Digital Commons Network^™

A Replication-Inducible Recombinant Vaccinia Virus System To Conditionally Transcribe The Entire Human Rhinovirus C Genome, Zhixin Jing

Master's Theses

No abstract provided.

Assessing The Impact Of Breastfeeding Cessation On The Reported Incidence Of Diarrhea In Infants Between The Ages Of 7 To 12 Months: A Secondary Data Analysis, Ana Francisca Diallo

Master's Theses

Background: Diarrheal diseases remain a major cause of childhood morbidity in the United States. Optimal breastfeeding has been identified as one of the most effective measure to prevent diarrheal diseases in childhood.

Purpose: To evaluate the impact of breastfeeding duration during the first 6 months on the incidence of diarrhea in infants between 7 and 12 months in the United States.

Method: A secondary data analysis was performed using mothers and infants participating in the Infant Feeding Practices Study II (2005-2007).

Results: Compared to those who breastfed for 6 months or more, infants who discontinued breastfeeding between 0 …

Week Of September 12, 2016, New York Medical College

InTouch

• All Roads Lead to New York Medical College
• Missing Type Campaign Launches Successful NYMC Blood Drive

Investigation On The Lipid Transfer Rates And The Polymer-Induced Clustering Between Lipid-Based Nanopartcles: Toward The Development Of Naked-Eye Biosensing, Yan Xia

Doctoral Dissertations

Archival abstract submitted

Temporal And Spatial Distribution Of Enterobius Vermicularis (Nematoda: Oxyuridae) In The Prehistoric Americas, Karl J. Reinhard, Adauto Araújo, Johnica J. Morrow

Karl Reinhard Publications

Investigations of Enterobius sp. infection in prehistory have produced a body of data that can be used to evaluate the geographic distribution of infection through time in the Americas. Regional variations in prevalence are evident. In North America, 119 pinworm positive samples were found in 1,112 samples from 28 sites with a prevalence of 10.7%. Almost all of the positive samples came from agricultural sites. From Brazil, 0 pinworm positive samples were found in 325 samples from 7 sites. For the Andes region, 22 pinworm positive samples were found in 411 samples from 26 sites for a prevalence of 5.3%. …

Path Of Selfless Service, Eric F. Spina

President's Blog: From the Heart

President Eric Spina calls the 2016 Alumni Award recipients "servant-leaders who inspire us with their lives of action and faith." Here's the full text of his remarks delivered at the Sept. 10 celebration on campus.

Chapman Is A National Voice For Reforming 'Wasteland Of The Mind', Deb Lucas

Browse All News

No abstract provided.

Boyd Briefs - Sept. 8, 2016, University Of Nevada, Las Vegas -- William S. Boyd School Of Law

Boyd Briefs / Road Scholars

Boyd Briefs provides weekly information regarding the activities and accomplishments of the faculty, students, and alumni of the William S. Boyd School of Law at the University of Nevada, Las Vegas.

Serving Underrepresented Graduate Students: Uab's Neural Conference, Jeff Hansen

Browse All News

No abstract provided.

Association Of Methicillin And Vancomycin Antibiotics Resistance In Staphylococcus Aureus Isolated From Wound Infection Patients, Mohammed Abdul Reda Yassen

Muthanna Medical Journal

Methicillin-resistant Staphylococcus aureus is the major cause of healthcare-associated bacteremia in most of Hospital and it increased risk of infection, morbidity and mortality especially, when associated vancomycin resistance in same infection. In this study 42 S. aureus were isolated from wound infection patients in Diwaniya hospital and S. aureus was isolated by selective medium out form 50 swab samples. The PCR assay was used for direct detection of methicillin (mecA) and vancomycin (van) antibiotics resistance gene in 42 S. aureus isolates. The results show only 5 isolates (11%) were have single methicillin resistance and there no single vancomycin resistance in …

2016 Proceedings Of The 23rd Annual Summer Research Symposium, College Of The Holy Cross

Summer Research Program

The symposium, now in its 23rd year, is a college-wide event that brings together faculty and students from all disciplines at Holy Cross and provides an opportunity to celebrate their accomplishments over the summer of 2016. It also provides an opportunity for students to witness the breadth of research possibilities both on and off campus, and to open a dialogue with members of the faculty about conducting research during the upcoming academic year and summer. This program lists participating students, the faculty with whom they worked, abstracts and funding sources of their projects. "The summer research program at Holy Cross …

Biallelic Hypomorphic Mutations In A Linear Deubiquitinase Define Otulipenia, An Early-Onset Autoinflammatory Disease, Qing Zhou, Xiaomin Yu, Erkan Demirkaya, Natalie Deuitch, Deborah Stone, Wanxia Li Tsai, Hye Sun Kuehn, Hongying Wang, Dan Yang, Yong Hwan Park, Amanda K. Ombrello, Mary Blake, Tina Romeo, Elaine F. Remmers, Jae Jin Chae, James C. Mullikin, Ferhat Güzel, Joshua D. Milner, Manfred Boehm, Sergio D. Rosenzweig, Massimo Gadina, Steven B. Welch, Seza Özen, Rezan Topaloglu, Mario Abinun, Daniel L. Kastner, Ivona Aksentijevich

Paediatrics Publications

Systemic autoinflammatory diseases are caused by mutations in genes that function in innate immunity. Here, we report an autoinflammatory disease caused by loss-of-function mutations in OTULIN (FAM105B), encoding a deubiquitinase with linear linkage specificity. We identified two missense and one frameshift mutations in one Pakistani and two Turkish families with four affected patients. Patients presented with neonatal-onset fever, neutrophilic dermatitis/panniculitis, and failure to thrive, but without obvious primary immunodeficiency. HEK293 cells transfected with mutated OTULIN had decreased enzyme activity relative to cells transfected with WT OTULIN, and showed a substantial defect in the linear deubiquitination of target molecules. Stimulated patients' …

Serving Underrepresented Graduate Students: Uab's Neural Conference, Jeff Hansen

Browse All News

No abstract provided.

Review Of Experimental Compounds Demonstrating Anti-Toxoplasma Activity, Madalyn M. Mcfarland, Sydney J. Zach, Xiaofang Wang, Lakshmi-Prasad Potluri, Andrew J. Neville, Jonathan L. Vennerstrom, Paul H. Davis

Biology Faculty Publications

Toxoplasma gondii is a ubiquitous apicomplexan parasite capable of infecting humans and other animals. Current treatment options for T. gondii infection are limited and most have drawbacks, including high toxicity and low tolerability. Additionally, no FDA-approved treatments are available for pregnant women, a high-risk population due to transplacental infection. Therefore, the development of novel treatment options is needed. To aid this effort, this review highlights experimental compounds that, at a minimum, demonstrate inhibition of in vitro growth of T. gondii. When available, host cell toxicity and in vivo data are also discussed. The purpose of this review is to facilitate …

Comprehensive Analysis Of Type 1 Fimbriae Regulation In Fimb -Null Strains From The Multidrug Resistant Escherichia Coli St131 Clone, Sohinee Sarkar, Leah W. Roberts, Minh Duy Phan, Lendl Tan, Alvin W. Lo, Kate M. Peters, David L. Paterson, Mathew Upton, Glen C. Ulett, Scott A. Beatson, Makrina Totsika, Mark A. Schembri

School of Biomedical Sciences

No abstract provided.

In Vivo And In Vitro Studies Of Polyamides That Are Active Antiviral Agents Against Hpv16, Edith Csiki-Fejer

Dissertations

Long-term, persistent infection with high-risk strains of human papillomavirus (HPV) is the precursor of most cervical cancers and an increasing number of the head and neck cancers. While HPV vaccines can protect patients under twenty-five years old from possible infections, no HPV antiviral drugs are available for the definitive treatment of preexisting or future viral infections. To treat current or future HPV infections, drugs that selectively block virus-specific processes, but do not damage the host cells, are needed. The compounds developed in our group are unique Imidazole-pyrrole polyamides, analogs of natural products Distamycin A and Netropsin that function by interfering …

Nutrition And Helicobacter Pylori: Host Diet And Nutritional Immunity Influence Bacterial Virulence And Disease Outcome, Kathryn P. Haley, Jennifer A. Gaddy

Peer Reviewed Articles

Helicobacter pylori colonizes the stomachs of greater than 50% of the world’s human population making it arguably one of the most successful bacterial pathogens. Chronic H. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with H. pylori is associated with an increased risk for more severe disease outcomes including B-cell lymphoma of mucosal-associated lymphoid tissue (MALT lymphoma) and invasive adenocarcinoma. Research aimed at elucidating determinants that mediate disease progression has revealed genetic differences in both humans and H. pylori which increase the risk for developing gastric cancer. Furthermore, host diet and …

The Neu1-Selective Sialidase Inhibitor, C9- Butyl-Amide-Dana, Blocks Sialidase Activity And Neu1-Mediated Bioactivities In Human Lung In Vitro And Murine Lung In Vivo, Sang W. Hyun, Anguo Liu, Zhenguo Liu, Alan S. Cross, Avelino C. Verceles, Sadagopan Magesh, Yadagiri Kommagalla, Chandrababunaidu Kona, Hiromune Ando, Irina G. Luzina, Sergei P. Atamas, Kurt H. Piepenbrink, Eric J. Sundberg, Wei Guang, Hideharu Ishida, Erik P. Lillehoj, Simeon E. Goldblum

Food for Health: Publications

Neuraminidase-1 (NEU1) is the predominant sialidase expressed in human airway epithelia and lung microvascular endothelia where it mediates multiple biological processes. We tested whether the NEU1-selective sialidase inhibitor, C9-butyl-amide-2-deoxy-2,3-dehydro-Nacetylneuraminic acid (C9-BA-DANA), inhibits one or more established NEU1-mediated bioactivities in human lung cells. We established the IC50 values of C9-BA-DANA for total sialidase activity in human airway epithelia, lung microvascular endothelia and lung fibroblasts to be 3.74 µM, 13.0 µM and 4.82 µM, respectively. In human airway epithelia, C9-BA-DANA dose-dependently inhibited flagellin-induced, NEU1-mediated mucin-1 ectodomain desialylation, adhesiveness for Pseudomonas aeruginosa and shedding. In lung microvascular endothelia, C9-BA-DANA reversed NEU1-driven restraint of …

The Cost Of Inter-Ethnic Conflicts In Ghana’S Northern Region: The Case Of The Nawuri-Gonja Conflicts, Emmanuel Debrah, Seidu Alidu, Isaac Owusu-Mensah

Journal of African Conflicts and Peace Studies

The article assesses the socio-economic and human repercussions of one of the fiercest ethnic conflicts in Ghana’s Northern Region on people and society. While Ghana remains a stable democracy, sporadic ethnic and chieftaincy conflicts have been a recurrent feature of the political process. Analyzing data from survey opinions and interviews from wide spectrum of respondents, the study noted that the Nawuri-Gonja conflicts have destroyed the fabric of the society leaving behind squalor, breakdown of healthcare, education and psychological trauma. Women and children have suffered rape assaults and unprecedented high rate of mortality due to malnourishments respectively. The plights of these …

Use Of Smartphones In Patient Care, Uday Venkat Mateti

Manipal Journal of Pharmaceutical Sciences

It is difficult to go to town, to a party or meet friends and socialize, without sighting someone using a smartphone. Increased level of smartphone usage is connected with enhancements in education, societal, and governmental participation, mostly in developing countries. Smartphones make it much easier to find answers for any question at anytime and anywhere by searching through “Google.” Healthcare apps make smartphones useful tools in the practice of evidence based medicine/pharmacy/nursing at the point of patient care. In addition, use of smartphones play a major role in “patient education, self-management or self-care, and remote monitoring of patients.”

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

The Global Economic And Health Burden Of Human Hookworm Infection., Sarah M Bartsch, Peter J. Hotez, Lindsey Asti, Kristina M Zapf, Maria Elena Bottazzi, David J. Diemert, Bruce Y Lee

Microbiology, Immunology, and Tropical Medicine Faculty Publications

BACKGROUND: Even though human hookworm infection is highly endemic in many countries throughout the world, its global economic and health impact is not well known. Without a better understanding of hookworm's economic burden worldwide, it is difficult for decision makers such as funders, policy makers, disease control officials, and intervention manufacturers to determine how much time, energy, and resources to invest in hookworm control.

METHODOLOGY/PRINCIPLE FINDINGS: We developed a computational simulation model to estimate the economic and health burden of hookworm infection in every country, WHO region, and globally, in 2016 from the societal perspective. Globally, hookworm infection resulted in …

Microfluidic Platform For Electrophysiological Recordings From Host-Stage Hookworm And Ascaris Suum Larvae: A New Tool For Anthelmintic Research, Janis Weeks, William Roberts, Kristin Robinson, Melissa Keaney, Jon Vermiere, Joseph Urban, Shawn Lockery, John M. Hawdon

Microbiology, Immunology, and Tropical Medicine Faculty Publications

The screening of candidate compounds and natural products for anthelmintic activity is important for discovering new drugs against human and animal parasites. We previously validated in Caenorhabditis elegans a microfluidic device (‘chip’) that records non-invasively the tiny electrophysiological signals generated by rhythmic contraction (pumping) of the worm's pharynx. These electropharyngeograms (EPGs) are recorded simultaneously from multiple worms per chip, providing a medium-throughput readout of muscular and neural activity that is especially useful for compounds targeting neurotransmitter receptors and ion channels. Microfluidic technologies have transformedC. elegans research and the goal of the current study was to validate hookworm andAscaris …

Evaluating Isolation Behaviors By Nurses Using Mobile Computer Workstations At The Bedside., Elizabeth L. Beam, Shawn G. Gibbs, Angela L. Hewlett, Peter C. Iwen, Suzanne L. Nuss, Philip W. Smith

Journal Articles: College of Nursing

This secondary analysis from a larger mixed methods study with a sequential explanatory design investigates the clinical challenges for nurses providing patient care, in an airborne and contact isolation room, while using a computer on wheels for medication administration in a simulated setting. Registered nurses, who regularly work in clinical care at the patient bedside, were recruited as study participants in the simulation and debriefing experience. A live volunteer acted as the standardized patient who needed assessment and intravenous pain medication. The simulation was video recorded in a typical hospital room to observe participating nurses conducting patient care in an …

Outpatient Antibiotic Prescribing Among United States Nurse Practitioners And Physician Assistants., Guillermo V Sanchez, Adam L Hersh, Daniel J Shapiro, James F. Cawley, Lauri A Hicks

Prevention and Community Health Faculty Publications

We examined US nurse practitioner (NP) and physician assistant (PA) outpatient antibiotic prescribing. Antibiotics were more frequently prescribed during visits involving NP/PA visits compared with physician-only visits, including overall visits (17% vs 12%, P < .0001) and acute respiratory infection visits (61% vs 54%, P < .001). Antibiotic stewardship interventions should target NPs and PAs.

Stability Analysis Of Extended One-Step Schemes For Stiff And Non-Stiff Delay Differential Equations, F. Ibrahim, F. A. Rihan, S. Turek

Applied Mathematics & Information Sciences

Herein, we provide a reliable and stable computational technique, based on a class of extended one-step methods for solving delay differential equations with constant and variable delays. Numerical stability properties of the schemes are investigated. The schemes are suitable for stiff and non-stiff problems. Numerical results and simulations are presented to demonstrate the effectiveness of the methodology.

Applied Health Sciences: 360 Section 002 Epidemiology Syllabus, Whitney Blondeau

Syllabus Collection

Epidemiology is the study of the distribution and determinants of health events among the human population. Topics include: history of disease; epidemiologic study design, data collection, analysis, presentation, and application in community diagnosis, risk assessment, and program evaluation. This course covers applications of epidemiologic methods and procedures to the study of the distribution and determinants of health and diseases, morbidity, injuries, disability, and mortality in populations. Epidemiologic methods for the control of conditions such as infectious and chronic diseases, mental disorders, community and environmental health hazards, and unintentional injuries are discussed. Other topics include quantitative aspects of epidemiology, for example, …

Ada Code Of Ethics (September 2016), American Dental Association

Code of Ethics

The ADA Code of Ethics has three main components: The Principles of Ethics, the Code of Professional Conduct and the Advisory Opinions. Contents may also include: Amendment to ADA Principles of Ethics and Code of Professional Conduct and Insert for the ADA Principles of Ethics and Code of Professional Conduct. The most current issue is available on the ADA’s website.

Research News Newsletter, Fall 2016, Research News Newsletter, Stony Brook University.

Research News

Quarterly newsletter from the Office of the Vice President for Research

Finding Aid For The Valenti Collection Of Early Aids Imprints, William M. Valenti

Finding Aids

In the 1980s, Dr. William M. Valenti became an early leader in the treatment of HIV/AIDS patients in Rochester, NY. The collection documents his career as a physician and as founder of Community Health Network, Inc., a not-for-profit community based medical facility for HIV care. The collection also documents the global medical response to the emergence of HIV/AIDS and changing cultural attitudes towards those infected with the virus. The collection includes published books and periodicals, newspaper clippings, and a small amount of graphic and audiovisual material.