Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (7019)
- Medicine and Health Sciences (3853)
- Social and Behavioral Sciences (3479)
- Physical Sciences and Mathematics (3090)
- Education (2462)
-
- Arts and Humanities (1971)
- Biology (1869)
- Engineering (1861)
- Law (1311)
- Psychology (1178)
- Ecology and Evolutionary Biology (1104)
- Animal Sciences (1102)
- Higher Education (894)
- Biochemistry, Biophysics, and Structural Biology (820)
- Plant Sciences (785)
- Medical Specialties (776)
- Environmental Sciences (769)
- Chemistry (761)
- Medical Sciences (741)
- Public Health (629)
- Sociology (561)
- Agriculture (500)
- Genetics and Genomics (496)
- History (473)
- Cell and Developmental Biology (466)
- Biomedical Engineering and Bioengineering (461)
- Zoology (438)
- Biochemistry (394)
- Earth Sciences (377)
- Biodiversity (368)
- Institution
-
- University of Nebraska - Lincoln (1663)
- University of South Florida (768)
- TÜBİTAK (577)
- Purdue University (573)
- Utah State University (525)
-
- University of Kentucky (521)
- City University of New York (CUNY) (520)
- Louisiana State University (520)
- Washington University School of Medicine (421)
- University of Plymouth (417)
- Brigham Young University (403)
- Nova Southeastern University (360)
- University of Arkansas, Fayetteville (356)
- Walden University (333)
- University of New Hampshire (326)
- Virginia Commonwealth University (324)
- Georgia Southern University (304)
- University of Rhode Island (300)
- Marshall University (274)
- University of Montana (261)
- University of South Carolina (256)
- Clemson University (243)
- Portland State University (243)
- West Virginia University (240)
- Marquette University (234)
- Old Dominion University (233)
- University of New Mexico (231)
- University of Alabama at Birmingham (227)
- University of Connecticut (218)
- Ohio University (212)
- Keyword
-
- Biological sciences (242)
- Humans (221)
- Education (197)
- Climate change (164)
- Animals (145)
-
- Applied sciences (145)
- Gender (139)
- Psychology (133)
- Female (127)
- Newspaper (126)
- Cancer (124)
- Biology (121)
- Depression (118)
- Male (113)
- Obesity (104)
- Health and environmental sciences (97)
- Georgia Southern University (96)
- Women (93)
- Ecology (89)
- Inflammation (89)
- Biological Sciences (88)
- Stress (85)
- Student newspaper (83)
- 2016 (80)
- Newsletter (79)
- Pure sciences (78)
- EIU (77)
- Eastern Illinois University (75)
- Evolution (75)
- Resilience (75)
- Publication
-
- Theses and Dissertations (962)
- Electronic Theses and Dissertations (542)
- Faculty Publications (518)
- Open Access Publications (402)
- Open Access Dissertations (363)
-
- Walden Dissertations and Doctoral Studies (321)
- Publications and Research (241)
- Dissertations (237)
- USF Tampa Graduate Theses and Dissertations (204)
- Master's Theses (202)
- All Forum Articles (196)
- Graduate Theses and Dissertations (194)
- Honors Theses (191)
- Doctoral Dissertations (174)
- Theses (172)
- Dissertations, Theses, and Capstone Projects (162)
- Food and Machinery (155)
- Articles (144)
- Open Access Theses (143)
- Animal Sentience (140)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (137)
- Nebraska Tractor Tests (136)
- Ocean and Coastal Law Journal (135)
- Turkish Journal of Biology (133)
- Euscorpius (126)
- School of Biological and Marine Sciences (120)
- Wayne State University Dissertations (119)
- Browse All News (117)
- Biology Faculty Publications (115)
- Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions) (115)
- Publication Type
Articles 20581 - 20610 of 29059
Full-Text Articles in Entire DC Network
Nonstandard Parental Employment Schedules And Father Involvement, Matthew Weinshenker
Nonstandard Parental Employment Schedules And Father Involvement, Matthew Weinshenker
Sociology Faculty Publications
This study assesses the impact of nonstandard employment schedules (shift work) on parenting among U.S. fathers of young children in dual-earner couples. The outcomes examined include total caregiving, caregiving without the mother present, and the elements of father involvement proposed by Pleck: positive engagement, warmth, and control. Models with latent variables and with lagged dependent variables are estimated using three waves of nationally-representative data from the Early Child Longitudinal Study – Birth Cohort (ECLS-B). The results indicate that employment scheduling mainly shapes the context in which involvement takes place. Compared to dual-earner couples who are each employed during the day, …
A Comparative Perspective: Recognition Of The Continuous Injury Trigger In Insurance Law In The United States And The United Kingdom, Emalie Diaz Sundale
A Comparative Perspective: Recognition Of The Continuous Injury Trigger In Insurance Law In The United States And The United Kingdom, Emalie Diaz Sundale
UC Law SF International Law Review
The standard Commercial General Liability coverage form obligates an insurer to indemnify the insured for bodily injury and property damages caused by an "occurrence" during the policy period. The form defines "occurrence" as "an accident, including continuous or repeated exposure to substantially the same harmful condition." When an injury occurs over a period of time, questions arise in pinning down a precise moment when such a continuous injury begins. The question of whether the resulting injury is covered under a given insurance policy, or, whether the insurance policy has been "triggered," vexes courts in the United States and the United …
Will Prime Minister Abe's Womenomics Break Glass Ceilings In Japan, Hiroko Goto
Will Prime Minister Abe's Womenomics Break Glass Ceilings In Japan, Hiroko Goto
UC Law SF International Law Review
No abstract provided.
The Paper Trail: An Arid Connection And A Book Of A Thousand Plants, Stephen L. Young, Peter Alpert
The Paper Trail: An Arid Connection And A Book Of A Thousand Plants, Stephen L. Young, Peter Alpert
West Central Research and Extension Center, North Platte
Following my Ph.D., I moved on to Nebraska, where as a beginning faculty member I was able to start a research program in ecology and continue to study what intrigued me most: plant competition and stress. It was during this time that I came across the paper by Peter Alpert (see his article below) and his colleagues on “Invasiveness, invasibility, and the role of environmental stress in preventing the spread of non-native plants” (Perspectives in Plant Ecology, Evolution and Systematics 3:52–66). It was an “aha” moment in reading about biological invasion research and the current consensus at that time regarding …
Invasion During Extreme Weather: Success And Failure In A Temperate Perennial Grassland, James C. Han, Stephen L. Young
Invasion During Extreme Weather: Success And Failure In A Temperate Perennial Grassland, James C. Han, Stephen L. Young
West Central Research and Extension Center, North Platte
Invasive and native plant species compete for resources in similar pools, with disturbances often favoring the invader. Yet, increased climate variability may be shifting the competitive edge back toward the natives. We conducted field studies in perennial grasslands to determine the effects of clipping and drought on resource availability (light and moisture) and subsequent establishment of Carduus nutans. We measured light penetration and soil moisture content in C. nutans monoculture, clipped and non clipped grassland with C. nutans, and bare ground control plots. We also tracked phenology of the invader and grasses. Our studies revealed that light was a limiting …
The Effect Of Adjuvants At High Spray Pressures For Aerial Applications, Bradley K. Fritz, W. Clint Hoffmann, Ryan S. Henry
The Effect Of Adjuvants At High Spray Pressures For Aerial Applications, Bradley K. Fritz, W. Clint Hoffmann, Ryan S. Henry
West Central Research and Extension Center, North Platte
Controlling droplet size is a critical part of making any successful agrochemical spray application. This is particularly true for higher-speed aerial applications where secondary atomization from air shear becomes the most dominant factor driving spray droplet size. Previous research has shown that higher spray pressures can result in larger droplet-sized sprays by increasing the exit velocity of the spray liquid from the nozzles, which in turn decreases the differential velocity between the spray liquid and surrounding airstream, reducing secondary breakup. This work explores the effects of higher-than-normal spray pressures on two typical aerial application nozzles in the presence of a …
Psychology, 2016-2017, University Of South Florida St. Petersburg
Psychology, 2016-2017, University Of South Florida St. Petersburg
Academic Learning Compacts
The Academic Learning Compact for 2016-2017 for Psychology.
Biology, 2016-2017, University Of South Florida St. Petersburg
Biology, 2016-2017, University Of South Florida St. Petersburg
Academic Learning Compacts
The Academic Learning Compact for 2016-2017 for the Bachelor's of Science in Biology.
Environmental Science And Policy, 2016-2017, University Of South Florida St. Petersburg
Environmental Science And Policy, 2016-2017, University Of South Florida St. Petersburg
Academic Learning Compacts
The Academic Learning Compact for 2016-2017 for the Bachelor's of Arts in Environmental Science and Policy.
Health Science, 2016-2017, University Of South Florida St. Petersburg
Health Science, 2016-2017, University Of South Florida St. Petersburg
Academic Learning Compacts
The Academic Learning Compact for 2016-2017 for Health Science.
An Integrative And Applicable Phylogenetic Footprinting Framework For Cis-Regulatory Motifs Identification In Prokaryotic Genomes, Bingqiang Liu, Hanyuan Zhang, Chuan Zhou, Guojun Li, Anne Fennell, Guanghui Wang, Yu Kang, Qi Liu, Qin Ma
An Integrative And Applicable Phylogenetic Footprinting Framework For Cis-Regulatory Motifs Identification In Prokaryotic Genomes, Bingqiang Liu, Hanyuan Zhang, Chuan Zhou, Guojun Li, Anne Fennell, Guanghui Wang, Yu Kang, Qi Liu, Qin Ma
School of Computing: Faculty Publications
Background: Phylogenetic footprinting is an important computational technique for identifying cis-regulatory motifs in orthologous regulatory regions from multiple genomes, as motifs tend to evolve slower than their surrounding non-functional sequences. Its application, however, has several difficulties for optimizing the selection of orthologous data and reducing the false positives in motif prediction.
Results: Here we present an integrative phylogenetic footprinting framework for accurate motif predictions in prokaryotic genomes (MP3). The framework includes a new orthologous data preparation procedure, an additional promoter scoring and pruning method and an integration of six existing motif finding algorithms as basic motif search …
Dynamic And Modularized Microrna Regulation And Its Implication In Human Cancers, Jiang Shu, Bruno Vieira Resende E Silva, Tian Gao, Zheng Xu, Juan Cui
Dynamic And Modularized Microrna Regulation And Its Implication In Human Cancers, Jiang Shu, Bruno Vieira Resende E Silva, Tian Gao, Zheng Xu, Juan Cui
School of Computing: Faculty Publications
MicroRNA is responsible for the fine-tuning of fundamental cellular activities and human disease development. The altered availability of microRNAs, target mRNAs, and other types of endogenous RNAs competing for microRNA interactions reflects the dynamic and conditional property of microRNA-mediated gene regulation that remains under-investigated. Here we propose a new integrative method to study this dynamic process by considering both competing and cooperative mechanisms and identifying functional modules where different microRNAs co-regulate the same functional process. Specifically, a new pipeline was built based on a meta-Lasso regression model and the proof-of-concept study was performed using a large-scale genomic dataset from ~4,200 …
A Spatio-Temporal Analysis Of Mitochondrial Dna Haplogroup I, Peter Revesz
A Spatio-Temporal Analysis Of Mitochondrial Dna Haplogroup I, Peter Revesz
School of Computing: Faculty Publications
The recent recovery of ancient DNA from a growing number of human samples shows that mitochondrial DNA haplogroup I was introduced to Europe after the end of the Last Glacial Maximum. This paper provides a spatio-temporal analysis of the various subhaplogroups of mitochondrial DNA I. The study suggests that haplogroup I diversified into haplogroups I1, I2’3, I4 and I5 at specific regions in Eurasia and then spread southward to Crete and Egypt.
Diurnal Regulation Of Cellular Processes In The Cyanobacterium Synechocystis Sp. Strain Pcc 6803: Insights From Transcriptomic, Fluxomic, And Physiological Analyses, Rajib Saha, Deng Liu, Allison Hoynes-O’Connor, Michelle Liberton, Jingjie Yu, Maitrayee Bhattacharyya-Pakrasi, Andrea Balassy, Fuzhong Zhang, Tae Seok Moon, Costas D. Maranas, Himadri B. Pakrasi
Diurnal Regulation Of Cellular Processes In The Cyanobacterium Synechocystis Sp. Strain Pcc 6803: Insights From Transcriptomic, Fluxomic, And Physiological Analyses, Rajib Saha, Deng Liu, Allison Hoynes-O’Connor, Michelle Liberton, Jingjie Yu, Maitrayee Bhattacharyya-Pakrasi, Andrea Balassy, Fuzhong Zhang, Tae Seok Moon, Costas D. Maranas, Himadri B. Pakrasi
Department of Chemical and Biomolecular Engineering: Faculty Publications
Synechocystis sp. strain PCC 6803 is the most widely studied model cyanobacterium, with a well-developed omics level knowledgebase. Like the lifestyles of other cyanobacteria, that of Synechocystis PCC 6803 is tuned to diurnal changes in light intensity. In this study, we analyzed the expression patterns of all of the genes of this cyanobacterium over two consecutive diurnal periods. Using stringent criteria, we determined that the transcript levels of nearly 40% of the genes in Synechocystis PCC 6803 show robust diurnal oscillating behavior, with a majority of the transcripts being upregulated during the early light period. Such transcripts corresponded to a …
Anisotropy, Band-To-Band Transitions, Phonon Modes, And Oxidation Properties Of Cobalt-Oxide Core-Shell Slanted Columnar Thin Films, Alyssa Mock, Rafał Korlacki, Chad Briley, Derek Sekora, Tino Hofmann, Peter M. Wilson, Alexander Sinitskii, Eva Schubert, Mathias Schubert
Anisotropy, Band-To-Band Transitions, Phonon Modes, And Oxidation Properties Of Cobalt-Oxide Core-Shell Slanted Columnar Thin Films, Alyssa Mock, Rafał Korlacki, Chad Briley, Derek Sekora, Tino Hofmann, Peter M. Wilson, Alexander Sinitskii, Eva Schubert, Mathias Schubert
Department of Electrical and Computer Engineering: Faculty Publications
Highly ordered and spatially coherent cobalt slanted columnar thin films (SCTFs) were deposited by glancing angle deposition onto silicon substrates, and subsequently oxidized by annealing at 475°C. Scanning electron microscopy, Raman scattering, generalized ellipsometry, and density functional theory investigations reveal shape-invariant transformation of the slanted nanocolumns from metallic to transparent metal-oxide core-shell structures with properties characteristic of spinel cobalt oxide. We find passivation of Co-SCTFs yielding Co-Al2O3core-shell structures produced by conformal deposition of a few nanometers of alumina using atomic layer deposition fully prevents cobalt oxidation in ambient and from annealing up to 475°C.
Anisotropy, Phonon Modes, And Free Charge Carrier Parameters In Monoclinic Β-Gallium Oxide Single Crystals, Mathias Schubert
Anisotropy, Phonon Modes, And Free Charge Carrier Parameters In Monoclinic Β-Gallium Oxide Single Crystals, Mathias Schubert
Department of Electrical and Computer Engineering: Faculty Publications
We derive a dielectric function tensor model approach to render the optical response of monoclinic and triclinic symmetrymaterials with multiple uncoupled infrared and far-infrared active modes.We apply our model approach to monoclinic β-Ga2O3 single-crystal samples. Surfaces cut under different angles from a bulk crystal, (010) and (201), are investigated by generalized spectroscopic ellipsometry within infrared and far-infrared spectral regions. We determine the frequency dependence of 4 independent β-Ga2O3 Cartesian dielectric function tensor elements by matching large sets of experimental data using a point-by-point data inversion approach. From matching our monoclinic model to …
Effect Of Obesity On The Skeletal Muscle Angiogenic Response Following Acute Resistance Exercise, Jessica Aryn Weiss
Effect Of Obesity On The Skeletal Muscle Angiogenic Response Following Acute Resistance Exercise, Jessica Aryn Weiss
Open Access Theses
With the rates of obesity remaining high, health risks are abundant. This includes an increased possibility of the development of insulin resistance and type 2 diabetes mellitus (T2DM). Several biochemical and histochemical characteristics associated with obesity have been reported, including a reduction in capillary density in the skeletal muscle and increased muscle fiber size. Resistance exercise is known to induce hypertrophy and increase skeletal muscle capillarization. Following acute resistance exercise, it is hypothesized angiogenic factors are reduced and angiostatic factors are increased in the skeletal muscle of obese individuals. Muscle biopsies from the vastus lateralis were obtained to investigate whether …
Health Theater, Govind Persad
Health Theater, Govind Persad
Sturm College of Law: Faculty Scholarship
"Security theater" has been defined as an effort to "provide the feeling of security instead of the reality. " The concept of security theater has been discussed in both the popular press and academic literature, but has not yet entered health law. This project suggests that a parallel category of "health theater" picks out a set ofpractices in medical screening and health care delivery that provide a mere simulacrum ofprotection against medical risk, rather than providing genuine medical benefit. Part I summarizes some of the distinctive advantages and disadvantages of health and security theater. Like security theater, health theater frequently …
Law, Science, And The Injured Mind, Govind Persad
Law, Science, And The Injured Mind, Govind Persad
Sturm College of Law: Faculty Scholarship
Even while we widely recognize legal liability for physical injury, we frequently discount mental, emotional, and psychological injury. We disfavor tort liability for emotional distress; we prohibit prisoners from suing for purely psychological injuries; and we tax the damages victims of emotional injury receive even while leaving damages for physical injury untaxed. This Article argues that neuroscientific, psychological, and technological advances challenge our traditional ideas about the set of injuries that are possible and that merit legal redress. The Article goes on to contend that, while these advances challenge our traditional ideas, they do not inevitably overturn traditional distinctions within …
Where Copyright Meets Privacy In The Big Data Era: Access To And Control Over User Data In Agriculture And The Role Of Copyright, Tesh W. Dagne
Where Copyright Meets Privacy In The Big Data Era: Access To And Control Over User Data In Agriculture And The Role Of Copyright, Tesh W. Dagne
Vanderbilt Journal of Entertainment & Technology Law
The application of big data in different sectors of the economy and its transformative value has recently attracted considerable attention. However, this transformation, driven by the application of advanced technologies that utilize big data—such as the Internet of Things (IoT), artificial intelligence (AI), and software systems—raises concerns about access to and control over the user data that results from the uptake in using digital technologies. This Article examines the role different legal regimes have in framing access to and control over various forms of user data from the perspective of technology users in the agriculture sector. This Article then goes …
Geography, 2016-2017, University Of South Florida St. Petersburg
Geography, 2016-2017, University Of South Florida St. Petersburg
Academic Learning Compacts
The Academic Learning Compact for 2016-2017 for the Bachelor's of Arts in Geography.
Soldier Enhancement: Ethical Risks And Opportunities, Matthew Beard, Jai Galliott, Sandra Lynch
Soldier Enhancement: Ethical Risks And Opportunities, Matthew Beard, Jai Galliott, Sandra Lynch
Philosophy Papers and Journal Articles
Over the past decade, interest in human enhancement has waxed and waned. The initial surge of interest and funding, driven by the US Army’s desire for a ‘Future Force Warrior’ has partly given way to the challenges of meeting operational demands abroad. However the ethical opportunities provided by soldier enhancement demand that investigation of its possibilities continue. Benefits include enhanced decision-making, improved force capability, reduced force size and lower casualty rates.
These benefits — and enhancement itself — carry concomitant risks, including morale issues due to tension between enhanced and unenhanced soldiers, the issues of enhanced veterans and ownership of …
2016 Intersession Catalog, Illinois Mathematics And Science Academy
2016 Intersession Catalog, Illinois Mathematics And Science Academy
Intersession Catalogs
No abstract provided.
Early Neurodevelopment: Notch Signaling, Axial Differentiation, Brain Patterning, And Neurogenesis, Adrian M. Bebenek '17
Early Neurodevelopment: Notch Signaling, Axial Differentiation, Brain Patterning, And Neurogenesis, Adrian M. Bebenek '17
Independent Study
The vastly complex, delicate nature of the nervous system calls for a highly effective development system. The development of the nervous system begins early in embryogenesis and is one of the last systems to be completed after birth. Deemed to be one of the most important steps in the evolutionary progression towards sophisticated life, the pathways regulating neurodevelopment are highly specialized and conserved. Embryonic neurodevelopment is an important starting point for the understanding of brain anatomy, function, and its neurobiology. The past few decades have brought about numerous technological advancements allowing for the study of the earliest stages of embryonic …
Imsa360: 2016, Imsa Fund
Imsa360: 2016, Imsa Fund
IMSA Fund Reports
About ten years ago I tried to explain to my wife what made IMSA such an important, life-changing place for me. That explanation turned into a 329 page novel (my first published young adult novel), that I still think only scratched the surface of what makes IMSA such a wondrous, rare, and crucial place.
Excerpt: From the President
An Opportunity Missed? A Constitutional Analysis Of Proposed Reforms To Tasmania's 'Hate Speech' Laws, Joshua Forrester, Augusto Zimmerman, Lorraine Finlay
An Opportunity Missed? A Constitutional Analysis Of Proposed Reforms To Tasmania's 'Hate Speech' Laws, Joshua Forrester, Augusto Zimmerman, Lorraine Finlay
Law Papers and Journal Articles
The Tasmanian government has proposed reforms to the ‘hate speech’ provisions in the Anti-Discrimination Act 1998 (Tas). However, these reforms are unsatisfactory. They do not address, and in fact compound, the constitutional invalidity of Tasmania’s ‘hate speech’ laws. In this article, we demonstrate that Tasmania’s present ‘hate speech’ laws, like equivalent provisions in other States and Territories, impermissibly infringe the implied freedom of political communication. We also demonstrate that certain proposed reforms further infringe the implied freedom of political communication. We will conclude by proposing elements of a constitutionally valid law against incitement to enmity.
A Point Mutation In Dna Polymerase Β (Polb) Gene Is Associated With Increased Progesterone Receptor (Pr) Expression And Intraperitoneal Metastasis In Gastric Cancer, Xiaohui Tan, Xiaoling Wu, Shuyang Ren, Hongyi Wang, Weaam Alshenawy, Wenmei Li, Jiantao Cui, Guangbin Luo, Robert S. Siegel, Sidney W. Fu, Youyong Lu
A Point Mutation In Dna Polymerase Β (Polb) Gene Is Associated With Increased Progesterone Receptor (Pr) Expression And Intraperitoneal Metastasis In Gastric Cancer, Xiaohui Tan, Xiaoling Wu, Shuyang Ren, Hongyi Wang, Weaam Alshenawy, Wenmei Li, Jiantao Cui, Guangbin Luo, Robert S. Siegel, Sidney W. Fu, Youyong Lu
Medicine Faculty Publications
Increased expression of progesterone receptor (PR) has been reported in gastric cancer (GC). We have previously identified a functional T889C point mutation in DNA polymerase beta (POLB), a DNA repair gene in GC. To provide a detailed analysis of molecular changes associated with the mutation, human cDNA microarrays focusing on 18 signal transduction pathways were used to analyze differential gene expression profiles between GC tissues with T889C mutant in POLB gene and those with wild type. Among the differentially expressed genes, notably, PR was one of the significantly up-regulated genes in T889C mutant POLB tissues, which were subsequently confirmed in …
Metataxonomic And Metagenomic Approaches Vs. Culture-Based Techniques For Clinical Pathology., Sarah K. Hilton, Eduardo Castro-Nallar, Marcos Pérez-Losada, Ian Toma, Timothy A. Mccaffrey, Eric P. Hoffman, Marc O. Siegel, Gary L. Simon, W. Evan Johnson, Keith Crandall
Metataxonomic And Metagenomic Approaches Vs. Culture-Based Techniques For Clinical Pathology., Sarah K. Hilton, Eduardo Castro-Nallar, Marcos Pérez-Losada, Ian Toma, Timothy A. Mccaffrey, Eric P. Hoffman, Marc O. Siegel, Gary L. Simon, W. Evan Johnson, Keith Crandall
Genomics and Precision Medicine Faculty Publications
Diagnoses that are both timely and accurate are critically important for patients with life-threatening or drug resistant infections. Technological improvements in High-Throughput Sequencing (HTS) have led to its use in pathogen detection and its application in clinical diagnoses of infectious diseases. The present study compares two HTS methods, 16S rRNA marker gene sequencing (metataxonomics) and whole metagenomic shotgun sequencing (metagenomics), in their respective abilities to match the same diagnosis as traditional culture methods (culture inference) for patients with ventilator associated pneumonia (VAP). The metagenomic analysis was able to produce the same diagnosis as culture methods at the species-level for five …
Effect Of The Il-1 Receptor Antagonist Kineret® On Disease Phenotype In Mdx Mice., Margaret E. Benny Klimek, Arpana Sali, Sree Rayavarapu, Jack Van Der Meulen, Kanneboyina Nagaraju
Effect Of The Il-1 Receptor Antagonist Kineret® On Disease Phenotype In Mdx Mice., Margaret E. Benny Klimek, Arpana Sali, Sree Rayavarapu, Jack Van Der Meulen, Kanneboyina Nagaraju
Genomics and Precision Medicine Faculty Publications
Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by mutations in the dystrophin gene. The pathology of DMD manifests in patients with progressive muscle weakness, loss of ambulation and ultimately death. One of the characteristics of DMD is muscle inflammation, and dystrophin-deficient skeletal muscles produce higher levels of the pro-inflammatory cytokine interleukin 1β (IL-1β) in response to toll like receptor (TLR) stimulation compared to controls; therefore, blocking the IL-1β pathway could improve the disease phenotype in mdx mice, a mouse model of DMD. Kineret® or IL-1Ra is a recombinant IL-1 receptor antagonist approved by the FDA for treating …
Glucocorticoid Receptor (Nr3c1) Variants Associate With The Muscle Strength And Size Response To Resistance Training., Garrett I Ash, Matthew A Kostek, Harold Lee, Theodore J Angelopoulos, Priscilla M Clarkson, Paul M Gordon, Niall M Moyna, Paul S Visich, Robert F Zoeller, Thomas B Price, Joseph M. Devaney, Heather Gordish-Dressman, Paul D Thompson, Eric P. Hoffman, Linda S Pescatello
Glucocorticoid Receptor (Nr3c1) Variants Associate With The Muscle Strength And Size Response To Resistance Training., Garrett I Ash, Matthew A Kostek, Harold Lee, Theodore J Angelopoulos, Priscilla M Clarkson, Paul M Gordon, Niall M Moyna, Paul S Visich, Robert F Zoeller, Thomas B Price, Joseph M. Devaney, Heather Gordish-Dressman, Paul D Thompson, Eric P. Hoffman, Linda S Pescatello
Genomics and Precision Medicine Faculty Publications
Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm2) pre- and post-resistance training. Subjects were genotyped for NR3C1 -2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers …