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Clinical Characteristics And Outcome Of Brucella Endocarditis, Na Du, Feng Wang

Turkish Journal of Medical Sciences

Background/aim: Brucella endocarditis, which is a rare condition, is the most common cause of death in human brucellosis, leading to severe cardiac complications. By collecting and analyzing clinical cases, we analyzed the clinical characteristics and outcome of Brucella endocarditis in endemic areas in China. Materials and methods: Presented here are 5 cases of Brucella endocarditis, all managed uniformly. We present the clinical, serological, and echocardiographic features; the therapeutic approach; and the follow-up of five patients with Brucella endocarditis. Results: There was a predominance of aortic involvement (4 cases) and a high incidence of left ventricular failure (5 cases). Polymerase chain …

Pityriasis Rosea: A Natural History Of Pediatric Cases In Thecentral Anatolia Region Of Turkey, Emi̇ne Çölgeçen, Çi̇ğdem Kader, Yilmaz Ulaş, Pinar Öztürk, Öznur Küçük, Mehmet Balci

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey. Materials and methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Results: The average age of patients at time of diagnosis was 12 ± 3.9 years. Cases were most common in the winter (rainy, snowy months; n = 14, 31%). Fifteen …

Treatment Efficacy And Superinfection Rates In Complicated Urinarytract Infections Treated With Ertapenem Or Piperacillin Tazobactam, Murat Di̇zbay, Hasan Selçuk Özger, Ömer Karaşahi̇n, Emi̇ne Füsun Karaşahi̇n

Turkish Journal of Medical Sciences

Background/aim: In this retrospective study, the efficacy of ertapenem and piperacillin tazobactam was compared in the treatment of complicated urinary tract infections (cUTIs). Treatment responses were also evaluated for both antibiotics. Materials and methods: A total of 230 patients were enrolled in the study. Of these, 170 received ertapenem and 60 received piperacillin-tazobactam. Results: In both groups, urine cultures after 48 h were negative for the initial uropathogen. The frequency of superinfection was 29.4% in the ertapenem group and 8.3% in the piperacillin-tazobactam group over the duration of treatment (P < 0.05). Urinary catheterization increased the superinfection risk 2.88-fold in the ertapenem group and diabetes mellitus increased the risk 8.50-fold in the piperacillin-tazobactam group (CI: 1.44-5.76 and 1.16-62.09, respectively, P < 0.05). The main pathogen isolated from superinfection in the ertapenem group after 48 h was Enterococcus spp. (71.4%). Conclusion: Both ertapenem and piperacillin-tazobactam were effective in the treatment of cUTIs caused by ESBL-producing microorganisms. A high frequency of superinfection in the ertapenem group was the result of Enterococcus and Pseudomonas spp., against which ertapenem is not active. In the presence of urinary catheterization, diabetes mellitus, and urological intervention, patients should be closely monitored for the development of a superinfection, especially patients receiving ertapenem.

Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf

Turkish Journal of Medical Sciences

Background/aim: Nevirapine is a reverse-transcriptase inhibitor widely used in combination therapy to treat HIV infection. Nevirapine is extensively metabolized in the liver and CYP2B6 is mainly responsible for oxidation of 3-hydroxynevirapine (3-OH NVP). This study aims to explore CYP2B6 activity by measuring 2-hydroxynevirapine (2-OH NVP) and 3-OH NVP in plasma and to identify factors associated with nevirapine pharmacokinetic parameters. Materials and methods: A total of 112 patients were recruited and treated with nevirapine-based antiretroviral therapy. Plasma nevirapine and metabolite concentrations were assayed using high-performance liquid chromatography via liquid-liquid extraction. Results: Thirty-nine (34.8%) of the patients had no 3-OH NVP detected …

Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz

Turkish Journal of Medical Sciences

Background/aim: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains. Materials and methods: Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted. Presence of blaOXA-23, blaOXA-48, blaOXA58, and NDM-1 was investigated by PCR. Results: In total, 44 carbapenem-resistant A. baumannii strains were detected. In addition, 57% (25/44) showed resistance to netilmicin and 2% …

Hst 3100 : Disasters And Public Health: Planning And Response, Health Studies

Approved Course Proposals

No abstract provided.

Studies Of The Effectiveness Of Bisphosphonate And Vanadium-Bisphosphonate Compounds In Vitro Against Axenic Leishmania Tarentolae, Amy Christensen, Craig C. Mclauchlan, Anne Dolbecq, Pierre Mialane, Marjorie A. Jones

Faculty Publications – Chemistry

Leishmaniasis is a disease that is a significant problem for people, especially in tropical regions of the world. Current drug therapies to treat the disease are expensive, not very effective, and/or of significant side effects. A series of alkyl bisphosphonate compounds and one amino bisphosphonate compound, as well as alendronate and zoledronate, were tested as potential agents against Leishmania tarentolae. Also, two polyoxometalates (POMs) with nitrogen-containing bisphosphonate ligands, vanadium/alendronate (V5(Ale)2) and vanadium/zoledronate (V3(Zol)3), were tested against L. tarentolae and compared to the results of the alendronate and zoledronate ligands alone. Of the compounds evaluated in this study, the V5(Ale)2 …

Model Lessons Geography Of Southern Iberia Institute - Portugal And Spain, Jack Davis, Jeff Salvati, Tabitha M. Richards, Denise Harrington, Jordan Kasler, Amanda Mattei, Heidi Wilson, Luke Ovgard, Karen Kraemer

Instructional Materials

Model Lessons Geography of Southern Iberia Institute - Portugal and Spain to use with The Student Atlas of Oregon.

Four Compounds Suppressing Growth Of Mycobacterium Tuberculosis, Ronald Bartzatt, Preeti Sule, Woojung Kim, Jeffrey D. Cirillo

Chemistry Faculty Publications

Aims: To demonstrate the efficacy of several small molecular weight compounds having hydrazide groups, for inhibiting the growth of Mycobacterium tuberculosis. To show these same compounds have favorable drug-likeness properties.

Study Design: To synthesize tuberculostats and test their antibacterial activity in-vitro.

Place and Duration of Study: University of Nebraska, Durham Science Center, 6001 Dodge Street, Omaha NE 68182, and Texas A&M Health Science Center, Department of Microbial Pathogenesis and Immunology, 8447 State Hwy 47, Medical Research and Education Building, Room #3012, Bryan, TX 7780. From January 2015 to June 2015.

Methodology: Hydrazide groups were formed by covalently bonding hydrazine …

Identifying Enriched Drug Fragments As Possible Candidates For Metabolic Engineering, Sunandini Sharma, Kritika Karri, Ishwor Thapa, Dhundy Bastola, Dario Ghersi

Interdisciplinary Informatics Faculty Publications

Background: Fragment-based approaches have now become an important component of the drug discovery process. At the same time, pharmaceutical chemists are more often turning to the natural world and its extremely large and diverse collection of natural compounds to discover new leads that can potentially be turned into drugs. In this study we introduce and discuss a computational pipeline to automatically extract statistically overrepresented chemical fragments in therapeutic classes, and search for similar fragments in a large database of natural products. By systematically identifying enriched fragments in therapeutic groups, we are able to extract and focus on few fragments …

The Geopolitics Of Reproductive Healthcare: Latina Immigrants’ Experiences As Non-Citizens And Biological Citizena In Atlanta, Ga, Rebecca E. Lane

Theses and Dissertations--Geography

This dissertation examines the experiences of Latina immigrants in Atlanta, GA in accessing and receiving reproductive healthcare. Although Atlanta is a new destination city for immigrant labor, the state of Georgia has passed anti-immigrant legislation, including a 2011 law that allows local police to check immigrants’ documentation while investigating unrelated violations. This localization of immigration policing heightens immigrants’ risk of detention and deportability. In combination with media discourses of illegality, local immigration policing instills fear in immigrants, which deters them from going out in public in order to perform everyday tasks such as seeing a doctor. Latinas immigrants’ ascribed illegality …

Patient-Prisoners: Venereal Disease Control And The Policing Of Female Sexuality In The United States, 1890-1945, Evelyn A. Sorrell

Theses and Dissertations--History

Sexual politics were central in the United States’ venereal disease control movement in the early decades of the twentieth century. This dissertation analyzes the evolution of the venereal disease control movement from the Progressive Era reformers focus on creating a single standard of morality to the Public Health Service’s (PHS) concern over maternal and economic health during the Great Depression. I examine the intersections of public health, gender, sexuality, and citizenship through reactions and policies addressing venereal disease. In particular, the United States’ entry into World War I heightened fears of moral and health crises, as military physicals uncovered a …

In Vitro Activity Of Polymyxin B And Meropenem Alone And In Combination Against Carbapenem-Resistant Enterobacteriaceae, Brandon T. Kulengowski

Theses and Dissertations--Pharmacy

Background: Infections caused by carbapenem-resistant Enterobacteriaceae such as Escherichia coli and Klebsiella pneumoniae are among the most urgent threats of the infectious disease realm. The incidence of these infections has only been increasing over the years and due to very limited treatment options, mortality is estimated at about 50%.

Methods: To evaluate the in vitro activity of meropenem and polymyxin B against carbapenem-resistant Enterobacteriaceae, antimicrobial susceptibility testing and time-kill studies were performed on K. pneumoniae clinical isolates representing a wide range of meropenem resistance (MICs 4 – 128 mg/L).

Results: Regrowth was observed at clinically relevant concentrations of meropenem alone …

Acute Kidney Injury In Patients Treated With Vancomycin And Piperacillin-Tazobactam: A Retrospective Cohort Analysis, Wilbur Cliff Rutter

Theses and Dissertations--Pharmacy

Empiric antimicrobial therapy often consists of the combination of Gram-positive coverage with vancomycin (VAN) and Gram-negative coverage, specifically an anti-pseudomonal beta-lactam, such as piperacillin-tazobactam (PTZ). Nephrotoxicity is commonly associated with VAN therapy; however, recent reports demonstrate increasing nephrotoxicity rates among patients treated with the combination of VAN and PTZ. This study evaluated the effect of the VAN/PTZ combination on acute kidney injury (AKI), as defined by the RIFLE criteria, compared to VAN and PTZ monotherapies.

Overall, 11,650 patients were analyzed, with 1,647 (14.1%) AKI cases occurring. AKI was significantly more frequent in the VAN/PTZ group (21%) compared to either monotherapy …

Clinical Outcomes Associated With Time To Antimicrobial Therapy Change From Vancomycin To Daptomycin In Staphylococcal Bacteremia, Sarah J. Tennant

Theses and Dissertations--Pharmacy

Background: Staphylococcus aureus is an aerobic, Gram positive commensal organism that is capable of causing a wide spectrum of disease. This study contributes to previously published literature regarding daptomycin versus vancomycin use in S. aureus bacteremia (SAB).

Methods: Adult patients admitted between 2010 and 2014, billed for ICD-9 code V09.0, 038.11, 038.12, 041.11, or 041.12, and received vancomycin and daptomycin were included in this retrospective analysis. Patients were stratified by time to change in antibiotics from vancomycin to daptomycin to the early switch (1-3 days), intermediate switch (4-7 days), or late switch (8 days or later) group. The primary outcome …

Molecular And Biochemical Signaling Underlying Arabidopsis-Bacterial/Virus/Fungal Interactions, Mohamed H. El-Shetehy

Theses and Dissertations--Plant Pathology

Systemic acquired resistance (SAR) is a form of inducible defense response triggered upon localized infection that confers broad-spectrum disease resistance against secondary infections. Several factors are known to regulate SAR and these include phenolic phytohormone salicylic acid (SA), phosphorylated sugar glycerol-3-phosphate (G3P), and dicarboxylic acid azelaic acid (AzA). This study evaluated a role for free radicals nitric oxide (NO) and reactive oxygen species (ROS) in SAR. Normal accumulation of both NO and ROS was required for normal SAR and mutations preventing NO/ROS accumulation and/or biosynthesis compromised SAR. A role for NO and ROS was further established using pharmacological approaches. Notably, …

Endosymbiotic Bacteria In The Bed Bug, Cimex Lectularius L. (Hemiptera: Cimicidae), Mark H. Goodman

Theses and Dissertations--Entomology

The return of bed bugs to prominence as an urban pest has precipitated an emphatic research response from the scientific community in an effort to better understand their biology and management. However, not all aspects of bed bug biology have received equal attention. The role of symbiotic bacteria in the normal function and biology of insects is often underappreciated, and this is true of bed bugs. Bed bugs have two main endosymbiotic bacteria, a Wolbachia species and a poorly-characterized gamma-proteobacterium referred to as BLS. However, their interactions with the host are poorly understood. I explored various aspects of these symbionts …

The Right To Refuse Vaccination: Revisiting Vaccination Exemptions And The “Best Interests Of The Child Standard”, Stephanie Jablonsky

Student Works

No abstract provided.

Disaster Preparedness And Response: A Survey Of U.S. Dental Hygienists, Brenda T. Bradshaw, Ann P. Bruhn, Tara L. Newcomb, Bridget T. Giles, Kathryn Simms

Dental Hygiene Faculty Publications

Purpose: The purpose of this study was to assess dental hygienists’ interests, current involvement, formal education, views, comfort levels, and intentions for involvement with disaster preparedness and response.

Methods: Dental hygienists (n=400) were asked to respond to a 21-item online survey. Data was analyzed using descriptive statistics, chi-square goodness-of-fit tests, and a paired-samples t-test. Common themes were identified and categorized from open-ended questions.

Results: A response rate of 84% (n=334) was obtained. Most respondents (97%) reported no involvement with disaster preparedness and response; however, a majority (86%) reported interest. Of those who indicated an interest in disaster preparedness and response, …

Paper/Polymer Hybrid Microfluidic Biochips For Infectious Disease Diagnosis, Maowei Dou

Open Access Theses & Dissertations

Infectious diseases frequently cause public health concerns and they often occur in high-poverty regions. Hence, a simple and low-cost method is in great need for immediate and early diagnosis of infectious diseases. Recently, microfluidic lab-on-a-chip offers a unique opportunity for various biomedical applications. Since different chip substrates have different advantages and limitations, hybrid devices can draw more benefits from different substrates. Therefore, we have developed three paper/polymer hybrid microfluidic biochips integrated with loop-mediated isothermal amplification (LAMP) for high-sensitivity infectious disease diagnosis.

We for the first time developed a low-cost paper/polydimethylsiloxane (PDMS) hybrid microfluidic biochip for rapid, sensitive and instrument-free detection …

A Conflict-Sensitive Approach To Conditional Cash Transfers In Indonesia: Can Ccts Reduce Conflict?, Glenys Kirana

CMC Senior Theses

Given that conditional cash transfers (CCTs) can be a very effective social welfare program to reduce poverty and improve education and health outcomes, but may exacerbate conflict, this thesis addresses strategies for conflict-sensitive formulation and implementation of CCTs in Indonesia. This thesis raises the immediate need to address poverty in Indonesia and seeks to learn from the successes and challenges of other CCTs, such as those enacted in Mexico, Brazil, Turkey, and the Philippines. This thesis also looks into existing literature comparing the effectiveness of CCTs to other social protection programs (SPPs) and finds that CCT is one of the …

Fruit And Vegetable Availability, Nutrition Education And Access Amongst Food Pantries In California, Maine, Mississippi And South Dakota, Sarah L. Fowler

All Graduate Theses, Dissertations, and Other Capstone Projects

This descriptive study explored the views of food pantry directors in four states regarding pantry fruit and vegetable stock and supply, nutrition education offered, and current practices and perceived barriers to providing access to food pantries to low-income individuals and families in need. This study examined these variables by surveying staff at the food pantries who have direct contact with the individuals and families who utilize the pantries. All survey responses were collected utilizing Qualtrics software and then analyzed in SPSS. There were 87 respondents from four different states, California, Maine, Mississippi, and South Dakota.

The reporting for both fresh …

Differential Gene Expression Of Minnesota (Mn) Hygienic Honeybees (Apis Mellifera) Performing Hygienic Behavior, Eric Northrup

All Graduate Theses, Dissertations, and Other Capstone Projects

Hygienic behavior is the ability to remove dead and diseased brood from the comb early as to limit the detrimental impact of the parasite or pathogen. Minnesota (MN) Hygienic bees are generalists of hygienic behavior with the ability to remove several brood infected with several pathogens including the Varroa mite. This study explored the mechanisms of MN Hygienic behavior by comparing the transcriptome of MN Hygienic bee brains to non-hygienic bee brains via cDNA microarray. The results suggest that the brains of MN Hygienic bees may have a greater number of dendritic connections or are more sensitive to neurotransmitters. Quantitative …

The Utilization Of Morphological And Genetic Diagnostic Techniques For The Description Of Trematode Species Collected From Waterbirds From Lake Winnibigoshish, Minnesota, Usa, Tyler Joseph Achatz

All Graduate Theses, Dissertations, and Other Capstone Projects

Historically, morphological techniques for species identification were the leading diagnostic methodology, however, the increased usage of genetic techniques has led to a decrease in reports of morphometrics. The decrease in morphological reports increases the chance of missing diagnostic morphometrics. The three studies described herein used morphological and genetic diagnostic methods to identify trematodes from five families in order to improve genetic and morphological information for trematode species identification.

The first study identified ten species of trematodes from intestines of waterbirds previously collected from Lake Winnibigoshish, Minnesota. Nine of the species were sequenced for 28S ribosomal DNA (rDNA). Two species were …

A Controversial Bill (H.R. 897) To Mosquito Control Programs: A Policy Analysis, Charles Guissou

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The primary purpose of this paper was to analyze the legal, financial, and administrative burdens of the Pesticides General Permit on mosquito control programs from a policy perspective. Mosquito control is often highly controversial, particularly when it involves the use of pesticides that have their own potentially serious health and environmental impacts. In 2009, the Environment Protection Agency issued the permit to be obtained by pesticide applicators before pesticides could be discharged into waterways in addition to existing Federal Insecticides, Fungicides, and Rodenticides Act (FIFRA) regulations. Some provisions of the permit could impact mosquito control activities. Therefore, in response to …

Social Network Analysis Of Cellphone Surveillance Data For Ebola In Sierra Leone, Jia B. Kangbai

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Aim: To explore and visualize the connectivity of suspected Ebola cases and surveillance callers who used cellphone technology in Moyamba District in Sierra Leone for Ebola surveillance, and to examine the demographic differences and characteristics of callers who make more calls as well as more likely to make at least one positive Ebola call.

Methods: Surveillance data for 393 suspected Ebola cases (192 males, 201 females) were collected from October 23, 2014 to June 28, 2015 using cellphone technology. UCINET and NetDraw were used to explore and visualize the social connectivity between callers and suspected Ebola cases. Poisson and logistic …

Evaluation Of Central Line Insertion Bundle Practices In A Trauma/Surgical Intensive Care Unit, Margaret A. Moore

DNP Projects

Central venous catheters, also known as central lines, serve an essential role in critical care settings across the globe. However, these lines put patients at an increased risk for hospital-acquired infections in the form of central line-associated bloodstream infections (CLABSI). In an effort to prevent these infections, evidence-based nursing interventions in the form of insertion and maintenance bundle are undertaken. It is the focus of this practice inquiry project to evaluate nurse adherence to central line insertion bundles before and after implementation of routine reporting of adherence rates within an ICU. The evaluation will provide insight to the degree of …

Oyster (Crassostrea Virginica) Recruitment Studies In The Great Bay Estuary, New Hampshire, Robert Lee Eckert

Master's Theses and Capstones

Oyster populations in New Hampshire’s Great Bay Estuary have experienced dramatic declines similar to populations along the east coast. These declines have caused ecosystem degradation in estuaries and prompted a focus on oyster reef restoration. Despite the large use of procured funds dedicated for oyster reef restoration, few quantifiable successes have occurred. Currently, there is no rigorous method for determining where a restored reef would have the highest probability for long-term success. However, consistent and substantial natural recruitment is a major factor to consider.

In this research, I identify historic trends in oyster populations, quantify the success and failures of …

Comorbidities Of Skin Disease In The Homeless And Medical Students Perspectives, Matthew David Coffman

Yale Medicine Thesis Digital Library

The homeless population is at increased risk for skin disease. Exposure to the elements and lack of access to medical care contribute to the problem. To date there have been few studies analyzing the medical comorbidities that put homeless patients at increased risk for skin disease. The aim of this study is to discover what medical conditions are associated with skin disease to allow physicians to better screen their homeless patients for skin disease. The secondary aim of this study is to determine whether medical students are being adequately trained to recognize medical conditions associated with skin disease. Data from …

The Role Of Oxytocin In Modulating Neural Oscillations In Nulliparous Women, Xiaoyue Mona Guo

Yale Medicine Thesis Digital Library

The hormone oxytocin (OT) has been implicated in social cognition and behavior as well as in modulating important affiliative relationships such as parenting; meanwhile, intranasal OT administration is gaining popularity as a means to modulate neural activity in brain regions during experimental tasks. However, the neural mechanisms underscoring the changes associated with OT administration have yet to be fully elucidated. Using electroencephalography (EEG), this thesis project aims to further our understanding of how OT affects brain activity and response to infant cues. In a double-blind placebo controlled design, OT’s effect on resting-state neural oscillations and event-related potentials (ERPs) to face …