Digital Commons Network^™

Recent Advances In Optical Diagnosis Of Oral Cancers: Review And Future Perspectives, Ola Ibrahim, Hugh Byrne, Fiona Lyng, Surya Singh, Jopi Mikkonen, Arto Koistinen, Arja Kullaa

Articles

Optical diagnosis techniques offer several advantages over traditional approaches, including objectivity, speed and cost, and these label-free, non-invasive methods have the potential to change the future work-flow of cancer management. The oral cavity is particularly accessible and thus such methods may serve as alternate/adjunct tools to traditional methods. Recently, in vivo human clinical studies have been initiated with a view to clinical translation of such technologies. A comprehensive review of optical methods in oral cancer diagnosis is presented. Following an introduction to the epidemiology and aetiological factors associated with oral cancers currently employed diagnostic methods and their limitations are presented. …

Structure-Activity Relationships Governing The Interaction Of Nanoparticles With Mammalian Cells- Predictive Models For Toxicology And Medical Appliances, Marcus A. Maher

Doctoral

Nanoscience is seen as one of the key enabling technologies of the 20th century and as its range of applications increases it is important to look at how nanomaterials interact with biological environments. Some of these interactions have given rise to toxic effects and thus, the creation of the field of nanotoxicology, it has also been noted that current methods of evaluating toxicity may not be sufficient to keep up with the rapidly emerging range of nanomaterials becoming available. It is clear that alternatives are necessary. In this thesis, a phenomenological rate equation model is constructed to simulate nanoparticle uptake …

Determination Of Critical Nucleation Number For A Single Nucleation Amyloid-Β Aggregation Model, Preetam Ghosh, Ashuwin Vaidya, Amit Kumar, Vijayaraghavan Rangachari

Department of Mathematics Faculty Scholarship and Creative Works

Aggregates of amyloid-β (Aβ) peptide are known to be the key pathological agents in Alzheimer disease (AD). Aβ aggregates to form large, insoluble fibrils that deposit as senile plaques in AD brains. The process of aggregation is nucleation-dependent in which the formation of a nucleus is the rate-limiting step, and controls the physiochemical fate of the aggregates formed. Therefore, understanding the properties of nucleus and pre-nucleation events will be significant in reducing the existing knowledge-gap in AD pathogenesis. In this report, we have determined the plausible range of critical nucleation number (n*, the number of monomers associated within the nucleus …

Shared Risk Factors For Mood-, Eating-, And Weight-Related Health Outcomes, A. B. Goldschmidt, M. Wall, T-H. J. Choo, Carolyn Becker, D. Neumark-Sztainer

Psychology Faculty Research

Objective: Given the overlap among depressive symptoms, disordered eating, and overweight, identifying shared risk factors for these conditions may inform public health interventions. This study aimed to examine cross-sectional and prospective relationships among these 3 conditions, and identify potential shared eating-related and psychosocial variable risk factors (i.e., body dissatisfaction, dieting, teasing experiences).

Method: A population-based sample (n = 1,902) self-reported depressive symptoms, disordered eating (binge eating, extreme weight control behaviors), weight status, and several putative risk factors (body satisfaction, dieting frequency, weight-related teasing) at 5-year intervals spanning early/middle adolescence, middle adolescence/early young adulthood, and early/middle young adulthood.

Results: There was …

Professional Development Of Elementary And Science Teachers In A Summer Science Camp: Changing Nature Of Science Conceptions, Ayhan Karaman

Australian Journal of Teacher Education

Many countries all over the world have recently integrated nature of science (NOS) concepts into their science education standards. Providing professional support to teachers about NOS concepts is crucially important for successful implementation of the standards. For this purpose, a summer science camp was offered to elementary and science teachers. The main objective of this research study was to investigate the progress in specific NOS concepts made by the participant teachers. The responses of the teachers regarding the NOS concepts were obtained through VNOS-C questionnaire and scored using a rubric developed by McDonald (2008). The scored teacher responses were analyzed …

Psychometric Evaluation Of The Physical Activity Enjoyment Scale In Adults With Functional Limitations, Carolyn J. Murrock, Abir K. Bekhet, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

Enjoyment is an important construct for understanding physical activity participation, and it has not been examined in adults with functional limitations. This secondary analysis reported the reliability and validity of the Physical Activity Enjoyment Scale (PACES) in a convenience sample of 40 adults with functional limitations. The participants completed the PACES, Center for Epidemiological Studies Depression Scale (CES-D), and the Late Life Function and Disability Instrument (LLFDI) prior to beginning a 12-week feasibility dance intervention study. Results indicated reliability as Cronbach's alpha was .95 and mean inter-item correlation was .52. To further support reliability, homogeneity of the instrument was evaluated …

Fluorescence Of Supported Phospholipid Bilayers Recorded In A Conventional Horizontal-Beam Spectrofluorometer, Elizaveta A. Kovrigina, Evgeni L. Kovrigin

Chemistry Faculty Research and Publications

Supported phospholipid bilayers are a convenient model of cellular membranes in studies of membrane biophysics and protein-lipid interactions. Traditionally, supported lipid bilayers are formed on a flat surface of a glass slide to be observed through fluorescence microscopes. This paper describes a method to enable fluorescence detection from the supported lipid bilayers using standard horizontal-beam spectrofluorometers instead of the microscopes. In the proposed approach, the supported lipid bilayers are formed on the inner optical surfaces of the standard fluorescence microcell. To enable observation of the bilayer absorbed on the cell wall, the microcell is placed in a standard fluorometer cell …

Genome Engineering: Drosophila Melanogaster And Beyond, Kjt Venken, A Sarrion-Perdigones, Pj Vandeventer, Ns Abel, Ae Christiansen, Kl Hoffman

Faculty, Staff and Students Publications

A central challenge in investigating biological phenomena is the development of techniques to modify genomic DNA with nucleotide precision that can be transmitted through the germ line. Recent years have brought a boon in these technologies, now collectively known as genome engineering. Defined genomic manipulations at the nucleotide level enable a variety of reverse engineering paradigms, providing new opportunities to interrogate diverse biological functions. These genetic modifications include controlled removal, insertion, and substitution of genetic fragments, both small and large. Small fragments up to a few kilobases (e.g., single nucleotide mutations, small deletions, or gene tagging at single or multiple …

Population Structure, Genetic Diversity, Geographic Distribution, And Morphology Of Two Boechera (Brassicaceae) Parental Species (Boechera Thompsonii And Boechera Formosa) And Of Their Resultant Hybrid Boechera Duchesnensis, Christina Elizabeth Fox Call

Theses and Dissertations

Background: Over the relatively short period of its evolutionary history, Boechera (Brassicaceae) has undergone rapid radiation that has produced 70+ morphologically distinct, sexual diploids. However, reproductive isolation has moved more slowly than morphological divergence in this group and the diploids appear to hybridize frequently where they coexist. Boechera duchesnensis appears to be the result of hybridization between its putative parents Boechera thompsonii and Boechera formosa. Objectives: The objectives of this study are to (i) analyze and document genetic diversity patterns in the population structure, - including allelic and heterozygosity frequencies - of B. thompsonii and B. formosa …

Glyphosate Induces Neurotoxicity In Zebrafish, Nicole M. Roy, Bruno Carneiro, Jeremy Ochs

Biology Faculty Publications

Glyphosate based herbicides (GBH) like Roundup^® are used extensively in agriculture as well as in urban and rural settings as a broad spectrum herbicide. Its mechanism of action was thought to be specific only to plants and thus considered safe and non-toxic. However, mounting evidence suggests that GBHs may not be as safe as once thought as initial studies in frogs suggest that GBHs may be teratogenic. Here we utilize the zebrafish vertebrate model system to study early effects of glyphosate exposure using technical grade glyphosate and the Roundup^® Classic formulation. We find morphological abnormalities including cephalic and …

Marine Disease Impacts, Diagnosis, Forecasting, Management And Policy, Kevin D. Lafferty, Eileen E. Hofmann

CCPO Publications

(First paragraph) As Australians were spending millions of dollars in 2014 to remove the coraleating crown of thorns sea star from the Great Barrier Reef, sea stars started washing up dead for free along North America’s Pacific Coast. Because North American sea stars are important and iconic predators in marine communities, locals and marine scientists alike were alarmed by what proved to be the world’s most widespread marine mass mortality in geographical extent and species affected, especially given its mysterious cause. Investigative research using modern diagnostic techniques implicated a never-before-seen virus [1]. The virus inspired international attention to marine diseases, …

Cognitive Loading, Affect Regulation And Aerodynamic Considerations In Uninhabited Aerial Vehicle Systems Refueling Operations, Sam Holley, Ian R. Mcandrew

Publications

Factors influencing aerodynamics involved in aerial refueling illustrate the potential for specialist operators to manage these operations for remotely piloted vehicles. The authors review aerodynamic characteristics of uninhabited aerial systems during refueling, drogue and boom design and associated flight dynamics, cognitive factors associated with control transfer and refueling, and affective components and their influence on decision making and operator performance. Attention is directed to cognitive loading and encoding challenges, with considerations for hippocampal mapping and hemispheric asymmetry. Implications for system state awareness are examined. Advantages for specially trained refueling pilot operators are discussed and recommendations given for areas of concentration.

A Qualitative Study Of Women’S Attitudes And Experiences Regarding Body Image And Disordered Eating Behaviors, Natalie Ann Kirtley

Theses and Dissertations

The current research study is responding to recent findings wherein, Fischer et al. (2013) report a risk rate based on EAT-26 scores in the range of 9.2% to 10.8% at BYU in comparison to the 15% they found reported in the literature using samples from other college campuses. Risk rates based on BSQ scores were reported in the 27.2% to 31.1% range, which was on par with a risk rate of 28.7% reported at a comparable university (Fischer et al., 2013). Fischer et al. (2013) conclude that while body shape concerns were estimated to be equal to or lower than …

Towards Dimensionality In Psychosis: A Conceptual Analysis Of The Dimensions Of Psychosis Symptom Severity, Jessica Abigail Carmona

Theses and Dissertations

Given the heterogeneity of symptoms allowed in the diagnosis of psychotic disorders, as well as other challenges of categorical diagnosis (e.g., First et al., 2002; Krueger, 1999), the increased specificity brought by dimensional ratings of underlying features is often important. Models using the factorial structure of psychotic symptoms perform as good as or better than traditional categorical models (Allardyce, Suppes, & Van Os, 2007). DSM-5 has provided such a system of ratings to aid clinicians, the Clinician Rated Dimensions of Psychosis Symptom Severity Scale (PSS; APA, 2013). In this approach, the clinician rates symptom severity in eight domains which emphasize …

Usd Magazine Spring 2016, University Of San Diego

University of San Diego Magazine (1992- )

From the President; Torero News; Torero Athletics; Nothing but Net; Men on a Mission; Alumni News; Alumni Update; Class Notes; Torero Trek

Regulating The Trade Of Commercial Surrogacy In India, Izabela Jargilo

Journal of International Business and Law

No abstract provided.

2016 March, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for March of 2016.

Still A New Problem For Defeasibility: A Rejoinder To Borges, John Nicholas Williams

Research Collection School of Social Sciences

I gave a new objection to the defeasibility theory of knowledge, namely that prohibits you from knowing that you know that p if your knowledge that p is a posteriori. Rodrigo Borges claims that Peter Klein has already satisfactorily replied to a version of my objection. He attempts to defend this reply and argues that my objection fails because a principle on which it is based is false. I show that my objection is not a version of the old one that Klein attempts (unsatisfactorily) to address, that Borges’s defence of Klein’s reply fails and that his argument against my …

Sanctions Under The Eu Generalised System Of Preferences And Foreign Policy: Coherence By Accident?, Clara Portela, Jan Orbie

Research Collection School of Social Sciences

This article investigates the relationship between the European Union's withdrawal of trade benefits for developing countries under the Generalised System of Preferences (GSP) and its sanctions under the Common Foreign and Security Policy (CFSP). Our expectation is that GSP withdrawals and CFSP sanctions will not cohere. However, our research reveals that GSP suspension has been coherent with CFSP sanctions when the latter exist prior to the decision-making process on GSP sanctions and when the International Labour Organisation has set up a Commission of Inquiry condemning the country, as with Myanmar/Burma and Belarus. The presence of separate institutional frameworks explains the …

Does Xunzi’S Ethics Of Ritual Need A Metaphysics?, Sor-Hoon Tan

Research Collection School of Social Sciences

Contemporary philosophers working on Chinese Philosophy, Confucianism in particular, disagree about the status of metaphysics in early Confucianism. Some maintain that metaphysics are absent by pointing to the overwhelming emphasis on practical concerns – ethical and political – in the early Confucian texts. Others insist that even if there were no explicit metaphysical discussion or theorizing, metaphysical assumptions are inevitable. However do these assumptions point to one definite metaphysical system, or are they so vague and ambiguous that different mutually incompatible metaphysics could be constructed from them and attributed arbitrarily to the early Confucians? The latter situation would weaken the …

Human Xq28 Inversion Polymorphism: From Sex Linkage To Genomics - A Genetic Mother Lode, Cait S. Kirby, Natalie Kolber, Asmaa M. Salih Almohaidi, Lou Ann Bierwert, Lori Saunders, Steven Williams, Robert Merritt

Biological Sciences: Faculty Publications

An inversion polymorphism of the filamin and emerin genes at the tip of the long arm of the human X-chromosome serves as the basis of an investigative laboratory in which students learn something new about their own genomes. Long, nearly identical inverted repeats flanking the filamin and emerin genes illustrate how repetitive elements can lead to alterations in genome structure (inversions) through nonallelic homologous recombination. The near identity of the inverted repeats is an example of concerted evolution through gene conversion. While the laboratory in its entirety is designed for college level genetics courses, portions of the laboratory are appropriate …

Identification And Characterization Of Serum Biomarkers Associated With Breast Cancer Progression, Adhari Abdullah Alzaabi

Theses and Dissertations

Despite the recognized advances in the treatment of breast cancer, it still accounts for 15% of all cancer-related deaths. 90% of breast cancer deaths are due to unpredicted metastasis. There is neither successful treatment for metastatic patients nor a specific test to predict or detect secondary lesions. Patients with primary tumor will be either over-treated with cytotoxic side effects or under-treated and risk recurrence. This necessitates the need for personalized treatment, which is hard to offer for such heterogeneous disease. Obstacles in treating breast cancer metastasis are mainly due to the gaps exist in the understanding of the molecular mechanism …

Temporal Fluctuations In Seawater Pco2 May Be As Important As Mean Differences When Determining Physiological Sensitivity In Natural Systems, Daniel P. Small, Marco Milazzo, Camilla Bertolini, Helen Graham, Chris Hauton, Jason M. Hall-Spencer, Samuel P.S. Rastrick

School of Biological and Marine Sciences

AbstractMost studies assessing the impacts of ocean acidification (OA) on benthic marine invertebrates have used stable mean pH/pCO2 levels to highlight variation in the physiological sensitivities in a range of taxa. However, many marine environments experience natural fluctuations in carbonate chemistry, and to date little attempt has been made to understand the effect of naturally fluctuating seawater pCO2 (pCO2sw) on the physiological capacity of organisms to maintain acid–base homeostasis. Here, for the first time, we exposed two species of sea urchin with different acid–base tolerances, Paracentrotus lividus and Arbacia lixula, to naturally fluctuating pCO2sw conditions at shallow water CO2 seep …

Russian Orthodox Religious Education Initiatives In Post-Soviet Russia: Update And Commentary, Joseph Loya, Tatiana Kravchuk

Occasional Papers on Religion in Eastern Europe

No abstract provided.

Spectral Pre And Post Processing For Infrared And Raman Spectroscopy Of Biological Tissues And Cells, Hugh Byrne, Peter Knief, Mark Keating, Franck Bonnier

Articles

Vibrational Spectroscopy, both infrared absorption and Raman spectroscopy, have attracted increasing attention for biomedical applications, from in vivo and ex vivo disease diagnostics and screening, to in vitro screening of therapeutics. There remain, however, many challenges related to the accuracy of analysis of physically and chemically inhomogeneous samples, across heterogeneous sample sets. Data preprocessing is required to deal with variations in instrumental responses and intrinsic spectral backgrounds and distortions in order to extract reliable spectral data. Data postprocessing is required to extract the most reliable information from the sample sets, based on often very subtle changes in spectra associated with …

The Research Express, Georgia Southern University

Research & Economic Development

• Grant Award Winners
• 8 Key Questions Considered by Reviewers of Grant Proposals
• U.S. House Supports New Bid to Require a “National Interest” Certification for NSF Grants
• Historical Trends for R&D Funding
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University Honors Program Newsletter, Honors College, Georgia Southern University

Honors College: News & Publications (2008-2020)

• Buffering. . . Re. . . search
• Searching for Blood Substitutes
• Theis Wins First Place
• Shaffer RISEs to the Occasion
• Another Successful Year at Camp
• Project Pura Vida!

1h, 13c And 15n Resonance Assignments And Secondary Structure Analysis Of Translation Initiation Factor 1 From Pseudomonas Aeruginosa, Alejandra Bernal, Yanmei Hu, Stephanie O. Palmer, Aaron Silva, James M. Bullard, Yonghong Zhang

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen and a primary cause of infection in humans. P. aeruginosa can acquire resistance against multiple groups of antimicrobial agents, including β-lactams, aminoglycosides and fluoroquinolones, and multidrug resistance is increasing in this organism which makes treatment of the infections difficult and expensive. This has led to the unmet need for discovery of new compounds distinctly different from present antimicrobials. Protein synthesis is an essential metabolic process and a validated target for the development of new antibiotics. Translation initiation factor 1 from P. aeruginosa (Pa-IF1) is the smallest of the three initiation factors that acts …

Mechanisms Of Methane Transport Through Populus Trichocarpa, Ellynne Marie Kutschera, M. A. K. Khalil, Andrew Rice, Todd Rosenstiel

Physics Faculty Publications and Presentations

Although the dynamics of methane (CH4) emission from croplands and wetlands have been fairly well investigated, the contribution of trees to global CH4 emission and the mechanisms of tree transport are relatively unknown. CH4 emissions from the common wetland tree species Populus trichocarpa (black cottonwood) native to the Pacific Northwest were measured under hydroponic conditions in order to separate plant transport mechanisms from the influence of soil processes. Roots were exposed to CH4 enriched water and canopy emissions of CH4 were measured. The average flux for 34 trials (at temperatures ranging from 17 to 25 °C) was 2.8 ± 2.2 …

Sieve Instrumental Variable Quantile Regression Estimation Of Functional Coefficient Models, Liangjun Su, Tadao Hoshino

Research Collection School Of Economics

In this paper we consider sieve instrumental variable quantile regression (IVQR) estimation of functional coefficient models where the coefficients of endogenous regressors are unknown functions of some exogenous covariates. We estimate the functional coefficients by the sieve-IVQR technique and establish the uniform consistency and asymptotic normality of the estimators. Based on the sieve estimates, we propose a nonparametric specification test for the constancy of the functional coefficients and study its asymptotic. We conduct simulations to evaluate the finite sample behavior of our estimator and test statistic, and apply our method to study the estimation of quantile Engel curves.