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Articles 691 - 720 of 73648
Full-Text Articles in Entire DC Network
Circulating Metabolites Associated With Protection Against Mycobacterium Tuberculosis Infection And Inhibition Of Mycobacterial Growth, Todia P Setiabudiawan, Lika Apriani, Julian Avila-Pacheco, Edwin Ardiansyah, Vinod Kumar, Bachti Alisjahbana, Ayesha J Verrall, Andrew R Dinardo, Agnes R Indrati, Vera P Mourits, L Charlotte J De Bree, Simone J C F M Moorlag, Clary B Clish, Leo A B Joosten, Arjan Van Laarhoven, Krista E Van Meijgaarden, Mihai G Netea, Simone A Joosten, Valerie A C M Koeken, Philip C Hill, Reinout Van Crevel
Circulating Metabolites Associated With Protection Against Mycobacterium Tuberculosis Infection And Inhibition Of Mycobacterial Growth, Todia P Setiabudiawan, Lika Apriani, Julian Avila-Pacheco, Edwin Ardiansyah, Vinod Kumar, Bachti Alisjahbana, Ayesha J Verrall, Andrew R Dinardo, Agnes R Indrati, Vera P Mourits, L Charlotte J De Bree, Simone J C F M Moorlag, Clary B Clish, Leo A B Joosten, Arjan Van Laarhoven, Krista E Van Meijgaarden, Mihai G Netea, Simone A Joosten, Valerie A C M Koeken, Philip C Hill, Reinout Van Crevel
Faculty, Staff and Students Publications
A significant proportion of individuals who are heavily exposed to infectious tuberculosis patients do not acquire Mycobacterium tuberculosis (Mtb) infection, as detected by an interferon gamma release assay (IGRA). We examined circulating metabolite profiles and metabolic genotypes in 199 heavily exposed IGRA-negative tuberculosis household contacts in Indonesia. Based on differentially abundant metabolites, activity of several pathways including arachidonic acid, arginine and proline, glutathione, and tryptophan metabolism, correlated with a negative IGRA at three months. SNPs near PRODH (involved in arginine and proline metabolism) were associated with circulating proline concentrations and persistently negative IGRA results, while SNPstudys near AFMID (involved in …
Clinical Course Of A Previously Healthy Patient With Chronic Active Ebv Infection, Carina H. Perdew, Nikita S. Raje, Thao P. Le, Cody D. Shopper
Clinical Course Of A Previously Healthy Patient With Chronic Active Ebv Infection, Carina H. Perdew, Nikita S. Raje, Thao P. Le, Cody D. Shopper
Research Showcase
Background: Epstein-Barr virus (EBV) infects over 90% of individuals worldwide. Acute EBV infection results in lifelong latent infection, but rarely causes chronic active EBV (CAEBV) infection or immunodeficiency-associated B-cell lymphoproliferative disease. There is no standard treatment approach, making the diagnosis and management of CAEBV challenging.
Objectives/Goal: Upon completion of this session, our aim is for audience members be able to discuss a rare complication of EBV infections and to better formulate management approaches for this multifaceted condition.
Methods/Design: Case Report
Results: A 15-year-old female with a history of atopic dermatitis, headaches, and secondary amenorrhea was hospitalized for persistent tachycardia and …
Retrospective Evaluation Of Steroid Utilization For Pneumonia Treatment In The Critically Ill Population, Cassandra Caringella Pharmd, Amina George Pharmd, Jill Argotsinger Pharmd
Retrospective Evaluation Of Steroid Utilization For Pneumonia Treatment In The Critically Ill Population, Cassandra Caringella Pharmd, Amina George Pharmd, Jill Argotsinger Pharmd
Scientific Day
Background/Significance:
Severe community-acquired pneumonia (CAP) is associated with significant morbidity and mortality in critically ill patients. Adjunctive corticosteroid therapy remains controversial. IDSA guidelines recommend routine steroid use in severe CAP, while SCCM guidelines support corticosteroids based on the recent landmark trial, CAPE COD.
Purpose:
This study evaluated the effect of adjunctive steroid therapy versus no steroid therapy on clinical outcomes in patients admitted to the intensive care unit (ICU) with severe CAP and real-world adherence to guideline endorsed steroid regimens. Risk factors associated with clinical failure were also assessed.
Methods:
We conducted a multi-center retrospective evaluation of adults ≥18 years …
Reassessing Skeletal Stress Indicators: Implications For Changing Population Health In The Freedman’S Cemetery, Dallas, Tx, Samantha M. Mccrane, Megan Fry, Siobhan A.E. Summers
Reassessing Skeletal Stress Indicators: Implications For Changing Population Health In The Freedman’S Cemetery, Dallas, Tx, Samantha M. Mccrane, Megan Fry, Siobhan A.E. Summers
Human Biology Open Access Pre-Prints
Inferring biological stress from stature and skeletal pathological conditions is common practice in bioarchaeology. Interpretations of these data can greatly enrich knowledge about past peoples’ lifestyles, cultural practices, and socio-political constraints and shifts. However, interpretations are not always clear, are often drawn from a single skeletal indicator of stress and not always subjected to statistical testing. In this study, we reanalyze archaeological data from 742 individuals buried at Freedman’s Cemetery in Dallas, Texas. We focus on four commonly used skeletal measures of ‘stress,’ broadly defined (stature, linear enamel hypoplasia, porotic cranial lesions [e.g., cribra orbitalia & porotic hyperostosis], and bone …
The Node Knows: Histopathology As The Key To Fever Of Unknown Origin In An Adolescent, Annette Mathew Do, Dana Nezon Md, Shalini Vootkur Md, Melissa Tesher Md
The Node Knows: Histopathology As The Key To Fever Of Unknown Origin In An Adolescent, Annette Mathew Do, Dana Nezon Md, Shalini Vootkur Md, Melissa Tesher Md
Scientific Day
Introduction/Background:
Fever of unknown origin (FUO) is a common pediatric presentation with a broad infectious and noninfectious differential. Histiocytic necrotizing lymphadenitis (HNL), also known as Kikuchi-Fujimoto disease (KFD), is a rare, self-limited condition characterized by prolonged fever and cervical lymphadenopathy. Diagnosis is often delayed due to nonspecific findings, with definitive confirmation requiring histopathologic evaluation. We describe a case of FUO and cervical lymphadenopathy ultimately diagnosed as HNL.
Description:
A 14-year-old female presented with one month of neck pain, tender cervical lymphadenopathy, and fevers. Initial outpatient treatment with amoxicillin-clavulanate did not result in improvement. Reevaluation demonstrated leukopenia and neutropenia, prompting hospital …
Resilience In The Age Of Covid-19: A Phenomenological Study Of Survivors 65 And Older, Kwajulyn Onothia Rucker
Resilience In The Age Of Covid-19: A Phenomenological Study Of Survivors 65 And Older, Kwajulyn Onothia Rucker
Doctoral Dissertations and Projects
Few studies have examined resilience among those aged 65+ during the COVID-19 pandemic. This research fills that gap, offering data to guide policies and treatments for future pandemics. The pandemic revealed factors influencing psychological resilience, with stressors linked to health issues becoming chronic worldwide. Older adults faced heightened stress, and 95.5% of COVID-19 deaths occurred in those 50 and older. Lockdowns increased isolation and depression, yet many showed resilience by drawing on strengths, social networks, and circumstances. Key themes from this study included faith, engagement, adaptability, and adversity. Most (80%) adapted well, feeling 'fine' or 'okay' and finding hope through …
Exploring The Role Of Self-Efficacy In Undergraduate Nursing Students: A Transcendental Phenomenological Study, Dorothy Elaine Rolling
Exploring The Role Of Self-Efficacy In Undergraduate Nursing Students: A Transcendental Phenomenological Study, Dorothy Elaine Rolling
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to explore the role of self-efficacy for nursing students whose primary language was not English and who were enrolled in higher education in the northeastern area of the United States. The theory guiding this study was Bandura’s theory on self-efficacy. The major tenets of the self-efficacy theory aligned with the metaparadigm of nursing (person, health, environment, nursing) and with the study’s focus, which was to explore how English as a second language (ESL) nursing students could successfully complete the registered nursing program at an institution of higher learning. The central research question was: …
Church Attendance, Post-Pandemic Stress, And Resilience Factors, Pavel Bugriyev
Church Attendance, Post-Pandemic Stress, And Resilience Factors, Pavel Bugriyev
Doctoral Dissertations and Projects
Stress levels among adults increased, and a sense of community loss occurred due to the COVID-19 pandemic and subsequent events. Despite previous studies establishing an association between religious practice and psychological well-being, much remains unknown about the differences in religious practice format (i.e., in person, virtually, and not at all) with post-pandemic stress and resilience-related traits. This quantitative cross-sectional study examined whether the format of church attendance (in-person, virtual, or no church attendance at all) was related to post-pandemic stress and resilience-related traits. Also, whether hope, making meaning out of hardship, and perceived social support statistically mediated the difference in …
Comparative Hematological And Biochemical Alterations Associated With Gram-Negative Bacterial Infections Of Lower Urinary Tract In Dogs And Cats, Mohamed Alasmar, Maged El-Ashker, Mohammed Albaloushi, Mayyadah Alkuwayti, Mohamed Marzok
Comparative Hematological And Biochemical Alterations Associated With Gram-Negative Bacterial Infections Of Lower Urinary Tract In Dogs And Cats, Mohamed Alasmar, Maged El-Ashker, Mohammed Albaloushi, Mayyadah Alkuwayti, Mohamed Marzok
The Thai Journal of Veterinary Medicine
The aim of this study was to investigate hematological and biochemical alterations associated with gram-negative bacterial lower urinary tract infections (UTIs) in dogs and cats. For this purpose, 56 dogs and 36 cats were examined between October 2022 and May 2023. Twenty-eight dogs and twenty-two cats with clinical signs of lower UTIs were confirmed using ultrasonography, urinalysis, hematobiochemical analysis, and molecular identification of recovered pathogen. In dogs, UTIs were significantly associated with pyuria (82%), crystalluria (85.7%), and proteinuria. There was also significant decrease in total protein and globulin levels compared to those in the control. A significant increase in BUN, …
Hantaviruses As Priority Zoonotic Diseases: A Comprehensive Review, Wimbuh Tri Widodo, Aswin Rafif Khairullah, Rahmania Ambarika, Widoretno Widoretno, Masri Sembiring Maha, Abdul Hadi Furqoni, Lisa Andriani Lienggonegoro, Bima Putra Pratama, M. Hasinuddin, Zakkiyatus Zainiyah, Eny Susanti, Mufarika Mufarika, Luluk Hermawati, Alvina Setiawardani, Syahputra Wibowo, Arif Nur Muhammad Ansori
Hantaviruses As Priority Zoonotic Diseases: A Comprehensive Review, Wimbuh Tri Widodo, Aswin Rafif Khairullah, Rahmania Ambarika, Widoretno Widoretno, Masri Sembiring Maha, Abdul Hadi Furqoni, Lisa Andriani Lienggonegoro, Bima Putra Pratama, M. Hasinuddin, Zakkiyatus Zainiyah, Eny Susanti, Mufarika Mufarika, Luluk Hermawati, Alvina Setiawardani, Syahputra Wibowo, Arif Nur Muhammad Ansori
The Thai Journal of Veterinary Medicine
Hantaviruses are zoonotic agents that play a significant role in global public health, primarily due to their ability to cause two highly severe clinical syndromes: Hemorrhagic Fever with Renal Syndrome (HFRS), which is predominant in Eurasia, and Hantavirus Cardiopulmonary Syndrome (HCPS/HPS), which is primarily found in the Americas. Although long recognized, the complex interactions between the virus, its rodent reservoir, and environmental factors make hantaviruses still a relevant epidemiological threat today. This review aims to provide a comprehensive overview of their virological characteristics, epidemiological patterns, pathogenesis mechanisms, risk factors, diagnostic methods, therapeutic options, prevention strategies, and the latest developments in …
Managing Maternal Anemia In Pregnancy: The Role Of Iron-Rich Foods And Supplementation, Carli Dibler
Managing Maternal Anemia In Pregnancy: The Role Of Iron-Rich Foods And Supplementation, Carli Dibler
InnovateHER Meeting 2026
Anemia during pregnancy is a large public health concern, which often leads to independent risk factors for fetal and maternal outcomes including postpartum hemorrhaging, cesarean sections, blood transfusions during and after the labor process, hysterectomies, preterm birth, and infectious diseases. Six level I-III studies were analyzed using the John Hopkins nursing evidence-based practice model. Findings showed that by using a combined approach of dietary intake and supplementation overall leads to better fetal and maternal outcomes compared to supplementation alone.
The Role Of Pharmacists In Preventing Antibiotic Resistance: A Narrative Review, Kristy Rahayu Martadiani, Widya Norma Insani, Sofa Dewi Alfian
The Role Of Pharmacists In Preventing Antibiotic Resistance: A Narrative Review, Kristy Rahayu Martadiani, Widya Norma Insani, Sofa Dewi Alfian
Pharmaceutical Sciences and Research
Antibiotic resistance is a serious global health threat, driven by irrational antibiotic use, including uncontrolled self-medication, use without proper indication, and non-adherence to medical instructions. This review aims to examine the strategic role of pharmacists in preventing antibiotic resistance through interventions at different points of healthcare services. While the discussion addresses the global pharmacist role, this review places particular emphasis on resource-limited settings, such as those in developing countries, where access to antibiotics is relatively unrestricted, regulatory enforcement is weak, and self-medication practices are more prevalent. Literature findings indicate that pharmacists play an important role as educators and supervisors of …
Combating Β-Lactamase Resistance: From Inhibitor Design To Substrate Evolution, Lian M.C. Jacobs
Combating Β-Lactamase Resistance: From Inhibitor Design To Substrate Evolution, Lian M.C. Jacobs
USF Tampa Graduate Theses and Dissertations
β-lactamase production by bacteria is a major mechanism of antibiotic resistance. These enzymes hydrolyze β-lactam antibiotics, preventing them from binding to and inhibiting PBPs. Although new β-lactam scaffolds and inhibitors are continually introduced into the clinic, resistance often emerges within a few years. Therefore, the development of cross-class inhibitors with novel scaffolds is critical to mitigate this resistance. In parallel, a deeper understanding of the structural and mechanistic basis of β-lactamase resistance is essential. Together, these approaches provide an effective strategy for combating antibiotic resistance.
The first project addressed the need of effective cross-class β-lactamase inhibitors capable of targeting SBL …
Va Dent J April, May And June 2015
Letter To The Editor A Malignant Infection Of Dental Origin, Marvin E. Pizer Dds, Ms, Ma, Ficd
Letter To The Editor A Malignant Infection Of Dental Origin, Marvin E. Pizer Dds, Ms, Ma, Ficd
Virginia Dental Journal
No abstract provided.
Diversity Regulations For Clinical Trials & The Underrepresentation Of Native American Women, Alka Meresh
Diversity Regulations For Clinical Trials & The Underrepresentation Of Native American Women, Alka Meresh
DePaul Journal of Health Care Law
The exclusion of women and racial minorities from research currently compromises the generalizability of findings. Native American women, are particularly underrepresented in clinical trials due to the complicated history between Native American health and the US government. Congress, the NIH, and the FDA are the most prominent actors involved in regulating the diversity of clinical trial participants. This article will identify and analyze the deficiencies of the current regulations promoting diversity in clinical trials and suggest some solutions to build community with Indigenous communities and promote their participation in clinical trials.
The Impact Of Covid-19 On Longevity Trends And Disparities Among Native Americans And Whites In The Four Corners States, Ashley M. Lenarz, Hyojun Park, Max T. Roberts, Anwesha Pan, Erin Trouth Hofmann, Eric N. Reither
The Impact Of Covid-19 On Longevity Trends And Disparities Among Native Americans And Whites In The Four Corners States, Ashley M. Lenarz, Hyojun Park, Max T. Roberts, Anwesha Pan, Erin Trouth Hofmann, Eric N. Reither
Sociology and Anthropology Student Research
Prior research has shown suboptimal health and longevity among Native Americans in the Four Corners region of the United States, which encompasses Arizona, New Mexico, Colorado, and Utah. Our study (1) investigates how life expectancy trends and disparities changed among non-Hispanic Native Americans and Whites in the Four Corners States (FCS) during the COVID-19 pandemic and (2) examines the extent to which longevity changes are directly attributable to COVID-19, relative to other causes of death. Data sources include mortality data from the National Center for Health Statistics and population data from the U.S. Census Bureau. Life expectancy at birth for …
Global Health Financing Of Diagonal Interventions: Building Resilient And Sustainable Health Systems In Sub-Saharan Africa, Lucy Kim
Master in Public Policy Theses
Background: Global health financing has historically prioritized disease-specific “vertical” programs over broader “horizontal” strengthening of general health systems. Vertical programs in HIV have led to unprecedented reductions in mortality worldwide, but HIV remains a significant public health threat in sub-Saharan Africa, where vertical strategies have long been criticized for creating fragmented health systems. In response, global health strategies have shifted towards combining vertical investments with broader horizontal activities, commonly referred to as “diagonal” programming. While evidence suggests that diagonal programming has the potential to create more resilient and sustainable health systems, evaluating its value for money is challenging due to …
Pfas Toxicity: What’S True, What’S Not, And What Really Matters, Jamie C. Dewitt, Ian T. Cousins, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Carla A. Ng, Martin Scheringer, Xenia Trier, Zhanyun Wang
Pfas Toxicity: What’S True, What’S Not, And What Really Matters, Jamie C. Dewitt, Ian T. Cousins, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Carla A. Ng, Martin Scheringer, Xenia Trier, Zhanyun Wang
Graduate School of Oceanography Faculty Publications
A substantial body of evidence exists demonstrating that exposure to per- and polyfluoroalkyl substances (PFASs) poses a risk to human health. Data from epidemiological studies of those exposed occupationally or environmentally demonstrate adverse health risks, and these health effects are concordant with data from toxicological studies. Systematic reviews, conducted by agencies, organizations, and independent scientists that synthesize and integrate these data streams, have concluded that a range of health risks arise from PFAS exposure, including different types of cancer, especially kidney and testicular cancer, metabolic alterations such as increased liver enzymes and increased cholesterol, immune dysfunction such as reduced vaccination …
Toxoplasmosis-Associated Immune Reconstitution Inflammatory Syndrome In A Patient With Newly Diagnosed Hiv/Aids, Shivam Singh, Divya Samat Md, Viraj Shah, Kelly Brenan-Rothschild, Anthony Donato
Toxoplasmosis-Associated Immune Reconstitution Inflammatory Syndrome In A Patient With Newly Diagnosed Hiv/Aids, Shivam Singh, Divya Samat Md, Viraj Shah, Kelly Brenan-Rothschild, Anthony Donato
Advances in Clinical Medical Research and Healthcare Delivery
Background: Cerebral toxoplasmosis is a common cause of central nervous system (CNS) lesions in advanced HIV, and initiation of antiretroviral therapy (ART) can precipitate immune reconstitution inflammatory syndrome (IRIS). Toxoplasma-related IRIS is rare but poses significant diagnostic and therapeutic challenges. Case Presentation: We report a 40-year-old male with advanced HIV (CD4 <35 cells/mm3, viral load 540,000 copies/mL) who initially presented with seizures and multiple ring-enhancing supratentorial lesions. Serology and cerebrospinal fluid (CSF) polymerase chain reaction (PCR) confirmedToxoplasma gondii, and he was treated with high-dose sulfamethoxazole-trimethoprim, dexamethasone, and ART. A lymph node biopsy revealed granulomatous inflammation with intracellularHistoplasmaspecies. One month later, following brief interruption of anti-toxoplasma therapy, he developed recurrent seizures and radiographic progression despite ART adherence. Repeat evaluation excluded other infections or malignancy. Brain biopsy confirmedT. gondii, and IRIS was diagnosed. The patient improved with re-initiation of high-dose anti-toxoplasma therapy, corticosteroids, and seizure prophylaxis. Discussion: This case illustrates paradoxical toxoplasmosis-associated IRIS in the context of advanced HIV and concurrent opportunistic infection. Early recognition, exclusion of alternative diagnoses, and continuation of ART with targeted antimicrobial therapy are essential. Conclusion: Clinicians should maintain a high index of suspicion for IRIS in HIV patients with CNS …35>
Adoption And Diffusion Of At-Home Medical Tests, Jerome Christia
Adoption And Diffusion Of At-Home Medical Tests, Jerome Christia
Atlantic Marketing Association Proceedings
No abstract provided.
A Shift In The Respiratory Syncytial Virus Seasonal Pattern: A Single–Center Retrospective Study In Anhui, China (2023–2025), Yan Lu, Jie Zhang, Keran Zhu, Li Wang, Shenggang Ding, Liping Yuan
A Shift In The Respiratory Syncytial Virus Seasonal Pattern: A Single–Center Retrospective Study In Anhui, China (2023–2025), Yan Lu, Jie Zhang, Keran Zhu, Li Wang, Shenggang Ding, Liping Yuan
Journal of Pediatric Infectious Diseases
Objective: Before the coronavirus disease 2019 pandemic, respiratory syncytial virus (RSV)-related hospitalizations followed a predictable seasonal pattern in Anhui, China, typically beginning in November and lasting until March of the following year. However, city-specific data for Anhui were limited. This study investigated the epidemiological patterns and risk factors associated with severe RSV-associated lower respiratory tract infection (LRTI) among hospitalized children in our centre. Methods: We reviewed the records of children aged ≤14 years who were hospitalized with RSV lower respiratory tract infection between June 2023 and May 2025. RSV infection was confirmed using reverse transcription-polymerase chain reaction testing. Data on …
Pertussis In Adolescents: Nonspecific Findings And The Importance Of Clinical Vigilance - A Single-Center Retrospective Study, Kaan Celebier, Furkan Kalayci, Merve Keser, Metin Yigit, Enes K. Kılıc, Yunus E. Ince, Ahmet A. Gungor, Hande Yigit, Betul Demircioglu Kalayci, Aslınur Özkaya Parlakay
Pertussis In Adolescents: Nonspecific Findings And The Importance Of Clinical Vigilance - A Single-Center Retrospective Study, Kaan Celebier, Furkan Kalayci, Merve Keser, Metin Yigit, Enes K. Kılıc, Yunus E. Ince, Ahmet A. Gungor, Hande Yigit, Betul Demircioglu Kalayci, Aslınur Özkaya Parlakay
Journal of Pediatric Infectious Diseases
Objective: In adolescents, pertussis commonly presents with a mild, atypical picture that can delay diagnosis, lead to its exclusion from the differential diagnosis list, and sustain community transmission. Typical paroxysms and laboratory abnormalities are frequently absent or subtle. We aimed to describe qPCR-confirmed adolescent cases and highlight diagnostic challenges. Methods: We retrospectively reviewed electronic records of patients presenting to general pediatrics and pediatric infectious diseases clinics between January 2019 and August 2025. Adolescents with a multiplex respiratory panel positive only for Bordetella pertussis were included; co-detections and incomplete data were excluded. Demographics, symptoms, examination and imaging findings, laboratory results, treatment, …
A Clinical Risk Stratification Approach For Sensorineural Hearing Loss In Pediatric Bacterial Meningitis: A Retrospective Cohort Study From Vietnam, Nguyen D. Pham, Toan M. Duong
A Clinical Risk Stratification Approach For Sensorineural Hearing Loss In Pediatric Bacterial Meningitis: A Retrospective Cohort Study From Vietnam, Nguyen D. Pham, Toan M. Duong
Journal of Pediatric Infectious Diseases
Objective: To address the long-term burden of sensorineural hearing loss (SNHL) following pediatric bacterial meningitis and the need for early identification of at-risk children, particularly in resource-limited settings where universal post-meningitis screening is impractical. This study aimed to develop a clinically accessible risk stratification approach, using routinely available variables, to support triage and prioritization of audiological follow-up. Methods: A retrospective cohort study was conducted at Children’s Hospital 1, Ho Chi Minh City, Vietnam. Children aged 1 month to 15 years, who were hospitalized with bacterial meningitis and underwent audiological assessment after recovery, were included. Hearing outcomes were evaluated by auditory …
The Diagnostic Role Of Trimethylamine N-Oxide In Pediatric Acute Appendicitis: An Exploratory Study, Mehmet Sarikaya, Fatma Ozcan Siki, Fadime Ovali, Husamettin Vatansev, İlhan Ciftci
The Diagnostic Role Of Trimethylamine N-Oxide In Pediatric Acute Appendicitis: An Exploratory Study, Mehmet Sarikaya, Fatma Ozcan Siki, Fadime Ovali, Husamettin Vatansev, İlhan Ciftci
Journal of Pediatric Infectious Diseases
Objective: Trimethylamine N-oxide (TMAO), a metabolite derived from gut microbiota, has been linked to various chronic inflammatory conditions. However, its potential role in acute inflammation, such as pediatric acute appendicitis, remains unclear. This exploratory diagnostic study aimed to assess the preliminary diagnostic performance of serum and urinary TMAO levels in differentiating appendicitis subtypes. Methods: In this prospective study, 137 pediatric patients who underwent surgery for suspected acute appendicitis were included. Based on histopathological findings, patients were categorized into negative, non-complicated, and complicated appendicitis groups. Serum and urinary TMAO levels were measured using liquid chromatography–tandem mass spectrometry. Group comparisons were performed …
Comparative Analysis Of Haematological, C-Reactive Protein, And Biochemical Markers In Paediatric Mycoplasma Pneumonia: Mono-Infection Versus Co-Infections, Xingjia Tang, Chongfeng Chen
Comparative Analysis Of Haematological, C-Reactive Protein, And Biochemical Markers In Paediatric Mycoplasma Pneumonia: Mono-Infection Versus Co-Infections, Xingjia Tang, Chongfeng Chen
Journal of Pediatric Infectious Diseases
Objective: To investigate the distinct patterns of haematological parameters, C-reactive protein (CRP) levels, and biochemical markers in paediatric patients with Mycoplasma pneumoniae pneumonia (MPP), comparing mono-infection to co-infections with Haemophilus influenzae (MPP-Hi) or influenza virus (MPP-Inf). Methods: A retrospective analysis was conducted on 140 paediatric patients with confirmed MPP. The patients were stratified into three groups: MPP mono-infection (n=64), MPP-Hi co-infection (n=36), and MPP-Inf co-infection (n=40). Clinical manifestations and laboratory parameters, including haematological profiles and CRP levels, were analysed and compared among the three groups. Results: The MPP-Hi co-infection group had significantly higher hypersensitive CRP levels (23.93 ± 21.26 mg/L) …
An Epidemiological Analysis Of Influenza Virus In The Context Of Covid-19 Pandemic, Mustafa Gençeli, Özge Metin Akcan, Talha Üstüntaş, Ebru Sümen, Sinan Saylık, Emine Özdemir, Ahsen N. Saylık, Methiye Doğan, Arif İ. Solak, Fatih Ercan, Mehmet Özdemir, Abdullah Akkuş, Hanife T. Çağlar, Ahmet O. Kılıç, Sevgi Pekcan
An Epidemiological Analysis Of Influenza Virus In The Context Of Covid-19 Pandemic, Mustafa Gençeli, Özge Metin Akcan, Talha Üstüntaş, Ebru Sümen, Sinan Saylık, Emine Özdemir, Ahsen N. Saylık, Methiye Doğan, Arif İ. Solak, Fatih Ercan, Mehmet Özdemir, Abdullah Akkuş, Hanife T. Çağlar, Ahmet O. Kılıç, Sevgi Pekcan
Journal of Pediatric Infectious Diseases
Objective: The global health interventions implemented during the COVID-19 pandemic fundamentally altered the transmission of communicable diseases. This study examines changes in influenza virus epidemiology within the Turkish public health system across different phases of the pandemic. Methods: This retrospective study analyzed 3,585 pediatric patients (aged 0–18 years) diagnosed with influenza between January 2018 and June 2023. We stratified the cohort into three periods based on admission dates: pre-COVID-19, the COVID-19 pandemic, and the post-COVID-19 period. Results: We observed a statistically significant increase in the mean age of patients during the pandemic period (p<0.001). The incidence of influenza B decreased significantly during the pandemic compared to other periods (p<0.001). The post-pandemic period was characterized by higher viral co-infection rates and increased hospitalization frequencies (p<0.001), though the duration of hospitalization decreased during the pandemic (p<0.001). In the post-pandemic phase, the typical November surge was less pronounced, with peak incidence shifting to January. Conclusion: The pandemic significantly altered influenza epidemiology, shifting viral subtype prevalence, incidence rates, co-infection patterns, seasonal trends, and mortality risks.
Incidence, Pathogen Distribution, And Hematological Responses In Neonatal Sepsis: A Three-Year Retrospective Study In The Uae, Asmaa Almilhem, Doha M. Moustafa, Izdehar Nached, Sana Al-Rawi, Yaser Ali, Mona Khalaf, Aisha Alkhaaldi
Incidence, Pathogen Distribution, And Hematological Responses In Neonatal Sepsis: A Three-Year Retrospective Study In The Uae, Asmaa Almilhem, Doha M. Moustafa, Izdehar Nached, Sana Al-Rawi, Yaser Ali, Mona Khalaf, Aisha Alkhaaldi
Journal of Pediatric Infectious Diseases
Objective: This study aimed to evaluate the incidence of neonatal sepsis per 1,000 live births, identify the prevalence of causative pathogens, and examine hematological differences between Gram-negative and Gram-positive neonatal sepsis. Methods: A retrospective study was conducted from January 1, 2021, to December 31, 2023, at Al Qassimi Women’s and Children’s Hospital (AQWCH), UAE. Neonates admitted to the NICU with positive blood cultures were included and categorized as early-onset (EONS) or late-onset (LONS) sepsis. Incidence rates (IRs) were calculated per 1,000 live births with 95% confidence intervals (CIs). Univariate logistic regression was initially performed to identify potential factors associated with …
The Role Of The Systemic Immune-Inflammation Index In Predicting Hospitalization In Children With Acute Gastroenteritis, Ebru Buldu, Sadiye Sert, Fatma Sargın, İbrahim Solak
The Role Of The Systemic Immune-Inflammation Index In Predicting Hospitalization In Children With Acute Gastroenteritis, Ebru Buldu, Sadiye Sert, Fatma Sargın, İbrahim Solak
Journal of Pediatric Infectious Diseases
Objective: Acute diarrhea in childhood is one of the most common infections in children and a leading cause of death from infectious diseases under five years of age worldwide. The Systemic Immune-Inflammation Index (SII) reflects the balance between inflammation and immune response. This study aimed to investigate the relationship between acute gastroenteritis (AGE) infection and SII in children. Methods: This retrospective study included 3,039 children, comprising 1,668 with AGE and 1,371 healthy controls. Hematologic parameters and SII were analyzed. Data was compared across patient and control groups, inpatients versus outpatients, and groups with viral versus parasitic AGE etiologies. Results: Of …
181st University Of Notre Dame Commencement, University Of Notre Dame
181st University Of Notre Dame Commencement, University Of Notre Dame
Commencement Programs
- SCHEDULE OF EVENTS 4
- HEARING IMPAIRED INFORMATION 9
- GRADUATE SCHOOL 10
- MENDOZA COLLEGE OF BUSINESS GRADUATE BUSINESS 32
- GRADUATE ARCHITECTURE 38
- LAW SCHOOL 39
- UNIVERSITY COMMENCEMENT CEREMONY 42
- COLLEGE OF ARTS AND LETTERS 44
- COLLEGE OF SCIENCE 51
- COLLEGE OF ENGINEERING 55
- MENDOZA COLLEGE OF BUSINESS 61
- SCHOOL OF ARCHITECTURE 67
- KEOUGH SCHOOL OF GLOBAL AFFAIRS 67
- VALEDICTORIAN CANDIDATES 68
- EMERITI FACULTY 68
- HONOR SOCIETIES 69
- AWARDS AND PRIZES 77
- TASSELS 100