Correlation Of F2-Isoprostane With Interleukin-6 And Interleukin-10 In Transfusion-Dependent Thalassemia Patients : A Cross-Sectional Study, Nurul Muhlisa, Yetti Hernaningsih, Puspa Wardhani, Mia Ratwita Andarsini, Zulfikar Ali Hasan

Folia Medica Indonesiana

Transfusion-dependent thalassemia (TDT)[-7pc]AU: Please Provide authors affiliations. is a condition in which patients require lifelong regular blood transfusions. However, regular blood transfusions carry a major risk of iron overload, which accumulates in the body and can trigger oxidative stress and chronic inflammation. Oxidative stress is characterized by an increase in reactive oxygen species (ROS), which can be assessed through the measurement of F2-Isoprostanes (8-iso-PGF2α). Excessive ROS affects cytokine production by inducing an inflammatory response, such as IL-6 and IL-10. This study aims to analyze the correlation between F2-isoprostane with Interleukin-6 and Interleukin-10 levels in TDT patients. This research …

Analysis Of Penis Size Differences In Patients With Severe Erectile Dysfunction Non-Responsive Pde5i With Mesenchymal Stem Cell Secretome From Umbilical Cord, Kristophorus Jonathan Wibowo, Reny I’Tishom, Mohammad Ayodhia Soebadi, Muhammad Hidayat Surya Atmaja, Supardi Supardi, Ria Margiana, Fatkhurrohmah Leo Amalia

Folia Medica Indonesiana

The ineffectiveness of PDE5i[-10pc]AU: Please provide the affiliation of all authors. therapy is indicated by the patient’s unresponsiveness to oral medication, evidenced by insufficient erection after four attempts with the dosage recommended by the manufacturer. Consequently, the application of regenerative therapy may be seen as an effort to stimulate a response or improvement in erectile function, especially in individuals with erectile dysfunction who exhibit no significant progress after utilizing PDE5 inhibitors. Regenerative therapy seeks to repair damaged erectile tissue, with the objective of enhancing erectile function and rehabilitating tissue impacted by existing comorbidities. The secretome denotes the aggregate of chemical …

Preliminary Laboratory Evaluation Of Rapid Diagnostic Test Prototype To Detect Hbsag In Whole Blood And Serum, Ema Qurnianingsih, Citrawati Dyah Kencono Wungu, Mochammad Amin, Dewi Setyawati, Yanna Debby Restifanny Yasan, Lina Lukitasari, Maria Inge Lusida, Soetjipto Soetjipto

Folia Medica Indonesiana

Chronic hepatitis B virus (HBV) remains a major global health issue,[-10pc]AU: Please provide ORCID ID for all authors.[-7pc]AU: Please provide affiliation’s for all authors. with over 250 million people affected worldwide. In Indonesia, HBV prevalence has declined from high to moderate endemicity, but challenges persist due to regional disparities, risk of mother-to-child transmission, and the predominance of B3 and C1 sub-genotype. Despite available preventive measures and diagnostic tools, approximately 90% of cases remain undiagnosed, particularly in low-resource settings, indicating the need for improved screening and control strategies. Therefore, this study aims to conduct preliminary performance tests of KODC hepatitis B …

Comparison Of Intraperitoneal And Intraductal Routes In The Growth Of N-Methyl-N-Nitrosourea-Induced Breast Cancer In Sprague Dawley Rats: A Systematic Review 2014–2024, Adilla Soraya Prameswari, Ruendhita Azzahra Sari Sompokan, Annisa Annisa, Rachma Greta Perdana Putri, Dewi Yuniasih, Muhamad Danian, Muhammad Tri Yoga Tianotak

Folia Medica Indonesiana

Breast cancer is one of the[-6pc]AU: Please provide affiliations for your paper. leading causes of death for women worldwide, characterized by malignant tumors in the mammary epithelium. Breast cancer modelling using Sprague Dawley animals induced by N-Methyl-N-Nitrosourea (MNU) compounds is commonly used through various administration routes. The intraperitoneal route is the conventional route and the intraductal route is a new route capable of directly targeting the mammary ducts. Both routes affect the speed and characteristics of breast cancer cells in experimental animals. This systematic review using PubMed and Scopus databases from 2014-2024 aims to compare the effects of intraperitoneal and …

Global Analysis Of Pyroptosis On Autoimmune Diseases: Bibliometric Study, Astri Dewayani, Kartika Afrida Fauzia

Folia Medica Indonesiana

Pyroptosis has gained increasing attention due to its role in immune responses and its implication in the pathogenesis of autoimmune diseases. Unlike apoptosis, pyroptosis is characterized by gasdermin D-mediated membrane pore formation and the release of pro-inflammatory cytokines. This bibliometric analysis aims to systematically explore trends, influential contributions, and emerging themes in the study of pyroptosis within the context of autoimmune diseases. Literature was retrieved from the Web of Science Core Collection covering publications from 2015–2024. A total of 1,271 English-language articles and reviews were analyzed using Biblioshiny and VOSviewer for performance metrics and network visualizations. Hotpots trend identification is …

Adapting To Aridity: Crop Production Trends Among Smallholder Farmers In Iramba District, Tanzania, Nashokigwa Shalua, Digna Wolfram Mlengule, Johnstone M. Andrea

Tanzanian Economic Review

Increasing crop production amid recurrent droughts remains a critical challenge for smallholder farmers in the semi-arid Iramba District; however, empirical evidence on crop production remains scarce. This paper analysed trends in crop production in Iramba District from 1995 to 2024. Mixed methods were used, and data were collected through structured interviews, focus group discussions, field observations, in-depth interviews and document reviews. Quantitative data were analysed using descriptive statistics while qualitative data were thematically analysed. The results indicate that 84.2% (n=95) of the households showed an increase in crop yields despite concurrent severe drought. Sunflower, maize, bulrush millet, and sorghum were …

Urban Transportation And Marketing Efficiency Among Tomato Marketers In Oyo State, Nigeria, Chuks O. Idiaye, Isaac Busayo Oluwatayo, Nafisat O. Tijani

ASEAN Marketing Journal

The study examined the effect of urban transportation on tomato marketing efficiency using major markets in Ibadan metropolis in south-west Nigeria as case study. The data used were collected from a total of 170 tomato marketers using a structured questionnaire. The locations of the markets included Ibarapa Central, Ibarapa East, Ibarapa North, Ido, Lagelu, and Akinyele. Descriptive statistics, Shepherd’s measure of efficiency and Multinomial regression were used to analyze the data collected. Findings from the study revealed that transportation plays a crucial role in the marketing of tomato in Oyo state, Nigeria and that mini-cabs are the most preferred means …

Assessment Perception: Delivery Matters, Nicole Marie Arcuri-Sanders, Chelsey Simmons

Educational Sciences and Organizations

Perception shapes how individuals experience the world and guides their actions toward personal goals. In counseling, clients’ accurate understanding of assessment results is essential for informed decision-making and effective treatment engagement. Mental health clinicians have an ethical responsibility to communicate findings in ways that safeguard client welfare and empower both clients and stakeholders to collaborate in care. This conceptual manuscript introduces the BRIEF (Brief, Relevant, Interpretive, Empathetic, and Factual) Feedback Integration Framework, a structured model for delivering assessment feedback ethically and accessibly. Integrating cognitive, developmental, and cultural considerations. BRIEF provides counselors, supervisors, and educators with a practical strategy for improving …

A Novel Mathematical Model Of Hiv Transmission Incorporating The Effects Of Treatment And Pre-Exposure Prophylaxis: Sensitivity Analysis And Numerical Simulations, Erick Manuel Delgado Moya

Mathematical Modelling and Numerical Simulation with Applications

Human immunodeficiency virus (HIV) continues to be a public health problem in many countries of the world, and Pre-exposure prophylaxis (PrEP) is a preventive method for HIV, which has shown great efficacy and is in use worldwide. This work presents a new mathematical model for HIV transmission incorporating PrEP use and evaluates the impact of PrEP along with its increasing use in a population. The construction of the model takes into account three forms of diagnosis: diagnosis of individuals in risky sexual contact, diagnosis after risky contact (diagnosis in the undiagnosed infected compartment), and diagnosis associated with attempting to enter …

Health Risk Assessment (Hra) In Home-Based Ironing Businesses: Risk Identification, Intervention, And Evaluation In Johar Baru District, Central Jakarta, Heru Alfares, Irawadi Darmaputra, Marsen Isbayuputra, Muhammad Ilyas

Occupational and Environmental Medicine Journal of Indonesia

Background Home-based ironing businesses in Johar Baru District, Central Jakarta, are part of the informal sector, vulnerable to health risks due to suboptimal working conditions. This study aims to identify, assess, and control health risks through a Health Risk Assessment (HRA) approach.

Methods Research methods include direct observation, interviews, environmental measurements, health screenings, and ergonomic surveys using the BRIEF (Baseline Risk Identification of Ergonomic Factor) instrument.

Results The results indicate that the temperature in the ironing area reaches 33°C, exceeding the comfort standard, and that 80% of workers have dark yellow urine, indicating a high risk of dehydration. Risk assessment …

Returning To Work On Chef With Graves’ Disease: A Case Report, Izzatul Abadiyah, Dewi Sumaryani Soemarko

Occupational and Environmental Medicine Journal of Indonesia

Background Graves’ disease has adverse effects on quality of life, because of somatic psychiatric symptoms and an inability to work. Chefs face many occupational hazards that can aggravate certain medical conditions, worsen the disease, and pose safety risks at work. This case report aims to assess the returning-to-work evaluation and program for a chef with Graves’ disease.

Case Description A forty-seven-year-old Indonesian male who was diagnosed with Graves’ disease from characteristic clinical features and biochemical abnormalities was admitted to the hospital with shortness of breath. TSH concentration was 0.001mU/L, FT4 concentration was 2.85 ng/dL, hemoglobin level was 10.6 g/dL, and …

The Concept Of Law In Biopower Duaa Nassar And Amer Shatara, Duaa Nassar, Amer Shatara

Journal of Arts and Social Sciences

The study aims to reveal the transformation of the concept of law in biopower, and the impact of this transformation on the formation of society. According to the perceptions of the French philosopher Michel Foucault, the concept of the norm emerged as an alternative to law, as the concept of law was transformed from a set of controls for the behavior of the individual or “citizen” in the state, to a “standard” based on discrimination between the population based on race and gender. The study follows a key question of how the norm as a legal alternative contributes to biopower …

Assurance And Empathy: Key Drivers Of Patient Satisfaction And Loyalty In Public-Insured Dental Services, Andi Mim. Amir, Hasanuddin Thahir, Lenni Indriani, Fuad H. Akbar, Eddy H. Habar, Irene E. Rieuwpassa

Journal of Dentomaxillofacial Science

Abstract

Objective: This study aimed to analyze the impact of dental healthcare service quality on patient satisfaction and loyalty among Social Health Insurance Administration Body (BPJS) participants at the Dental Clinic of Dr. Sumantri Hospital, Parepare, Indonesia, one of main referral hospital in South Sulawesi, Indonesia

Methods: A cross-sectional quantitative study was conducted involving 160 patients selected through convenience sampling. Data were collected using an Indonesian-adapted SERVQUAL questionnaire that assessed five dimensions of service quality (tangibility, reliability, responsiveness, assurance, and empathy), patient satisfaction, and loyalty. Descriptive statistics, reliability analysis, and multiple linear regression were used for data analysis.

Results: Service …

Antibacterial Effect Of Moringa Oleifera Extract, Chitosan, And Calcium Hydroxide Against Porphyromonas Gingivalis: A Preliminary In Vitro Study, Adilah Zf. Djerman, Muhammad F. Sabirin, Erna A. Sutanto, Nisrina E. Nasrun, Maria Tanumiharja

Journal of Dentomaxillofacial Science

Objective: Given the role of Porphyromonas gingivalis in pulp inflammation and the potential of natural agents to enhance conventional medicaments, this study aimed to investigate the antibacterial activity of Moringa oleifera extract and chitosan, in combination with calcium hydroxide [Ca(OH)₂], against P. gingivalis

Material and Methods: The laboratory experiment used 12 groups with three replicates (36 samples in total). The groups included: (1) Moringa oleifera with Ca(OH)₂, (2) chitosan with Ca(OH)₂, and (3) M. oleifera, chitosan, and Ca(OH)₂ mixture. Each group had four subgroups: Ca(OH)₂ control and concentration ratios of 1:1, 1.5:1, and 2:1. Antibacterial activity was measured via disc …

Antibacterial Activity Of Ethanol Extract Of Cocoa Beans (Theobroma Cacao L): In Silico And In Vitro Study, Rudy Joelijanto, Rina Sutjiati

Journal of Dentomaxillofacial Science

Objective: This study was conducted to determine the minimum inhibitory concentration (MIC) of cocoa beans ethanol extract gel on Streptococcus mutans, and prediction interaction between the active compound of cocoa bean (Theobroma cacao L.) and the antibacterial protein in silico.

Various bioactive compounds including polyphenols have been found in cocoa beans, which have essential properties such as antibacterial effects. Material and Methods: The research was conducted in silico and in vitro study. The study was divided into 8 treatment groups and 4 repetitions. The sample group used was cocoa beans extract concentration of 25%; 12,5%; 6,25%; 3,12%; 1,56%; 0,78%; …

Comparative Analysis Of Groundwater Quality Based On Chemical Parameters Around Final Disposal Sites Using Open Dumping And Sanitary Landfill Methods, Shiesil Rizqia Amadia, Mika Vernicia Humairo

Preventia: The Indonesian Journal of Public Health

The main environmental issue at landfill sites is the seepage of leachate into the ground, which contaminates surrounding aquifers. Communities residing within one kilometer of landfill sites are at high risk of environmental pollution. This study aimed to analyze differences in groundwater quality around landfills applying open dumping and sanitary landfill methods, and to compare groundwater quality at safe and unsafe distances from these sites. The research was conducted around the Cipayung landfill in Depok (open dumping) and the Talangagung landfill in Kepanjen (sanitary landfill). The study adopted an analytical observational approach using a cross-sectional design. The independent variables included …

The Role Of Climate And Population Density In The Spread Of Dengue Fever: A Spatial Analysis Of Padang City 2022–2024, Nailul Hikmi, Aria Gusti

Preventia: The Indonesian Journal of Public Health

In 2023, Padang city had a dengue fever incidence rate of 46.5 per 100,000 population, an increase compared to the previous year. Climate change, with the transition from the dry to the rainy season, contributed to a surge in dengue fever cases. This study aims to determine the relationship between environmental factors and the incidence of dengue fever in Padang City from 2022 to 2024. This study uses an ecological study design with a sample of all dengue fever cases recorded by the Padang City Health Office. Climate data was obtained from the Indonesian Agency for Meteorological, Climatological, and Geophysical …

The Indonesian Guardianship And Indonesian Private International Law, Tiurma Mangihut Pitta Allagan, Dinda R. Himmah, Amirah Hisana

Indonesia Law Review

The increasing of number of cross-border legal relationships, especially family legal relationships, is inevitable. For instance, it is also commonly accepted for a foreign national to have a legal-bond with children from another country, which is also known as intercountry adoption, guardianship and fostership. This paper aims to analyze and classify guardianship involving international dimension within the jurisdiction of Indonesia. The examination of this legal question would be on the basis of Indonesian Private International Law (PIL). The choice of law and the choice of jurisdiction are the basic analysis, further, as to whether the guardianships are in line with …

Green Bonds As A Green Investment To Prevent Greenwashing And Green Financial Crime In Indonesia, Cita Yustisia Serfiyani

Indonesia Law Review

Overcoming the climate crisis should not only be pursued from the aspect of technological invention but also from the financial aspect through issuing securities instruments that align with the green economy mission. Unfortunately, irresponsible parties such as corporations still use the green economy concept for personal gain through greenwashing and green financial crime. The presence of green bonds as green instruments shows a positive trend towards improving the quality of environmentally friendly technological innovations, building green infrastructure, and increasing income in line with increasing public participation in climate issues. However, its application in Indonesia is constrained by the complexity of …

Floating Nuclear Power Plants On The Horizon. Do We Need A Revised Brussels Convention On The Liability Of The Operators Of Nuclear Ships?, Jakub Handrlica

Indonesia Law Review

Adopted in 1962, the Brussels Convention on the Liability of the Operators of Nuclear Ships has been considered an obsolete instrument for the last 60 years. In light of renewed interest in floating nuclear power plants (FNPPs), this article revisits the regime of this half-forgotten Convention and calls for its modernisation. The fact is that a robust legal framework for liability and compensation must accompany any prospective deployment of FNPPs. This article argues that adopting a Revised Brussels Convention will help address these challenges. This article aims to identify the reasons for this modernisation and to outline its significant features. …

Penerapan Media Card Education Output Untuk Meningkatkan Keterlibatan Aktif Siswa Smp Pada Materi Mengapresiasi Kebudayaan Lokal, Thania Carolline, Abd. Mu'id Aris Shofa

Journal of Innovation and Teacher Professionalism

This study aimed to explore the use of various instructional media to support effective classroom learning. A qualitative descriptive case-study approach was employed. The participants were 30 Grade X students at SMP Muhammadiyah 01 Malang. Data were collected through classroom observations, interviews with teachers and students, and analysis of learning documents. Data were analyzed using the Miles and Huberman interactive model, which includes data reduction, data display, and conclusion drawing. The findings showed that the use of varied instructional media, including social media and digital technology, increased student engagement and enriched their learning experiences. Traditional instructional media also continued to …

Green Tea (Camellia Sinensis) And Cognitive Health: A Systematic Review Of Mechanisms, Clinical Evidence, And Neuroprotective Potential, Elisha Rosalyn Rosdah, Eka Febri Zulissetiana, Irfannuddin Irfannuddin

Folia Medica Indonesiana

Cognitive decline, often a precursor to neurodegenerative diseases like Alzheimer's, is a growing global health challenge. Green tea (Camellia sinensis), rich in bioactive compounds such as epigallocatechin-3-gallate (EGCG) and L-theanine, has demonstrated promise in supporting cognitive function and reducing cognitive decline. This systematic review evaluated the recent evidence on the effects of green tea on cognition and its underlying mechanisms. The authors conducted a comprehensive search of PubMed, SpringerLink, and ScienceDirect for open-access articles published between January 2020 and April 2025. This systematic review included studies examining the impact of green tea on cognitive function in humans and …

Kegagalan Kepastian: Membingkai Ulang Manajemen Strategis Melalui Kompleksitas, Brian Hoffni

Jurnal Manajemen dan Usahawan Indonesia

This paper explores the integration of complexity theory into the field of strategic management, arguing that traditional, positivist-based models—such as the planning school, positioning school, and resource-based view—are increasingly inadequate for addressing the volatility, uncertainty, complexity, and ambiguity (VUCA) of contemporary business environments. While classical theories emphasize linearity, stability, and top-down control, complexity theory reconceptualizes organizations as complex adaptive systems (CAS) characterized by emergence, nonlinearity, and continuous learning. Drawing on insights from both historical and contemporary strategic paradigms, this study proposes that complexity theory does not replace but rather extends classical frameworks by enabling more adaptive, iterative, and resilient approaches …

Efektivitas Pendekatan Teaching At The Right Level (Tarl) Dalam Meningkatkan Hasil Belajar Siswa Kelas V Sekolah Dasar, Nur Azlina, Putri Rohadatul Aisy, Siti Mas'ula

Journal of Innovation and Teacher Professionalism

This study aimed to analyze the effectiveness of the Teaching at the Right Level (TaRL) approach in improving learning outcomes in Natural and Social Sciences among Grade V students at SDN Sawojajar 5 Malang. It used a quantitative pre-experimental method with a One-Group Pretest–Posttest design. The participants were 28 students from Grade V-A selected through purposive sampling. Data were collected using pretest and posttest instruments as well as observation. The average pretest score was 60.36, while the average posttest score after the TaRL intervention was 91.43. Hypothesis testing produced a Sig. (2-tailed) value of 0.000, lower than 0.05, indicating that …

Pemanfaatan Nearpod Sebagai Media Pembelajaran Matematika Berbasis Gamifikasi Pada Materi Segitiga Dan Segi Empat Kelas Viii Smp, Intan Faraminda Putri, Erry Hidayanto, Sri Indayani

Journal of Innovation and Teacher Professionalism

Low student motivation is a major challenge in education today, particularly in mathematics. One solution is to use gamification-based instructional media such as Nearpod. The application offers interactive features, including quizzes, polls, simulations, and dynamic presentations, which can create an enjoyable and engaging learning environment. This study employed a qualitative approach to explore the benefits of using Nearpod in mathematics instruction. The participants were 32 students in Grade VIII-H at SMPN 18 Malang. Data were collected through open-ended surveys and observations of student activities during lessons. The findings showed that Nearpod improved students’ understanding of triangles and quadrilaterals, created a …

Characterization And Biocompatibility Test Of Chitosan-Alginate-Fucoidan Hydrogel As Potential Socket Preservation Material: In Vitro Study, Ainiyyah F. Zaizafun, Nurlindah Hamrun, Erni Marlina, Lenni Indriani, Nurhayaty Natsir, Asdar Gani, Arifin

Journal of Dentomaxillofacial Science

Objective: This study aimed to characterize and evaluate the in vitro biocompatibility of chitosan-alginate-fucoidan hydrogel at different concentrations as a potential socket preservation material.

Material and Methods: Hydrogels were prepared using various concentrations of chitosan-alginate-fucoidan formulas. Alginate and fucoidan which were extracted from brown algae, were dissolved in purified water with stirring, then mixed with chitosan from white shrimp skin, which was prepared in 2% acetic acid. The hydrogels were characterized using scanning electron microscopy (SEM) and Fourier transform-infrared spectroscopy (FTIR). Biocompatibility was assessed using KUSA cells through cell viability, cytotoxicity, and cell adhesion. Data were analyzed using a one-way …

Serum Level Of Il-4 And Il-13 And Their Association With Disease Pathogenesis In Patients With Eczema, Shurooq Salim Murad, Heyam Qaid Mohammad

Al-Qadisiyah Medical Journal

Background: As the most common chronic skin illness with a genetic foundation, eczema is an inflammatory skin condition driven by cytokines. People with AD suffer from a significant burden that affects their physical, mental, social, and financial well-being.  The cytokines are important in eczema disease. Interleukins regulate immunity. Lack impairs immunity or causes autoimmune disorders. Objectives: This study is aiming to investigate whether inflammatory cytokine (IL-4, IL-13) levels in the blood correlate with eczema disorder. Methods: This case-control study is based on 60 patients who have been diagnosed with eczema disorder with a 60-person apparently healthy control group. 4 ml …

Investigating The Role Of Cornichon-Homolog 3 (Cnih3) In Opioid Use, Contributing Risk Factors, And Associated Neural Substrates, Tania Lintz

Arts & Sciences Graduate Student Theses and Dissertations

Opioid misuse remains rampant as potent synthetic opioids such as fentanyl flood the market. Large-scale genetic tools like the GWAS identify previously unrecognized targets and biomarkers in opioid misuse with the hopes of combating the opioid epidemic and opioid use disorder (OUD). One such target is the AMPA receptor (AMPAR) auxiliary protein Cornichon Homolog-3 (CNIH3), which determines AMPAR subunit composition and kinetics. Though CNIH3 was identified as a gene of interest in OUD, its role in opioid use and accompanying risk factors has not been studied. Using mice with a CNIH3 deletion, we assess the role of CNIH3 in risk …

Relationships Between Larval Fish Drift, Time Of Day And Discharge In An Ozark Stream, Daniel D. Magoulick, Christy L. Graham

Biological Sciences Faculty Publications and Presentations

We examined the relationship between larval fish numbers and discharge during a high flow event in Bear Creek, Arkansas, a small Ozark stream. Additionally, we examined the relationship between fish numbers and time of day, and the spatial distribution of families and size classes. A total of 3,083 fish from five families were collected. Leuciscidae was the dominant family collected, followed by Percidae, and Catostomidae. Larval fish in Bear Creek were not susceptible to increased discharge from the flood event, as all three families exhibited strong significant negative relationships to discharge at night when discharge began to decline. Larval fish …

Centering Ai Literacy: Exploring Brazilian International Students’ Perceptions Of Chatgpt And Peer Tutoring, Leigh Ann Dunning, Raissa Borges De Oliveira Leal

The Writing Center Journal

For English as an Additional Language (EAL) students, generative AI (GenAI) offers meaningful support for writing in English, while also introducing a new set of challenges. Supporting EAL students in developing AI literacy is crucial to their growth as confident, adaptable writers, and writing center tutors are uniquely positioned to facilitate this development. This case study explores the experiences of undergraduate Brazilian international students at a small liberal arts college who received writing feedback from both peer writing center tutors and ChatGPT. Findings indicate that students valued the human connection, contextual understanding, and rhetorical support offered by peer tutors, while …