Digital Commons Network^™

Neuronostatin Acts Via Gpr107 To Increase Camp-Independent Pka Phosphorylation And Proglucagon Mrna Accumulation In Pancreatic Α-Cells, Mollisa M. Elrick, Willis K. Samson, John A. Corbett, Alison S. Salvatori, Lauren M. Stein, Grant R. Kolar, Aaron Naatz, Gina L.C. Yosten

Biological Sciences Faculty Research & Creative Works

Neuronostatin (NST) is a recently described peptide that is produced from the somatostatin preprohormone in pancreatic α-cells. NST has been shown to increase glucagon secretion from primary rat pancreatic islets in low-glucose conditions. Here, we demonstrate that NST increases proglucagon message in α-cells and identify a potential mechanism for NST's cellular activities, including the phosphorylation of PKA following activation of the G protein-coupled receptor, GPR107. GPR107 is abundantly expressed in the pancreas, particularly, in rodent and human α-cells. Compromise of GPR107 in pancreatic α-cells results in failure of NST to increase PKA phosphorylation and proglucagon mRNA levels. We also demonstrate …

Hypothalamic Action Of Phoenixin To Control Reproductive Hormone Secretion In Females: Importance Of The Orphan G Protein-Coupled Receptor Gpr173, Lauren M. Stein, Chloe W. Tullock, Stacy K. Mathews, David Garcia-Galiano, Carol F. Elias, Willis K. Samson, Gina L.C. Yosten

Biological Sciences Faculty Research & Creative Works

Sexual maturation and maintenance of reproductive function are regulated by neurohormonal communication between the hypothalamus, pituitary, and gonads (referred to as the HPG axis). Phoenixin (PNX) is a newly identified, endogenous peptide abundantly produced in the hypothalamus and shown to be an important mediator of ovarian cyclicity. However, the underlying mechanisms by which phoenixin functions within the HPG axis are unknown. Previous in vitro studies demonstrated a direct action of PNX on gonadotrophs to potentiate gonadotrophin-releasing hormone (GnRH) induced luteinizing hormone (LH) secretion. Therefore, we hypothesized that centrally derived phoenixin regulates the preovulatory LH surge required for ovarian cyclicity. We …

Horizons Fall 2016, Nova Southeastern University

Horizons

No abstract provided.

Horizons Spring 2016, Nova Southeastern University

Horizons

Features

• Science Comes Alive 3
• Breaking Free 8
• Diving In 14
• Realizing Potential 20
• Distinguished Alumni Achievement Awards 23
• A Vision for Panama’s Future 28
• Miniaci Family Receives President’s Award 34
• Shark Circle Members Honored 35
• Caring for the Gulf Coast 38
• Looking Ahead 44

Departments

• Message from the President 2
• Alumni Notes 26
• Alumni Profile - Brenda Ellis 32
• Faculty Profile - Michael Flynn 36
• Athletics - Cross Country Runner Wins in Sportsmanship 42

First Look 2016, Nova Southeastern University

First Look

No abstract provided.

University Of Texas At Tyler Course Catalog, 2016 - 2017, University Of Texas At Tyler

Catalogs

No abstract provided.

Mechanistic Abstraction, Worth Boone, Gualtiero Piccinini

Philosophy Faculty Works

We provide an explicit taxonomy of legitimate kinds of abstraction within constitutive explanation. We argue that abstraction is an inherent aspect of adequate mechanistic explanation. Mechanistic explanations—even ideally complete ones—typically involve many kinds of abstraction and therefore do not require maximal detail. Some kinds of abstraction play the ontic role of identifying the specific complex components, subsets of causal powers, and organizational relations that produce a suitably general phenomenon. Therefore, abstract constitutive explanations are both legitimate and mechanistic.

Indicators Of Climate Change And Social Vulnerability In Fishing Dependent Communities Along The Eastern And Gulf Coasts Of The U.S. Marine Policy, Lisa Colburn, Michael Jepson, Changhua Weng, Tarsila Seara, Jeremy Weiss

Biology and Environmental Science Faculty Publications

Changing climatic conditions are affecting the relationship between fishing communities and the marine resources they depend on. This shift will require an adaptive response on the part of policy makers and fishery managers. In the U.S., the National Oceanic and Atmospheric Administration (NOAA) established, in its fisheries agency (NOAA Fisheries), a set of social indicators of fishing community vulnerability and resilience to evaluate the impacts of changes in fishery management regimes. These indicators enhance the analytical capabilities within NOAA Fisheries for conducting fisheries social impact assessments and informing ecosystem-based fishery management. Building on the existing Community Social Vulnerability Indicators (CSVIs), …

Bath Salt-Induced Psychosis: Nursing Assessment, Diagnosis, Treatment, And Outcomes, Brandie Marie Stiles, Anne F. Fish, Cynthia A. Cook, Victor Silva

Nursing Faculty Works

Purpose: To review what is known about the assessment, diagnosis, treatment, and outcomes of patients with bath salt-induced psychosis. Design and Methods: Comprehensive review and synthesis of research, case reports, and state-level data. Findings: Of the 42 case reports found, only 18 confirmed the presence of bath salts through laboratory testing. Twelve of the confirmed cases died. In most of the case reports, law enforcement was involved prior to hospitalization due to bizarre behaviors, delusions, and hallucinations. Practice Implications: Due to the severity of both physical and psychological symptoms in patients in bath salt-induced psychosis, nurses, other healthcare providers, police, …

Isu Today - January 26, 2016, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Cosmos, Earth, And Man, David H. Bailey, Jeffrey M. Bradshaw, John S. Lewis, Gregory L. Smith, Michael R. Stark

Interpreter Foundation Books

I’ve long resisted the claim, typically (as in C. S. Lewis’s allegorical exchange between the pilgrim John and Mr. Enlightenment) assumed rather than explicitly argued, that no well-educated person, and certainly nobody with a solid grounding in modern science, can rationally choose to be a religious believer.2 So I was delighted with the proposal that The Interpreter Foundation organize and sponsor a conference on the relationship between science and Mormonism. When Dr. David Bailey called me regarding the possibility of such a conference, I jumped at the opportunity.

Novel Photodynamic Cancer Therapy Agent And Biochemical Phosphate Sensor Based On Nanomaterials, Alaa Fadhel

Electronic Theses and Dissertations

Biochemical research and clinical studies have revolutionized the field of medicine in both diagnosis and therapy. Researchers in the field of biochemistry and biotechnology are using nanomaterials in different applications to develop devices and materials that offer benefits to both patients and the health care industry. These include biochemical sensors, enzyme encapsulation, biomarkers, and drug delivery improvements for the treatment of cancer. This dissertation focuses on investigating two biochemical aspects using nanomaterials; namely therapy and clinical diagnosis. For therapy purposes, Silica nanoparticles were used as drug delivery system to develop a new photodynamic cancer therapy agent photo-acid generator (PAG) that …

Annual Report, 2016, University Of Arkansas, Fayetteville. Dale Bumpers College Of Agricultural, Food And Life Sciences. Dept. Of Biological And Agricultural Engineering

Biological and Agricultural Engineering Department Annual Report

No abstract provided.

Graduate Catalog Of Studies, 2015-2016, University Of Arkansas, Fayetteville

Graduate School Catalog of Studies

No abstract provided.

Annual Report, 2016-2017, Humboldt State University Library

Library Publications

• Campus collaborations
• Library instruction & SkillShops
• Innovative spaces and programs
• Dynamic community building & learning events
• HSU Press publications

Our Gmo Labeling Debate: Human Health, The Environment, And The Precautionary Principle, Kate Porfilio 16

Honor Scholar Theses

No abstract provided.

The Emergence Of The Innovative Entity: Is The Patent System Left Behind?, 16 J. Marshall Rev. Intell. Prop. L. 66 (2016), Talya Ponchek

UIC Review of Intellectual Property Law

This article is concerned with the question of whether the United States patent system achieves its goal, set by policymakers, to promote innovation. The article provides a systematic review of two bodies of literature and how each of them perceives the process and identity of the innovator. First, a review of the development of U.S. patent system, from pre-legislation England to the U.S. federal system, alongside the developments of the classical reasoning for property rights allocation, revealing that as the Anglo-American patent system is rooted in the privileges system, it views innovation as the creation of an individual inventor. Second, …

Suscetibilidade De Adultos De Bemisia Tabaci Biótipo B A Inseticidas, Danilo A.S. Esashika, Miguel Michereff-Filho, Cristina S. Bastos, Alice K. Inoue-Nagata, Antônio M. Dias, Matheus G.P.M. Ribeiro

Department of Entomology: Faculty Publications

A associação de alguns vírus fitopatogênicos com seus vetores pode ou não alterar a ação do controle químico. Este trabalho objetivou avaliar a suscetibilidade de moscas-brancas virulíferas (com aquisição do begomovírus Tomato severe rugose virus, ToSRV) e avirulíferas (sem aquisição do ToSRV) aos principais inseticidas registrados para o seu controle na cultura do tomateiro. Foram realizados ensaios com plantas de tomateiro e discos foliares de feijão- -de-porco. Os tratamentos foram arranjados em esquema fatorial de 7 (seis inseticidas + controle) e de 5 (quatro inseticidas + controle) x 2 [mosca-branca (MB) virulífera (V) ou avirulífera (AV)] e dispostos no delineamento …

Urinformed December 2016, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Urinformed Summer 2016, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Ecosystem Services Of Woody Crop Production Systems, Ronald S. Zalesny Jr., John A. Stanturf, Emile S. Gardiner, James H. Perdue, Timothy M. Young, David R. Coyle, William L. Headlee, Gary S. Bañuelos, Amir Hass

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Short-rotation woody crops are an integral component of regional and national energy portfolios, as well as providing essential ecosystem services such as biomass supplies, carbon sinks, clean water, and healthy soils. We review recent USDA Forest Service Research and Development efforts from the USDA Biomass Research Centers on the provisioning of these ecosystem services from woody crop production systems. For biomass, we highlight productivity and yield potential, pest susceptibility, and bioenergy siting applications. We describe carbon storage in aboveground woody biomass and studies assessing the provision of clean and plentiful water. Soil protection and wildlife habitat are also mentioned, in …

The Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Variations In The Intensity Of Specialized Science, Technology, Engineering, And Mathematics (Stem) High Schools, Colby Tofel-Grehl, Carolyn M. Callahan

Teacher Education and Leadership Faculty Publications

Educators and policymakers in the United States advocate the development of specialized STEM (science, technology, engineering, and mathematics) schools, but little is known about the unique features and practices of these schools. Because no meaningful differences have been found attributable to model type (Tofel-Grehl & Callahan, 2014), the current study purposefully sampled 6 specialized STEM schools in the United States that provided different levels of STEM experiences for students related to highly varied goals and missions using a grounded theory approach. Schools were found to fall into two categories, high and low STEM intensity, based on five major traits. Schools …

Disease Lab, Jim Powell, Matthew Lewis

Laboratory Experiences in Mathematical Biology

Students use transparencies and dry erase markers to simulate the spread of a zombie virus among a fixed population. Students are then challenged to create their own "disease" and develop an ODE model for the resulting data. From this exercise students gain greater understanding of population and SIR models, disease dynamics, parameter estimation and compartment modeling.

Yeast Lab, Matthew Lewis, Jim Powell

Laboratory Experiences in Mathematical Biology

Yeast are grown in a small, capped ask, generating carbon dioxide which is trapped in an inverted jar full of colored water. The volume of carbon dioxide produced can either be measured directly or using time-lapse imagery on an iPad or similar. Students are then challenged to model the resulting data. From this exercise students gain greater understand- ing of ODE compartment models, parameter estimation, population dynamics and limiting factors.

Leaky Bucket Lab, Jim Powell, Jim Haefner, Brynja Kohler

Laboratory Experiences in Mathematical Biology

Students test Torrecelli’s law and develop and compare their own alternative models to describe the dynamics of water draining from perforated containers. From this exercise students gain experience and perspective using a classic model as well as greater understanding of ODE compartment models, parameter estimation and fluid flows.

Stream Lab, Miro Kummel, Andrea Bruder, Jim Powell, Brynja Kohler, Matthew Lewis

Laboratory Experiences in Mathematical Biology

Dead leaves, ping-pong balls or plastic golf balls are floated down a small stream. The number of leaves/balls passing recording stations along the stream are tallied. Students are then challenged to develop a transport model for the resulting data. From this exercise students gain greater understanding of PDE modeling, conservation laws, parameter estimation as well as mass and momentum transport processes.

Gene Expression Profiling Of Odorant Binding Proteins In The Tsetse Fly Glossina Brevipalpis, Mary K. Murithi

All Master’s Theses

Glossina brevipalpis is a vector of trypanosomes that cause Animal African Trypanosomiasis. Chemoreception in tsetse flies is critical for identifying larvipositioning sites, hosts and mates. Odorant binding proteins (OBPs) are thought to mediate insect chemoreception by shuttling odours to receptors on olfactory sensory neurons. Little is known about the roles of OBPs in tsetse fly chemoreception. The genome of G. brevipalpis has been sequenced and 28 OBPs identified. This study aimed at profiling the expression levels of G. brevipalpis OBP genes at different starvation periods and developmental stages. Glossina morsitans morsitans OBP genes retrieved from VectorBase were queried against G. …

Evaluation Of Yield, Chemical Composition And Antimicrobial Activity Of Essential Oils Of Tagetes Minuta L. (Asteraceae) Against Selected Phytopathogens, Martin .. Gakuubi

All Master’s Theses

Phytopathogenic fungi and bacteria cause enormous crop yield losses worldwide. Over the years, management of plant pathogens has primarily relied on the use of synthetic chemical antimicrobials and development of disease resistant varieties. Exploration for biologically active compounds from plants with an aim of discovery and development of novel and eco-friendly biopesticides to combat current and emerging phytopathogens has received increased interest in the recent past. This study aimed at extraction of Tagetes minuta essential oils (EOs), evaluation of the antimicrobial activity of the essential oils against selected phytopathogenic fungi and bacteria and characterization of chemical composition of the essential …

Proximal Muscle Weakness And Debility Secondary To Polymyositis: A Case Report, Adam Meidinger

Physical Therapy Scholarly Projects

BACKGROUND AND PURPOSE: Polymyositis (PM) is the most common inflammatory myopathy in persons over age 50. It predominantly causes weakness at proximal musculature including the trunk, hips, thighs, shoulders, upper arms, and neck leading to challenges with ambulation and mobility, community activities, and difficulty swallowing, eating, and talking. Studies have shown physical therapy to be a staple in the plan of care for treatment of PM to aid in the restoration of muscle function and to improve or prevent further loss of strength. The purpose of this case report is to outline physical therapy's role in the treatment of a …