Digital Commons Network^™

Faculty Liederabend, "An Evening Of German Art Song", Eileen Moremen, Leah Partridge, Todd Wedge, Jana Young, Judy Cole, John Warren, Laura Najarian, Ryan Gregory

Bailey School of Music Concert Programs

An evening of German lieder and chamber music written by several great composers including Georg Frederich Händel, Franz Schubert, Louis Spohr, and Mátyás Seiber performed by KSU faculty members. This concert features sopranos Leah Partridge, Jana Young, and Eileen Moremen, tenor Todd Wedge, clarinetist John Warren, bassoonist Laura Najarian, pianist Judy Cole, and student violinist Ryan Gregory.

The Current Volume 26 : Issue 17, Nova Southeastern University

Student Newspapers

No abstract provided.

Sociology Criminology Senior Interns At The Athens Courthouse, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Ubiquitin-Proteasome System: Potential Therapeutic Targets For Alzheimer’S Disease And Spinal Cord Injury, Bing Gong, Miroslav Radulovic, Maria E. Figueiredo-Pereira, Christopher Cardozo

Publications and Research

The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in eukaryotes. Herein, we will review advances in the understanding of the role of several proteins of the UPS in Alzheimer’s disease (AD) and functional recovery after spinal cord injury (SCI). The UPS consists of many factors that include E3 ubiquitin ligases, ubiquitin hydrolases, ubiquitin and ubiquitin-like molecules, and the proteasome itself. An extensive body of work links UPS dysfunction with AD pathogenesis and progression. More recently, the UPS has been shown to have vital roles in recovery of function after SCI. The ubiquitin hydrolase (Uch-L1) has been proposed to …

Mike Davis, Mike Davis, Meg Miner

All oral histories

Davis was WESN manager and reflects on Myers' support for the station. He cites this as an empowering experience, when someone believes in you. Davis is now an academic and has been an administrator and draws on the experiences he had as a student in his interactions with students today. He thinks the administration isn't usually visible on a college campus but that his presences and way of emphasizing the unique qualities of IWU students was intended to make students feel welcome. Davis also describes the condition of Myers' office.

Executive Committee - Agenda, 1/26/2016, Academic Senate

Academic Senate Agendas

No abstract provided.

Development Of A Glucose-Powered Biobattery For Implantation And Use In Humans, Carson Sparks, Cody Maughan, Lucas Smith, Carson Sparks

Research on Capitol Hill

With current demands for implantable electrical devices increasing, the need for a more stable and biocompatible source of power is becoming increasingly necessary. Several battery types and materials were evaluated. Ultimately, an abiotic biobattery was designed with the goal of implantation in the human body. Nafion, single-walled carbon nanotubes (SWCNTs), and gold were used to create an abiotic biobattery that is powered by glucose.

The SWCNTs were used to create the cathode, the gold was used to fabricate the anode, and the Nafion acted as the separator between the cathode and anode. A thin Nafion membrane was evaluated for overlaying …

Plant Diseases And Pests In Utah Raspberries, Sean Christensen

Research on Capitol Hill

Very little information exists on pathogens and pests that affect Utah raspberry production. In fact a survey of Utah raspberry growers at the 2015 USU Urban and Small Farms conference showed that 72% said the largest problem they had was with diseases and pests, and 71% of those did not know what the diseases actually were.

Several viruses, bacteria, pests, and nutrient deficiencies can have a large influence on raspberry yield. This survey was designed to raise awareness among Utah raspberry growers, help them to better prepare for, and manage these possible disease problems. This will be increasingly more important …

Improved Production Of Promising Antioxidant, Resveratrol, In Escherichia Coli, Chad Skidmore

Research on Capitol Hill

Resveratrol is a promising antioxidant natural product. Studies have shown that it is effective against heart disease, cancer, Alzheimer's disease, diabetes, and harmful UV rays. This health-benefiting molecule is present in plants such as peanuts, berries, and the skin of red grapes.

A growth time of 10 months makes Japanese knotweed an impractical source of resveratrol. A more efficient way to produce resveratrol has been found by using E. coli as tiny biological factories.

Zeta Potential: Key To Harvesting Algae For Biofuels And Bioproducts, Celeste Hancock, Michael Flores

Research on Capitol Hill

• Algae is an effective and sustainable resource for creating a broad spectrum of bioproducts.
• Scientists have found it challenging to harvest algae due to the difficulty of collecting algae when in an aqueous solution such as wastewater.
• Rotating Algal Biofilm Reactors (RABRs) coated with carbon nanotubes have proved effective. The RABR floats in an aqueous environment and attracts charged algal particles in suspension.
• The tendency for algae to favor suspension over coagulation occurs only when particles of algae are sufficiently charged. This charge can be measured by analyzing the electric potential at the interface between the surface of a particle …

Potential Regulation Of Deadly Water-Borne Shigella Bacteria Pathogenesis Through The Shigella Infection Protein Spa47, Jamie Kingsford

Research on Capitol Hill

• Shigella is a gram-negative, bacterial pathogen typically found in contaminated water sources.
• Each year, Shigella is responsible for over 90 million infections and 100,000 deaths stemming from symptoms of severe dysentery, fever, nausea and vomiting.
• A needle-like apparatus found on the surface of Shigella allows the bacterium to infect host cells.
• Each needle-apparatus has an associated ATPase, a protein that can hydrolyze ATP into ADP and P_i.
• The Shigella needle-apparatus ATPase Spa47 is predicted to provide the energy for infection.
• Spa47 has been shown to be essential for infection – without Spa47, no infection will occur.
• We were …

Beyond The Fiber: Novel Spider Silk Coatings And Adhesives, Danielle A. Gaztambide, Breton A. Day

Research on Capitol Hill

Natural spider silks have long been recognized for their combination of incredible strength and elasticity. Spider silk is more elastic than nylon, tougher than Kevlar, and stronger than steel by weight. Due to an inability to farm spiders, much work has been done to produce spider silks in transgenic hosts for large -scale production. Our work was done using recombinant spider silk proteins produced in transgenic goats and the bacteria E. coli.

More recently spider silks have also been recognized for their biocompatibility and lack of immunogenicity. Spider silks' incredible strength and ability to be implanted safely within the body …

Insecticides Are Not Always The Answer For Combatting Pests In Onion Fields, Harlie Hutchinson

Research on Capitol Hill

Onion thrips are the insect vector of a severe virus in onion, Iris yellow spot virus. The thrips and virus are primary threats to the economic stability of onion production worldwide. Overuse of insecticides to suppress onion thrips has resulted in the development of resistance, reduced performance of insecticides, and reduced onion yields.

There is a compelling desire to find alternatives to better manage these pests. In this study, we assessed onion thrips populations on onions with low and high nitrogen rates, and near and far from corn and wheat, two common neighboring crops in the onion farm-scape.

Blog Consumption And International Relations, Michael A. Allen

Political Science Faculty Publications and Presentations

International relations professors have sought to incorporate current events into their curriculum through various mechanisms. A traditional way to incorporate the news into the classroom is to have students either subscribe and read a particular newspaper, or watch the nightly news, and hold them responsible for that information. However, with the growing body of professional political science blogs available to the general public, we now have access to immediate current event updates framed through the lens of political science. This manuscript tests to see if having students regularly read professional political science blogs increases student achievement on multiple choice exams …

Reelin Rescues Congnitive Function, Edwin Weeber, Lisa Zhao, Melinda Peters

USF Patents

Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, …

The Sun Star Vol 35 No 15 ( January 26th, 2016), N/A N/A

Sun Star

No abstract provided.

The Sun Star, Vol. 35 No. 15 (January 26, 2016), N/A N/A

Sun Star

No abstract provided.

Uno Calendar Event-Cfe-Cheating Lessons Book Discussion, Uno Center For Faculty Excellence

Business/Finance/Operations

Cheating Lessons examines entrenched conditions within the classroom that promote cheating and makes on argument for rethinking the way we approach teaching to ameliorate those conditions.

Chapter 8: Autocorrelation Function, Mutual Information, And Correlation Dimension, Nathaniel Hunt

Journal Articles

In this chapter, we will discuss in greater detail the autocorrelation function and the mutual information we mentioned in Chapter 3 on the reconstruction of the state space. We will also cover a new measure called the correlation dimension, which quantifies the dimensionality of an attractor.

Chapter 5: Surrogation, Sara A. Myers

Journal Articles

One of the goals of time series analysis is to understand the underlying mechanisms that generate different dynamics for different time series. If a time series is not a product of random process, then we can assume that some kind of dynamics govern the time series. The question is what kinds of dynamics are controlling the time series. For nonlinear time series analysis, our focus is on nonlinear dynamics, and one of the goals is to characterize those dynamics by applying nonlinear tools. However, it is important to establish evidence of nonlinearity in a time series first in order to …

The Tubulation Activity Of A Fission Yeast F-Bar Protein Is Dispensable For Its Function In Cytokinesis, Nathan A. Mcdonald, Yoshimasa Takizawa, Anna Feoktistova, Ping Xu, Melanie D. Ohi, Craig W. Vander Kooi, Kathleen L. Gould

Molecular and Cellular Biochemistry Faculty Publications

F-BAR proteins link cellular membranes to the actin cytoskeleton in many biological processes. Here we investigated the function of the Schizosaccharomyces pombe Imp2 F-BAR domain in cytokinesis and find that it is critical for Imp2's role in contractile ring constriction and disassembly. To understand mechanistically how the F-BAR domain functions, we determined its structure, elucidated how it interacts with membranes, and identified an interaction between dimers that allows helical oligomerization and membrane tubulation. Using mutations that block either membrane binding or tubulation, we find that membrane binding is required for Imp2's cytokinetic function but that oligomerization and tubulation, activities often …

Physiological Response To Reward And Extinction Predicts Alcohol, Marijuana, And Cigarette Use Two Years Later, Karen J. Derefinko, Tory A. Eisenlohr-Moul, Jessica R. Peters, Walter Roberts, Erin C. Walsh, Richard Milich, Donald R. Lynam

Department of Psychological Sciences Faculty Publications

Background: Physiological responses to reward and extinction are believed to represent the behavioral activation system (BAS) and behavioral inhibition system (BIS) constructs of Reinforcement Sensitivity Theory and underlie externalizing behaviors, including substance use. However, little research has examined these relations directly. Methods: We assessed individuals’ cardiac pre-ejection periods (PEP) and electrodermal responses (EDR) during reward and extinction trials through the “number elimination game” paradigm. Responses represented BAS and BIS, respectively. We then examined whether these responses provided incremental utility in the prediction of future alcohol, marijuana, and cigarette use. Results: Zero-inflated Poisson (ZIP) regression models were used to examine the …

Hydrogen Utilization Potential In Subsurface Sediments, Rishi R. Adhikari, Clemens Glombitza, Julia C. Nickel, Chloe H. Anderson, Ann G. Dunlea, Arthur J. Spivack, Richard W. Murray, Steven D'Hondt, Jens Kallmeyer

Graduate School of Oceanography Faculty Publications

Subsurface microbial communities undertake many terminal electron-accepting processes, often simultaneously. Using a tritium-based assay, we measured the potential hydrogen oxidation catalyzed by hydrogenase enzymes in several subsurface sedimentary environments (Lake Van, Barents Sea, Equatorial Pacific, and Gulf of Mexico) with different predominant electron-acceptors. Hydrogenases constitute a diverse family of enzymes expressed by microorganisms that utilize molecular hydrogen as a metabolic substrate, product, or intermediate. The assay reveals the potential for utilizing molecular hydrogen and allows qualitative detection of microbial activity irrespective of the predominant electron-accepting process. Because the method only requires samples frozen immediately after recovery, the assay can be …

Cd147 And Downstream Adamtss Promote The Tumorigenicity Of Kaposi's Sarcoma-Associated Herpesvirus Infected Endothelial Cells, Lu Dai, Jimena Trillo-Tinoco, Yihan Chen, Karlie Bonstaff, Luis Del Valle, Chris Parsons, Augusto C. Ochoa, Jovanny Zabaleta, Bryan P. Toole, Zhiqiang Qin

School of Medicine Faculty Publications

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi's sarcoma (KS), which preferentially arise in immunocompromised patients and lack effective therapeutic options. We have previously shown that KSHV or viral protein LANA up-regulates the glycoprotein CD147, thereby inducing primary endothelial cell invasiveness. In the current study, we identify the global network controlled by CD147 in KSHV-infected endothelial cells using Illumina microarray analysis. Among downstream genes, two specific metalloproteases, ADAMTS1 and 9, are strongly expressed in AIDS-KS tissues and contribute to KSHV-infected endothelial cell invasiveness through up-regulation of IL-6 and VEGF. By using a KS-like nude …

Chapter 2: Time Series, Sara A. Myers

Journal Articles

Time series is “simply a list of numbers assumed to measure some process sequentially in time” (Stergiou et al. 2004). Mathematicians have a more formal definition, that is, a set or a sequence of observations, with each one recorded at specific times, or at least sequentially (Brockwell and Davis 2002; Box et al. 2008). Time series are created from multiple sources for research purposes to understand various behaviors. For example, social scientists could collect graduation rates, physiologists record heart rates, economists study consumer spending, and climatologists examine weather patterns. Basically, any time observations are taken repeatedly over time, from any …

Biodistribution And Pharmacokinetics Study Of Sirna-Loaded Anti-Ntsr1-Mab-Functionalized Novel Hybrid Nanoparticles In A Metastatic Orthotopic Murine Lung Cancer Model., Maryna Perepelyuk, Chellappagounder Thangavel, Yi Liu, Robert B. Den, Bo Lu, Adam E. Snook, Sunday A. Shoyele

Department of Radiation Oncology Faculty Papers

Small interfering RNA (siRNA) is effective in silencing critical molecular pathways in cancer. The use of this tool as a treatment modality is limited by lack of an intelligent carrier system to enhance the preferential delivery of this molecule to specific targets in vivo. In the present study, the in vivo behavior of novel anti-NTSR1-mAb-functionalized antimutant K-ras siRNA-loaded hybrid nanoparticles, delivered by i.p. injection to non-small-cell lung cancer in mice models, was investigated and compared to that of a naked siRNA formulation. The siRNA in anti-NTSR1-mAb-functionalized hybrid nanoparticles was preferentially accumulated in tumor-bearing lungs and metastasized tumor for at least …

The Bg News January 26, 2016, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January, 26, 2016. Volume 95-Issue 38.

Sustainable Solutions

Sustainable Solutions Newsletter (2016-2021)

• Director's Message
• Upcoming Events
• RecycleMania
• Sustainability Speakers
• Environmental Community Cinema
• No Impact Week
• Campus Community Garden
• Campus Composting
• Afterschool Garden Program
• Residence Hall Recycling Incentive Program
• Tailgate Recycling
• Greenfest
• Georgia Campus Sustainability Network

Novel Biomarker Of Oxidative Stress Is Associated With Risk Of Death In Patients With Coronary Artery Disease, Emir Veledar

All Publications

BACKGROUND: Free radical scavengers have failed to improve patient outcomes, promoting the concept that clinically important oxidative stress may be mediated by alternative mechanisms. We sought to examine the association of emerging aminothiol markers of nonfree radical mediated oxidative stress with clinical outcomes. METHODS AND RESULTS: Plasma levels of reduced (cysteine and glutathione) and oxidized (cystine and glutathione disulphide) aminothiols were quantified by high performance liquid chromatography in 1411 patients undergoing coronary angiography (mean age 63 years, male 66%). All patients were followed for a mean of 4.7 +/- 2.1 years for the primary outcome of all-cause death (n=247). Levels …

Vitamin D Deficiency: "At Risk" Patient Populations And Potential Drug Interactions, Dana Lycans Md, Elias Salloum Md, Matthew K. Wingate Md, Thomas Melvin Md, Grant S. Buchanan Md, Franklin D. Shuler Md, Phd

Marshall Journal of Medicine

Vitamin D is known to play an essential role in calcium homeostasis; however, excessive amounts can have harmful effects. Calcium and vitamin D levels are known to be influenced by drug interactions and pathology ranging from of cancer to cardiovascular disease. Vitamin D supplementation has become widespread, and it is important for clinicians to understand the way that certain conditions and medications interact with vitamin D and calcium homeostasis. The purpose of this review is to outline the benefits and adverse effects of vitamin D and how its levels are affected by certain pathologic and pharmacologic interactions.