Digital Commons Network^™

Neurocognitive Dysfunction In Brain Tumor Patients Following Radiation Therapy: A Review Of Biological Hypotheses, Current Treatment Outcomes, And Novel Therapeutic Strategies, Raj Singh

Marshall Journal of Medicine

Given the difficulty of surgical resection of brain neoplasms located adjacent to vital structures of the brain as well as the challenges posed by the blood-brain-barrier for the efficacy of chemotherapeutic agents, whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS) are often turned to for patients with brain metastases as well as primary brain neoplasms. Though radiation therapy may be successful in local control of these tumors, many patients experience treatment-related neurocognitive issues later in life. In this review, we examine cognitive dysfunction in brain tumor patients following radiation therapy, with an emphasis on the pediatric population. Articles were …

Technology: An Essential Component Of Today's College Education, William F. Herlehy

Bollinger-Rosado Teaching & Learning Effectiveness Symposium Proceedings

The growing educational failures of the colleges and universities of the United States are a major concern of the 1990's and are not showing a great deal of promise for the 21st century. The overabundance of committee reports that describe and prescribe for our schools, the evidence presented in those reports, and the analyses that are offered combine to form a persuasive argument that there is a profound crisis (AACC, 1995).

Technological developments have so outpaced the understanding of it provided by almost all college programs that we have become a people who are unable to comprehend the technology we …

Professor Receives Nih Grant For Breast Cancer Research, Sarah Gardner, Dave Albee

Press Releases

Dr. Maggie Louie, associate professor in the Department of Natural Sciences and Mathematics, has received a third grant from the National Institutes of Health (NIH) in support of her ongoing research focused on the role environmental contaminants play in breast cancer and new studies examining how oxidative stress impacts the development and progression of breast cancer cells.

Cseas Weekly Bulletin (January 25, 2016), Center For Southeast Asian Studies

CSEAS Bulletin

No abstract provided.

New Records And Updated Checklist Of Phlebotomine Sand Flies (Diptera: Psychodidae) From Liberia, P. J. Obenauer, L. M. Rueda, S. S. El-Hossary, N. Watany, C. A. Stoops, L. S. Fakoli, F. K. Bolay, J W. Diclaro Ii

United States Navy: Publications

Phlebotomine sand flies from three counties in Liberia were collected from January 2011 to July 2013. In total, 3,118 sand flies were collected: 18 species were identified, 13 of which represented new records for Liberia. An updated taxonomic checklist is provided with a brief note on sand fly biology, and the disease vector potential for species is discussed.

Aesthetics In Cross-Cultural Perspective, Davies Stephen

Theoretical Studies in Literature and Art

In this paper I attempt reconcile two apparently opposed views: artworks are embedded in culturally relative art-historical contexts and cannot be fully understood without an awareness of these contexts, yet artworks trade in themes that are universally and perennially of human interest, such as war and peace, and shape these to cater to shared, biologically based perceptual systems. The first explains some of the difficulties we face in understanding and appreciating art cross-culturally. The second indicates why, nevertheless, a degree of cross-cultural artistic appreciation is possible. As well, our grasp of the challenges and possibilities of the media from which …

Role Of Proteolipid Protein In Hsv-1 Entry In Oligodendrocytic Cells, Raquel Bello-Morales, Antonio Jesús Crespillo, Beatriz Praena, Enrique Tabarés, Yolanda Revilla, Elena García, Alberto Fraile-Ramos, Wia Baron, Claude Krummenacher, José Antonio López-Guerrero

College of Science & Mathematics Departmental Research

Herpes simplex virus type 1 (HSV-1) has the ability to enter many different hosts and cell types by several strategies. This highly prevalent alphaherpesvirus can enter target cells using different receptors and different pathways: fusion at a neutral pH, low-pH-dependent and low-pH-independent endocytosis. Several cell receptors for viral entry have been described, but several observations suggest that more receptors for HSV-1 might exist. In this work, we propose a novel role for the proteolipid protein (PLP) in HSV-1 entry into the human oligodendrocytic cell line HOG. Cells transfected with PLP-EGFP showed an increase in susceptibility to HSV-1. Furthermore, the infection …

Report For Nmdgf Permit: 3520, 2015, Claudette Horn

Natural Heritage New Mexico Documents

Document from New Mexico Department of Game & Fish Scientific permit.

Unh Researchers Invent Low-Cost Method To Monitor Lakes For Airborne Toxins, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Ceramide Induces Human Hepcidin Gene Transcription Through Jak/Stat3 Pathway., Sizhao Lu, Sathish Kumar Natarajan, Justin L. Mott, Kusum K. Kharbanda, Duygu Dee Harrison-Findik

Journal Articles: Biochemistry & Molecular Biology

Changes in lipid metabolism and iron content are observed in the livers of patients with fatty liver disease. The expression of hepcidin, an iron-regulatory and acute phase protein synthesized by the liver, is also modulated. The potential interaction of lipid and iron metabolism is largely unknown. We investigated the role of lipid intermediate, ceramide in the regulation of human hepcidin gene, HAMP. Human hepatoma HepG2 cells were treated with cell-permeable ceramide analogs. Ceramide induced significant up-regulation of HAMP mRNA expression in HepG2 cells. The effect of ceramide on HAMP expression was mediated through transcriptional mechanisms because it was completely blocked …

The Utah Statesman, January 25, 2016, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

John Kearney Named An American Association Of Immunologists Career Award Recipient, Jeff Hansen

Browse All News

No abstract provided.

Daily Eastern News: January 25, 2016, Eastern Illinois University

January

No abstract provided.

Climate Controls Multidecadal Variability In U. S. Extreme Sea Level Records, Thomas Wahl, Don P. Chambers

Marine Science Faculty Publications

We investigate the links between multidecadal changes in extreme sea levels (expressed as 100 year return water levels (RWLs)) along the United States coastline and large‐scale climate variability. We develop different sets of simple and multiple linear regression models using both traditional climate indices and tailored indices based on nearby atmospheric/oceanic variables (winds, pressure, sea surface temperature) as independent predictors. The models, after being tested for spatial and temporal stability, are capable of explaining large fractions of the observed variability, up to 96% at individual sites and more than 80% on average across the region. Using the model predictions as …

Usft Scholar Commons Annual Report: Fy 2014-2015, Chelsea Johnston, Carol Ann Borchert, Jason Boczar

Digital Commons @ USF Publications

In fall 2011, the Academic Resources Unit of the University of South Florida (USF) Library officially launched Scholar Commons, an institutional repository (IR) intended to serve as a virtual showcase for USF’s research and creative energies. Scholar Commons, which can be accessed at: http://scholarcommons.usf.edu/, provides digital preservation and free open access (OA) to scholarly works produced by the USF Community. Our vision is to become a vehicle to drive research communication across academic disciplines.

Through our dedication to and outreach of scholarly communications, we have generated many positive outcomes. This report chronicles our initiatives during the 2014/2015 fiscal year …

Utilizing Human Induced Pluripotent Stem Cells In The Study Of Alcohol Use Disorder, Richard Lieberman

Doctoral Dissertations

Alcohol use disorder is a complex, heterogeneous disorder that affects ≈14% of the U.S. population. Much of what is known about the molecular effects of alcohol on the brain has been derived from studies utilizing rodent or human post-mortem tissue model systems. The advent of induced pluripotent stem cell (iPSC) technologies allows for the examination of phenotypically- and genetically-characterized human neural cells in vitro. Much of the work presented in this dissertation explores the utility of iPSCs in the study of alcohol use disorder. We start by exploring whether human iPSC-derived neural cells can recapitulate the findings in animal …

Anthropology Alum Preserves History In Job At Archaeological Conservancy, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Estrogen Receptor Alpha (Esr1)-Dependent Regulation Of The Mouse Oviductal Transcriptome, Katheryn L. Cerny, Rosanne A. C. Ribeiro, Myoungkun Jeoung, Chemyong Ko, Phillip J. Bridges

Animal and Food Sciences Faculty Publications

Estrogen receptor-α (ESR1) is an important transcriptional regulator in the mammalian oviduct, however ESR1-dependent regulation of the transcriptome of this organ is not well defined, especially at the genomic level. The objective of this study was therefore to investigate estradiol- and ESR1-dependent regulation of the transcriptome of the oviduct using transgenic mice, both with (ESR1KO) and without (wild-type, WT) a global deletion of ESR1. Oviducts were collected from ESR1KO and WT littermates at 23 days of age, or ESR1KO and WT mice were treated with 5 IU PMSG to stimulate follicular development and the production of ovarian estradiol, and the …

Vol. 50, No. 02 (January 25, 2016)

Indiana Law Annotated

No abstract provided.

Crow's Nest, January 25, 2016, Crow's Nest Staff

Crow's Nest

The January 25, 2016, issue of the Crow's Nest.

Whalesong 2016-01-25, N/A N/A

Whalesong

No abstract provided.

Unh Researchers Invent Low-Cost Method To Monitor Lakes For Airborne Toxins, Lori Wright

Media Relations

No abstract provided.

Effect Of Base-Pairing Partner On The Thermodynamic Stability Of The Diastereomeric Spiroiminodihydantoin Lesion, Brian Gruessner, Megana Dwarakanath, Elizabeth Stewart, Yoon Bae, Elizabeth R. Jamieson

Chemistry: Faculty Publications

Oxidation of guanine by reactive oxygen species and high valent metals produces damaging DNA base lesions like 8-oxo-7,8-dihydroguanine (8-oxoG). 8-oxoG can be further oxidized to form the spiroiminodihydantoin (Sp) lesion, which is even more mutagenic. DNA polymerases preferentially incorporate purines opposite the Sp lesion, and DNA glycosylases excise the Sp lesion from the duplex, although the rate of repair is different for the two Sp diastereomers. To further understand the biological processing of the Sp lesion, differential scanning calorimetry (DSC) studies were performed on a series of 15-mer DNA duplexes. The thermal and thermodynamic stability of each of the Sp …

Ceramide Induces Human Hepcidin Gene Transcription Through Jak/Stat3 Pathway., Sizhao Lu, Sathish Kumar Natarajan, Justin L. Mott, Kusum K. Kharbanda, Duygu Dee Harrison-Findik

Journal Articles: Biochemistry & Molecular Biology

Changes in lipid metabolism and iron content are observed in the livers of patients with fatty liver disease. The expression of hepcidin, an iron-regulatory and acute phase protein synthesized by the liver, is also modulated. The potential interaction of lipid and iron metabolism is largely unknown. We investigated the role of lipid intermediate, ceramide in the regulation of human hepcidin gene, HAMP. Human hepatoma HepG2 cells were treated with cell-permeable ceramide analogs. Ceramide induced significant up-regulation of HAMP mRNA expression in HepG2 cells. The effect of ceramide on HAMP expression was mediated through transcriptional mechanisms because it was completely blocked …

Faculty Senate Bill Fsb-2016-01-25-01: University Curriculum Committee, Armstrong State University

Armstrong Faculty Senate: Bills, Motions & Resolutions (Archived)

Faculty Senate Bill FSB-2016-01-25-01: University Curriculum Committee

Unh Researchers Invent Low-Cost Method To Monitor Lakes For Airborne Toxins, Lori Tyler Gula

UNH Today Archive

No abstract provided.

Racial Disparities In Outcomes Following Kidney Transplantation: A Single-Center Experience, Vani Nilakantan, Maharaj Singh, Ruth M. Perez, Yang Shi, Ahmed Dalmar, Brittany T. Last, Ajay Sahajpal

Journal of Patient-Centered Research and Reviews

Purpose

Kidney transplantation remains the best treatment option for end-stage renal disease. However, despite overall improvements in patient and graft survival rates after kidney transplantation, differences in outcomes still exist among different racial and ethnic groups, with African-Americans having lower graft survival. Gaps continue to exist in the understanding of how demographic factors contribute to the varying outcomes among racial/ethnic groups.

Methods

We retrospectively evaluated kidney transplant outcomes in four racial/ethnic groups over a 12-year period at a large tertiary care center. Primary and secondary study outcomes were patient and graft survival across groups. To determine factors that might predict …

Experimental Evidence For Drought Induced Alternative Stable States Of Soil Moisture, David A. Robinson, Scott B. Jones, Inma Lebron, Sabine Reinsch, Maria T. Dominguez, Andrew R. Smith, Davey L. Jones, Miles R. Marshall, Bridget A. Emmett

Plants, Soils, and Climate Faculty Publications

Ecosystems may exhibit alternative stable states (ASS) in response to environmental change. Modelling and observational data broadly support the theory of ASS, however evidence from manipulation experiments supporting this theory is limited. Here, we provide long-term manipulation and observation data supporting the existence of drought induced alternative stable soil moisture states (irreversible soil wetting) in upland Atlantic heath, dominated by Calluna vulgaris (L.) Hull. Manipulated repeated moderate summer drought, and intense natural summer drought both lowered resilience resulting in shifts in soil moisture dynamics. The repeated moderate summer drought decreased winter soil moisture retention by ∼10%. However, intense summer drought, …

My News

My News (2014-2020)

• Georgia Southern receives grant from Gene Haas Foundation
• MLK Celebration this week features Dr. Steve Perry
• 'Live from Nashville' takes the stage at the PAC this week
• Cashawn Myers discusses importance of agriculture
• Braves' Terry Pendleton speaks at All­Star Banquet
• Award­winning journalists discuss 'Voting as an Informed Citizen' at Georgia Southern

Phenotypic Features Of Circulating Leukocytes From Non-Human Primates Naturally Infected With Trypanosoma Cruzi Resemble The Major Immunological Findings Observed In Human Chagas Disease, Renato Sathler-Avelar, Danielle Marquete Vitelli-Avelar, Armanda Moreira Mattoso-Barbosa, Marcelo Perdigão-De-Oliveira, Ronaldo Peres Costa, Silvana Maria Elói-Santos, Matheus De Souza Gomes, Laurence Rodrigues Do Amaral, Jane F. Vandeberg, John L. Vandeberg

School of Medicine Publications

Background: Cynomolgus macaques (Macaca fascicularis) represent a feasible model for research on Chagas disease since natural T. cruzi infection in these primates leads to clinical outcomes similar to those observed in humans. However, it is still unknown whether these clinical similarities are accompanied by equivalent immunological characteristics in the two species. We have performed a detailed immunophenotypic analysis of circulating leukocytes together with systems biology approaches from 15 cynomolgus macaques naturally infected with T. cruzi (CH) presenting the chronic phase of Chagas disease to identify biomarkers that might be useful for clinical investigations.

Methods and findings: Our data established that …