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2016

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Articles 20521 - 20550 of 29059

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Bait Flavor Preference And Immunogenicity Of Onrab Baits In Domestic Dogs On The Navajo Nation, Arizona, Are R. Berentsen, Scott Bender, Peggy Bender, David Bergman, Amy T. Gilbert, Hannah M. Rowland, Kurt C. Vercauteren Jan 2016

Bait Flavor Preference And Immunogenicity Of Onrab Baits In Domestic Dogs On The Navajo Nation, Arizona, Are R. Berentsen, Scott Bender, Peggy Bender, David Bergman, Amy T. Gilbert, Hannah M. Rowland, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Rabies is responsible for an estimated 59,000 human deaths worldwide, and domestic dogs are the primary reservoir and vector of the disease. Among some nations, widespread vaccination has led to elimination of rabies in domestic dogs, yet dogs are still susceptible to rabies infection from interactions with wildlife reservoirs. On Tribal lands in the United States, less than 20% of domestic dogs are vaccinated for rabies, and parenteral vaccination is often unfeasible. Oral rabies vaccination may provide a solution, but a suitable bait flavor and vaccine must be identified. We evaluated 5 bait flavors (bacon, cheese, egg, fish, and sweet) …

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An Approach Based On Neural Computation To Simulate Transition Metals Using Tight Binding Measurements, Adel Belayadi, Boualem Bourahla, Leila Ait-Gougam, Fawzia Mekideche-Chafa Jan 2016

An Approach Based On Neural Computation To Simulate Transition Metals Using Tight Binding Measurements, Adel Belayadi, Boualem Bourahla, Leila Ait-Gougam, Fawzia Mekideche-Chafa

Turkish Journal of Physics

A theoretical study of neural networks modeling, based on the tight binding approach, is proposed in this study. The aim of the present contribution is to establish a network topology to compute the binding energy parameters of transition metals. However, because of the different types of crystallization fcc, bcc, hcp, and sc of transition metals, neural network topology determination cannot be easily established, i.e. it would not be able to collect the data to feed the neurocomputing model. Hence, in order to overcome this problem, it would be helpful to distinguish one common structure from fcc, bcc, hcp, and sc. …

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Determination Of The Effective Atomic Numbers Of Fe$_{X}$Cu$_{1-X} $Binary Ferroalloys Using A Nondestructive Technique: Rayleigh-To-Compton Scattering Ratio, Mehmet Büyükyildiz Jan 2016

Determination Of The Effective Atomic Numbers Of Fe$_{X}$Cu$_{1-X} $Binary Ferroalloys Using A Nondestructive Technique: Rayleigh-To-Compton Scattering Ratio, Mehmet Büyükyildiz

Turkish Journal of Physics

The aim of the present study is to determine effective atomic numbers ($Z_{eff})$ of Fe$_{x}$Cu$_{1-x} $ binary ferroalloys using scattering of 59.54 keV gamma photons at 130$^{\circ}$ ($x=4.36{{\unicode{x212B}}}^{-1})$ scattering angle. For this purpose, the Rayleigh ($R)$ and Compton ($C)$ scattering intensities for the given alloys were measured using a monoenergetic beam of 59.54 keV gamma rays and the Rayleigh-to-Compton scattering ratio $R/C $was determined. Then the $Z_{eff}$ values of these alloys were determined by interpolating the $R/C$ of the material using the $R/C$ data of adjacent elements in between the $R/C$ of the alloys. For comparison, $Z_{eff}$s of alloys were …

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Renaissance Beauty = Today’S Ugly: Socioculturally Relative Appearance Factors And Attractiveness Judgments, Don Osborn Jan 2016

Renaissance Beauty = Today’S Ugly: Socioculturally Relative Appearance Factors And Attractiveness Judgments, Don Osborn

Psychology Faculty Publications and Presentations

By comparing photos of portraits of the faces of Renaissance courtesans to photos of attractive contemporary women’s faces this study estimates the importance of sociocultural factors in the personal perception of faces. Physical attractiveness is an important causal factor in choosing a sex partner, so the difference between averaged attractiveness judgments, a focus of attractiveness research, and individual attractiveness judgment, most relevant to choosing a sex partner, is important. Except for modesty and faithfulness, 13 normally attractive contemporary models were rated much more positively by college student participants (N = 189) than were eight celebrated Renaissance courtesans, both in …

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The Effect Of Stress Coping Techniques In Sports, Lestter Yeh Jan 2016

The Effect Of Stress Coping Techniques In Sports, Lestter Yeh

CMC Senior Theses

The first part of this literature review goes over the biological and psychological aspects of stress. The cause of stress can be linked back to a primitive instinct known as “fight or flight.” The “fight or flight” instinct is triggered by several chemical reactions in the body starting from a signal from the amygdala to the sympathetic nervous system. Stress can also be categorized into internal and external stress. Further research links stress to sports. Many studies show that stress coping techniques such as meditation, self-talk, rituals, etc. are beneficial to athletes during competition. Suggested avenues of further research are …

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Hemoglobin–Oxygen Affinity In High-Altitude Vertebrates: Is There Evidence For An Adaptive Trend?, Jay F. Storz Jan 2016

Hemoglobin–Oxygen Affinity In High-Altitude Vertebrates: Is There Evidence For An Adaptive Trend?, Jay F. Storz

Jay F. Storz Publications

In air-breathing vertebrates at high altitude, fine-tuned adjustments in hemoglobin (Hb)–O2 affinity provide an energetically efficient means of mitigating the effects of arterial hypoxemia. However, it is not always clear whether an increased or decreased Hb–O2 affinity should be expected to improve tissue O2 delivery under different degrees of hypoxia, due to the inherent trade-off between arterial O2 loading and peripheral O2 unloading. Theoretical results indicate that the optimal Hb–O2 affinity varies as a non-linear function of environmental O2 availability, and the threshold elevation at which an increased Hb–O2 affinity becomes advantageous …

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Dicta, Vol.16, No.1, 2016, Suffolk University Law School Jan 2016

Dicta, Vol.16, No.1, 2016, Suffolk University Law School

Dicta

DICTA is the student newspaper of Suffolk University Law School. This collection represents a small selection of the paper's full print run; paper copies of the full run of issues are available at the Moakley Archive.

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Suffolk Journal, Vol. 76, No. 17, 4/6/2016, Suffolk Journal Jan 2016

Suffolk Journal, Vol. 76, No. 17, 4/6/2016, Suffolk Journal

Suffolk Journal

No abstract provided.

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Suffolk Journal, Vol. 80, No. 8, 11/16/2016, Suffolk Journal Jan 2016

Suffolk Journal, Vol. 80, No. 8, 11/16/2016, Suffolk Journal

Suffolk Journal

No abstract provided.

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Seasonal Variation In The Ndvi–Species Richness Relationship In A Prairie Grassland Experiment (Cedar Creek), Ran Wang, John A. Gamon, Rebecca A. Montgomery, Philip A. Townsend, Arthur I. Zygielbaum, Keren Bitan, David Tilman, Jeannine Cavender-Bares Jan 2016

Seasonal Variation In The Ndvi–Species Richness Relationship In A Prairie Grassland Experiment (Cedar Creek), Ran Wang, John A. Gamon, Rebecca A. Montgomery, Philip A. Townsend, Arthur I. Zygielbaum, Keren Bitan, David Tilman, Jeannine Cavender-Bares

School of Natural Resources: Faculty Publications

Species richness generally promotes ecosystem productivity, although the shape of the relationship varies and remains the subject of debate. One reason for this uncertainty lies in the multitude of methodological approaches to sampling biodiversity and productivity, some of which can be subjective. Remote sensing offers new, objective ways of assessing productivity and biodiversity. In this study, we tested the species richness–productivity relationship using a common remote sensing index, the Normalized Difference Vegetation Index (NDVI), as a measure of productivity in experimental prairie grassland plots (Cedar Creek). Our study spanned a growing season (May to October, 2014) to evaluate dynamic changes …

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Androgyny/Hermaphroditism: Hebrew Bible, Jennifer J. Williams Jan 2016

Androgyny/Hermaphroditism: Hebrew Bible, Jennifer J. Williams

Faculty Publications

The Hebrew Bible lacks a term for androgyny or hermaphroditism. The term tumtumim, which identifies persons of indeterminate or “hidden” sex, appears later in rabbinic texts. Nevertheless, sexual fluidity, ambiguity, intersexed persons, and persons with a combination of masculine and feminine characteristics appear in the Genesis creation stories and prophetic texts. While gender transgression is relevant to the general discussion, this entry from The Oxford Encyclopedia of the Bible and Gender Studies: Oxford Biblical Studies Online focuses primarily on ancient understandings, namely those presented in the Hebrew Bible, of those of “both sexes.”

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Promotion Of Stem Education In Vocational And Professional Education And Training (Vpet), Kam Fat, Jonathan Lee, Sai Lok, Eric Liu Jan 2016

Promotion Of Stem Education In Vocational And Professional Education And Training (Vpet), Kam Fat, Jonathan Lee, Sai Lok, Eric Liu

Staff Publications

Vocational and Professional Education and Training (VPET) enhances learners to acquire professional knowledge, apply practical skills and develop positive workplace attitudes to support the long-term development of a country or a city. Established in 1982, the Vocational Training Council (VTC) is the largest vocational and professional education and training provider (VTC 2016) in Hong Kong. Through a wide range of pre-employment and in-service programmes, it establishes valuable credentials for approximately 250,000 students each year with internationally recognised qualifications. As a member institution of VTC, the Hong Kong Institute of Vocational Education (IVE) offers fulltime and part-time programmes - covering an …

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Anticancer Activity Of A Monobenzyltin Complex C1 Against Mda-Mb-231 Cells Through Induction Of Apoptosis And Inhibition Of Breast Cancer Stem Cells, S. Fani, B. Kamalidehghan, Kong Mun Lo, S.E. Nigjeh, Y.S. Keong, F. Dehghan, R. Soori, Mahmood Ameen Abdulla, K.M. Chow, Hapipah Mohd Ali, F. Hajiaghaalipour, E. Rouhollahi, N.M. Hashim Jan 2016

Anticancer Activity Of A Monobenzyltin Complex C1 Against Mda-Mb-231 Cells Through Induction Of Apoptosis And Inhibition Of Breast Cancer Stem Cells, S. Fani, B. Kamalidehghan, Kong Mun Lo, S.E. Nigjeh, Y.S. Keong, F. Dehghan, R. Soori, Mahmood Ameen Abdulla, K.M. Chow, Hapipah Mohd Ali, F. Hajiaghaalipour, E. Rouhollahi, N.M. Hashim

Research Publications (2016 to 2020)

In the present study, we examined the cytotoxic effects of Schiff base complex, [N-(3,5-dichloro-2-oxidobenzylidene)-4-chlorobenzyhydrazidato](o-methylbenzyl)aquatin(IV) chloride, and C1 on MDA-MB-231 cells and derived breast cancer stem cells from MDA-MB-231 cells. The acute toxicity experiment with compound C1 revealed no cytotoxic effects on rats. Fluorescent microscopic studies using Acridine Orange/Propidium Iodide (AO/PI) staining and flow cytometric analysis using an Annexin V probe confirmed the occurrence of apoptosis in C1-treated MDA-MB-231 cells. Compound C1 triggered intracellular reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) releases in treated MDA-MB-231 cells. The Cellomics High Content Screening (HCS) analysis showed the induction of intrinsic pathways …

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Application Of Raw And Composted Recycled Paper Mill Sludge On The Growth Of Khaya Senegalensis And Their Effects On Soil Nutrients And Heavy Metals, R. Abdullah, C.F. Ishak, W.R. Kadir, R.A. Bakar Jan 2016

Application Of Raw And Composted Recycled Paper Mill Sludge On The Growth Of Khaya Senegalensis And Their Effects On Soil Nutrients And Heavy Metals, R. Abdullah, C.F. Ishak, W.R. Kadir, R.A. Bakar

Research Publications (2016 to 2020)

The paper industry performs an essential role in the global economy of the world. A study was conducted on the paper mill sludge that is applied on the Khaya senegalensis for 4 crop cycle for 1 year growth at glasshouse, Faculty of Agriculture, Universiti Putra Malaysia. Paper Mill Sludge (PMS) and composted Recycled Paper Mill Sludge (RPMS) was used with nitrogen (0, 150, 300 and 600 kg ha-1) at the ratio of 1:1 (Recycled Paper Mill Sludge (RPMS): Empty Fruit Bunch (EFB). The growth parameters were measured twice a month for 6 months. Plant nutrients and heavy metal uptake were …

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Assessment Of Natural Radioactivity Levels And Radiation Hazards In Agricultural And Virgin Soil In The State Of Kedah, North Of Malaysia, G. Alzubaidi, F.B. Hamid, I. Abdul Rahman Jan 2016

Assessment Of Natural Radioactivity Levels And Radiation Hazards In Agricultural And Virgin Soil In The State Of Kedah, North Of Malaysia, G. Alzubaidi, F.B. Hamid, I. Abdul Rahman

Research Publications (2016 to 2020)

The activity concentrations of naturally occurring radionuclides 226Ra, 232Th, and 40K were determined in 30 agricultural and virgin soil samples randomly collected from Kedah, north of Malaysia, at a fertile soil depth of 0–30 cm. Gamma-ray spectrometry was applied using high-purity germanium (HPGe) gamma-ray detector and a PC-based MCA. The mean radioactivity concentrations of 226Ra, 232Th, and 40K were found to be 102.08 ± 3.96, 133.96 ± 2.92, and 325.87 ± 9.83 Bq kg−1, respectively, in agricultural soils and 65.24 ± 2.00, 83.39 ± 2.27, and 136.98 ± 9.76 Bq kg−1, respectively, in virgin soils. The radioactivity concentrations in agricultural …

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Automated Identification Of Monogeneans Using Digital Image Processing And K-Nearest Neighbour Approaches, E.Y. Kalafi, W.B. Tan, C. Town, S.K. Dhillon Jan 2016

Automated Identification Of Monogeneans Using Digital Image Processing And K-Nearest Neighbour Approaches, E.Y. Kalafi, W.B. Tan, C. Town, S.K. Dhillon

Research Publications (2016 to 2020)

Background: Monogeneans are flatworms (Platyhelminthes) that are primarily found on gills and skin of fishes. Monogenean parasites have attachment appendages at their haptoral regions that help them to move about the body surface and feed on skin and gill debris. Haptoral attachment organs consist of sclerotized hard parts such as hooks, anchors and marginal hooks. Monogenean species are differentiated based on their haptoral bars, anchors, marginal hooks, reproductive parts' (male and female copulatory organs) morphological characters and soft anatomical parts. The complex structure of these diagnostic organs and also their overlapping in microscopic digital images are impediments for developing fully …

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Cell Cycle Arrest And Apoptosis Induction Via Modulation Of Mitochondrial Integrity By Bcl-2 Family Members And Caspase Dependence In Dracaena Cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma, A.M. Alabsi, K.L. Lim, I.C. Paterson, R. Ali-Saeed, B.A. Muharram Jan 2016

Cell Cycle Arrest And Apoptosis Induction Via Modulation Of Mitochondrial Integrity By Bcl-2 Family Members And Caspase Dependence In Dracaena Cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma, A.M. Alabsi, K.L. Lim, I.C. Paterson, R. Ali-Saeed, B.A. Muharram

Research Publications (2016 to 2020)

Dracaena cinnabari Balf.f. is a red resin endemic to Socotra Island, Yemen. Although there have been several reports on its therapeutic properties, information on its cytotoxicity and anticancer effects is very limited. This study utilized a bioassay-guided fractionation approach to determine the cytotoxic and apoptosis-inducing effects of D. cinnabari on human oral squamous cell carcinoma (OSCC). The cytotoxic effects of D. cinnabari crude extract were observed in a panel of OSCC cell lines and were most pronounced in H400. Only fractions DCc and DCd were active on H400 cells; subfractions DCc15 and DCd16 exhibited the greatest cytotoxicity against H400 cells …

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Electrochemical Immunosensor Based On Antibody-Nanoparticle Hybrid For Specific Detection Of The Dengue Virus Ns1 Biomarker, N.T. Darwish, A.H. Alrawi, S.D. Sekaran, Y. Alias, Sook Mei Khor Jan 2016

Electrochemical Immunosensor Based On Antibody-Nanoparticle Hybrid For Specific Detection Of The Dengue Virus Ns1 Biomarker, N.T. Darwish, A.H. Alrawi, S.D. Sekaran, Y. Alias, Sook Mei Khor

Research Publications (2016 to 2020)

Dengue virus infection is a very deadly disease that threatens human lives in subtropical and tropical regions. Thus, for early and reliable diagnosis of Dengue virus infection, a sensitive, specific, and label-free electrochemical immunosensor was developed for the direct detection of the unstructured protein NS1. The NS1 biosensor was designed with a biosensing surface consisting of antifouling moieties and biorecognition molecules to enhance the specificity of the immunosensor for target analyte detection in complicated biological samples such as human sera. The immunosensor exhibited a wide detection range (54000 ng/mL) based on electrochemical impedance spectroscopy (EIS) measurements with a coefficient of …

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Esterification Of Glycerol From Biodiesel Production To Glycerol Carbonate In Non‑Catalytic Supercritical Dimethyl Carbonate, Zul Ilham Jan 2016

Esterification Of Glycerol From Biodiesel Production To Glycerol Carbonate In Non‑Catalytic Supercritical Dimethyl Carbonate, Zul Ilham

Research Publications (2016 to 2020)

Conversion of glycerol from biodiesel production to glycerol carbonate was studied by esterification with dimethyl carbonate in a non-catalytic supercritical condition. It was found that in a non-catalytic supercritical condition, glycerol at higher purity gave higher yield of glycerol carbonate at 98 wt% after reaction at 300 °C/20–40 MPa/15 min. The yield of glycerol carbonate was observed to increase with molar ratio, temperature, pressure and time until a certain equilibrium limit. The existence of impurities such as water and remnants of alkaline catalyst in crude glycerol will direct the reaction to produce glycidol. Although impurities might not be desirable, the …

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Evaluation Of Basic Knowledge On Food Safety And Food Handling Practices Amongst Migrant Food Handlers In Peninsular Malaysia, Kwai Lin Thong Jan 2016

Evaluation Of Basic Knowledge On Food Safety And Food Handling Practices Amongst Migrant Food Handlers In Peninsular Malaysia, Kwai Lin Thong

Research Publications (2016 to 2020)

This study was aimed to measure the basic knowledge on food safety and food handling practices among migrant food handlers as these information is scarce in Malaysia. A cross-sectional study was conducted face-to-face amongst 383 migrant food handlers from three major cities in Peninsular Malaysia through questionnaire. Socio-demographic information of all respondents was collected. Questions on food safety knowledge (i.e. food cleanliness and hygiene, symptom of foodborne illnesses and foodborne pathogens) and food handling practices were assessed. The compiled data were analyzed by using the Statistical Packages for Social Science (SPSS) 16.0. Overall, migrant food handlers had poor level of …

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Office Of The Vice Provost For Research Annual Report - 2016, Office Of The Vice Provost For Research, East Tennessee State University Jan 2016

Office Of The Vice Provost For Research Annual Report - 2016, Office Of The Vice Provost For Research, East Tennessee State University

Annual Reports

No abstract provided.

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Identification Of Gingival Crevicular Fluid Sampling, Analytical Methods, And Oral Biomarkers For The Diagnosis And Monitoring Of Periodontal Diseases: A Systematic Review, Z.N. Majeed, K. Philip, A.M. Alabsi, S. Pushparajan, D. Swaminathan Jan 2016

Identification Of Gingival Crevicular Fluid Sampling, Analytical Methods, And Oral Biomarkers For The Diagnosis And Monitoring Of Periodontal Diseases: A Systematic Review, Z.N. Majeed, K. Philip, A.M. Alabsi, S. Pushparajan, D. Swaminathan

Research Publications (2016 to 2020)

Background. Several studies in the last decades have focused on finding a precise method for the diagnosis of periodontal disease in its early stages. Aim. To evaluate from current scientific literature the most common and precise method for gingival crevicular fluid (GCF) sample collection, biomarker analytical methods, and the variability of biomarker quantification, even when using the same analytical technique. Methodology. An electronic search was conducted on in vivo studies that presented clinical data on techniques used for GCF collection and biomarker analysis. Results. The results showed that 71.1%, 24.7%, and 4.1% of the studies used absorption, microcapillary, and washing …

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Optimizing Tapered Microfiber Sensor Design And Simulation, S. Al-Askari, B.A. Hamida, S. Khan, Sulaiman Wadi Harun Jan 2016

Optimizing Tapered Microfiber Sensor Design And Simulation, S. Al-Askari, B.A. Hamida, S. Khan, Sulaiman Wadi Harun

Research Publications (2016 to 2020)

Refractive index sensors measure the evanescent field energy to sense various environmental parameters. Evanescent field-based sensors depend on the tapered area geometry which is one of the important factors for optimising the sensor performance as well as achieving better sensitivity and higher resolution. Tapering fabrication process needs to be controlled properly in order to achieve the optimal design. A two-dimensional model of the tapered sensor is proposed and simulated using Finite Element Analysis software, COMSOL Multiphysics. The light scattering phenomenon is visualized for taper and waist areas. The effects of the taper length, the waist length and the waist diameter …

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Preparation Methods For Improving Peek’S Bioactivity For Orthopedic And Dental Application: A Review, D. Almasi, N. Iqbal, M. Sadeghi, I. Sudin, M.R. Abdul Kadir, T. Kamarul Jan 2016

Preparation Methods For Improving Peek’S Bioactivity For Orthopedic And Dental Application: A Review, D. Almasi, N. Iqbal, M. Sadeghi, I. Sudin, M.R. Abdul Kadir, T. Kamarul

Research Publications (2016 to 2020)

There is an increased interest in the use of polyether ether ketone (PEEK) for orthopedic and dental implant applications due to its elastic modulus close to that of bone, biocompatibility, and its radiolucent properties. However, PEEK is still categorized as bioinert due to its low integration with surrounding tissues. Many studies have reported on methods to increase the bioactivity of PEEK, but there is still one-preparation method for preparing bioactive PEEK implant where the produced implant with desirable mechanical and bioactivity properties is required. The aim of this review is to present the progress of the preparation methods for improvement …

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Redox Control Of Antioxidant And Antihepatotoxic Activities Ofcassia Surattensisseed Extract Against Paracetamol Intoxication In Mice: In Vitro And In Vivo Studies Of Herbal Green Antioxidant, U.S. Uthaya Kumar, Y. Chen, J.R. Kanwar, S. Sasidharan Jan 2016

Redox Control Of Antioxidant And Antihepatotoxic Activities Ofcassia Surattensisseed Extract Against Paracetamol Intoxication In Mice: In Vitro And In Vivo Studies Of Herbal Green Antioxidant, U.S. Uthaya Kumar, Y. Chen, J.R. Kanwar, S. Sasidharan

Research Publications (2016 to 2020)

The therapeutic potential of Cassia surattensis in reducing free radical-induced oxidative stress and inflammation particularly in hepatic diseases was evaluated in this study. The polyphenol rich C. surattensis seed extract showed good in vitro antioxidant. C. surattensis seed extract contained total phenolic content of 100.99 mg GAE/g dry weight and there was a positive correlation () between total phenolic content and the antioxidant activities of the seed extract. C. surattensis seed extract significantly () reduced the elevated levels of serum liver enzymes (ALT, AST, and ALP) and relative liver weight in paracetamol-induced liver hepatotoxicity in mice. Moreover, the extract significantly …

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Roles Of Cofactors And Chromatin Accessibility In Hox Protein Target Specificity, C.Y. Beh, S. El-Sharnouby, A. Chatzipli, S. Russell, S.W. Choo, R. White Jan 2016

Roles Of Cofactors And Chromatin Accessibility In Hox Protein Target Specificity, C.Y. Beh, S. El-Sharnouby, A. Chatzipli, S. Russell, S.W. Choo, R. White

Research Publications (2016 to 2020)

Background: The regulation of specific target genes by transcription factors is central to our understanding of gene network control in developmental and physiological processes yet how target specificity is achieved is still poorly understood. This is well illustrated by the Hox family of transcription factors as their limited in vitro DNA-binding specificity contrasts with their clear in vivo functional specificity. Results: We generated genome-wide binding profiles for three Hox proteins, Ubx, Abd-A and Abd-B, following transient expression in Drosophila Kc167 cells, revealing clear target specificity and a striking influence of chromatin accessibility. In the absence of the TALE class homeodomain …

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Feeling And Healing Eco-Social Catastrophe: The "Horrific" Slipstream Of Danis Goulet's Wakening, Salma Monani Jan 2016

Feeling And Healing Eco-Social Catastrophe: The "Horrific" Slipstream Of Danis Goulet's Wakening, Salma Monani

Environmental Studies Faculty Publications

Cree/Métis filmmaker Danis Goulet’s science fiction short Wakening (2013) is set in Canada’s near future, yet the film reveals a slipstream of time where viewers are invited to contemplate the horrors of ecosocial crises—future, past, and present. I argue Wakening, as futuristic ecohorror, produces horrific feelings in the moment of its viewing that are inevitably entangled with the past, inviting its audiences to experience the monstrous contexts of Indigenous lives across time. To articulate this temporal dynamism, I overlay two key conceptual understandings: Walter Benjamin’s critiques of Western progress and historicism, and Indigenous notions of a Native slipstream. When brought …

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Ph-Sensitive Phlip® Coated Niosomes, Mohan C. Pereira, Monica Pianella, Da Wei, Anna Moshnikova, Carlotta Marianecci, Maria Carafa, Oleg A. Andreev, Yana Reshetnyak Jan 2016

Ph-Sensitive Phlip® Coated Niosomes, Mohan C. Pereira, Monica Pianella, Da Wei, Anna Moshnikova, Carlotta Marianecci, Maria Carafa, Oleg A. Andreev, Yana Reshetnyak

Physics Faculty Publications

Nanomedicine is becoming very popular over conventional methods due to the ability to tune physico-chemical properties of nanovectors, which are used for encapsulation of therapeutic and diagnostic agents. However, the success of nanomedicine primarily relies on how specifically and efficiently nanocarriers can target pathological sites to minimize undesirable side effects and enhance therapeutic efficacy. Here, we introduce a novel class of targeted nano drug delivery system, which can be used as an effective nano-theranostic for cancer. We formulated pH-sensitive niosomes (80–90 nm in diameter) using non-ionic surfactants Span20 (43–45 mol%), cholesterol (50 mol%) and 5 mol% of pH (Low) Insertion …

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Novel Ph-Sensitive Cyclic Peptides, Dhammika Weerakkody, Anna Moshnikova, Naglaa Salem El-Sayed, Ramona-Cosmina Adochite, Gregory Slaybaugh, Jovana Golijanin, Rakesh K. Tiwari, Oleg A. Andreev, Keykavous Parang, Yana Reshetnyak Jan 2016

Novel Ph-Sensitive Cyclic Peptides, Dhammika Weerakkody, Anna Moshnikova, Naglaa Salem El-Sayed, Ramona-Cosmina Adochite, Gregory Slaybaugh, Jovana Golijanin, Rakesh K. Tiwari, Oleg A. Andreev, Keykavous Parang, Yana Reshetnyak

Physics Faculty Publications

A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical studies revealed the molecular mechanism of peptides action and localization within the lipid bilayer of the membrane at high and low pHs. The symmetric, c[(WE)4WC], and asymmetric, c[E4W5C], cyclic peptides translocated amanitin, a polar cargo molecule of similar size, across the lipid bilayer and induced cell death in a pH- and concentration-dependent manner. Fluorescently-labelled peptides were evaluated for targeting …

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Probe For The Measurement Of Cell Surface Ph In Vivo And Ex Vivo, Michael Anderson, Anna Moshnikova, Donald M. Engelman, Yana K. Reshetnyak, Oleg A. Andreev Jan 2016

Probe For The Measurement Of Cell Surface Ph In Vivo And Ex Vivo, Michael Anderson, Anna Moshnikova, Donald M. Engelman, Yana K. Reshetnyak, Oleg A. Andreev

Physics Faculty Publications

We have developed a way to measure cell surface pH by positioning a pH-sensitive fluorescent dye, seminaphtharhodafluor (SNARF), conjugated to the pH low insertion peptide (pHLIP). It has been observed that many diseased tissues are acidic and that tumors are especially so. A combination of effects acidifies tumor cell interiors, and cells pump out lactic acid and protons to maintain intracellular pH, acidifying the extracellular space. Overexpression of carbonic anhydrases on cell surfaces further contributes to acidification. Thus, the pH near tumor cell surfaces is expected to be low and to increase with distance from the membrane, so bulk pH …

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