Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2016

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 18871 - 18900 of 29104

Full-Text Articles in Entire DC Network

Searching For Nature Through Frames Of Meat Production And Consumption, Elena Klonoski Jan 2016

Searching For Nature Through Frames Of Meat Production And Consumption, Elena Klonoski

Sociology Honors Papers

The relationship between meat production/consumption and the permeable boundary of nature-society has been largely ignored. Because meat consumption and production is at the crossroads of environmental sociology, sociology of food, and sociology of animal ethics, elements of each field are necessary to fully understand the closely intertwined concepts of nature and meat. By drawing from each of these sub-areas and using Brewster and Bell’s (2009) analytic ‘Goffmanian’ frames, this study explores how natural (unguided) and social (human controlled) frames of meat are used to separate modern society from nature. Semi-structured interviews (n=20), including image elicitation, were conducted with individuals at …

Go to article

Elasmobranchii: A Survey Study On The Impact Of Our Everyday Choices In Marine Environments, Zoe Davis Jan 2016

Elasmobranchii: A Survey Study On The Impact Of Our Everyday Choices In Marine Environments, Zoe Davis

Biology Honors Papers

Oceans cover two‐thirds of our total planet surface area, ignoring the significance of depth, and even so, humans affect and change the ocean daily. This change is not often intentional or conscious, but rather is usually indirect. The hypothesis that humans do not consider how their actions affect the ocean unless they are educated on the subject matter and/or live within 25 miles of a coastline was examined through two survey studies. The purpose was to observe actions that affected the ocean and see if there were any trends with participants knowing which actions were positive for the ocean or …

Go to article

Zootaxa: Guide To The Parasites Of Fishes Of Canada Part V: Nematoda, Hisao P. Arai, John W. Smith Jan 2016

Zootaxa: Guide To The Parasites Of Fishes Of Canada Part V: Nematoda, Hisao P. Arai, John W. Smith

Biology Faculty Publications

Keys are provided for the identification of the nematode species known to be parasites of Canadian fishes. The nematodes are described and illustrated, with a note of the site(s) they occupy in named fish host(s) and their geographical distribution. Parasite records are given by author and date, full details of which can be found in a bibliography of over 800 references. Diagnoses and keys for 22 Families, 47 genera and 88 species of nematodes are also given, together with a glossary of terms, a host-parasite list, and indices to both nematode parasites and hosts

Go to article

The "Nature" Of Legal Dispute Bargaining, Robert J. Condlin Jan 2016

The "Nature" Of Legal Dispute Bargaining, Robert J. Condlin

Faculty Scholarship

The longstanding debate over the relative merits of adversarial and communitarian theories of legal dispute bargaining has been in somewhat of a holding pattern for several years, but recent research in the field of cognitive neuroscience may break the logjam. Laboratory experiments and case studies in that field have shown how dispositions and capacities for social cooperation inherited from natural selection and evolution predispose humans to configure disputing as a mixture of argument over factual reality, disagreement over the interpretation of normative standards, and a search for impartial resolutions that protect the interests of everyone involved equally. This neurobiological inheritance …

Go to article

Inheritance Law And The Marital Presumption After Obergefell, Paula A. Monopoli Jan 2016

Inheritance Law And The Marital Presumption After Obergefell, Paula A. Monopoli

Faculty Scholarship

No abstract provided.

Go to article

Crhbp Polymorphisms Predict Chronic Pain Development Following Motor Vehicle Collision, S. D. Linnstaedt, A. V. Bortsov, A. C. Soward, R. Swor, D. A. Peak, J. Jones, N. Rathlev, D. C. Lee, R. Domeier, P. L. Hendry, S. A. Mclean Jan 2016

Crhbp Polymorphisms Predict Chronic Pain Development Following Motor Vehicle Collision, S. D. Linnstaedt, A. V. Bortsov, A. C. Soward, R. Swor, D. A. Peak, J. Jones, N. Rathlev, D. C. Lee, R. Domeier, P. L. Hendry, S. A. Mclean

Journal Articles

Musculoskeletal pain (MSP) is a common sequela of traumatic stress exposure. While biologic factors contributing to chronic MSP after motor vehicle collision (MVC) have traditionally focused on tissue injury, increasing evidence suggests that neuro/stress/immune processes mediated by stress system activation may play a more dominant role. In a previous study we found that genetic variants in the hypothalamic-pituitary-adrenal (HPA) axis-related gene FKBP5 influence vulnerability to persistent MSP 6 weeks after MVC. In the present cohort study (n = 855) we evaluated whether genetic variants in several other important HPA axis-related genes, including the glucocorticoid receptor (NR3C1), corticotropin-releasing hormone receptor R1 …

Go to article

Relationship Between Obesity And Clinical Outcome In Adults With Acute Myeloid Leukemia: A Pooled Analysis From Four Calgb (Alliance) Clinical Trials, J. J. Castillo, F. Mulkey, S. Geyer, J. E. Kolitz, W. Blum, B. L. Powell, S. L. George, R. A. Larson, R. M. Stone Jan 2016

Relationship Between Obesity And Clinical Outcome In Adults With Acute Myeloid Leukemia: A Pooled Analysis From Four Calgb (Alliance) Clinical Trials, J. J. Castillo, F. Mulkey, S. Geyer, J. E. Kolitz, W. Blum, B. L. Powell, S. L. George, R. A. Larson, R. M. Stone

Journal Articles

Obesity has been previously suggested as an adverse prognostic marker in patients with acute leukemia. To evaluate the relationship between obesity and clinical outcome, disease-free survival (DFS) and overall survival (OS), in patients with acute myelogenous leukemia (AML), including acute promyelocytic leukemia (APL), we performed a pooled analysis of four CALGB (Alliance) clinical trials. Our study included 446 patients with APL from CALGB 9710, and 1,648 patients between 18 and 60 years of age with non-APL AML from CALGB 9621, 10503, and 19808. Obesity was defined as BMI >/=30 kg/m(2) . Multivariate Cox proportional-hazard regression models were fitted for DFS …

Go to article

Pulmonary Arterial Hypertension: A Current Review Of Pharmacological Management, S. Sahni, M. Ojrzanowski, S. Majewski, A. Talwar Jan 2016

Pulmonary Arterial Hypertension: A Current Review Of Pharmacological Management, S. Sahni, M. Ojrzanowski, S. Majewski, A. Talwar

Journal Articles

Pulmonary hypertension (PHTN) is a rare and devastating disease characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance, which eventually leads to right ventricular failure and death. At present there is no cure for pulmonary arterial hypertension (PAH); however over the past decade targeted pharmaceutical options have become available for the treatment of PAH. Prior to evaluation for therapeutic options a definitive diagnosis of pulmonary arterial hypertension must be made via comprehensive physical exam and definitive diagnostic testing. Screening test of choice remains echocardiography and gold standard for definitive diagnosis is right heart catheterization. Once the establishment …

Go to article

Dietary Total Isoflavone Intake Is Associated With Lower Systolic Blood Pressure: The Coronary Artery Risk Development In Young Adults (Cardia) Study, S. I. Richardson, L. M. Steffen, K. Swett, C. Smith, L. Burke, X. Zhou, J. M. Shikany, C. J. Rodriguez Jan 2016

Dietary Total Isoflavone Intake Is Associated With Lower Systolic Blood Pressure: The Coronary Artery Risk Development In Young Adults (Cardia) Study, S. I. Richardson, L. M. Steffen, K. Swett, C. Smith, L. Burke, X. Zhou, J. M. Shikany, C. J. Rodriguez

Journal Articles

The effect of dietary isoflavone intake on systolic blood pressure (SBP) has not been studied in a large community-based cohort inclusive of African Americans. The authors analyzed data from the year 20 examination of the Coronary Artery Risk Development in Young Adults (CARDIA) study, including medical history, physical examination, and dietary intake surveys for 3142 participants. Multivariable linear regression models controlled for age, sex, body mass index, smoking, physical activity, and intakes of alcohol and total energy. Effect modification by race was tested. Overall, patients with hypertension had a lower daily intake of total dietary isoflavones (2.2+/-5.2 mg/d vs 4.1+/-11.7 …

Go to article

Angiotensin Ii Down-Regulates Nephrin-Akt Signaling And Induces Podocyte Injury: Roleof C-Abl, Q. Yang, Y. Ma, Y. Liu, W. Liang, X. Chen, Z. Ren, H. Wang, P. C. Singhal, G. Ding Jan 2016

Angiotensin Ii Down-Regulates Nephrin-Akt Signaling And Induces Podocyte Injury: Roleof C-Abl, Q. Yang, Y. Ma, Y. Liu, W. Liang, X. Chen, Z. Ren, H. Wang, P. C. Singhal, G. Ding

Journal Articles

Recent studies have shown that nephrin plays a vital role in angiotensin II (Ang II)-induced podocyte injury and thus contributes to the onset of proteinuria and the progression of renal diseases, but its specific mechanism remains unclear. c-Abl is an SH2/SH3 domain-containing nonreceptor tyrosine kinase that is involved in cell survival and regulation of the cytoskeleton. Phosphorylated nephrin is able to interact with molecules containing SH2/SH3 domains, suggesting that c-Abl may be a downstream molecule of nephrin signaling. Here we report that Ang II-infused rats developed proteinuria and podocyte damage accompanied by nephrin dephosphorylation and minimal interaction between nephrin and …

Go to article

Simulation For Operational Readiness In A New Freestanding Emergency Department: Strategy And Tactics, R L. Kerner, K Gallo, M Cassara Do, J D'Angelo, A Egan, J G. Simmons Jan 2016

Simulation For Operational Readiness In A New Freestanding Emergency Department: Strategy And Tactics, R L. Kerner, K Gallo, M Cassara Do, J D'Angelo, A Egan, J G. Simmons

Journal Articles

© 2016 by the Society for Simulation in Healthcare. Statement Simulation in multiple contexts over the course of a 10-week period served as a core learning strategy to orient experienced clinicians before opening a large new urban freestanding emergency department. To ensure technical and procedural skills of all team members, who would provide care without on-site recourse to specialty backup, we designed a comprehensive interprofessional curriculum to verify and regularize a wide range of competencies and best practices for all clinicians. Formulated under the rubric of systems integration, simulation activities aimed to instill a shared culture of patient safety among …

Go to article

Impact Of The 2008 Beijing Olympics On The Risk Of Pregnancy Complications, V. Assibey-Mensah, K. Liu, S. W. Thurston, T. P. Stevens, J. Zhang, C. Kane, Y. Pan, B. Weinberger, D. Q. Rich, +2 Additional Authors Jan 2016

Impact Of The 2008 Beijing Olympics On The Risk Of Pregnancy Complications, V. Assibey-Mensah, K. Liu, S. W. Thurston, T. P. Stevens, J. Zhang, C. Kane, Y. Pan, B. Weinberger, D. Q. Rich, +2 Additional Authors

Journal Articles

Taking advantage of the natural experiment of the 2008 Beijing Olympics (August 8 to September 24), when air pollution levels decreased by 13% to 60%, the authors assessed whether having >/=1 pregnancy month during the Olympics was associated with decreased risks of hypertensive disorders (HDs) and/or fetal-placental conditions (FPCs). Singleton births to mothers with >/=1 pregnancy month in 2008 or 2009 (N = 56,155) were included. Using generalized additive models, the authors estimated the risk of HDs and FPCs associated with (1) the 2008 Olympics compared with the same dates in 2009, and (2) increased mean ambient PM10 (particulate matter …

Go to article

Hydroxycarbamide Versus Chronic Transfusion For Maintenance Of Transcranial Doppler Flow Velocities In Children With Sickle Cell Anaemia-Tcd With Transfusions Changing To Hydroxyurea (Twitch): A Multicentre, Open-Label, Phase 3, Non-Inferiority Trial, R. E. Ware, B. R. Davis, W. H. Schultz, R. C. Brown, B. Aygun, S. Sarnaik, I. Odame, B. Fuh, R. J. Adams, +36 Additional Authors Jan 2016

Hydroxycarbamide Versus Chronic Transfusion For Maintenance Of Transcranial Doppler Flow Velocities In Children With Sickle Cell Anaemia-Tcd With Transfusions Changing To Hydroxyurea (Twitch): A Multicentre, Open-Label, Phase 3, Non-Inferiority Trial, R. E. Ware, B. R. Davis, W. H. Schultz, R. C. Brown, B. Aygun, S. Sarnaik, I. Odame, B. Fuh, R. J. Adams, +36 Additional Authors

Journal Articles

BACKGROUND: For children with sickle cell anaemia and high transcranial doppler (TCD) flow velocities, regular blood transfusions can effectively prevent primary stroke, but must be continued indefinitely. The efficacy of hydroxycarbamide (hydroxyurea) in this setting is unknown; we performed the TWiTCH trial to compare hydroxyurea with standard transfusions. METHODS: TWiTCH was a multicentre, phase 3, randomised, open-label, non-inferiority trial done at 26 paediatric hospitals and health centres in the USA and Canada. We enrolled children with sickle cell anaemia who were aged 4-16 years and had abnormal TCD flow velocities (>/=200 cm/s) but no severe vasculopathy. After screening, eligible …

Go to article

The Frequency And Outcome Of Lupus Nephritis: Results From An International Inception Cohort Study, J. G. Hanly, A. G. O'Keeffe, L. Su, M. B. Urowitz, J. Romero-Diaz, C. Gordon, S. C. Bae, E. M. Ginzler, C. Aranow, V. Farewell, +35 Additional Authors Jan 2016

The Frequency And Outcome Of Lupus Nephritis: Results From An International Inception Cohort Study, J. G. Hanly, A. G. O'Keeffe, L. Su, M. B. Urowitz, J. Romero-Diaz, C. Gordon, S. C. Bae, E. M. Ginzler, C. Aranow, V. Farewell, +35 Additional Authors

Journal Articles

OBJECTIVE: To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. METHODS: Patients in the Systemic Lupus International Collaborating Clinics inception cohort (

Go to article

High-Dose Hypofractionated Radiotherapy Is Effective And Safe For Tumors In The Head-And-Neck, S. Teckie, B. H. Lok, S. Rao, S. I. Gutiontov, Y. Yamada, S. L. Berry, M. J. Zelefsky, N. Y. Lee Jan 2016

High-Dose Hypofractionated Radiotherapy Is Effective And Safe For Tumors In The Head-And-Neck, S. Teckie, B. H. Lok, S. Rao, S. I. Gutiontov, Y. Yamada, S. L. Berry, M. J. Zelefsky, N. Y. Lee

Journal Articles

No abstract provided.

Go to article

Quinomycin A Targets Notch Signaling Pathway In Pancreatic Cancer Stem Cells, S. Ponnurangam, P. R. Dandawate, A. Dhar, O. W. Tawfik, R. R. Parab, P. D. Mishra, P. Ranadive, R. Sharma, G. Mahajan, D. Subramaniam, +7 Additional Authors Jan 2016

Quinomycin A Targets Notch Signaling Pathway In Pancreatic Cancer Stem Cells, S. Ponnurangam, P. R. Dandawate, A. Dhar, O. W. Tawfik, R. R. Parab, P. D. Mishra, P. Ranadive, R. Sharma, G. Mahajan, D. Subramaniam, +7 Additional Authors

Journal Articles

Cancer stem cells (CSCs) appear to explain many aspects of the neoplastic evolution of tumors and likely account for enhanced therapeutic resistance following treatment. Dysregulated Notch signaling, which affects CSCs plays an important role in pancreatic cancer progression. We have determined the ability of Quinomycin to inhibit CSCs and the Notch signaling pathway. Quinomycin treatment resulted in significant inhibition of proliferation and colony formation in pancreatic cancer cell lines, but not in normal pancreatic epithelial cells. Moreover, Quinomycin affected pancreatosphere formation. The compound also decreased the expression of CSC marker proteins DCLK1, CD44, CD24 and EPCAM. In addition, flow cytometry …

Go to article

Better Medicine, Lehigh Valley Health Network Jan 2016

Better Medicine, Lehigh Valley Health Network

Better Medicine

No abstract provided.

Go to article

Sayre: Undergraduate Catalog 2016-2017, Southwestern Oklahoma State University Jan 2016

Sayre: Undergraduate Catalog 2016-2017, Southwestern Oklahoma State University

Undergraduate Catalogs

No abstract provided.

Go to article

Downregulation Of Cystathionine γ Lyase And Endothelial Nitric Oxide Synthase And Reduced Responsiveness Of α1a Adrenergic Receptors In The Kidneys Of Left Ventricular Hypertrophied Wistar Kyoto Rats, Ashfaq Ahmad, Munavvar Abdul Sattar, Hassaan Anwer Rathore, Safia Akhtar Khan, Nor Azizan Abdullah, Edward James Johns Jan 2016

Downregulation Of Cystathionine γ Lyase And Endothelial Nitric Oxide Synthase And Reduced Responsiveness Of α1a Adrenergic Receptors In The Kidneys Of Left Ventricular Hypertrophied Wistar Kyoto Rats, Ashfaq Ahmad, Munavvar Abdul Sattar, Hassaan Anwer Rathore, Safia Akhtar Khan, Nor Azizan Abdullah, Edward James Johns

Turkish Journal of Biology

This article explores the relationship between the renal expression of cystathionine gamma lyase (CSE) and endothelial nitric oxide synthase (eNOS) and the responsiveness of α1A adrenergic receptors in the renal vasculature following left ventricular hypertrophy (LVH) in rats. LVH was established by administering isoprenaline (5 mg/kg, 5 injections subcutaneously, 72 h apart) with 62 mg/L caffeine in drinking water for 2 weeks. Renal vasoconstrictor responses were measured using local administration of adrenergic agonists noradrenaline (NA), phenylephrine (PE), and methoxamine (ME) and the selective α1A adrenergic antagonist 5-methylurapidil (5-MeU). Mean arterial blood pressure was higher (144 ± 9 vs. 116 ± …

Go to article

Cloning And Abiotic Stress Resistance Analyses Of A New Proline-Glycine-Alaninehistidine-Rich Protein Gene From Ipomoea Batatas (L.) Lam., Xiang Tao, Bin Yong, Huan-Huan Shao, Xin-Rong Ma Jan 2016

Cloning And Abiotic Stress Resistance Analyses Of A New Proline-Glycine-Alaninehistidine-Rich Protein Gene From Ipomoea Batatas (L.) Lam., Xiang Tao, Bin Yong, Huan-Huan Shao, Xin-Rong Ma

Turkish Journal of Biology

Sweet potato [Ipomoea batatas (L.) Lam.] is one of the top six most important crops in the world in terms of production. It has the capacity to tolerate marginal growing conditions better than most other crops. In this study, a proline- and glycine-rich protein encoding gene, IbPGAHRP1, was isolated and characterized from the transcriptome of sweet potato cultivar Xushu 18. Sequence analyses showed that proline, glycine, alanine, and histidine account for 62.6% of the total amino acid residues. Two proline-rich tandem repeats, an alanine-rich repeat, a histidine-rich tandem repeat, and five XYPP motifs were present in IbPGAHRP1. Sequence similarity analysis …

Go to article

Effect Of Polyamines On Somatic Embryogenesis Via Mature Embryo In Wheat, Murat Aydin, Arash Hossein Pour, Kami̇l Hali̇loğlu, Meti̇n Tosun Jan 2016

Effect Of Polyamines On Somatic Embryogenesis Via Mature Embryo In Wheat, Murat Aydin, Arash Hossein Pour, Kami̇l Hali̇loğlu, Meti̇n Tosun

Turkish Journal of Biology

Plant tissue culture via somatic embryogenesis plays a key role in wheat genetic transformation studies. Therefore, the production of embryogenic calli with a high regeneration capacity is a prerequisite for efficient plant regeneration. Although immature embryos are the best type of explants for plant regeneration via somatic embryogenesis, the use of mature embryos has remarkable advantages compared to immature embryos as explants. However, the regeneration capacity of mature embryos is still lower than that of immature embryos. Plant regeneration from somatic embryos can only occur when they are mature enough. Moreover, the maturation of somatic embryos and their conversion into …

Go to article

High Levels Of Polyphosphate Kinase Affect Not Only Endotoxin Production But Also Acid Tolerance Of Bacillus Thuringiensis, Tuğrul Doruk, Zeynep Gi̇rgi̇n Ersoy, Mehmet Sali̇m Öncel, Sedef Tunca Gedi̇k Jan 2016

High Levels Of Polyphosphate Kinase Affect Not Only Endotoxin Production But Also Acid Tolerance Of Bacillus Thuringiensis, Tuğrul Doruk, Zeynep Gi̇rgi̇n Ersoy, Mehmet Sali̇m Öncel, Sedef Tunca Gedi̇k

Turkish Journal of Biology

Inorganic phosphate is stored as a polyphosphate (polyP) polymer inside every living cell. This polymer is synthesized by the polyP kinase (PPK) enzyme using the terminal phosphate of ATP as substrate and it performs important functions in the cell. In this study, effects of high levels of PPK on Bacillus thuringiensis subsp. israelensis were analyzed. Recombinant Bti ppk, a PPK overproducer, was found to uptake more phosphate into the cell and produce a consistently higher amount of endotoxin than the wild type under culture conditions including a range of temperatures (25 °C, 30 °C, and 37 °C), pH values (pH …

Go to article

Copper Enriches Efficacy Of Dp44mt In Breast Cancer Cells, Ufuk Özer Jan 2016

Copper Enriches Efficacy Of Dp44mt In Breast Cancer Cells, Ufuk Özer

Turkish Journal of Biology

Neoplastic cells need essential metals, such as iron and copper, for cellular functions and rapid growth. Metal chelation and changes in their redox cycle in favor of oxidative stress may be critical for making these cells vulnerable to cell death. The HER2-overexpressing breast cancer cell line, MCF7-HER2, and its vehicle control, MCF7-vec cells, were treated with CuCl2, FeSO4, and Dp44mT. Reactive oxygen species (ROS) production in response to these chemicals was detected with flow cytometry, and cell viability was measured by MTT assay in the cells. ROS levels were relatively increased by Dp44mT in the cells, and this was reversed …

Go to article

Identification And Cloning Of Highly Epitopic Regions Of Clostridium Novyi Alpha Toxin, Najme Gord Noshahri, Mohsen Fathi Najafi, Ali Makhdoumi Kakhki, Behjat Majidi, Mohsen Mehrvarz Jan 2016

Identification And Cloning Of Highly Epitopic Regions Of Clostridium Novyi Alpha Toxin, Najme Gord Noshahri, Mohsen Fathi Najafi, Ali Makhdoumi Kakhki, Behjat Majidi, Mohsen Mehrvarz

Turkish Journal of Biology

The aim of the present study is to provide a strategy for predicting the production of antigenic regions of Clostridium novyi alpha toxin. The selection is based on B-cell epitopes and MHCII binding protein by immunoinformatics tools. The study resulted in identifying antigenic regions in the beginning and middle (3-17 and 965-997 amino acid residues) as suitable binders to MHCII and the carboxyl terminal of the protein (1800-1958 amino acid residues) in B-cell epitopes. The appropriate region in B-cell epitopes was chosen for cloning. The presence of recombinant protein was detected with immunological methods. Subsequently, BALB/C mice were immunized with …

Go to article

Plantlet Regeneration From Young Leaf Segments Of Curaua (Ananas Erectifolius), An Amazon Species, Carolina Moreira, Helena Andrade, Suzan Bertolucci, Osmar Lameira, Aliyu Mohammed, José Eduardo Pinto Jan 2016

Plantlet Regeneration From Young Leaf Segments Of Curaua (Ananas Erectifolius), An Amazon Species, Carolina Moreira, Helena Andrade, Suzan Bertolucci, Osmar Lameira, Aliyu Mohammed, José Eduardo Pinto

Turkish Journal of Biology

The present study reports the first efficient in vitro regeneration of Ananas erectifolius via indirect organogenesis. Leaf segments (leaf base, middle, and apex) excised from 3- or 5-week-old in vitro plantlets were cultured on 1/4 strength MS medium supplemented with different concentrations and combinations of plant growth regulators. The explants were also exposed to pulse treatment with thidiazuron (TDZ) and 2,4-dichlorophenoxyacetic acid (2,4-D) for different periods of time. The results showed that using juvenile rather than old explants enhanced the frequency of callus induction (35.0% and 16.0%, respectively). Among the explant types tested, only leaf base segments induced calli; the …

Go to article

High Dietary Fructose Load Aggravates Lipid Metabolism In The Liver Of Wistar Rats Through Imbalance Between Lipogenesis And Fatty Acid Oxidation, Ana Teofilovic, Biljana Bursac, Ana Djordjevic, Danijela Vojnovic Milutinovic, Gordana Matic, Natasa Velickovic Jan 2016

High Dietary Fructose Load Aggravates Lipid Metabolism In The Liver Of Wistar Rats Through Imbalance Between Lipogenesis And Fatty Acid Oxidation, Ana Teofilovic, Biljana Bursac, Ana Djordjevic, Danijela Vojnovic Milutinovic, Gordana Matic, Natasa Velickovic

Turkish Journal of Biology

Fructose ingestion is often associated with hepatic steatosis and hypertriglyceridemia. The homeostasis of hepatic lipids is mainly determined by the interplay of lipogenesis and fatty acid β-oxidation. In this study, we hypothesized that high fructose intake disturbs hepatic lipid metabolism through an imbalance between these processes. Therefore, we analyzed the effects of a 9-week-long consumption of a 60% fructose solution on physiological parameters, glycemia, and blood lipid profiles in male Wistar rats. The expression of key regulators of fatty acid oxidation (FAO) and lipogenesis in the liver were assessed by western blot and quantitative polymerase chain reaction. The results showed …

Go to article

Preparation And Characterization Of Acellular Porcinepericardium For Cardiovascular Surgery, Ha Le Bao Tran, Trang Thi Huyen Dinh, My Thi Ngoc Nguyen, Quan Minh To, Anh Tho Tuan Pham Jan 2016

Preparation And Characterization Of Acellular Porcinepericardium For Cardiovascular Surgery, Ha Le Bao Tran, Trang Thi Huyen Dinh, My Thi Ngoc Nguyen, Quan Minh To, Anh Tho Tuan Pham

Turkish Journal of Biology

The aim of this study was to fabricate and characterize acellular porcine pericardium that can be used to patch cardiovascular repair. Porcine pericardial tissues were treated with 10 mM Tris-HCl and sodium dodecyl sulfate (SDS) at different concentrations and time intervals. The optimal decellularization protocol was determined according to elimination of cellular components and DNA via histology and DNA quantification, respectively. There were no significant changes in stress and fracture strain after decellularization. Liquid extracts from the decellularized pericardium caused no cytotoxicity towards human fibroblasts, were capable of supporting an appropriate attachment of human endothelial progenitor cells, and did not …

Go to article

Cytotoxic Effects Of Peanut Phenolic Compounds Possessing Histone Deacetylase Inhibitory Activity On Human Colon Cancer Cell Lines, Somprasong Saenglee, Sanun Jogloy, A. Patanothai, Thanaset Senawong Jan 2016

Cytotoxic Effects Of Peanut Phenolic Compounds Possessing Histone Deacetylase Inhibitory Activity On Human Colon Cancer Cell Lines, Somprasong Saenglee, Sanun Jogloy, A. Patanothai, Thanaset Senawong

Turkish Journal of Biology

Phenolic compounds present in our diet play an important role in colon cancer chemoprevention. Previous results demonstrated that peanut testa extract inhibited both histone deacetylase (HDAC) activity and the growth of colon cancer cells. In this study, four identified phenolic compounds in peanut testae (resveratrol, p-coumaric acid, ferulic acid, and sinapinic acid) were investigated for their HDAC inhibitory and anticancer activities against colon cancer cell lines. In vitro study revealed that resveratrol exhibited the greatest HDAC inhibitory activity. Molecular docking studies demonstrated that all four compounds could bind both HDAC1 and HDAC2. Resveratrol exhibited the most effective antiproliferative activity against …

Go to article

The Sensitivity Of 5-Formylcytosine To Doxorubicin Regardless Of Dna Damage, Selcen Çeli̇k Uzuner, Chris O'Neill Jan 2016

The Sensitivity Of 5-Formylcytosine To Doxorubicin Regardless Of Dna Damage, Selcen Çeli̇k Uzuner, Chris O'Neill

Turkish Journal of Biology

We have previously shown that DNA damage induced by doxorubicin was associated with an increase in the level of DNA methylation, 5meC, in mouse embryonic fibroblasts using a developed immunostaining methodology. Doxorubicin (also known as adriamycin), which induces double-strand DNA breaks, has been widely used in cancer therapy. Cytosine modifications are dynamically regulated in the genome during lifespan, but abnormal changes in the 5meC pattern can be associated with diseases in particular cancer progressions and DNA damage. One of the side effects of cancer therapy is that chemotherapeutic agents can damage healthy cells as well as cancerous cells. In this …

Go to article

Selective Suppression Of Tumor Cells By A Tumor-Specific Bicistronic Lentiviral Vector, Saeed Ranjbar, Mohammad Sadegh Hashemzadeh, Shahryar Khoshtinat Nikkhoi, Alireza Farasat, Mahdi Tat, Majdedin Ghalavand, Ruhollah Dorostkar Jan 2016

Selective Suppression Of Tumor Cells By A Tumor-Specific Bicistronic Lentiviral Vector, Saeed Ranjbar, Mohammad Sadegh Hashemzadeh, Shahryar Khoshtinat Nikkhoi, Alireza Farasat, Mahdi Tat, Majdedin Ghalavand, Ruhollah Dorostkar

Turkish Journal of Biology

Lentiviral gene delivery is now considered as a major candidate in the future of cancer therapy. To avoid common side-effects associated with methods of cancer therapy, the survivin promoter shows great promise due to its high expression level in multiple cancers. In this research, using a 2A peptide, Noxa was coexpressed with hemagglutinin neuraminidase (HN) driven by the survivin promoter (Surp). Coding genes of Noxa and HN were connected to the upstream and downstream of a 2A peptide using SOE PCR. After cloning of Noxa-2A-HN and Surp into the lentiviral vector, the final construct was transfected to SK-BR3 tumor cells …

Go to article

First Prev Next Last