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Endothelial Hspa12b Is A Novel Protein For The Preservation Of Cardiovascular Function In Polymicrobial Sepsis Via Exosome Mir-126, Xia Zhang

Electronic Theses and Dissertations

Sepsis is the most frequent cause of mortality in most intensive care units. Cardiovascular dysfunction is a major complication associated with sepsis, with high mortality rates up to 70%. Currently, there is no effective treatment approach for sepsis.

The integrity of the endothelium is fundamental for the homeostasis of the cardiovascular system. Sepsis induces endothelial cell injury which is the key factor for multiple organ failure. The increased expression of adhesion molecules and chemokines in endothelial cell promotes leukocytes infiltration into the tissue. The loss of tight junction proteins and increased permeability of the endothelial cells will provoke tissue hypoxia …

Results Of A Nine Month Home-Based Physical Activity Intervention For People Living With Hiv., Jason R. Jaggers, Joanna M. Snead, Felipe Lobelo, Gregory A. Hand, Wesley D. Dudgeon, Vivek K. Prasad, Stephanie Burgess, Steven N. Blair

Faculty and Staff Scholarship

Background: The purpose of this investigation was to test the feasibility of a home-based moderate-intensity physical activity (MPA) program for people living with HIV/AIDS (PLWHA) currently taking antiretroviral therapy (ART). Methods: 68 participants recruited for a 9-month home-based PA intervention aimed to reduce risk factors of cardiovascular disease for PLWHA taking ART. All participants received an educational weight loss workbook and a pedometer for self-monitoring of physical activity. The intervention group received elastic Therabands® for strength training in addition to telephone based behavioral coaching. Clinical assessments were conducted at baseline and each follow-up which also included psychometric questionnaires and PA …

Characterization Of The Role Of Host And Dietary Factors In The Establishment Of Bacteria In The Gastrointestinal Tract, Janina A. Krumbeck

School of Biological Sciences: Dissertations, Theses, and Student Research

Probiotic bacteria and synbiotics are used as therapeutic and prophylactic agents. The majority of probiotic and synbiotic applications contain bacterial strains that are allochthonous to the human gastrointestinal (GI) tract. Accordingly, many bacterial strains do not survive digestion, or are not capable of persisting and competing the resident gut microbiota, and are therefore washed out of the GI tract shortly after the treatment is discontinued. This might reduce the health effects of these treatments. Therefore, research is needed to address the ecological challenges that probiotic strains encounter in the GI tract in order to develop probiotic regimens. Determining which ecological …

Innate Immunity In Chickens: In Vivo Responses To Different Pathogen Associated Molecular Patterns, Kristen Alicia Byrne

Graduate Theses and Dissertations

Pattern recognition receptors (PRRs) on host cells recognize motifs known as pathogen associated molecular patterns (PAMPs) that are common to groups of microbes. Examples include LPS on Gram-negative bacteria, the structural motif PGN common to all bacteria, MDP the smallest immunostimulatory unit of PGN, and poly I:C the dsRNA analog. PAMP recognition by and stimulation of the innate immune system is crucial to an individual’s ability to quickly limit microbial growth and stimulate the adaptive immune system. Characterization of the in vivo immune responses initiated by PAMPs has not been directly addressed. Using growing feathers (GF) as a novel intradermal …

Antibacterial Activity Of Pluchea Indica And Piper Betle Ethanol Extract On Staphylococcus Epidermidis And Pseudomonas Aeruginosa, Nela Simanjuntak, Umi Yuniarni, Diki Prayugo

Pharmacology and Clinical Pharmacy Research

Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonas aeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 …

Ototopical Quinolones Versus Ototopical Aminoglycosides For Suppurative Otitis Media And Acute Otitis Externa: Summary, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Rrh Library Newsletter, August 2016, Libraries At Rochester Regional Health

Rochester Regional Health authored publications and proceedings

Newsletter sections include: Immunization; Nursing Reference Center Database Demo; Used Book Sale

Extraction, Purification And Characterization Of An Antibiotic-Like Compound Produced By Rhodococcus Sp. Mtm3w5.2, Pushpavathi Reddyvari Manikindi

Electronic Theses and Dissertations

The bacterium Rhodococcus is a potential source for novel antimicrobial metabolites. Recently, the Rhodococcus strain MTM3W5.2 was isolated from a soil sample collected from Morristown, East Tennessee and was found to produce an inhibitor molecule that is active against similar Rhodococcus species. The aim of this research is to extract, purify, and characterize the active compound. The compound was obtained from both agar and broth cultures of strain MTM3W5.2 and purified by primary fractionation of crude extract on a Sephadex LH-20 column, followed by semi-preparative reversed phase column chromatography. Final purification was achieved using multiple rounds of an analytical C …

Tlr3 Signaling In Human Bdca-3 Dendritic Cells Results In The Formation Of Several Ilt3 And Ilt4 Populations, Nicholas J. Colletti

Seton Hall University Dissertations and Theses (ETDs)

Dendritic cells (DCs) represent a population of innate immune cells that are highly efficient at promoting immune responses. DCs are capable of presenting antigens to both CD4 and CD8 T cells. DC presentation and interaction with T cells can result in either immune stimulation or tolerance. This study intends to phenotype a rare subset of DCs found in the human blood and is distinguishable by the expression of various surface markers including: lineage markers (Lin), HLADR, CD1c, and CD141 or BDCA-3. Stimulating BDCA-3 DCs with Poly I:C, a toll-like receptor (TLR) 3 agonist, resulted in the up-regulation of various canonical …

Effects Of Tcpb Mutations On Biogenesis And Function Of The Toxin-Coregulated Pilus, The Type Ivb Pilus Of Vibrio Cholerae, Yang Gao, Caitlyn A. Hauke, Jarrad M. Marles, Ronald K. Taylor

Dartmouth Scholarship

Vibrio cholerae is the etiological agent of the acute intestinal disorder cholera. The toxin-coregulated pilus (TCP), a type IVb pilus, is an essential virulence factor of V. cholerae. Recent work has shown TcpB is a large minor pilin encoded within the tcp operon. TcpB contributes to efficient pilus formation and is essential for all TCP functions. Here we have initiated a detailed, targeted mutagenesis approach to further characterize this salient TCP component. We have identified (thus far) 20 residues of TcpB, which affect either the steady state level of TcpB or alter one or more TCP functions. This study …

Frequency And Outcome Of Meningitis In Pediatric Intensive Care Unit Of Pakistan, Amna Jawaid, Surriya Bano, Anwarul Haque, Khubaib Arif

Department of Emergency Medicine

Meningitis is a leading cause of morbidity and mortality worldwide in intensive care settings. The aim of this study was to assess the frequency and outcome in children with meningitis through a retrospective chart review done in pediatric intensive care unit of a tertiary care hospital from January 2000 to December 2014. During these 14 years, 64 patients were admitted with meningitis in pediatric intensive care unit. Out of 64, 36 were diagnosed with pyogenic meningitis, 18 patients with viral meningitis, and 10 with tuberculous meningitis. Most complications were observed in the initial 48 hours. Most common presentation was altered …

Supervision Of Primary Care Behavioral Health Trainees: A Survey Of Current Practices, Karly Anna Branch

Theses and Dissertations

The current study surveyed 39 supervisors of primary care (PC) psychology trainees at the practicum, internship, and postdoctoral levels regarding various aspects of training, including structure and techniques used, expected competencies, perceived barriers, and their own supervision training received. These results provide a descriptive analysis of current practices of the sampled PC psychology supervisors, which are intended to inform development of best practices in supervision of PC psychology trainees. No statistically significant group differences between training levels regarding the number of competencies trainees were expected to achieve prior to program entry were found; however, sample size was a limitation. Implications …

Phylogenomics Of Rickettsia Parkeri Isolates From The Eastern United States, Stephanie L. Grizzard

Biomedical Sciences Theses & Dissertations

Rickettsia parkeri is a tick-borne pathogen that causes R. parkeri rickettsiosis, a spotted fever rickettsiosis. The main vector of R. parkeri in the eastern United States is Amblyomma maculatum, also known as the Gulf Coast tick (GCT). The GCT has been undergoing a northward expansion from the original historic range. Whether R. parkeri expands with the GCT or has a local reservoir is unknown. Currently, there are R. parkeri-positive GCTs as far north as Delaware and New York. Expansion patterns for the GCT and R. parkeri remain unresolved but some studies point to long-distance host drop-offs as a …

Inspiring Health Worker Motivation With Supportive Supervision: A Survey Of Lady Health Supervisor Motivating Factors In Rural Pakistan, Fauziah Rabbani, Leah Shipton, Wafa Aftab, Kashif Sangrasi, Shagufta Perveen, Aysha Zahidie

Community Health Sciences

BACKGROUND:

Community health worker motivation is an important consideration for improving performance and addressing maternal, newborn, and child health in low and middle-income countries. Therefore, identifying health system interventions that address motivating factors in resource-strained settings is essential. This study is part of a larger implementation research project called Nigraan, which is intervening on supportive supervision in the Lady Health Worker Programme to improve community case management of pneumonia and diarrhea in rural Pakistan. This study explored the motivation of Lady Health Supervisors, a cadre of community health workers, with particular attention to their views on supportive supervision.

METHODS:

Twenty-nine …

Medical School Watercooler Newsletter - July 31, 2016, Lindsey Lyle

Watercooler Newsletter

This is the July 31, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• COM Class of 2020 Introduced to Medical School During Orientation
• Med School Café - Expert Advice for the Community
• 43rd Annual Research Day Features Keynote Speaker, Medical Student Research Presentations
• Dr. Kevin Green Featured on FOX10
• USA Graduate Student Publishes Article in The Journal of Immunology

Spread Of Tylodelphys Mashonense (Digenea: Diplostomidae) By Grey Heron Ardea Cinerea And Great White Egret A. Alba In Lake Victoria, Tanzania, Fred D. Chibwana, Gamba Nkwengulila

Tanzania Journal of Science

Despite the fact that Tylodelphys mashonense, parasites of the cranial cavity of the catfish Clarias gariepinus, are ubiquitous in freshwater systems, little is known on their spread. As such, we examined a total of 152 piscivorous birds, belonging to 6 species; 43 great cormorant Phalacrocorax carbo, 33 grey heron Ardea cinerea, 26 hamerkop Scopus umbretta, 22 great white egret Ardea alba, 15 marabou stork Leptoptilos crumeniferus and 13 pied kingfisher Ceryle rudis foraging in the Lake Victoria. Out of the six bird species only A. cinerea and A. alba were found infected by T. mashonense with prevalence of 42.4% and …

An Analysis Of The Implementation Of The Policy To Integrate Of National Defense Components In Managing Non-Military Threats In The Health Sector, Sugeng Winarno, Prastuti Soewondo

Journal of Indonesian Health Policy and Administration

This research was based on the Minister of Defense’s Decree No. 16/2012 that stated that all national defense components to integrate into one unit when they encounter military and non-military threats. The Ministry of Health, as the main player, and other governmental and private agencies would also play a role in overcoming complex and multidimensional non-military threats, especially in the health sector. Among those threats are infectious diseases such as HIV/AIDS and Ebola. We aim to discover the implementation process of the law above in the management of those two diseases. This was a qualitative analytical research with in-depth interviews. …

Human Papilloma Virus-Related Cervical Dysplasia, Shaylyn D. Webster

Nursing Student Class Projects (Formerly MSN)

Among sexually active men and women, the human papilloma virus (HPV) is one of the most common sexually transmitted infections. With more than 200 different genotypes of HPV known, there are more than 500,000 cases each year in the United States alone (Lowy, 2016). The virus is associated with nearly all cervical cancers, anal cancers, vaginal cancers, penile cancers, and head and neck cancers (Jorge & Wright, 2016). In women, the virus is capable of causing slow cellular changes on the cervix, and this dysplasia is graded based on severity (Jorge & Wright, 2016).

The statistics related to the prevalence …

Impact Of Stool Testing At Lehigh Valley Health Network With The Implementation Of A New Comprehensive Stool Pcr Test, Amanda Guth, Amy Slenker Md

Research Scholars Poster Presentation

No abstract provided.

Prevalence Of Ticks Infected With Human Pathogens In The Lehigh Valley: Molecular Surveillance, Emily Davidson

Research Scholars Poster Presentation

Davidson, E., (2016, July, 29) Prevalence of Ticks Infected with Human Pathogens in the Lehigh Valley: Molecular Surveillance. Poster presented at LVHN Research Scholar Program Poster Session, Lehigh Valley Health Network, Allentown, PA.

Prevalence Of Ticks Infected With Human Pathogens In The Lehigh Valley: Collection And Assessment Of Tick Abundance, Thomas Yanushefski

Research Scholars Poster Presentation

No abstract provided.

A Comparison Of Imaging Modalities For The Diagnosis Of Osteomyelitis, Brandon J. Smith, Md, Grant S. Buchanan, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Osteomyelitis is an increasingly common pathology that often poses a diagnostic challenge to clinicians. Accurate and timely diagnosis is critical to preventing complications that can result in the loss of life or limb. In addition to history, physical exam, and laboratory studies, diagnostic imaging plays an essential role in the diagnostic process. This narrative review article discusses various imaging modalities employed to diagnose osteomyelitis: plain films, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, bone scintigraphy, and positron emission tomography (PET). Articles were obtained from Pubmed and screened for relevance to the topic of diagnostic imaging for osteomyelitis. The authors …

Linezolid Induced Delirium In The Absence Of Serotonin Syndrome: A Psychiatric Consultation/Liaison Case Report, Hani Nazha, Md, Nathan T. Harrington, Md

Marshall Journal of Medicine

Delirium is one of the most common mental illnesses that can affect elderly patients and patients with advanced medical problems. Because these patients are frequently on multiple medications and/or are more sensitive to medications secondary to their age, interactions with current medications, or existing medical problems; medication toxicity is frequently the etiology behind their delirium. This is a case report of a patient admitted for cellulitis that developed delirium from Linezolid however did not develop any other signs or symptoms of Serotonin Syndrome; a known side effect of Linezolid. This distinctive case highlights the importance of a careful analysis of …

Public Health West Virginia 3.0, Danny Scalise, Mba Ii, David Didden, Md

Marshall Journal of Medicine

Public health across West Virginia and the nation faces a time of tremendous change. Health is influenced by individual lifestyle, social networks, living and working conditions, and general environmental conditions. As a result, the West Virginia Bureau for Public Health created the West Virginia Public Health Impact Task Force (PHITF) to develop an innovative, custom fit public health system in West Virginia. With goals of improving health, improving quality, and reducing costs, the PHITF recommended a health in all policies approach which combines innovative patient-centered public health services in every community, and asks that local public health partner with stakeholders …

Zika Virus, Nurto A. Abdulla

Nursing Student Class Projects (Formerly MSN)

Zika virus infection, a mosquito-borne flavivirus that causes febrile illness associated with rash, has been rapidly emerging in the Western Hemisphere over the past few months. The virus was rarely identified until outbreaks occurred on Yap Island in the Federated States of Micronesia in 2007, Fresh Polynesia in 2013, and Easter Island in 2014 (Chen & Hamer, 2016). The virus was initially detected in Brazil in 2015, in the northeast, and was subsequently identified in other states and several South American countries, including Colombia, Ecuador, Suriname, Venezuela, French Guyana, and Paraguay. Local transmission has been documented in Central America in …

Temporal And Spatial Distribution Of Cetacean Strandings Focusing On The Bottlenose Dolphin (Tursiops Truncatus) With A Synthesis Of Potential Causes, April D. Clark

HCNSO Student Capstones

A comprehensive review of the literature and a quantitative statistical analysis of that information are presented. A total of 6,015 cetaceans stranded at 36 locations from 24 peer reviewed articles published between 1999 and 2014 are documented, with the two most common stranding locations being the Canary Islands - accounting for 49 of the total cetacean stranding events - and Cape Cod - accounting for 31 of total cetacean stranding events. The documented cetacean stranding events included 805 for bottlenose dolphins (Tursiops truncatus) at a total of ten locations from 11 peer reviewed articles. When all single stranding …

Managing Our Microbial Mark: What We Can Learn About Pay For Performance From Ebola's Arrival At Our Shores, Ann Marie Marciarille

Faculty Works

The narrative of Ebola’s arrival in the United States has been overwhelmed by our fear of a West African-style epidemic. The real story of Ebola’s arrival is about our healthcare system’s failure to identify, treat, and contain healthcare associated infections. Having long been willfully ignorant of the path of fatal infectious diseases through our healthcare facilities, this paper considers why our reimbursement and quality reporting systems made it easy for this to be so. West Africa’s challenges in controlling Ebola resonate with our own struggles to standardize, centralize, and enforce infection control procedures in American healthcare facilities.

The Weekly Challenger, July 28, 2016, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The July 28, 2016, issue of The Weekly Challenger.

Chemotherapy Induced Neutropenia And Increased Risk For Sepsis, Megan E. Moore-Weber

Nursing Student Class Projects (Formerly MSN)

Available treatment options for patients diagnosed with cancer include surgery, the administration of chemotherapeutic agents, radiation therapy, or a combination of these modalities. Chemotherapeutic agents utilized to treat cancer have a variety of potential side effects. One of the most common and well known side effects associated with the administration of chemotherapeutic agents is neutropenia. Neutropenia places oncology patients at an increased risk of contracting infections which may lead to a life threatening complication known as sepsis. Sepsis is an extremely dangerous oncologic emergency requiring prompt medical treatment. Failure to recognize symptoms associated with sepsis in the neutropenic patient and …

Volume 53, Number 50: July 27, 2016, University Of North Dakota

University Letter Archive

No abstract provided.