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The Role Of Oxytocin In Modulating Neural Oscillations In Nulliparous Women, Xiaoyue Mona Guo

Yale Medicine Thesis Digital Library

The hormone oxytocin (OT) has been implicated in social cognition and behavior as well as in modulating important affiliative relationships such as parenting; meanwhile, intranasal OT administration is gaining popularity as a means to modulate neural activity in brain regions during experimental tasks. However, the neural mechanisms underscoring the changes associated with OT administration have yet to be fully elucidated. Using electroencephalography (EEG), this thesis project aims to further our understanding of how OT affects brain activity and response to infant cues. In a double-blind placebo controlled design, OT’s effect on resting-state neural oscillations and event-related potentials (ERPs) to face …

Association Of Tuberculosis And Macrophage Migration Inhibitory Factor In A South African Population, Duncan Reid Reid

Yale Medicine Thesis Digital Library

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays an important role in the pathogenesis of autoimmune inflammatory diseases. Functional promoter variants in the MIF gene influence host susceptibility to different infectious diseases, including tuberculosis (TB). However, the effect of functional MIF promoter variants in subjects with co-infection with human immunodeficiency virus (HIV) and TB, who comprise over 12 percent of new TB cases globally and 60 percent of new TB cases in South Africa, has been examined only in one prior study. Here, an association study was carried out in a clinically well-defined rural population in KwaZulu-Natal, …

Medicine@Yale September/October 2016 Volume 12, Issue 2, Yale School Of Medicine Department Of Surgery

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Investigating The Roles Of Zinc-Binding Protein (Zbp-89) And Rela (Nfkb-P65) In The Regulation Of Matrix Metalloproteinase 1 (Mmp1) Gene Expression, Nelly Khaselev

PCOM Biomedical Studies Student Scholarship

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases with the unique ability to breakdown virtually the entire extracellular matrix (ECM). Through ECM remodeling, MMPs play an important role in normal development, tissue repair, angiogenesis, and apoptosis. Studies have shown that unregulated MMP expression plays a role in many cancers and chronic inflammatory diseases. Previous research has used gene sequence analysis ofthe MMP-1 promoter to identify a putative ZBP-89 binding site at -1969 bp. Chromatin immuneprecipitation experiments showed that both ZBP-89 and Re!A (p65) could bind to this binding site. In this thesis research, transfection experiments were used to explore …

Tickborne Disease Prevention Among State Agencies, Karla R. Armenti, K. Dopfel, K. Bush

Institute on Disability

No abstract provided.

Evidence And Evidence Gaps In Adolescent Health, George Patton, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

The momentum to bring adolescents and young adults to center stage in global health and international development is palpable. Adolescents are increasingly seen as a crucial group for the success of the newly adopted Agenda for Sustainable Development [1]. Sitting within the Agenda for Sustainable Development framework, the 2030 Global Strategy for Women's, Children's and Adolescents' Health has extended the Every Woman, Every Child agenda to adolescence [2]. The strategy articulates the need for adolescent responsive health systems as well as social determinants, a focus that extends to legal and policy environments [3]. Countries seeking to adopt this more holistic …

Evaluation Of The Efficacy Of Candidate Probiotics For Disease Prevention In Shellfish Hatcheries, Saebom Sohn

Open Access Dissertations

In the United States of America, oyster production is an important component of the seafood economy in many communities in coastal states. The severe impact of disease outbreaks and mass mortality of oyster larvae in hatcheries impacts production, since the oyster industry is largely dependent on hatchery and nursery production. The use of probiotics has been proposed as a potential preventative measure to limit the impact of bacterial diseases in shellfish hatcheries. In previous laboratory studies, the probiotic bacteria Phaeobacter inhibens S4 and Bacillus pumillus RI06-95 improved the survival of eastern oyster (Crassostrea virginica) larvae against the pathogens …

Antimicrobial Resistance Patterns And Protective Effects Of Statins In Bacteremic Patients, Ajinkya Pawar

Open Access Dissertations

The significant increase in antimicrobial resistance over the past few years is a serious global public health concern, particularly as the development of new antimicrobial agents had been slow for many years. Infections with resistant organisms are associated with poor clinical outcomes and higher cost burdens. Determining antimicrobial resistance patterns can help identify problem areas and modify treatment practices to improve clinical outcomes. Additionally, identifying adjunctive therapies can also help improve clinical outcomes among infected patients. The objectives, hypotheses, methods and results of this dissertation are threefold:

Manuscript 1: The objective was to analyze antimicrobial resistance trends in E. faecalis …

Dry Powder Aerosol Nanocomposite Microparticles For The Treatment Of Pulmonary Diseases, Zimeng Wang

Open Access Dissertations

Dry powder aerosols have attracted increasing attention for the treatment of pulmonary diseases due to their capability of providing direct and efficient drug delivery to the lungs. Unfortunately, barriers exist in the implementation of dry powder pulmonary delivery systems, including: (1) dry powder aerosols with aerodynamic diameters smaller than 1 μm will often be exhaled; (2) particles with aerodynamic diameters above 5 μm tend to deposit in the mouth, throat or upper lung mucosa and will then be eliminated due to mucosal clearance mechanisms; and (3) particles larger than 1 μm that deposit in the deep lung area may be …

Looking Into Malaria, Ahmad Ahmad

A with Honors Projects

According to the Centers for Disease Control, malaria has been a concern for more than 4000 years, with symptoms being described in ancient medical writings, and remains a prevalent health concern. In this student paper, the author reports on the history of the disease, it's epidemiology, diagnosis and treatment.

Fogging Practices Of Iowa Counties For Mosquito Abatement, Alex Jay Davey

Graduate Research Papers

Global warming has been associated with an increase of mosquito-borne diseases. Mosquito-borne diseases currently have no prescription remedies. The counties across the state of Iowa will increase their fogging procedure, to supplement the increase in mosquitos and mosquito-borne diseases. This study examined which chemicals each county uses for mosquito abatement, the patterns and frequency of spraying, and what patterns of human exposure may be occurring. The county auditor was identified and recruited via email. The county auditors across the state forwarded the email message to the Environmental Health Director, in each county. At county level, they are not in control …

Objective Bayesian Analysis Of A Generalized Lognormal Distribution, Shengnan Li

Dissertations, Master's Theses and Master's Reports

The generalized lognormal distribution plays an important role in various aspects of life testing experiments. We examine Bayesian analysis of this distribution using objective priors (in the general sense of priors constructed using some formal rules) for the model parameters in this paper. Specifically, the derivation of explicit expressions for multiple types of the Jeffreys priors, the reference priors with different group ordering of the parameters, and the first-order matching priors. We investigate the important issue of proper posterior distributions. It is shown that only two of them lead to proper posterior distributions. Monte Carlo simulations are conducted to compare …

Inhibition Of Bacterial Growth And Prevention Of Bacterial Adhesion With Localized Nitric Oxide Delivery, Julia Osborne

Dissertations, Master's Theses and Master's Reports

Bacterial infections continue to be a problem at the site of an indwelling medical device, and over the years, various bacterial strains have become more resistant to current antibiotic treatments. Bacterial infection at an indwelling medical device can be dangerous and affect the performance of the medical device which can ultimately lead to the failure of the device due to bacterial resistance to treatment.

Nitric Oxide (NO) has been shown to possess antibacterial properties to prevent and inhibit bacterial growth. NO releasing coatings on indwelling medical devices could provide a reduction in bacterial infections that occur at the device site …

Global Mortality Impact Of The 1957–1959 Influenza Pandemic, Cecile Viboud, Lone Simonsen, Rodrigo Fuentes, Jose Flores, Mark A. Miller, Gerardo Chowell

Global Health Faculty Publications

Background. Quantitative estimates of the global burden of the 1957 influenza pandemic are lacking. Here we fill this gap by modeling historical mortality statistics.

Methods. We used annual rates of age- and cause-specific deaths to estimate pandemic-related mortality in excess of background levels in 39 countries in Europe, the Asia-Pacific region, and the Americas. We modeled the relationship between excess mortality and development indicators to extrapolate the global burden of the pandemic.

Results. The pandemic-associated excess respiratory mortality rate was 1.9/10 000 population (95% confidence interval [CI], 1.2–2.6 cases/10 000 population) on average during 1957–1959. Excess mortality rates varied 70-fold …

Marine Infectious Disease Dynamics And Outbreak Thresholds: Contact Transmission, Pandemic Infection, And The Potential Role Of Filter Feeders, Gorka Bidegain, Eric N. Powell, John M. Klinck, Tal Ben-Horin, Eileen E. Hofmann

CCPO Publications

Disease-causing organisms can have significant impacts on marine species and communities. However, the dynamics that underlie the emergence of disease outbreaks in marine ecosystems still lack the equivalent level of description, conceptual understanding, and modeling context routinely present in the terrestrial systems. Here, we propose a theoretical basis for modeling the transmission of marine infectious diseases (MIDs) developed from simple models of the spread of infectious disease. The models represent the dynamics of a variety of host-pathogen systems including those unique to marine systems where transmission of disease is by contact with waterborne pathogens both directly and through filter-feeding processes. …

Vitamin D Levels In Black African Adults At The Aga Khan University Hospital Nairobi, Elizabeth Muringa Kagotho

Master of Medicine in Clinical Pathology

Introduction: Vitamin D has been known for centuries for its benefits in bone health. Recent observational studies have however demonstrated its benefits in infectious diseases such as tuberculosis and non-communicable diseases such as diabetes mellitus, cardiovascular diseases and cancer. This has led to a dramatic increase in testing among adults. The cut-offs for vitamin D deficiency have been debated for decades and the current cut off is derived from a Caucasian population. Studies done among black African adults in Africa are few and have shown that vitamin D deficiency ranges from 5-91%. In view of the difference in skin colour, …

Differences In Rhodococcus Equi Infections Based On Immune Status And Antibiotic Susceptibility Of Clinical Isolates In A Case Series Of 12 Patients And Cases In The Literature, Praveen Gundelly, Yasuhiro Suzuki, Julie A. Ribes, Alice C. Thornton

Internal Medicine Faculty Publications

Rhodococcus equi is an unusual zoonotic pathogen that can cause life-threatening diseases in susceptible hosts. Twelve patients with R. equi infection in Kentucky were compared to 137 cases reported in the literature. Although lungs were the primary sites of infection in immunocompromised patients, extrapulmonary involvement only was more common in immunocompetent patients (P > 0.0001). Mortality in R. equi-infected HIV patients was lower in the HAART era (8%) than in pre-HAART era (56%) (P > 0.0001), suggesting that HAART improves prognosis in these patients. Most (85–100%) of clinical isolates were susceptible to vancomycin, clarithromycin, rifampin, aminoglycosides, ciprofloxacin, and imipenem. …

Unraveling The Dose-Response Puzzle Of L. Monocytogenes: A Mechanistic Approach, S. M.Ashrafur Rahman, Daniel Munther, Aamir Fazil, Ben Smith, Jianhong Wu

Mathematics and Statistics Faculty Publications

Food-borne disease outbreaks caused by Listeria monocytogenes continue to impose heavy burdens on public health in North America and globally. To explore the threat L. monocytogenes presents to the elderly, pregnant woman and immuno-compromised individuals, many studies have focused on in-host infection mechanisms and risk evaluation in terms of dose-response outcomes. However, the connection of these two foci has received little attention, leaving risk prediction with an insufficient mechanistic basis. Consequently, there is a critical need to quantifiably link in-host infection pathways with the dose-response paradigm. To better understand these relationships, we propose a new mathematical model to describe the …

First Do No Harm: Protecting Patients Through Immunizing Health Care Workers, Rene F. Najera, Dorit R. Reiss

Health Matrix: The Journal of Law-Medicine

The article discusses the how immunizing health care worker can help protecting vulnerable patients and mandatory vaccination of health care workers in New Jersey (Valent v. Board of Review, Department of Labor).

Hiv-Serodiscordant Couples, Pre-Exposure, Prophylaxis And Relationship Satisfaction, Eli Latto

Theses, Dissertations, and Projects

This mixed-methods study explored the use of post-exposure prophylaxis (PrEP) and relationship satisfaction in HIV-serodiscordant couples. “Serodiscordant” refers to couples in which one partner is living with Human Immunodeficiency Virus (HIV) and one is not. PrEP is a daily dose of the antiretroviral medication Truvada, taken as a prevention measure by HIVnegative individuals at substantial risk for contracting the virus. This study was conducted via an anonymous online survey with both quantitative and open-ended questions to determine whether there is any relationship between the use of PrEP and relationship satisfaction in HIVserodiscordant couples. Data was analyzed by comparing people in …

Follicular Lymphoma Tregs Have A Distinct Transcription Profile Impacting Their Migration And Retention In The Malignant Lymph Node, Hristina Nedelkovska, Alexander F. Rosenberg, Shannon P. Hilchey, Ollivier Hyrien, W. Richard Burack, Sally A. Quataert, Christina M. Baker, Mitra Azadniv, Stephen L. Welle, Stephen M. Ansell, Minsoo Kim, Steven H. Bernstein

Biology

We have previously shown that regulatory T cells (Tregs) infiltrating follicular lymphoma lymph nodes are quantitatively and qualitatively different than those infiltrating normal and reactive nodes. To gain insight into how such Treg populations differ, we performed RNA sequence (RNAseq) analyses on flow sorted Tregs from all three sources. We identify several molecules that could contribute to the observed increased suppressive capacity of follicular lymphoma nodal tregs, including upregulation of CTLA-4, IL-10, and GITR, all confirmed by protein expression. In addition, we identify, and confirm functionally, a novel mechanism by which Tregs target to and accumulate within a human tumor …

The Evaluation Of Eprinomectin (Longrange®) On Long-Term Parasitic Infection In Nursing Calves During Summer Grazing®, Lyndsea D. Seibert

LSU Master's Theses

One of the most significant threats to the well-being and performance of grazing livestock are gastrointestinal nematode (GIN) parasitic infections. Allowing a large GIN burden to manifest can cause a significant cost in terms of productivity in grazing cattle. Beef producers commonly rely greatly on the efficacy of broad-spectrum anthelmintics, to not only kill resident worms but to also prevent the establishment of ingested infective stage larvae (L3) for a period following treatment. Eprinomectin (LONGRANGE®, E-LR) is the first extended-release injectable cattle dewormer that claims to provide cattle producers season-long persistent parasite control for 100 to 150 d in a …

The International Health Regulations: The Governing Framework For Global Health Security, Lawrence O. Gostin, Rebecca Katz

Georgetown Law Faculty Publications and Other Works

• The International Health Regulations (IHR) are the governing framework for global health security yet require textual and operational reforms to remain effective, particularly as parallel initiatives are developed.
• The World Health Organization (WHO) is the agency charged with oversight of the IHR, and its leadership and efficient functioning are prerequisites for the effective implementation of the IHR.
• We reviewed the historical origins of the IHR and their performance over the past 10 years and analyzed all of the ongoing reform panel efforts to provide a series of politically feasible recommendations for fundamental reform.
• This article offers proposals for fundamental reform—with …

Maternal Mortality: A Policy Comparison Between Nigeria And India., Rachel Quarles

Dissertations and Theses

A staggering number of women die from preventable deaths each year from causes related to pregnancy and childbirth. India hosts the greatest number of actual maternal deaths in the world, although Nigeria’s ratio of maternal deaths to live births is greater than India’s. This thesis focuses on the experience of these two countries in order to determine if India’s governmental policies, level of government corruption, and traditional practices directly lead to its comparably better maternal health statistics. India has demonstrated lower ratios of maternal mortality and more consistent improvement in maternal health indicators than Nigeria as a result of stronger …

Planning Guide For A Total Market Approach To Increase Access To Family Planning—Module 1: Landscape Assessment, Christopher Brady, Laura Weeden, Jane Hutchings, Jerry Parks

Reproductive Health

PATH has drawn on its global experience from our total market approach (TMA) work in the Democratic Republic of Congo, Myanmar, Nicaragua, Uganda, and Vietnam to produce a TMA planning guide to increase access to family planning. The guide and toolkit (Planning Guide for a Total Market Approach to Increase Access to Family Planning: Toolkit and Glossary), produced by The Evidence Project, contain practical information and specific tools to help organizations and other planners conduct a landscape assessment, the first phase in developing a TMA. | These resources are part of a larger toolkit, which also includes an …

Intrahepatic Cholestasis Of Pregnancy With Severe Elevation Of Bile Acids In The Setting Of Acute Hepatitis C Infection, Megan L. Lawlor, Agatha S. Critchfield

Obstetrics and Gynecology Faculty Publications

Intrahepatic cholestasis of pregnancy (ICP) is a complication of pregnancy resulting in elevation of serum bile acid levels. ICP is often associated with underlying liver disease, including hepatitis C. Bile acids in relationship to the acute infection of hepatitis C virus have not yet been delineated in the literature. A 26-year-old gravida 4 para 2103 with dichorionic, diamniotic twin gestation and history of intravenous drug abuse developed ICP in the setting of acute hepatitis C infection. In addition to clinical symptoms of pruritus and right upper quadrant pain, she developed severe elevation in bile acids, 239 micromol/L, and transaminitis aspartate …

Measuring Quality Of Care: A Review Of Previously Used Methodologies And Indicators, Katherine Tumlinson

Reproductive Health

Despite successful efforts to increase financial and geographic access to family planning services in many parts of the developing world, large numbers of women with a desire to delay or limit future pregnancies are not using contraceptive methods. Several multi-country, large-scale facility surveys incorporate indicators for measuring the quality of family planning service delivery. These facility surveys use data collection tools such as facility audits, provider and client questionnaires, and third party observation guides. A limited body of research indicates that the validity of these tools is low, however, while large variations in analytical approaches inhibit use of existing literature …

Restauración De La Diplomacia Y Sus Implicaciones: Los Próximos Pasos En Las Relaciones Entre Los Estados Unidos Y Cuba, Emily Chambard

CMC Senior Theses

This thesis explores the implications of the recent restoration of diplomatic relations between the United States and Cuba. Through historical analysis and discussion of the ‘Cuban Thaw’ beginning in 2009, it proposes certain courses of immediate and long-term action for both nations, but specifically the United States, to guarantee future collaboration and mutual gain. Its conclusions emphasize the unique nature of current circumstances, which have opened a window of opportunity never before seen in the history of US-Cuban relations. The causes are one, the succession of Fidel Castro by his brother, Raúl, who has already demonstrated more progressive policy action …

Cathepsin B Modulates Lysosomal Biogenesis And Host Defense Against Francisella Novicida Infection, Xiaopeng Qi, Si Ming Man, R. K. Malireddi, Rajendra Karki, Christopher Lupfer, Prajwal Gurung, Geoffrey Neale, Clifford S. Guy, Mohamed Lamkanfi, Thirumala-Devi Kanneganti

College of Natural and Applied Sciences

Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans. In this study, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and autophagy. Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida. Genetic deletion or pharmacological inhibition of cathepsin B down-regulated mechanistic target of rapamycin activity and prevented cleavage of the lysosomal calcium channel TRPML1. These events drove transcription of lysosomal and autophagy genes via transcription factor EB, which increased lysosomal …

Prevalence And Outcome Of Headache In Tuberculous Meningitis, Sanjeev Kumar, Rajesh Verma, Ravindra K. Garg, Hardeep S. Malhotra, Praveen K. Sharma

Neurosciences

Objective: To evaluate headache severity, and its correlation with clinical, cerebrospinal fluid, and neuroimaging parameters of tuberculous meningitis (TBM) patients, and its impact on outcome. Methods: This prospective observational study was conducted at King George’s Medical University, Lucknow, India between October 2012 and March 2014. Ninety-five newly diagnosed TBM patients underwent detailed clinical, laboratory, and neuroimaging evaluation. A numeric rating scale was used to assess the headache severity, and patients were grouped into mild, moderate, severe, and intolerable groups. Patient outcome was evaluated at 6-months follow up. Results: Holocranial stabbing type headache ( p =0.002), modified Barthel index ≤12 (p …