A Virulence Factor In Pseudogymnoascus Destructans Skin Infection, Miroslav Flieger, Hana Bandouchova, Jan Cerny

KIP Articles

Pathogenic and non-pathogenic related microorganisms differ in secondary metabolite production. Here we show that riboflavin overproduction by a fungal pathogen and its hyperaccumulation in affected host tissue exacerbates a skin infection to necrosis. In white-nose syndrome (WNS) skin lesions caused by Pseudogymnoascus destructans, maximum riboflavin concentrations reached up to 815 μg ml−1, indicating bioaccumulation and lack of excretion. We found that high riboflavin concentrations are cytotoxic under conditions specific for hibernation, affect bats’ primary fibroblasts and induce cell detachment, loss of mitochondrial membrane potential, polymerization of cortical actin, and cell necrosis. Our results explain molecular pathology of WNS, where a …

National Cave And Karst Research Institute 2015-2016 Annual Report, National Cave And Karst Research Institute

KIP Articles

No abstract provided.

Comparison Of Joint Angles For Feet And Leg Conformation Traits Between Gilts At Selection And At Their Second Gestation And Sows Parity 5 And Above, Joseph D. Stock, Julia A. Calderón Díaz, Benny E. Mote, Kenneth J. Stalder

Department of Animal Science: Faculty Publications

This study is a portion from the validation process of an objective methodology to measure feet and leg joint angles and to evaluate their relationship with sow longevity. Joint angle measurements from five feet and leg conformation traits (knee, hock, front and rear pasterns and rear stance) that have been previously described in the literature as being related with sow longevity were obtained from maternal gilts at selection and during their second gestation and compared with those obtained from 45 crossbred sows parity 5 and above. Significant differences (P < 0.05) between parities were identified in the knee, both pasterns, hock and rear stance joint angle measurements. These results suggest that as pigs age, structural changes occur. The range of which these changes occur could carry implications for the use of objective feet and leg angles towards future selection programs and protocols.

Genomic Differences Between Preweaning Survival And Mortality Of Piglets Following Pedv Outbreaks, Francesca Bertolini, John C.S. Harding, Benny Mote, Graham S. Plastow, Max Rothschild

Department of Animal Science: Faculty Publications

Porcine Epidemic Diarrhea (PED) is a serious and potentially devastating disease in the US and Canadian pig industries. To investigate if there is genetic resistance to PEDV a total of 156 dead and 106 surviving neonatal piglets infected with PEDV were genotyped with over 60,000 genetic markers to investigate genetic differences between the two groups. This allows for the identification of genomic regions that could be linked to susceptibility/resistance to virus infection and in cellular components that are involved in the PED virus infection cycle, providing new insights on the genetic resistance to this disease.

Joint Angles For Feet And Leg Conformation Traits In Second Gestation Sows, Joseph D. Stock, Julia A. Calderón Díaz, Benny Mote, Kenneth J. Stalder

Department of Animal Science: Faculty Publications

This study is a portion from the validation process of an

objective methodology to measure feet and leg joint angles

and to evaluate their relationship with sow longevity. Five

feet and leg conformation traits (knee, hock, front and rear

pasterns and rear stance) that have been described in the

literature as being related with sow longevity were selected

for this study. Profile and rear stance digital images were

obtained from 277 sows during their 2nd gestation (26.7 ±

17.2 days of gestation; range 0 to 87 days). Sows were

obtained from a single gilt population and were moved to

three …

Genetic And Genomic Basis Of Antibody Response To Porcine Reproductive And Respiratory Syndrome (Prrs) In Gilts And Sows, Nick V. Serão, Robert A. Kemp, Benny Mote, Philip Willson, John C.S. Harding, Stephen C. Bishop, Graham S. Plastow, Jack C.M. Dekkers

Department of Animal Science: Faculty Publications

Background: Our recent research showed that antibody response to porcine reproductive and respiratory syndrome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative trait loci (QTL) on Sus scrofa chromosome 7 (SSC7; QTL_MHC and QTL₁₃₀) accounted for ~40 % of the genetic variance for S/P. Objectives of this study were to estimate genetic parameters for PRRS S/P in gilts during acclimation, identify regions associated with S/P, and evaluate the accuracy of genomic prediction of S/P across populations with different prevalences of …

Rumen Bacterial Community Composition In Holstein And Jersey Cows Is Different Under Same Dietary Condition And Is Not Affected By Sampling Method, Henry A. Paz, Christopher L., Makala J. Muller, Paul J. Kononoff, Samodha C. Fernando

Department of Animal Science: Faculty Publications

The rumen microbial community in dairy cows plays a critical role in efficient milk production. However, there is a lack of data comparing the composition of the rumen bacterial community of the main dairy breeds. This study utilizes 16S rRNA gene sequencing to describe the rumen bacterial community composition in Holstein and Jersey cows fed the same diet by sampling the rumen microbiota via the rumen cannula (Holstein cows) or esophageal tubing (both Holstein and Jersey cows). After collection of the rumen sample via esophageal tubing, particles attached to the strainer were added to the sample to ensure representative sampling …

Development Of Economic Selection Indices For Beef Cattle Improvement, Kathleen P. Ochsner

Department of Animal Science: Faculty Publications

Profitability is the primary goal for most beef cattle producers. The main source of long-term profitability for a beef cattle operation lies in its production efficiency relative to other operations (Harris, 1970). There are numerous approaches to achieve greater efficiency including nutrition, reproduction, management, and genetics. The goal in animal breeding and genetics is to improve animal populations and future generations of animals (Dekkers et al., 2004). Expected progeny differences (EPD) are the traditional genetic tools used to select parents. A drawback to EPD is that they represent genetic merit in only one trait while in reality multiple traits influence …

Genomic Selection For Feed Efficiency Traits, Kashly Rene Schweer

Department of Animal Science: Faculty Publications

Feed costs comprise the majority of variable expenses in beef cattle systems making feed efficiency an important economic consideration within the beef industry (Koch et al., 1963; Dickerson et al., 1974). Aside from the direct economic impact of this trait complex at the individual producer level, the projections of global population growth provide extra pressure for efficient beef cattle production as producers try to combat the growing food demand with limited resources (Eggen, 2012). Improved feed efficiency also has an environmental impact through a decreased carbon footprint as more efficient cattle have fewer days to finish, emitting less methane throughout …

Vegfa Splicing: Divergent Isoforms Regulate Spermatogonial Stem Cell Maintenance, Kevin M. Sargent, Debra T. Rozell, Ningxia Lu, William E. Pohlmeier, Andrea S. Cupp

Department of Animal Science: Faculty Publications

Despite being well-known for regulating angiogenesis in both normal and tumorigenic environments, vascular endothelial growth factor A (VEGFA) has been recently implicated in male fertility, namely in the maintenance of spermatogonial stem cells (SSC). The VEGFA gene can be spliced into multiple distinct isoforms that are either angiogenic or antiangiogenic in nature. Although studies have demonstrated the alternative splicing of VEGFA, including the divergent roles of the two isoform family types, many investigations do not differentiate between them. Data concerning VEGFA in the mammalian testis are limited, but the various angiogenic isoforms appear to promote seminiferous cord formation and to …

Genome To Phenome: Improving Animal Health, Production, And Well-Being – A New Usda Blueprint For Animal Genome Research 2018–2027, Caird Rexroad, Jeffrey Vallet, Lakshmi Kumar Matukumalli, James Reecy, Derek Bickhart, Harvey Blackburn, Mark Boggess, Hans Cheng, Archie Clutter, Noelle Cockett, Catherine Ernst, Janet E. Fulton, John Liu, Joan Lunney, Holly Neibergs, Catherine Purcell, Timothy P. L. Smith, Tad Sonstegard, Jerry Taylor, Bhanu Telugu, Alison Van Eenennaam, Curtis P. Van Tassell, Kevin Wells

Department of Animal Science: Faculty Publications

In 2008, a consortium led by the Agricultural Research Service (ARS) and the National Institute for Food and Agriculture (NIFA) published the “Blueprint for USDA Efforts in Agricultural Animal Genomics 2008–2017,” which served as a guiding document for research and funding in animal genomics. In the decade that followed, many of the goals set forth in the blueprint were accomplished. However, several other goals require further research. In addition, new topics not covered in the original blueprint, which are the result of emerging technologies, require exploration. To develop a new, updated blueprint, ARS and NIFA, along with scientists in the …