Digital Commons Network^™

An N Of One: My Review Of Management Of Type 1 Diabetes, Myself As Patient, Jarred Daugherty

BU Well

As technology has advanced, so has the management of diabetes. Insulin, the essential medication for type 1 diabetes, is marketed in an array of formulations and devices. Continuous glucose monitors (CGM) can be inserted to measure blood glucose every 5 minutes. The rise of social media has given diabetics online support groups, where they can share their story and learn from others overcoming similar challenges. So, how well do the current diabetes management strategies work? My name Is Jarred and I’m a type 1 diabetic. I have tried many of these products and this article is a review of my …

Foreword, Mary Graham

BU Well

No abstract provided.

Anti-Oxidant Addition To Cd-Cho Media To Prevent Damage Induced By Uv Disinfection, Emma Dare

Cell Culture Engineering XV

Ultraviolet (UV) irradiation is an advantageous sterilization technique in the biopharmaceutical industry as it is capable of targeting non-enveloped viruses and smaller viruses that are difficult to remove via conventional filtration. Unfortunately, cell culture media contains many components that, upon exposure to light, undergo phototransformations that subsequently lead to poor cell growth. We have shown previously Chinese Hamster Ovary (CHO) cell culture performance was affected at fluences above 200 mJ/cm² due to the depletion of several key nutritional components (pyruvate, tryptophan, tyrosine, pyridoxine, pyridoxamine, thiamine) and the accumulation of reaction by-products (acetate, formate, sarcosine). Our objective was to determine …

2016 Commencement Program, Whittier College

Commencement Programs

Whittier College's One Hundred Thirteenth Commencement, May 13, 2016

Commencement Address: Maria Contreras-Sweet, Administrator United States Small Business Administration

Ocean Acidification Accelerates The Growth Of Two Bloom-Forming Macroalgae, Craig S. Young, Christopher J. Gobler

School of Marine & Atmospheric Sciences Faculty Publications

While there is growing interest in understanding how marine life will respond to future ocean acidification, many coastal ecosystems currently experience intense acidification in response to upwelling, eutrophication, or riverine discharge. Such acidification can be inhibitory to calcifying animals, but less is known regarding how non-calcifying macroalgae may respond to elevated CO2. Here, we report on experiments performed during summer through fall with North Atlantic populations of Gracilaria and Ulva that were grown in situ within a mesotrophic estuary (Shinnecock Bay, NY, USA) or exposed to normal and elevated, but environmentally realistic, levels of pCO2 and/or nutrients (nitrogen and phosphorus). …

Foraging Choices Of Vampire Bats In Diverse Landscapes: Potential Implications For Land‐Use Change And Disease Transmission, Daniel G. Streicker, Jacob E. Allgeier

KIP Articles

In Latin America, the common vampire bat Desmodus rotundus is the primary reservoir of rabies, a zoonotic virus that kills thousands of livestock annually and causes sporadic and lethal human rabies outbreaks. The proliferation of livestock provides an abundant food resource for this obligate blood‐feeding species that could alter its foraging behaviour and rabies transmission, but poor understanding of the dietary plasticity of vampire bats limits understanding of how livestock influences rabies risk. We analysed individual‐ and population‐level foraging behaviour by applying δ 13 C and δ 15 N stable isotope analysis to hair samples from 183 vampire bats captured …

Sequencing And Analysis Of A Miraculin Homolog From Two Ragweed Species, Kyj R. Mandzy

Undergraduate Theses

Our lab has previously isolated the gene for miraculin, a taste-modifying protein, from the pollen of Ambrosia trifida. This weedy plant, commonly known as Giant Ragweed, is a major producer of pollen that causes hay fever. The cDNA sequence of this gene was used to design PCR primers for the amplification and sequencing of genomic DNA from this species, as well as a related species, common ragweed (Ambrosia artemisiifolia). These genomic sequences were analyzed in terms of intron structure, phylogenetics, and protein structure and function. These gene sequences provide novel insights into the possible roles of proteases …

Overcoming Sin: Comparing Dante’S Inferno And The New Testament To Cormac Mccarthy’S Outer Dark And Child Of God, Tammy S. Hanson

LSU New Orleans Theses and Dissertations

There are many textual and thematic similarities between Dante’s Inferno and Cormac McCarthy’s Outer Dark. There are also significant textual similarities between the New Testament and McCarthy’s third novel, Child of God. Juxtaposing Outer Dark and Child of God to Inferno and the New Testament, respectively, suggests a common trope that redemption requires characters’ name and repent of sin.

An Exploration Of Adolescent Obesity Determinants, Anastasia King Smith

USF Tampa Graduate Theses and Dissertations

In 2010, approximately two-thirds of adults and one-fifth of the adolescent population in the United States were considered either overweight or obese, resulting in the United States having the highest per capita obesity rate among all OECD countries. A considerable body of literature regarding health behavior, health outcomes, and public policy exists on what the Centers for Disease Control and Prevention considers an obesity epidemic. In response to the growing problem of childhood obesity, the Child Nutrition and WIC Reauthorization Act of 2004 (CNRA), which required that schools participating in the National School Lunch Program and/or School Breakfast Program have …

Volume Cxxxiii, Number 23, May 13, 2016, Lawrence University

The Lawrentian

No abstract provided.

The Murray Ledger And Times, May 13, 2016, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Five Challenges In Australian School Education, Geoff N. Masters Ao

Policy Insights

There is no shortage of challenges in school education. Some of the biggest challenges we face can appear frustratingly intractable. Despite reform efforts, regular government reviews and ongoing calls for change, progress in addressing our most significant challenges is often slow and solutions continue to elude us. In this paper Professor Geoff Masters discusses five significant challenges facing school education.

1. Equipping students for the 21st Century, including by increasing reading, mathematical and scientific literacy levels;
2. Reducing disparities between Australia's schools, particularly along socioeconomic lines, by ensuring that every student has access to an excellent school and excellent teaching;
3. Reducing the …

Let There Be Light: Social Enterprise, Solar Power, And Sustainable Development, Tonia Warnecke

Faculty Publications

Energy poverty is a major problem in the developing world, with nearly 1.3 billion people lacking household electricity. Strikingly, the electrification rate is not only low, but is falling in many countries as population growth outpaces efforts to give more people access to electricity. Seizing the opportunities presented by rapid changes in technology and the availability of renewable energy at continually falling costs, social enterprises have begun to light the darkness and fill in the gap between the public and private provision of electricity. We review the extent of energy poverty and explain why neither the public, nor the private …

Otter Realm, May 12, 2016, California State University, Monterey Bay

The Otter Realm

Done With the B.S.: $upporting $cholars -- Illustrating the future of science: Graduate students design textbook illustrations -- Stick up for a change -- Funding the future: Seaside Scholars -- Getting the best shot of Cuba's LGBTQ Pride -- Promoting students' health & wellness -- Committed to the cause: President's Award recipients -- Alumni Vision Award -- Social Justice Award for awareness of HCV -- Fun in the Sun -- Do you mind? Exploring the quality of mental health services at CSUMB -- Growing up, are we ready? -- General Election 2016: Which Candidate will you support? -- Sex on …

Production Of Stable, Immunogenic Foot-And-Mouth Disease Vaccine In A Chemicallydefined, Serum-Free Medium Optimized For Bhk-21 Cells, Paul Gulde

Cell Culture Engineering XV

BHK-21 cells are an important bioprocessing host for the production of recombinant proteins and vaccines. The largest application of these cells is the production of Foot-and-Mouth Disease (FMD) and Rabies vaccines for the animal health market. Commercial FMD vaccine production relies on classical cell culture media supplemented with bovine serum. This serum is sourced locally from FMD-vaccinated cattle and thus requires antibody precipitation with PEG to allow supplementation during cell culture scale-up. This step diminishes the nutritional value of sera and also increases variability. To reduce serum use during the virus production phase, the process depends on media supplementation with …

Insights From The Pollination Drop Proteome And The Ovule Transcriptome Of Cephalotaxus At The Time Of Pollination Drop Production, Cary Pirone-Davies, Natalie Prior, Patrick Von Aderkas, Derek Smith, Darryl Hardie, William E. Friedman, Sarah Mathews

Faculty Publications

© The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. Background and Aims Many gymnosperms produce an ovular secretion, the pollination drop, during reproduction. The drops serve as a landing site for pollen, but also contain a suite of ions and organic compounds, including proteins, that suggests diverse roles for the drop during pollination. Proteins in the drops of species of Chamaecyparis, Juniperus, Taxus, Pseudotsuga, Ephedra and Welwitschia are thought to function in the conversion of sugars, defence against pathogens, and pollen growth and development. To better understand gymnosperm pollination biology, the pollination …

High Salt Induces Anti-Inflammatory Mφ2-Like Phenotype In Peripheral Macrophages, Suneetha Amara, Margaret M. Whalen, Venkataswarup Tiriveedhi

Chemistry Faculty Research

Macrophages play a critical role in inflammation and antigen-presentation. Abnormal macrophage function has been attributed in autoimmune diseases and cancer progression. Recent evidence suggests that high salt tissue micro-environment causes changes in macrophage activation. In our current report, we studied the role of extracellular sodium chloride on phenotype changes in peripheral circulating monocyte/macrophages collected from healthy donors. High salt (0.2M NaCl vs basal 0.1M NaCl) treatment resulted in a decrease in MΦ1 macrophage phenotype (CD11b+CD14highCD16low) from 77.4±6.2% (0.1M) to 29.3±5.7% (0.2M, p<0.05), while there was an increase in MΦ2 macrophage phenotype (CD11b+ CD14lowCD16high) from 17.2±5.9% (0.1M) to 67.4±9.4% (0.2M, p<0.05). ELISA-based cytokine analysis demonstrated that high salt treatment induced decreased expression of in the MΦ1 phenotype specific pro-inflammatory cytokine, TNFα (3.3 fold), IL-12 (2.3 fold), CCL-10 (2 fold) and CCL-5 (3.8 fold), but conversely induced an enhanced expression MΦ2-like phenotype specific anti-inflammatory cytokine, IL-10, TGFβ, CCL-17 (3.7 fold) and CCR-2 (4.3 fold). Further high salt treatment significantly decreased phagocytic efficiency of macrophages and inducible nitric oxide synthetase expression. Taken together, these data suggest that high salt extracellular environment induces an anti-inflammatory MΦ2-like macrophage phenotype with poor phagocytic and potentially reduced antigen presentation capacity commonly found in tumor microenvironment.

Development Of A Course-Based Undergraduate Research Experience To Introduce Drug-Receptor Concepts, Hollie I. Swanson, Ok-Kyong Park-Sarge, Thushani Rodrigo-Peiris, Lin Xiang, Vincent M. Cassone

Pharmacology and Nutritional Sciences Faculty Publications

Course-based research experiences (CUREs) are currently of high interest due to their potential for engaging undergraduate students in authentic research and maintaining their interest in science, technology, engineering, and mathematics (STEM) majors. As part of a campuswide initiative called STEMCats, which is a living learning program offered to freshman STEM majors at the University of Kentucky funded by a grant from Howard Hughes Medical Institute, we have developed a CURE for freshmen interested in pursuing health care careers. Our course, entitled “Drug–Drug Interactions in Breast Cancer,” utilized a semester-long, in-class authentic research project and instructor-led discussions to engage students in …

Long-Term High Fat Diet Has A Profound Effect On Body Weight, Hormone Levels, And Estrous Cycle In Mice, Tandra R. Chakraborty, Laxminarasimha Donthireddy, Debasis Adhikary, Sanjoy Chakraborty

Publications and Research

Background: Obesity causes several health complications along with disruption of the reproductive system. The aim of the current study was to determine how long-term intake of very high fat diet (VHFD) changes the hormonal milieu, affecting the cellular morphology and reproductive cycle in female mice.

Material/Methods: Mice were fed on normal diet (ND) and VHFD for 2 weeks, 12 weeks, and 25–27 weeks. We assessed changes in body weight, food consumption, energy intake, cellular and tissue morphology, hormonal levels (leptin, insulin, and estradiol), and vaginal smears were performed at various time points to determine the length and cellularity at each …

Interventions For Treating Hyperemesis Gravidarum., Rupsa Boelig, Samantha J Barton, Gabriele Saccone, Anthony J Kelly, Steve J Edwards, Vincenzo Berghella

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0.3% to 1.0% of pregnancies, and is one of the most common indications for hospitalization during pregnancy. While a previous Cochrane review examined interventions for nausea and vomiting in pregnancy, there has not yet been a review examining the interventions for the more severe condition of hyperemesis gravidarum.

OBJECTIVES: To assess the effectiveness and safety, of all interventions for hyperemesis gravidarum in pregnancy up to 20 weeks' gestation.

SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register and the Cochrane Complementary Medicine Field's …

Immune Function In Amazonian Horticulturalists, Aaron D. Blackwell, Benjamin C. Trumble, Ivan Maldonado Suarez, Jonathan Stieglitz, Bret Beheim, J. Josh Snodgrass, Hillard Kaplan, Michael Gurven

ESI Publications

Background—Amazonian populations are exposed to diverse parasites and pathogens, including protozoal, bacterial, fungal, and helminthic infections. Yet much of our understanding of the immune system is based on industrialised populations where these infections are relatively rare.

Aim—We examine distributions and age-related differences in 22 measures of immune function for Bolivian forager-horticulturalists and US and European populations.

Subjects and Methods—Subjects were 6,338 Tsimane aged 0–90 years. Blood samples collected between 2004–2014 were analysed for 5-part blood differentials, C-reactive protein, erythrocyte sedimentation rate (ESR), and total immunoglobulins E, G, A, and M. Flow cytometry was used to quantify naive …

What Influences Do Age, Gender And Race/Ethnicity Have On The Overall Health Consequences Of Excess Lead In Children?, Jessica J. Smith

Research Papers

After Flint, Michigan governmental authorities introduced a more corrosive water source into an already aging water system without adequate corrosion control, the percentage of children with elevated blood lead levels increased, particularly in socioeconomically disadvantaged neighborhoods. The main objective of this research paper is to clarify influences of age, gender and race, ethnicity have on the overall health consequences of excess lead in children. There are studies that focus on the short and long term effects of neurological, hypertension, renal, and developmental on children. However, since specific demographic evidence is still limited, future research is still needed to implement a …

Blended Learning Format For Pediatrics Clinical Rotation, Student Perspective, Erik Langenau, Robert Lee, Marci Fults

Research Day

Introduction. Traditional medical educational models are shifting to incorporate learning technologies and online educational activities. Combining online and blended learning with the more traditional face-to-face clinical instruction appears to provide opportunity to engage leaners at remote clinical training sites. Objective. The purpose of this research study is to describe and evaluate the effectiveness of the blended-learning format for 3rd year medical students who participated in the pediatric blended learning supplement by investigating post-exercise survey responses, end-of-rotation examination (COMAT) scores and final course grades. Methods. Of the 264 third year students who completed the four-week clerkship in the 2014/15 academic year, …

Variables Related To Parent Perception Of Wellness Management., Dana Neumann, Nicole Ferrigno, Sarah Allen, Phd., Rosemary Vickers, D.O.

Research Day

Discipline, toilet training, development, and behavioral modification have been shown as issues that parents feel are not adequately addressed by the pediatrician (Combs-Orme, T., Holden, N. B., & Herrod, H. G., 2011). Research has also demonstrated that skill building (Mortensen, J. A., & Mastergeorge, A. M., 2014), nutrition, sleep (Combs-Orme, T., Holden, N. B., & Herrod, H. G., 2011, Scholer, S. J., Hudnut-Beumler, J., Mukherjee, A., & Dietrich, M. S., 2015), social emotional learning (Combs-Orme, T., Holden, N. B., & Herrod, H. G., 2011), and connection with medical providers (Mortensen, J. A., & Mastergeorge, A. M., 2014), are essential to …

Why Do We Educate At The Margins? Jc:Hem Webinar Reflections, Mary Mcfarland

Jesuit Higher Education: A Journal

On February 24, 2016, Jesuit Commons: Higher Education at the Margins (JC:HEM) sponsored a one hour webinar entitled, “Why Do We Educate at the Margins: How Jesuit Higher Education Is Empowering Communities at the Edge of Societies.” Mr. Nicholas Griffin, Chief Operating Officer of JC:HEM, introduced the webinar. Three speakers focused on the past, present and future of JC:HEM. Dr. Mary McFarland, International Director, JC:HEM, was the first speaker, and her comments were transcripted and appear below. Additional speakers were Dr. Carey Treado, Chief Academic Officer, JC:HEM, and Ms. Cindy Bonfini-Hotlosz, Chief Information Officer, JC:HEM. This webinar carries forward important …

Spartan Daily, May 11, 2016, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2016

Volume 146, Issue 41

Substance Use Behaviors Of College Students: Differences By Living Arrangement, Marcus B. Long

Dissertations

Traditional-age college students are continuing to live with their parents at higher percentages than at any time during recent history. However, little research has been conducted during the last 15 years on multiple substance use behaviors of this population and how those behaviors compare to traditional-age students who live in residence halls on campuses.The purpose of this study is to better understand the differences in alcohol, cigarette, and marijuana usage behaviors of traditional-age students who live with their parents and those who live in residence halls, as well as how those behaviors change as students age in both environments. Using …

The Murray Ledger And Times, May 11, 2016, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The Data Do Not Seem To Support A Benefit To Bcaa Supplementation During Periods Of Caloric Restriction, Brad P. Dieter, Brad Jon Schoenfeld, Alan A. Aragon

Publications and Research

J Int Soc Sports Nutr 13:1-015-0112-9, 2016 describe the efficacy of branched chain amino acid (BCAA) supplementation and resistance training for maintaining lean body mass during a calorie-restricted diet, and claim that this occurs with concurrent losses in fat mass. However, the reported results appear to be at odds with the data presented on changes in fat mass. This letter discusses the issues with the paper.

Volume 53, Number 39: May 11, 2016, University Of North Dakota

University Letter Archive

No abstract provided.