Digital Commons Network^™

Cycling State That Can Lead To Glassy Dynamics In Intracellular Transport, Monika Scholtz, Stanislav Burov, Kimberly L. Weirich, Björn J. Scholtz, S.M. Ali Tabei, Margaret L. Gardel, Aaron R. Dinner

Faculty Work

Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observed experimentally. Analysis of the model trajectories, as well as experimental particle tracking data, reveals a state in which motors cycle unproductively at junctions of three or more filaments. We formulate a master equation for these junction dynamics and show that the time required to escape from this vortexlike state can account for the …

Antibody Titers To Bed Bug Salivary Proteins In Chickens From An Infested Broiler Breeder House, J. Goddard, J. S. Portugal, K. Maschek

Midsouth Entomologist

Bed bugs (Hemiptera: Cimicidae) might be significant pests in poultry operations, especially in broiler breeder houses. In this study, chickens in breeder houses, known to be infested with bed bugs, demonstrated antibodies to bed bug salivary gland extract, while those not exposed to bed bugs, did not. Antibody titers ranged from 1:160 to 1:640. These results document for the first time that chickens in commercial production, when exposed to bed bug biting, produce antibody responses to proteins contained in bed bug saliva.

Building A Culture Of Academic Integrity [Baker], Kimberly M. Baker

UNIversitas: Journal of Research, Scholarship, and Creative Activity

The decision to invite keynote speaker James M. Lang to the conference, and the creation of the morning plenary panel in particular, was born out of a book group that Martha Reineke and I participated in on Lang’s book, Cheating Lessons: Learning from Academic Dishonesty (2013). In this book, Lang argues that our best strategies for reducing cheating involve using effective pedagogies that focus on promoting learning. Thus, in contrast to approaches to academic dishonesty that focus on teaching students to fear the consequences of being caught and corresponding surveillance strategies that assume all students are potential cheaters, Lang’s …

Commandant Of Lubizec: Fiction And The Holocaust In The Twilight Of The Survivor Era, Stephen J. Gaies

UNIversitas: Journal of Research, Scholarship, and Creative Activity

Seventy years after the liberation of the camps, Holocaust scholarship remains as vibrant and self-renewing as ever. Important works have been published in recent years; many have helped to shift the spotlight onto topics to which too little attention had been paid. For example, researchers like Omer Bartov, Timothy Snyder and Robert DesBois have focused on the war in the East and mass murder in the western Soviet Union, where some one and a half million Jews were shot by firing squads in what is now often referred to, following DesBois and the title of his book, as the Holocaust …

Visual, Vibratory, And Olfactory Cues Affect Interactions Between The Red Spider Mite Tetranychus Evansi And Its Predator Phytoseiulus Longipes, Ginette Yèyinou Azandémè-Hounmalon, Baldwyn Torto, Komi Kouma Mokpokpo Fiaboe, Sevgan Subramanian, Serge Kreiter, Thibaud Martin

All Peer-Reviewed Publications

Phytoseiulus longipes Evans (Mesostigmata: Phytoseiidae) is an exotic predator widely used in biological control programs for the red spider mite Tetranychus evansi Baker & Pritchard (Acari: Tetranychidae) in East Africa. However, little is known about the cues mediating this prey/predator interaction. Here, we performed behavioral assays to test the involvement of visual, vibratory, and olfactory cues using a combination of dead/living insects enclosed in either perforated or non-perforated transparent/opaque capsules. We monitored insect responses with a video tracking system and analyzed the data with Ethovision software. Our results showed avoidance behavior of T. evansi in the presence of live P. …

A Study On Sanguinarine As An Antileukemic Agent- Involvement Of Reactive Oxygen Species-Ceramide-Akt Apoptotic Signaling Pathway, Anees Rahman Cheratta

Dissertations

Dysregulation of apoptosis is a prime hallmark of leukemia. Therefore, drugs which restore the sensitivity of leukemic cells to apoptotic stimuli are promising candidates in the treatment of leukemia. The main objective of this dissertation was to examine the antileukemic effect of sanguinarine, in vitro, and to further examine the signaling mechanisms that may be involved. This study demonstrates that in human leukemic cells, sanguinarine activates a caspase-dependent apoptotic cell death pathway that is characterized by reactive oxygen species-dependent ceramide generation, and subsequent inhibition of Akt signaling pathway. In addition, sanguinarine also induces reactive oxygen species-dependent glutathione depletion and …

Ws-2 Introgression In A Proportion Of Arabidopsis Thaliana Col-0 Stock Seed Produces Specific Phenotypes And Highlights The Importance Of Routine Genetic Verification, Mon-Ray Shao, Vikas Shedge, Hardik Kundariya, Fredric R. Lehle, Sally Ann Mackenzie

Department of Agronomy and Horticulture: Faculty Publications

Arabidopsis thaliana is an important model organism with a robust network of resources that has been of enormous value to the plant science research community. The use of isogenic material as a reference point or control is critical for many types of experiments in plant molecular biology and genetics. Recently, we noticed that some seed from a common source of the widely used Columbia-0 (Col-0) strain gave rise to plants showing features atypical for this strain. Whole-genome DNA-sequencing and allelespecific PCR assays confirmed that the abnormal individuals contain multiple introgressions from the ecotype Wassilewskija-2 (Ws-2), as described below. This …

App, Cams, And Maps: Engaging Students Through Technology, Sanne Unger, Carrie Simpson

Faculty and Staff Publications & Presentations

No abstract provided.

Flipped Teaching And Learning In English Language Programmes In Higher Education, Rania M Rafik Khalil

English Language and Literature

Flipped teaching over the past fifteen years has invaded the classrooms of schools and has helped evolve the teaching strategy of different disciplines. Although the concept emerged as inverted teaching to allow space for active learning in the classroom, flipped teaching today, has found its way to higher education settings. Higher education institutions such as Harvard University, have used this approach in physics and other disciplines. Literature reviews however, show that there is little research in the field of English as a Foreign Language which can be found related to using the flipped approach. This paper aims to share the …

Explicit Time Deficit In Schizophrenia: Systematic Review And Meta-Analysis Indicate It Is Primary And Not Domain Specific, V Ciullo, G Spalletta, C Caltagirone, Re Jorge, F Piras

Faculty, Staff and Students Publications

Although timing deficits are a robust finding in schizophrenia (SZ), the notion of a genuine time perception disorder in SZ is still being debated because distortions in timing might depend on neuropsychological deficits that are characteristics of the illness. Here we used meta-analytic methods to summarize the evidence of timing deficits in SZ and moderator analyses to determine whether defective timing in SZ arises from nontemporal sources or from defective time perception. PubMed Services, PsycNET, and Scopus were searched through March 2015, and all references in articles were investigated to find other relevant studies. Studies were selected if they included …

Preferential Depletion Of Zinc Within Costa Rica Upwelling Dome Creates Conditions For Zinc Co-Limitation Of Primary Production, P. Dreux Chappell, Jagruti Vedmati, Karen E. Selph, Heather A. Cyr, Bethany D. Jenkins, Michael R. Landry, James W. Moffett

OES Faculty Publications

The Costa Rica Dome (CRD) is a wind-driven feature characterized by high primary production and an unusual cyanobacterial bloom in surface waters. It is not clear whether this bloom arises from top-down or bottom-up processes. Several studies have argued that trace metal geochemistry within the CRD contributes to the composition of the phytoplankton assemblages, since cyanobacteria and eukaryotic phytoplankton have different transition metal requirements. Here, we report that total dissolved zinc (Zn) is significantly depleted relative to phosphate (P) and silicate (Si) within the upper water column of the CRD compared with other oceanic systems, and this may create conditions …

Micro- And Nanoparticulate Cancer Vaccines: A Vision For The Future, Lipika Chablani

Pharmacy Faculty/Staff Publications

In lieu of an abstract, here is the article's first paragraph:

Formulation scientists are constantly challenged with unique opportunities to deliver chemotherapeutic drug molecules to cancer patients. With the growing rate of cancer diagnoses, new therapies are being introduced to pave their way to the market. Along with drug delivery, these formulation approaches are being screened for formulation, design, and development of cancer vaccines. Can a vaccine be formulated to obtain a protective or therapeutic immune response against cancer?

Frequency, Incidence, And Prevalence, Saeed Dastgiri

Saudi Medical Journal

No abstract provided.

Taking A Closer Look At Campus Civic Health: Are We Measuring Dutiful Or Actualized Citizenship On Campus?, Adam Van Liere, Jeremy Arney, Jo Arney

eJournal of Public Affairs

As participants in the Campus and Community Civic Health Initiative, the authors used National Conference on Citizenship (NCoC) measures to gauge civic health on their campus. By embedding their research study in a capstone class, they were able to interview representatives of student organizations, faculty, and campus offices regarding activities in the areas covered by the indicators. These indicators include activities such as volunteering, group membership and participation, using the Internet to educate about community issues, serving as a liaison with the community, to name a few. The study uncovered a strong civic campus culture, but the results were seemingly …

Missouri S&T Magazine Spring 2016, Missouri S&T Marketing And Communications Department, Miner Alumni Association

Missouri S&T Magazine

No abstract provided.

Long-Read Single Molecule Real-Time Full Gene Sequencing Of Cytochrome P450-2d6., Wanqiong Qiao, Yao Yang, Robert Sebra, Geetu Mendiratta, Andrea Gaedigk, Robert J. Desnick, Stuart A. Scott

Manuscripts, Articles, Book Chapters and Other Papers

The cytochrome P450-2D6 (CYP2D6) enzyme metabolizes ∼25% of common medications, yet homologous pseudogenes and copy number variants (CNVs) make interrogating the polymorphic CYP2D6 gene with short-read sequencing challenging. Therefore, we developed a novel long-read, full gene CYP2D6 single molecule real-time (SMRT) sequencing method using the Pacific Biosciences platform. Long-range PCR and CYP2D6 SMRT sequencing of 10 previously genotyped controls identified expected star (*) alleles, but also enabled suballele resolution, diplotype refinement, and discovery of novel alleles. Coupled with an optimized variant-calling pipeline, CYP2D6 SMRT sequencing was highly reproducible as triplicate intra- and inter-run nonreference genotype results were completely concordant. Importantly, …

Multiple Behavior Change Intervention To Improve Detection Of Unmet Social Needs And Resulting Resource Referrals., Jeffrey D. Colvin, Jessica L. Bettenhausen, Kaston D. Anderson-Carpenter, Vicki Collie-Akers, Laura Plencner, Molly Krager, Brooke Nelson, Sara Donnelly, Julia Simmons, Valeria Higinio, Paul J. Chung

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: It is critical that pediatric residents learn to effectively screen families for active and addressable social needs (ie, negative social determinants of health). We sought to determine 1) whether a brief intervention teaching residents about IHELP, a social needs screening tool, could improve resident screening, and 2) how accurately IHELP could detect needs in the inpatient setting.

METHODS: During an 18-month period, interns rotating on 1 of 2 otherwise identical inpatient general pediatrics teams were trained in IHELP. Interns on the other team served as the comparison group. Every admission history and physical examination (H&P) was reviewed for IHELP …

Caregiver Opinion Of In-Hospital Screening For Unmet Social Needs By Pediatric Residents., Jeffrey D. Colvin, Jessica L. Bettenhausen, Kaston D. Anderson-Carpenter, Vicki Collie-Akers, Paul J. Chung

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Child health is strongly influenced by social determinants. Little is known about the opinions of primary caregivers regarding the physicians' role in addressing social needs. Our objective was to examine caregivers' opinions about that role and any associations between those opinions, previous exposure to screening for needs by pediatric residents, and socioeconomic status (SES).

METHODS: Cross-sectional survey study of caregivers of hospitalized children. The survey collected information on caregiver opinion regarding their ability to ask physicians for help with social needs, whether physicians know how to help with those needs, and whether physicians should ask about social needs. The …

Cd33 Expression And Its Association With Gemtuzumab Ozogamicin Response: Results From The Randomized Phase Iii Children's Oncology Group Trial Aaml0531., Jessica A. Pollard, Michael Loken, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Richard Aplenc, Irwin D. Bernstein, Alan S. Gamis, Todd A. Alonzo, Soheil Meshinchi

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: CD33 is variably expressed on acute myeloid leukemia (AML) blasts and is targeted by gemtuzumab ozogamicin (GO). GO has shown benefit in both adult and pediatric AML trials, yet limited data exist about whether GO response correlates with CD33 expression level.

PATIENTS AND METHODS: CD33 expression levels were prospectively quantified by multidimensional flow cytometry in 825 patients enrolled in Children's Oncology Group AAML0531 and correlated with response to GO.

RESULTS: Patients with low CD33 expression (lowest quartile of expression [Q1]) had no benefit with the addition of GO to conventional chemotherapy (relapse risk [RR]: GO 36% v No-GO 34%, …

Instrumented Lumbar Corpectomy And Spinal Reconstruction Comparing Rhbmp-2/Compression-Resistant Matrix, Rhbmp-2/Absorbable Collagen Sponge/Ceramic Granules Mixture, And Autograft In Two Different Devices: A Study In Sheep, Jeffrey M. Toth, David G. Schwartz, Jean-Piere Mobasser, Joseph Williams

Biomedical Engineering Faculty Research and Publications

Study Design. Fusion success with rhBMP-2 and autograft in titanium or PEEK corpectomy devices was evaluated in a sheep lumbar corpectomy model. The 6 treatment groups included titanium mesh or PEEK corpectomy devices filled with rhBMP-2 on a compression-resistant matrix (CRM) carrier; rhBMP-2 in a morselized absorbable collagen sponge (ACS) carrier combined with resorbable ceramic granules; and autograft.

Objective. The aim of this study was to determine fusion rates associated with 2 different preparations of rhBMP-2 as well as autograft in an instrumented ovine lumbar corpectomy model 6 months postoperatively.

Summary of Background Data. Vertebral reconstruction with corpectomy devices requires …

A Measurement Of Historical And Contemporary Functional Diversity On The Monahan Reclaimed Grassland, Jacob A. Heil

Electronic Theses & Dissertations

In 1984 a portion of the Monahan, a PSU Biology field site, was reclaimed to establish a native grassland community and to prevent runoff of acidic groundwater. In the years since then, several student projects have analyzed the vegetation community on the site, estimating the biodiversity found there. In this study, conducted in 2014, the biodiversity of the Monahan was measured using four indices of functional diversity. Functional diversity describes the variety of ecological functions in a community; functional diversity indices measure and describe these functions instead of individual species. Results from two past graduate theses were compared to the …

Excessive Interatrial Adiposity Is Associated With Left Atrial Remodeling, Augmented Contractile Performance In Asymptomatic Population, Ricardo Cury

All Publications

PURPOSE:

Pericardial adipose tissue had been shown to exert local effects on adjacent cardiac structures. Data regarding the mechanistic link between such measures and left atrial (LA) structural/functional remodeling, a clinical hallmark of early stage heart failure (HF) and atrial fibrillation (AF) incidence, in asymptomatic population remain largely unexplored.

METHODS:

This retrospective analysis includes 356 subjects free from significant valvular disorders, atrial fibrillation, or clinical HF. Regional adipose tissue including pericardial and periaortic fat volumes, interatrial septal (IAS), and left atrioventricular groove (AVG) fat thickness were all measured by multidetector computed tomography (MDCT) (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, …

Sleep In The Context Of Healthy Aging And Psychiatric Syndromes, Daniel Kay, Joseph M. Dzierzewski

Faculty Publications

Humans spend approximately 1/3 of their lives asleep. Whether due to evolutionary or ontogenetic factors, sleep and psychiatric disorders change with age. While much of sleep remains an enigma, the field of sleep research is experiencing an exponential increase in its understanding of the causes, correlates, and consequences of sleep disturbances. Although the relationship between age-related sleep and psychiatric conditions is a common clinical observation, empirical investigations into these associations remain scarce. Thus, treating patients with symptoms of sleep disorders in the context of psychiatric conditions remains a major challenge. This chapter reviews the state-of-the-science of sleep disorders in the …

Student-Conducted Farmer Video Interviews, Jenn K. Simons, Justin Van Wart, Charles Francis, Kristyn Harms

Department of Agronomy and Horticulture: Faculty Publications

High school agricultural education teachers have expressed concern about the lack of easily accessible educational materials dealing with contemporary topics in sustainable agriculture. There are numerous textbooks and monographs available for farmers and students at the college level, including the highly practical resources available from the Sustainable Agriculture Research and Education (SARE) book series on soil fertility (Magdoff and van Es, 2010), cover crops (Bowman et al., 2007) and building a farm business (DiGiacomo et al., 2003), among others. Although these are full of color photos and easily accessible graphs and tables, they are still in the print media category. …

Significance Of Tumor Marker Ca15-3 In Metastatic Breast Cancer, Hoor Fatima, Amir Maqbool, Marium Siddiqui, Ghulam H, Habiba Sohail, Omema Saleem, Afarina Ahmed

Department of Medicine

Secondary spread of cancer to bones is commonest and frequent phenomenon and enhances the need of special care for sufferers. Bone metastases mostly are the first complication of different variety of cancers which increase the need of care and expensive facilities. Blood dissemination is another common route, might be due to the venous drainage from visceral organs directly into the axial bones. CA 15-3 is a mucinous tumor markers derived from MUC1 gene, provides better guide line about the treatment, recurrence and prognosis.

Aim: Aim of the study was to signify the role of tumor marker CA15-3 in metastatic breast …

Occupational Health Of Self-Employed Skilled Labourers And Daily-Wage Workers In Pakistan., Noor Ul-Ain Baloch, Abdul Rehman Alvi, Muhammad Awais

Department of Surgery Docs

No abstract provided.

Learning To Find Topic Experts In Twitter Via Different Relations, Wei Wei, Gao Cong, Chunyan Miao, Feida Zhu, Guohui Li

Research Collection School Of Computing and Information Systems

Expert finding has become a hot topic along with the flourishing of social networks, such as micro-blogging services like Twitter. Finding experts in Twitter is an important problem because tweets from experts are valuable sources that carry rich information (e.g., trends) in various domains. However, previous methods cannot be directly applied to Twitter expert finding problem. Recently, several attempts use the relations among users and Twitter Lists for expert finding. Nevertheless, these approaches only partially utilize such relations. To this end, we develop a probabilistic method to jointly exploit three types of relations (i.e., follower relation, user-list relation and list-list …

History Driven Program Repair, Xuan-Bach D. Le, David Lo, Claire Le Goues

Research Collection School Of Computing and Information Systems

Effective automated program repair techniques have great potential to reduce the costs of debugging and maintenance. Previously proposed automated program repair (APR) techniques often follow a generate-and-validate and test- case-driven procedure: They first randomly generate a large pool of fix candidates and then exhaustively validate the quality of the candidates by testing them against existing or provided test suites. Unfortunately, many real-world bugs cannot be repaired by existing techniques even after more than 12 hours of computation in a multi-core cloud environment. More work is needed to advance the capabilities of modern APR techniques. We propose a new technique that …

Golding's The Spire As An Architectonic Novel, Stephan Schaffrath

CLCWeb: Comparative Literature and Culture

In his article "Golding's The Spire as an Architectonic Novel" Stephan Schaffrath analyzes William Golding's work as an excellent example of one of Mikhail Bakhtin's early critical concepts. In contrast to most literary entertainment which thrives on the readers' suspension of disbelief, The Spire challenges readers to actively and consciously interpret its text, thus raising readers' awareness as participants in the reading act. The Spire achieves this by presenting readers with a novelistic world seen more or less through the eyes of a pseudo narrator, a third-person narration style that consistently and regularly — yet subtly — delves into the …

Proceedings Of The 2015 Asian American/Pacific Islander Nurses Association Conference: Biological Measures: A Role In Nursing Self-Management Research, Asian American Pacific Islander Nurses Association

Asian/Pacific Island Nursing Journal

N/A