Digital Commons Network^™

The Characterization Of A Putative Perilipin-5 Splice Variant, Cara C. Hardy

Undergraduate Honors Thesis Projects

Lipid droplets, or LDs, are very important and dynamic organelles in cells. LDs are stores

of fat for use in metabolism, membrane construction, and signaling. Dysfunction of lipid droplet formation or breakdown can lead to many health risks, such as atherosclerosis and diabetes. Lipid droplet regulation occurs primarily via a dynamic and complex coat of proteins on the surface of the droplet. This work sought to characterize a novel variant, or new protein, derived from the sequence of the parent chain of perilipin-5, which we have termed perilipin-5B. Perilipin-5 is a member of the perilipin family of lipid droplet coat …

Message From The Faculty Editor, Mary Savin

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Instructions For Authors, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Toward A More Inclusive Community: The Legacy Of Female Reformers In The Progressive State, Carol Nackenoff

Political Science Faculty Works

No abstract provided.

“‘Tis The Time’S Plague When Madmen Lead The Blind”: How The Irs Can Prevent Pyramid-Scheme Formation (And Why It Should), James Walsh

Case Western Reserve Law Review

No abstract provided.

Yale Medicine : Alumni Bulletin Of The School Of Medicine, Winter 2016, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Winter 2016 issue of Yale Medicine: alumni bulletin of the School of Medicine, v. 50, no. 2. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965).

Comorbidities Of Skin Disease In The Homeless And Medical Students Perspectives, Matthew David Coffman

Yale Medicine Thesis Digital Library

The homeless population is at increased risk for skin disease. Exposure to the elements and lack of access to medical care contribute to the problem. To date there have been few studies analyzing the medical comorbidities that put homeless patients at increased risk for skin disease. The aim of this study is to discover what medical conditions are associated with skin disease to allow physicians to better screen their homeless patients for skin disease. The secondary aim of this study is to determine whether medical students are being adequately trained to recognize medical conditions associated with skin disease. Data from …

Reentering Survivors: Invisible At The Intersection Of The Criminal Legal System And The Domestic Violence Movement, Courtney Cross

Scholarly Works

Like all returning citizens, women coming home after incarceration face significant challenges to successful reentry. In addition to the collateral consequences of their criminal convictions, reentering women also encounter uniquely gendered obstacles. This Article explores one such obstacle: the relationship between women's reentry and domestic violence. Women on probation or parole who are also experiencing domestic violence too often fall into a blind spot in which the structure of community supervision pressures them to remain in unsafe homes and also punishes them when the abuse they endure interferes with their ability to comply with the conditions of their release. Because …

Reconciling The Premium Tax Credit: Painful Complications For Lower And Middle-Income Taxpayers, Francine J. Lipman, James E. Williamson

Scholarly Works

The Patient Protection and Affordable Care Act (ACA) makes available to certain middle and lower-income individuals a refundable tax credit, the Premium Tax Credit (PTC), designed to help them pay the premiums on their qualified health care plans. To achieve Congress’s goal of making health insurance affordable, the PTC is most often provided directly to an individual’s insurance provider each month in advance of actually claiming the PTC on the individual’s year-end annual tax return. Of the almost twelve million individuals who have enrolled in health insurance through the federal and state health exchanges in 2015, 85% of these individuals …

Off-Label Drug Marketing, The First Amendment, And Federalism, David Orentlicher

Scholarly Works

In this article, Professor Orentlicher explores free speech and federalism issues arising from FDA regulation of off-label uses and off-label marketing of drugs. In light of the FDA's desire to respect state government authority, together with other considerations discussed in this article, he argues for the rejection of the analysis of the Caronia court and to give the FDA significant leeway in its regulation of off-label marketing.

Controlling Health Care Spending: More Patient "Skin In The Game?", David Orentlicher

Scholarly Works

In this article, Professor Orentlicher explores the high cost of healthcare and the trend in health insurance to shift the cost of health care to patients in an attempt to influence their behavior and health decisions. He examines such strategies as reference pricing, scaled cost-sharing, and employee wellness programs.

Effects Of Nox-1 Inhibition On Real-Time Blood Nitric Oxide And Hydrogen Peroxide In Acute Hyperglycemia, Ashley Mawhinney

PCOM Biomedical Studies Student Scholarship

Hyperglycemia has been associated with vascular endothelial dysfunction in part by a reduction in nitric oxide (NO) production and increased oxidative stress (e.g., increased superoxide (SO) and hydrogen peroxide (H₂O₂). Endothelial-derived NO can be significantly reduced by increased SO/H₂O₂ in part by the activation of NADPH oxidase during hyperglycemia. Of the 7 NADPH oxidase isoforms, NADPH oxidase isoform 1 (NOX1) is mainly expressed in the vasculature and may play a major role in hyperglycemia induced oxidative stress and vascular endothelial dysfunction. This hypothesis was tested by measuring blood NO and H2O2 levels in …

A Tale Of Two Cases, Paul J. Larkin Jr.

Washington and Lee Law Review

No abstract provided.

Microbial Mat Communities Along An Oxygen Gradient In A Perennially Ice-Covered Antarctic Lake, Anne D. Jungblut, Ian Hawes, Tyler J. Mackey, Megan Krusor, Peter T. Doran, Dawn Y. Sumner, Jonathan A. Eisen, Colin Hillman, Alexander K. Goroncy

Faculty Publications

© 2016, American Society for Microbiology. Lake Fryxell is a perennially ice-covered lake in the McMurdo Dry Valleys, Antarctica, with a sharp oxycline in a water column that is density stabilized by a gradient in salt concentration. Dissolved oxygen falls from 20 mg liter-1 to undetectable over one vertical meter from 8.9-to 9.9-m depth. We provide the first description of the benthic mat community that falls within this oxygen gradient on the sloping floor of the lake, using a combination of micro- and macroscopic morphological descriptions, pigment analysis, and 16S rRNA gene bacterial community analysis. Our work focused on three …

Evidence And Evidence Gaps In Adolescent Health, George Patton, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

The momentum to bring adolescents and young adults to center stage in global health and international development is palpable. Adolescents are increasingly seen as a crucial group for the success of the newly adopted Agenda for Sustainable Development [1]. Sitting within the Agenda for Sustainable Development framework, the 2030 Global Strategy for Women's, Children's and Adolescents' Health has extended the Every Woman, Every Child agenda to adolescence [2]. The strategy articulates the need for adolescent responsive health systems as well as social determinants, a focus that extends to legal and policy environments [3]. Countries seeking to adopt this more holistic …

The Effectiveness Of A Group Motor Skill Intervention Program In Children With Developmental Coordination Disorder: Program Frequency Matters., Priscila M. Caçola, Melvin Ibana, Michael Romero, Jennifer Chuang

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to investigate the effects of two group programs on visual-motor integration, motor proficiency, gross-motor skills, and parental perception of motor difficulties in children with developmental coordination disorder (DCD). We compared whether the frequency of two programs (10 one hour sessions - once/week for 10 weeks verses 24 one hour sessions – twice/week for 12 weeks) produced different changes in motor skills. Methods: Children in the two programs were assessed before and after each program with the MABC-2, DCD-Q, BOT-2, Beery-VMI-6, and the TGMD-2 assessments. The emphasis of the programs was on group activities …

Evaluation Of The Efficacy Of Candidate Probiotics For Disease Prevention In Shellfish Hatcheries, Saebom Sohn

Open Access Dissertations

In the United States of America, oyster production is an important component of the seafood economy in many communities in coastal states. The severe impact of disease outbreaks and mass mortality of oyster larvae in hatcheries impacts production, since the oyster industry is largely dependent on hatchery and nursery production. The use of probiotics has been proposed as a potential preventative measure to limit the impact of bacterial diseases in shellfish hatcheries. In previous laboratory studies, the probiotic bacteria Phaeobacter inhibens S4 and Bacillus pumillus RI06-95 improved the survival of eastern oyster (Crassostrea virginica) larvae against the pathogens …

The Potential Of Indonesian Microalgal Strains To Support Eastern White Shrimp (Litopenaeus Vannamei) Aquaculture, Wa Iba

Open Access Dissertations

Indonesia is well known for abundant aquatic resources, both marine and freshwater, including fishes, zooplankton and phytoplanktonic microalgae. However, relatively little information is available about microalgal resources despite their potential to be used as live feed in the hatchery phase of aquaculture of a number of marine species. The use of local microalgae is desirable in local hatcheries because they tend to grow better with high yield under local conditions, thus reducing the risk of culture crash and production cost while preventing disease vectors that may introduced by foreign microalgae strains. In this dissertation, the potential of Indonesian microalgae to …

Walkability In Upper East Texas Cities And Implications For Physical Activity And Health, Wycliffe W. Njororai Simiyu, Fletcher J. Njororai, Billystrom Aronya Jivetti

Health & Kinesiology Faculty Publications and Presentations

Introduction: Physical activity is an important intervention strategy against the increasing cases of overweight and obesity in the USA and many other parts of the world. Walking has been identified as a component of physical activity that can easily be incorporated into one’s lifestyle. Recent studies on physical activity have focused on promoting walking as a health enhancing endeavor. Purpose: This study examined the walkability of the environments in 57 cities drawn from 22different counties in upper east Texas within the USA. Methods and materials: The data for all the 57 key cities in upper east Texas were collected from …

Ms Gigi Tung Oi-Lai 董愛麗女士

Honorary Fellowship 榮譽院士

No abstract provided.

Integrative Behavioral Couple Therapy For Intercultural Couples: Helping Couples Navigate Cultural Differences, Caroline Kalai

Theses and Dissertations

Integrative Behavioral Couple Therapy (IBCT), an empirically supported and evidence-based third-wave behavioral approach for treatment of couples, is examined in this multiple case study. Specifically, the qualitative experiences of therapists using IBCT in their work with intercultural couples are examined through each therapist’s typed responses to open-ended questions. Each participating therapist in this study contributes by describing one case in which IBCT was used to help the couple navigate cultural differences as part of treatment. This study describes the various stressors faced by intercultural couples, therapists’ formulations of cultural differences, change processes and change mechanisms during treatment, and similarities and …

Economic Impact Of Mandatory Labeling, Laine Honneger

A with Honors Projects

Genetically modified organisms are wildey discussed topic in the agriculture industry. This paper summarizes the economic impact of labeling products that contain genetically modified ingredients.

Do Vertebral Chemical Signatures Distinguish Juvenile Blacktip Shark (Carcharhinus Limbatus) Nursery Regions In The Northern Gulf Of Mexico?, Justin P. Lewis, William F. Patterson Iii, John K. Carlson, Katherine Mclachlin

Faculty Publications

Identifying and protecting shark nurseries is a common management strategy used to help rebuild overfished stocks, yet we know little about connectivity between juvenile and adult populations. By analysing trace metals incorporated into vertebral cartilage, it may be possible to infer natal origin based on nursery-specific chemical signatures. To assess the efficacy of this approach, we collected juvenile blacktip sharks (Carcharhinus limbatus; n = 93) from four regions in the Gulf of Mexico in 2012 and 2013 and analysed their vertebral centra with laser ablation-inductively coupled plasma-mass spectrometry. We observed significant regional differences in six element : Ca …

The Maternal Personhood Of Cattle And Plants At A Hindu Center In The United States, Daniel S. Capper

Faculty Publications

Religious experiences with sacred nonhuman natural beings considered to be “persons” remain only vaguely understood. This essay provides a measure of clarification by engendering a dialogue between psychoanalytic self psychology on one side and, on the other, religious experiences of cattle and Tulsi plants as holy mothers at a Hindu cattle sanctuary in the United States. Ethnographic data from the Hindu center uncover experiences of sacred maternal natural beings that are tensive, liminal, and colored with affective themes of nurturance, respect, and intimacy, much like psychoanalytic maternal selfobjects. Devotees protect cattle and ritually venerate plants because these actions facilitate a …

Groundhog Oracles And Their Forebears, Daniel S. Capper

Faculty Publications

Groundhog Day animal weather forecasting ceremonies continue to proliferate around the United States despite a lack of public confidence in the oracles. This essay probes religio-historical and original ethnographic perspectives to offer a psychological argument for why these ceremonies exist. Employing Paul Shepard’s notion of a felt loss of sacred, intimate relationships with nonhuman nature, as well as Peter Homans’ concept of the monument that enables mourning, this essay argues that groundhog oracles serve as monuments that allow humans experientially to attempt to heal lost sacred relationships with animals like weather forecasting bears, hedgehogs, and badgers

Drug Therapy For Obesity With Anti-Aging Genes Modification, Ian J. Martins

Research outputs 2014 to 2021

Nutritional regulation and drug therapy has been the focus of the current obesity epidemic in various countries in the world. Epigenetics is the major mechanism for the development of insulin resistance and obesity with unhealthy diets, oxidative stress and environmental factors relevant to alterations in gene expression with effects on mitochondrial biogenesis, adipose tissue lipid metabolism and energy expenditure. Anti-aging genes are involved in the regulation of adipogenesis with increased sensitivity to anti-aging gene dysfunction associated with adipocyte-neuron interactions compared to other cells. Unhealthy diets downregulate adipocyte anti-aging genes associated with the development of Non Alcoholic Fatty Liver Disease (NAFLD) …

Periodization Strategies In Older Adults: Impact On Physical Function And Health, Jennifer Conlon, Greg Haff, James J. Tufano, Robert Newton

Research outputs 2014 to 2021

Purpose

This study compared the effect of periodized versus nonperiodized (NP) resistance training (RT) on physical function and health outcomes in older adults.

Methods

Forty-one apparently healthy untrained older adults (women = 21, men = 20; 70.9 ± 5.1 yr; 166.3 ± 8.2 cm; 72.9 ± 13.4 kg) were recruited and randomly stratified to a NP, block periodized, or daily undulating periodized training group. Outcome measures were assessed at baseline and after a 22-wk × 3 d·wk⁻¹ RT intervention, including; anthropometrics, body composition, blood pressure and biomarkers, maximal strength, functional capacity, balance confidence, and quality of life.

Results

Thirty-three …

Regular Fat And Reduced Fat Dairy Products Show Similar Associations With Markers Of Adolescent Cardiometabolic Health, Theresa A. O'Sullivan, Alexandra P. Bremmer, Trevor A. Mori, Lawrence J. Beilin, Charlotte Wilson, Katherine Hafekost, Gina L. Ambrosini, Rae Chi Huang, Wendy H. Oddy

Research outputs 2014 to 2021

Reduced fat dairy products are generally recommended for adults and children over the age of two years. However, emerging evidence suggests that dairy fat may not have detrimental health effects. We aimed to investigate prospective associations between consumption of regular versus reduced fat dairy products and cardiometabolic risk factors from early to late adolescence. In the West Australian Raine Study, dairy intake was assessed using semi-quantitative food frequency questionnaires in 860 adolescents at 14 and 17-year follow-ups; 582 of these also had blood biochemistry at both points. Using generalized estimating equations, we examined associations with cardiometabolic risk factors. Models incorporated …

The Effects Of Ocean Acidification On Zooplankton: Using Natural Co2 Seeps As Windows Into The Future, Joy Smith

School of Biological and Marine Sciences Theses

Since the beginning of the Industrial Revolution, carbon dioxide (CO2) has been emitted into the atmosphere at rates unprecedented to Earth’s history. Nearly 30% of the anthropogenic CO2 in the atmosphere has been absorbed in surface waters of the ocean, pushing carbonate chemistry towards increased bicarbonate ions and hydrogen protons and decreased carbonate ions. Consequently, seawater pH has decreased from pre-Industrial Revolution levels of 8.2 to current levels of 8.1, and it is expected to continue to drop to 7.8 by the year 2100 if carbon emissions continue as predicted. The combination of these effects is referred to as ocean …

Impacts Of Waterborne Copper And Silver On The Early Life Stage (Els) Of Zebrafish (Danio Rerio): Physiological, Biochemical And Molecular Responses, Sahib Mohammadbakir

School of Biological and Marine Sciences Theses

Toxic metals are major pollutants of the aquatic environment and are able to cause survival impairment of the early life stage of the aquatic organisms. They can affect the osmoregulatory system and electrolyte balance in fishes as well as the expression of genes which are essential in the formation and development of the organs at the early embryonic stages of development. There are a lack of studies concerning the toxic effects of waterborne copper and silver on the osmoregulation, electrolytes balance and expression the genes which are responsible for the formation and development of heart and metal binding proteins in …