Digital Commons Network^™

Roles Of Cofactors And Chromatin Accessibility In Hox Protein Target Specificity, C.Y. Beh, S. El-Sharnouby, A. Chatzipli, S. Russell, S.W. Choo, R. White

Research Publications (2016 to 2020)

Background: The regulation of specific target genes by transcription factors is central to our understanding of gene network control in developmental and physiological processes yet how target specificity is achieved is still poorly understood. This is well illustrated by the Hox family of transcription factors as their limited in vitro DNA-binding specificity contrasts with their clear in vivo functional specificity. Results: We generated genome-wide binding profiles for three Hox proteins, Ubx, Abd-A and Abd-B, following transient expression in Drosophila Kc167 cells, revealing clear target specificity and a striking influence of chromatin accessibility. In the absence of the TALE class homeodomain …

Feeling And Healing Eco-Social Catastrophe: The "Horrific" Slipstream Of Danis Goulet's Wakening, Salma Monani

Environmental Studies Faculty Publications

Cree/Métis filmmaker Danis Goulet’s science fiction short Wakening (2013) is set in Canada’s near future, yet the film reveals a slipstream of time where viewers are invited to contemplate the horrors of ecosocial crises—future, past, and present. I argue Wakening, as futuristic ecohorror, produces horrific feelings in the moment of its viewing that are inevitably entangled with the past, inviting its audiences to experience the monstrous contexts of Indigenous lives across time. To articulate this temporal dynamism, I overlay two key conceptual understandings: Walter Benjamin’s critiques of Western progress and historicism, and Indigenous notions of a Native slipstream. When brought …

Ph-Sensitive Phlip® Coated Niosomes, Mohan C. Pereira, Monica Pianella, Da Wei, Anna Moshnikova, Carlotta Marianecci, Maria Carafa, Oleg A. Andreev, Yana Reshetnyak

Physics Faculty Publications

Nanomedicine is becoming very popular over conventional methods due to the ability to tune physico-chemical properties of nanovectors, which are used for encapsulation of therapeutic and diagnostic agents. However, the success of nanomedicine primarily relies on how specifically and efficiently nanocarriers can target pathological sites to minimize undesirable side effects and enhance therapeutic efficacy. Here, we introduce a novel class of targeted nano drug delivery system, which can be used as an effective nano-theranostic for cancer. We formulated pH-sensitive niosomes (80–90 nm in diameter) using non-ionic surfactants Span20 (43–45 mol%), cholesterol (50 mol%) and 5 mol% of pH (Low) Insertion …

Novel Ph-Sensitive Cyclic Peptides, Dhammika Weerakkody, Anna Moshnikova, Naglaa Salem El-Sayed, Ramona-Cosmina Adochite, Gregory Slaybaugh, Jovana Golijanin, Rakesh K. Tiwari, Oleg A. Andreev, Keykavous Parang, Yana Reshetnyak

Physics Faculty Publications

A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical studies revealed the molecular mechanism of peptides action and localization within the lipid bilayer of the membrane at high and low pHs. The symmetric, c[(WE)₄WC], and asymmetric, c[E₄W₅C], cyclic peptides translocated amanitin, a polar cargo molecule of similar size, across the lipid bilayer and induced cell death in a pH- and concentration-dependent manner. Fluorescently-labelled peptides were evaluated for targeting …

Probe For The Measurement Of Cell Surface Ph In Vivo And Ex Vivo, Michael Anderson, Anna Moshnikova, Donald M. Engelman, Yana K. Reshetnyak, Oleg A. Andreev

Physics Faculty Publications

We have developed a way to measure cell surface pH by positioning a pH-sensitive fluorescent dye, seminaphtharhodafluor (SNARF), conjugated to the pH low insertion peptide (pHLIP). It has been observed that many diseased tissues are acidic and that tumors are especially so. A combination of effects acidifies tumor cell interiors, and cells pump out lactic acid and protons to maintain intracellular pH, acidifying the extracellular space. Overexpression of carbonic anhydrases on cell surfaces further contributes to acidification. Thus, the pH near tumor cell surfaces is expected to be low and to increase with distance from the membrane, so bulk pH …

Pet Imaging Of Extracellular Ph In Tumors With 64Cu- And 18F-Labeled Phlip Peptides: A Structure–Activity Optimization Study, Dustin Wayne Demoin, Linden C. Wyatt, Kimberly J. Edwards, Dalya Abdel-Atti, Mirkka Sarparanta, Jacob Pourat, Valerie A. Longo, Sean D. Carlin, Donald M. Engelman, Oleg A. Andreev, Yana K. Reshetnyak, Nerissa Viola-Villegas, Jason S. Lewis

Physics Faculty Publications

pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two positron emitting radionuclides (⁶⁴Cu and ¹⁸F) were used to label the NOTA- and NO2A-derivatized Var3, Var7, and WT peptides for in vivo biodistribution studies in 4T1 orthotopic tumor-bearing BALB/c mice. All of the constructs were radiolabeled with ⁶⁴Cu or [¹⁸F]-AlF in good yield. The in vivo biodistribution of the 12 constructs in 4T1 orthotopic allografted …

Winona State University 2013 Volleyball Program Covers And Inserts, Winona State University

Volleyball Programs

No abstract provided.

Activation Of Amp-Activated Protein Kinase By Metformin Induces Protein Acetylation In Prostate And Ovarian Cancer Cells, Luciano Galdieri, Himavanth Gatla, Ivana Vancurova, Ales Vancura

Open Access Publications

No abstract provided.

Regulators Of Complement Activity Mediate Inhibitory Mechanisms Through A Common C3b‐Binding Mode, Federico Forneris, Jin Wu, Xiaoguang Xue, Daniel Ricklin, Zhuoer Lin, Georgia Sfyroera, Apostolia Tzekou, Elena Volokhina, Joke Cm Granneman, Richard Hauhart, Paula Bertram, M. Kathryn Liszewski, John P. Atkinson, John D. Lambris, Piet Gros

Open Access Publications

No abstract provided.

Opsin Repertoire And Expression Patterns In Horseshoe Crabs: Evidence From The Genome Of Limulus Polyphemus (Arthropoda: Chelicerata)., Wesley C. Warren, Patrick Minx, Michael J. Montague, Lucinda Fulton, Richard K. Wilson, Et Al

Open Access Publications

No abstract provided.

Premorbid Personality Indicators: A Tool To Identify Those Who Have Liability For Schizophrenia, Daniel V. Hudak Jr.

All-Inclusive List of Electronic Theses and Dissertations

Schizophrenia is an often-debilitating mental illness whose etiology remains unknown, although a number of conceptualizations have been suggested. Among the most prominent of these conceptualizations is the diathesis-stress model, which posits that liability to the disorder is genetically mediated, although ultimate expression is dependent upon exposure to various environmental stressors. Meehl (1962) is arguably most responsible for this conceptualization of schizophrenia. Identifying those who are liable for schizophrenia has the potential to inform treatment which may lead to better outcomes. In an effort to better understand the developmental process of schizophrenia and to identify those who may be at increased …

The Clinical Utility Of Standardized Test Observation In Diagnosis Of Adhd, Sarah K. Thomas

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study was to investigate the clinical utility of a standardized observation measure in the diagnostic assessment of ADHD in children. Evidenced-based assessment of ADHD recommends the use of multiple informants and multiple methods, and ADHD diagnostic criteria requires impairment in at least two settings. Commonly, parent and teacher reports of child behavior differ and blur the diagnostic picture, so standardized observations during testing may provide additional useful diagnostic information. Archival data from 140 children (age 5 – 12) referred to a university-based ADHD evaluation clinic was utilized in the present study. Testing observations measured by the …

A New Glucocerebrosidase-Deficient Neuronal Cell Model Provides A Tool To Probe Pathophysiology And Therapeutics For Gaucher Disease, Hideji Fujiwara, Rohini Sidhu, Benoit Renvoise, Daniel S. Ory, Et Al

Open Access Publications

No abstract provided.

Molecular Signatures Of Natural Selection For Polymorphic Genes Of The Human Dopaminergic And Serotonergic Systems: A Review, Daniel R. Taub, Joshua Page

Open Access Publications

No abstract provided.

N-Cadherin Is Key To Expression Of The Nucleus Pulposus Cell Phenotype Under Selective Substrate Culture Conditions, Priscilla Y. Hwang, Liufang Jing, Jun Chen, Foon-Lian Lim, Ruhang Tang, Hyowon Choi, Kenneth M. Cheung, Makarand V. Risbud, Charles A. Gersbach, Farshid Guilak, Victor Y. Leung, Lori A. Setton

Open Access Publications

No abstract provided.

Functional Variants Of Human Papillomavirus Type 16 Demonstrate Host Genome Integration And Transcriptional Alterations Corresponding To Their Unique Cancer Epidemiology, Robert Jackson, Bruce A. Rosa, Sonia Lameiras, Sean Cuninghame, Josee Bernard, Wely B. Floriano, Paul F. Lambert, Alain Nicolas, Ingeborg Zehbe

Open Access Publications

No abstract provided.

Attitudes Towards Tax Evasion In Turkey And Australia: A Comparative Study, Robert W. Mcgee, Ken Devos, Serkan Benk

College of Business and Economics

The authors conducted a survey of 502 Turkish and Australian undergraduate and graduate business and economic students to determine their views regarding the ethics of tax evasion. These two groups were selected on the premise that their views represented the perceptions of two very different cultures, which has not been investigated in previous studies. The survey instrument required students to indicate their level of agreeableness to 18 general statements representing various scenarios in the socio-economic environment. The statements in the survey reflected the three main viewpoints regarding the ethics of tax evasion which have emerged from the literature to date. …

Potential Population And Assemblage Influences Of Non-Native Trout On Native Nongame Fish In Nebraska Headwater Streams, Kelly C. Turek, Mark A. Pegg, Kevin L. Pope, Steve Schainost

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Non-native trout are currently stocked to support recreational fisheries in headwater streams throughout Nebraska. The influence of non-native trout introductions on native fish populations and their role in structuring fish assemblages in these systems is unknown. The objectives of this study were to determine (i) if the size structure or relative abundance of native fish differs in the presence and absence of non-native trout, (ii) if native fish-assemblage structure differs in the presence and absence of non-native trout and (iii) if native fish-assemblage structure differs across a gradient in abundances of non-native trout. Longnose dace Rhinichthys cataractae were larger in …

Influence Of Anglers’ Specializations On Catch, Harvest, And Bycatch Of Targeted Taxa, Kevin L. Pope, Christopher J. Chizinski, Christopher L. Wiley, Dustin R. Martin

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Fishery managers often use catch per unit effort (CPUE) of a given taxon derived from a group of anglers,those that sought said taxon, to evaluate fishery objectives because managers assume CPUE for this group of anglers is most sensitive to changes in fish taxon density. Further, likelihood of harvest may differ for sought and non-sought taxa if taxon sought is a defining characteristic of anglers’ attitude toward harvest.We predicted that taxon-specific catch across parties and reservoirs would be influenced by targeted taxon after controlling for number of anglers in a party and time spent fishing (combine to quantify fishing effort …

The Chemical Constituents Of New Essential Oils From Endemic And Sub Endemic Plants Of Mongolian Gobi, Sanduin Shatar, Jordanka Stavena, Milka Todorova, Shataryn Altantsetseg

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

The new essential oil-Endemic and sub endemic plants in Outer Mongolian Gobi were isolated by hydro distillation from the aerial parts of Brachanthemum gobicum Krasch, B. mongolicum Krach, B. mongolorum Grub., Asterothamnus centrali-asiaticus Novopork, A. molliusculus Novopork., Ajania trifida (Turcz) Tzvel, A. achilleoides (Turcz) Tzvel., Ferula ferulaeoides (Stend) Eug. Kor., Artemisia davajamczii Darijima., A. caespitosa Ldb, A. subchrysolepis Filat, A. schischkinii Krasch, A.intricata Franch, A.ordasica Krasch, A.gobica (Krasch) Grub., A. sphalerocephala Krasch that grown in wild in Outer Mongolian Gobi. The essential oils were analyzed by a combination of Capillary GC and GC-MS and their main constituents were described.

An Update Of The Family-Level Taxonomy Of Vascular Plants In Mongolia, M. Urgamal, Ch. Sanchir

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

A new comprehensive checklist of Mongolian vascular plant families includes descriptions of all accepted plant families, each with a basionym, homonym, and full list of synonyms. The list is a completely revised update of GUBANOV’s conspectus (1996) of the Mongolian flora. The currently list covers a total of 3,113 species, subspecies and 683 genera, 112 families of vascular plants, belonging to 39 orders, 14 classes or clades and 5 divisions of the vascular plants in the flora of Mongolia.

Morphological Variation Of Mesobuthus Eupeus Mongolicus (Birula, 1911) (Scorpiones: Buthidae) In Mongolia, Mike Heddergott, D. Pohl, Michael Stubbe, Annegret Stubbe, P. Steinbach

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

In the present study, we investigated morphological variation of Mesobuthus eupeus mongolicus (Birula, 1911) in Mongolia. Samples were collected in 16 sites located in the provinces Bayankhongor, Khovd, Dundgovi, Dornogovi, Govisümber and Ömnögovi. Statistical analyses (Kruska-Wallis one-way ANOVA, PCA and hierarchical cluster analysis) showed that (a) morphologically the M. e. mongolicus males sampled in Dundgovi, Dornogovi, Govisümber and Ömnögovi were similar to each other, while the populations of Bayankhongor and Khovd were differentiated, and (b) the females from Bayankhongor, Dundgovi, Dornogovi, Govisümber and Ömnögovi had a similar morphology, while the population from Khovd was differentiated.

Geographical Distribution Of The Genus Mesobuthus (Scorpiones: Buthidae) In Mongolia, Mike Heddergott, Michael Stubbe, W. Stubbe, P. Steinbach, Annegret Stubbe

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

In the present study, we surveyed the diversity of scorpions in six provinces of Mongolia (Bayankhongor, Khovd, Dundgovi, Dornogovi, Govisümber and Ömnögovi) between 2001 and 2012. A total of 385 individuals were collected at 17 different sites. In addition to opportunistic sampling, animals were collected after detection with ultraviolet light. Only species from the genus Mesobuthus have been reported from Mongolia thus far. It was possible to confirm the occurrence of the species Mesobuthus eupeus mongolicus and report the presence of M. martensii martensii for the first time. We could not confirm the presence of M. caucasicus przewalskii and suggest …

Investigation Of Bats In The Darkhad Wetlands, Jargalsaikhan Ariunbold

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

The Darkhadyn Khotgor wetlands are located in the northern part of Mongolia and are transected by both small and large rivers such as the Shishged and the Tengis. Many small lakes are present and the large lake ‘Tsagaan nuur’ (English: White lake) is upstream of the Yenisei river. It is a land rich in biodiversity with pristine waters and an extreme continental climate. The Darkhadyn Khotgor wetlands are composed of three ecological zones, Siberian Taiga, forested steppe, and meadow valley. The area is surrounded by Ulaan Taiga strictly protected area (SPA) in the western part, Khoridol Saridag Mountains SPA in …

New Data On Feeding Ecology Of Bubo Bubo And Asio Otus (Aves: Strigidae) In Mongolia, Michael Stubbe, Nayamsuren Batsaikhan, Oliver Lindecke, Ravčigijn Samjaa, Annegret Stubbe

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

New materials of 10 Eagle owl Bubo bubo localities from Mongolia were analyzed. The feeding ecology of Long-eared owl Asio otus was studied by the investigation of pellets from 4 roosting or nesting places in S-Mongolia. All together in the prey of Bubo bubo were analyzed 1098 vertebrates (1017 mammals, 39 birds, 41 reptiles, 1 fish), involving about 22 mammal species. The pellets were dominantly those of Lagomorpha with 23.3% in SW-Mongolia, Dipodidae in W-, SW- and S-Mongolia (37.3%, 23.4%, 30.2%), Cricetidae in SW- and S-Mongolia (13.6%, 17.6%), Gerbillidae in W- and S-Mongolia (19%, 32.1%) and Arvicolidae in W- and …

A Revised Checklist Of Mongolian Mammal Species, V. S. Lebedev, A. A. Bannikova, Ya. Adiya, S. Shar, A. V. Surov

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

A revised annotated checklist of Mongolian mammals is presented, supplemented with comments on modifications in species- and genus-level taxonomy introduced over the last 30 years. The checklist includes 140 species compared to 124 species recognized three decades ago by SOKOLOV & ORLOV (1980). Since then, four species were newly described; seven species were registered for the first time on Mongolian territory. Names for more than 20 taxa have changed, on most occasions this change occurred not for purely nomenclatural reasons but rather as a result of taxonomic revisions at the species level which have elevated the rank of many nominal …

Historische Und Aktuelle Daten Zum Wolf In Der Mongolei, D. Eregdenedagva, Ravčigijn Samjaa, Michael Stubbe, Annegret Stubbe

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

Zusammenfassung Die Mongolei beherbergt trotz intensiver Verfolgung einen der besten Wolfsbestände Eurasiens. Der Wolf kommt als wertvoller Großsäuger in allen Vegetationszonen der Mongolei vor. Bereits zahlreiche Steinzeichnungen künden von Mensch-, Haus- und Wildtierkonflikten mit dem wehrhaften Beutegreifer Wolf. Er ist und bleibt ein Konkurrent des Nomaden und andererseits ein wertvoller Pelzlieferant und Regulator in den Nahrungsnetzen. Die geringe menschliche Besiedlung und die in freier Weidewirtschaft gehaltenen Haustiere sowie eine reiche Fauna an kleinen und großen Wildsäugetieren bereiten der Wolfspopulation optimale nahrungsökologische Bedingungen. Seit geraumer Zeit hat die Haustierhaltung die 50 Millionengrenze überschritten. Der ökonomische Schaden des Wolfes in der Viehwirtschaft …

Systematic Review Of Symptom Clusters In Cardiovascular Disease, Holli A. Devon, Karen Vuckovic, Catherine J. Ryan, Susan Barnason, Julie J. Zerwic, Bunny J. Pozehl, Paula Schulz, Yaewon Seo, Lani Zimmerman

College of Nursing--Lincoln Campus: Faculty Publications

Background: Although individual symptoms and symptom trajectories for various cardiovascular conditions have been reported, there is limited research identifying the symptom clusters that may provide a better understanding of patients’ experiences with heart disease.

Aims: To summarize the state of the science in symptom cluster research for patients with acute coronary syndrome, myocardial infarction, coronary artery bypass surgery, and heart failure through systematic review and to provide direction for the translation of symptom cluster research into the clinical setting.

Methods: Databases were searched for articles from January 2000 through to May 2015 using MESH terms “symptoms, symptom clusters, acute coronary …

Honors Day, 2016, Murray State University

Honors Day Programs

Honors Day Programs, Murray State University. (Digitization and metadata processed by Madison Erwin.)

Winter 2016, Seattle University

Seattle University Magazine

No abstract provided.