Digital Commons Network^™

Identification Of Plant Extracts That Inhibit The Formation Of Diabetes-Linked Iapp Amyloid, Ana Lucia Fuentes, Kathleen Hennessy, Jacob Pascual, Nicole Pepe, In Wang, Cynthia Chaggan, Jessica Martinez, Evelyn Rivera, Paola Cota, Christina Cunha, Luiza A. Nogaj, David A. Moffet

Chemistry and Biochemistry Faculty Works

The extracts of 27 vegetables, spices and herbs were screened for their functional ability to inhibit the aggregation of islet amyloid polypeptide (IAPP, amylin) into toxic amyloid aggregates. The aggregation of IAPP has been directly linked to the death of pancreatic β-islet cells in type 2 diabetes. Inhibiting the aggregation of IAPP is believed to have the potential to slow, if not prevent entirely, the progression of this disease. As vegetables, spices and herbs are known to possess many different positive health effects, the extracts of 27 plants (abundant within the United States and spanning several plant families) were screened …

Retigabine Holds Kv7 Channels Open And Stabilizes The Resting Potential, Aaron Corbin-Leftwich, Sayeed M. Mossadeq, Junghoon Ha, Iwona Ruchala, Audrey Han Ngoc Le, Carlos A. Villalba-Galea

School of Pharmacy Faculty Articles

The anticonvulsant Retigabine is a KV7 channel agonist used to treat hyperexcitability disorders in humans. Retigabine shifts the voltage dependence for activation of the heteromeric KV7.2/KV7.3 channel to more negative potentials, thus facilitating activation. Although the molecular mechanism underlying Retigabine's action remains unknown, previous studies have identified the pore region of KV7 channels as the drug's target. This suggested that the Retigabine-induced shift in voltage dependence likely derives from the stabilization of the pore domain in an open (conducting) conformation. Testing this idea, we show that the heteromeric KV7.2/KV7.3 channel has at least two open states, which we named O1 …

The Subject Librarian Newsletter, Biology, Spring 2016, Patti Mccall

Libraries' Newsletters

No abstract provided.

Research Highlights: (January – March 2016), Reteka Sexena

Indian Journal of Research in Homoeopathy

No abstract provided.

Table Of Contents, Editorial Board, Law School Faculty And Administration, University Of Nevada, Las Vegas -- William S. Boyd School Of Law

Nevada Law Journal

No abstract provided.

Biology, Genetics, Nurture, And The Law: The Expansion Of The Legal Definition Of Family To Include Three Or More Parents, Myrisha S. Lewis

Nevada Law Journal

No abstract provided.

Liver And Other Gastrointestinal Cancers Are Frequent In Mexican Americans, Ariana L. Garza, Kristina Vatcheva, Jen-Jung Pan, Mohammad H. Rahbar, Michael Fallon, Joseph B. Mccormick, Susan P. Fisher-Hoch

School of Mathematical & Statistical Sciences Faculty Publications

Background

Disease patterns in Mexican-American health-disparity populations differ from larger United States populations.

Aims

Determine frequency of gastrointestinal cancers in Mexican Americans.

Methods

We analyzed self-reported data from the Cameron County Hispanic Cohort where we find high rates of risk factors for cancer: obesity (48.5%), diabetes (30.7%). Participants provided cancer histories about themselves and first and second degree relatives. Logistic regression models assessed risk factors. Frequencies of cancer sites were ranked and validated using concurrent age local cancer registry data.

Results

Among 9,249 individuals (participants and their relatives) there were 1,184 individuals with reports of cancer. Among cohort participants under …

Identification Of An Association Of Tnfaip3 Polymorphisms With Matrix Metalloproteinase Expression In Fibroblasts In An Integrative Study Of Systemic Sclerosis-Associated Genetic And Environmental Factors*, Peng Wei, Yang Yang, Xinjian Guo, Nainan Hei, Syeling Lai, Shervin Assassi, Mengyuan Liu, Filemon Tan, Xiaodong Zhou

Faculty, Staff and Students Publications

OBJECTIVE: Systemic sclerosis (SSc) is a fibrotic disease attributed to both genetic susceptibility and environmental factors. This study was undertaken to investigate the associations between SSc-associated genetic variants and the expression of extracellular matrix (ECM) genes in human fibroblasts stimulated with silica particles in time-course and dose-response experiments.

METHODS: A total of 200 fibroblast strains were examined for ECM gene expression after stimulation with silica particles. The fibroblasts were genetically profiled using Immunochip assays and then subjected to whole-genome genotype imputation. Associations of genotypes and gene expression were first analyzed in a Caucasian cohort and then validated in a meta-analysis …

March 2016 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

14-3-3Ζ Regulation Of Metastasis Through Mediation Of Liprin-Α And Liprin-Β, Rachel Hynes

Theses and Dissertations

Cancer is a set of varied and diverse diseases that share common characteristics, such as active proliferation, increased replicative potential, and tissue invasion or metastasis. One protein, 14-3-3ζ, is shown to be upregulated in a number of different cancers and also correlates with poor patient prognosis, recurrence, and mortality. This protein comes from a family of adapter proteins known for their scaffolding ability, pro- and anti-oncogenic capabilities, and affinity for phosphorylated substrates. It has been shown previously to participate in cancer progression, subversion of apoptosis, and to increase chemoresistance. Herein we will discuss the ability of 14-3-3ζ to promote distant-site …

Polymer Coated Urea In Kentucky Bluegrass, Jessica Chelise Buss

Theses and Dissertations

Nitrogen (N) is the most commonly over-applied nutrient in urban environments because of the large visual and growth increases. This over-application has led to an increase in the loss of N gas in the forms of ammonia and nitrous oxide, as well as an increase in nitrate leaching to surface and groundwater. Furthermore, excess N results in increased maintenance costs and landfill volume due to increased shoot growth from mowed clipping removal. Polymer coated urea (PCU) has proven to be an excellent source to these losses of N to the environment, but rate and timing parameters need study. A two-year …

Constitutional Lawyers And The Inter-American Court’S Varied Authority, Alexandra Huneeus

Law and Contemporary Problems

No abstract provided.

Cryptosporidium Parvum: Is It Invincible?, Caitlin Wonnacott

Midsouth Entomologist

Cryptosporidium is a coccidian protozoan parasite that can affect mammals, reptiles, and birds. A coccidian is a single-celled protozoan that affects the epithelial lining of the intestinal walls of hosts it parasitizes. This parasite has a unique life cycle and can withstand common measures of sterilization. The infective oocyte stage is resistant and hardy. It takes on two forms where each goes to different places within the host. Contamination of water sources has led to large outbreaks of cryptosporidiosis, even though the water met and passed the standards for drinking water. Conclusions from previous studies will help lead the way …

What Is Leishmaniasis?, Kimberly Wilson

Midsouth Entomologist

Leishmaniasis is a parasitic disease that can cause painful sores to cover one's body. It is found in parts of the tropics, subtropics, and southern Europe. Leishmaniasis is caused by infection with a complex of protozoan organisms, Leishmania spp, which are spread by the bite of infected phlebotomine sand flies (Diptera: Psychodidae). There are several different forms of leishmaniasis in people. The most common are cutaneous and visceral. The cutaneous type causes skin sores. The visceral type affects internal organs like the spleen, liver, and sometimes bone marrow.

Hacking Discovery For Better Ux, Edward Corrado, Frierson Eric, Athena Hoeppner

Faculty Scholarship and Creative Works

No abstract provided.

Analysis Of Tumor Template From Multiple Compartments In A Blood Sample Provides Complementary Access To Peripheral Tumor Biomarkers., William M Strauss, Chris Carter, Jill Simmons, Erich Klem, Nathan Goodman, Behrad Vahidi, Juan Romero, Michael Masterman-Smith, Ruth O'Regan, Keerthi Gogineni, Lee Schwartzberg, Laura Austin, Paul W Dempsey, Massimo Cristofanilli

Kimmel Cancer Center Faculty Papers

Targeted cancer therapeutics are promised to have a major impact on cancer treatment and survival. Successful application of these novel treatments requires a molecular definition of a patient's disease typically achieved through the use of tissue biopsies. Alternatively, allowing longitudinal monitoring, biomarkers derived from blood, isolated either from circulating tumor cell derived DNA (ctcDNA) or circulating cell-free tumor DNA (ccfDNA) may be evaluated. In order to use blood derived templates for mutational profiling in clinical decisions, it is essential to understand the different template qualities and how they compare to biopsy derived template DNA as both blood-based templates are rare …

A Systems Approach To Animal Communication, Eileen A. Hebets, Andrew B. Barron, Christopher N. Balakrishnan, Mark E. Hauber, Paul H. Mason, Kim L. Hoke

Eileen Hebets Publications

Why animal communication displays are so complex and how they have evolved are active foci of research with a long and rich history. Progress towards an evolutionary analysis of signal complexity, however, has been constrained by a lack of hypotheses to explain similarities and/or differences in signalling systems across taxa. To address this, we advocate incorporating a systems approach into studies of animal communication—an approach that includes comprehensive experimental designs and data collection in combination with the implementation of systems concepts and tools. A systems approach evaluates overall display architecture, including how components interact to alter function, and how function …

Comparison Of Clinical And Sociodemographic Features Of Bipolar Disorder Patients With Those Of Social Anxiety Disorder Patients Comorbid With Bipolar Disorder In Turkey, Tonguç D. Berkol, Ebru Kırlı, Serkan Islam, Rasim Pınarbaşı, İlker Özyıldırım

Saudi Medical Journal

Objectives: To assess the impact of social anxiety disorder (SAD) comorbidity on the clinical features, illness severity, and response to mood stabilizers in bipolar disorder (BD) patients. Methods: This retrospective study included bipolar patients that were treated at the Department of Psychiatry, Haseki Training and Research Hospital, Istanbul, Turkey in 2015, and who provided their informed consents for participation in this study. The study was conducted by assessing patient files retrospectively. Two hundred bipolar patients were assessed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition axis-I (SCID-I) in order to detect all possible …

Book Reviews, Usawc Press

The US Army War College Quarterly: Parameters

No abstract provided.

Fluid Flow Characterization In Rapid Prototyped Common Iliac Artery Aneurysm Molds, Daniel Cole Greinke

Master's Theses

The goal of this project was to determine whether i) fused deposition modeling could be employed to manufacture molds for vascular constructs, ii) whether vascular constructs could be created from these molds, and iii) to verify practical equivalence between observed fluid velocities. Dye tracking was to be employed to characterize fluid velocity profiles through the in vitro vascular constructs, including a half-vessel model and a full vessel model of an iliac artery aneurysm. A PDMS half-vessel construct was manufactured, and the movement of dye through the construct was tracked by a cellphone camera. Thresholds were applied to each video in …

Arsenic Analysis: Comparative Arsenic Groundwater Concentration In Relation To Soil And Vegetation, Rominna E. Valentine Vecorena

Electronic Theses, Projects, and Dissertations

Arsenic (As) is a toxic semi-metallic element found in groundwater, soils, and plants. Natural and anthropogenic sources contribute to the distribution of arsenic in the environment. Arsenic’s toxic and mobile behavior is associated with its speciation ability. There are two types of arsenic available to the environment, inorganic and organic arsenic. Of the two, inorganic arsenic is more toxic to humans and more mobile in the environment. Two inorganic compounds responsible for arsenic contamination are trivalent arsenite, As (III), and pentavalent arsenate, As (V). Trivalent arsenate is considered to be more soluble, toxic, and mobile than pentavalent arsenate. Arsenic’s absorptive …

Role Of Heme Oxygenase-1 In The Pathogenesis And Tumorigenicity Of Kaposi's Sarcoma-Associated Herpesvirus, Lu Dai, Jing Qiao, David Nguyen, Amanda P. Struckhoff, Lisa Doyle, Karlie Bonstaff, Luis Del Valle, Chris Parsons, Bryan P. Toole, Rolf Renne, Zhiqiang Qin

School of Medicine Faculty Publications

Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several malignancies, including Kaposi's Sarcoma (KS), which preferentially arise in immunocompromised patients such as HIV+ subpopulation and lack effective therapeutic options. Heme oxygenase-1 (HO-1) has been reported as an important regulator of endothelial cell cycle control, proliferation and angiogenesis. HO-1 has also been found to be highly expressed in KSHV-infected endothelial cells and oral AIDS-KS lesions. We previously demonstrate that the multifunctional glycoprotein CD147 is required for KSHV/LANA-induced endothelial cell invasiveness. During the identification of CD147 controlled downstream genes by microarray analysis, we found that the expression of HO-1 is significantly …

Mapping Of Defects In Individual Silicon Nanocrystals Using Real- Space Spectroscopy, Dmitry A. Kislitsyn, Vancho Kocevski, Jon M. Mills, Sheng-Kuei Chiu, Christian F. Gervasi, Benjamen N. Taber, Ariel E. Rosenfield, Olle Eriksson, Ján Rusz, Andrea Mitchell Goforth, George V. Nazin

Chemistry Faculty Publications and Presentations

The photophysical properties of silicon semiconductor nanocrystals (SiNCs) are extremely sensitive to the presence of surface chemical defects, many of which are easily produced by oxidation under ambient conditions. The diversity of chemical structures of such defects and the lack of tools capable of probing individual defects continue to impede understanding of the roles of these defects in SiNC photophysics. We use scanning tunneling spectroscopy to study the impact of surface defects on the electronic structures of hydrogen-passivated SiNCs supported on the Au(111) surface. Spatial maps of the local electronic density of states (LDOS) produced by our measurements allowed us …

Remaking Selves, Repositioning Selves, Or Remaking Space: An Examination Of Asian American College Students' Processes Of "Belonging", Michelle Samura

Education Faculty Articles and Research

"Only a few studies have examined Asian American students’ sense of belonging (Hsia, 1988; Lee & Davis, 2000; Museus & Maramba, 2010). Scholars who study Asian American college students have suggested that Asian Americans are awkwardly positioned as separate from other students of color vis-à-vis the model minority stereotype (Hsia, 1988; Lee & Davis, 2000). Furthermore, Asian Americans often are viewed as overrepresented on college campuses, yet they remain under-served by campus support programs and resources and overlooked by researchers. Many Asian Americans have gained access to higher education, but the ways in which they belong on campuses is unclear. …

Art From The Macchiaioli To The Futurists: Idealized Masculinity In The Art Of Signorini And Balla, Melissa Ann Bush

Theses and Dissertations

Beginning around 1850, Italians found themselves in the midst of an identity crisis. Europeans in France and England had surpassed Italians in terms of political, economic, and social progress. Italians seemed trapped in the past, clinging to their magnificent artistic heritage. However, new cultural and social movements were on the rise in Italy that attempted to throw off the domination of other European entities and forge a promising future for Italy. The Macchiaioli, a group of Italian modern artists who painted from 1853 to 1908, were the first group to address contemporary social issues such as class struggle and national …

Examining The Link Between Exercise And Marital Arguments In Clinical Couples, Bailey Alexandra Selland

Theses and Dissertations

This study examines the following research question: Are couples that exercise on a given day more likely to experience fewer and less intense arguments in their relationship that day? Other variables examined include relationship effect, stress level, and argument topics. Participants were 36 couples in a treatment-as-usual setting who completed the Daily Diary of Events in Couple Therapy (DDECT). Results suggested that female hours of exercise were significantly related to increased report of relationship argument intensity for both men and women. Male hours of exercise were not significantly related to any variables, however male daily stress was significantly related to …

How Important Is A Postdoc For A Teaching Career?, Amy Cheng Vollmer, V. Balke, C. Frantz, T. E. Hanson

Biology Faculty Works

No abstract provided.

Genetic Structure Of Micromeria (Lamiaceae) In Tenerife, The Imprint Of Geological History And Hybridization On Within-Island Diversification, Pamela Puppo, Manuel Curto, Harald Meimberg

Biological Sciences Faculty Research

Geological history of oceanic islands can have a profound effect on the evolutionary history of insular flora, especially in complex islands such as Tenerife in the Canary Islands. Tenerife results from the secondary connection of three paleo-islands by a central volcano, and other geological events that further shaped it. This geological history has been shown to influence the phylogenetic history of several taxa, including genus Micromeria (Lamiaceae). Screening 15 microsatellite markers in 289 individuals representing the eight species of Micromeria present in Tenerife, this study aims to assess the genetic diversity and structure of these species and its relation with …

Assessing And Responding To Substance Misuse In Law Enforcement, Ted R. Miller, Deborah M. Galvin

Southern Illinois University Law Journal

Law enforcement personnel face the challenge of misuse of alcohol, illegal drugs, and prescription drugs.  Police officers may themselves misuse substances, and they may be aware of misuse among their family members or colleagues.  This paper assesses the extent of substance misuse among law enforcement personnel and provides lessons about how to structure effective prevention programs. Lessons are drawn from programs supported by Substance Abuse and Mental Health Services Administration (SAMHSA) cooperative agreements.  Successful implementation of prevention programs requires support from top management; an understanding of workplace culture; awareness of substance use attitudes and patterns of employees, management, and union …

Equilibrium Circulation And Stress Distribution In Viscoelastic Creeping Flow, Joseph A. Biello, Becca Thomases

Mathematics Sciences: Faculty Publications

An analytic, asymptotic approximation of the nonlinear steady-state equations for viscoelastic creeping flow, modeled by the Oldroyd-B equations with polymer stress diffusion, is derived. Near the extensional stagnation point the flow stretches and aligns polymers along the outgoing streamlines of the stagnation point resulting in a stress-island, or birefringent strand. The polymer stress diffusion coefficient is used, both as an asymptotic parameter and a regularization parameter. The structure of the singular part of the polymer stress tensor is a Gaussian aligned with the incoming streamline of the stagnation point a smoothed δ-distribution whose width is proportional to the square-root of …