Digital Commons Network^™

High Prevalence Of Chlamydia Trachomatis And Neisseria Gonorrhoeae Infections In Anal And Pharyngeal Sites Among A Community-Based Sample Of Men Who Have Sex With Men And Transgender Women In Lima, Peru, Segundo R. Leon, Eddy R. Segura, Kelika A. Konda, Juan A. Flores, Alfonso Silva-Santisteban, Jerome T. Galea, Thomas J. Coates, Jeffrey D. Klausner, Carlos F. Caceres

Social Work Faculty Publications

Objectives: This study aimed to characterise the epidemiology of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections among men who have sex with men (MSM) and transgender women (TW) in Lima, Peru.

Setting: Cross-sectional study in Lima, Peru.

Participants: We recruited a group of 510 MSM and 208 TW for a subsequent community-based randomised controlled trial. The presence of CT and NG were evaluated using Aptima Combo2 in pharyngeal and anal swabs. We also explored correlates of these infections. Primary and secondary outcome measures: Study end points included overall prevalence of C. trachomatis and N. gonorrhoeae in anal and pharyngeal …

Effect Of A Knowledge-Based And Skills-Based Programme For Physicians On Risk Of Sexually Transmitted Reinfections Among High-Risk Patients In China: A Cluster Randomised Trial, Don Operario, Debin Wang, Nickolas D. Zaller, Mei-Fen Yang, Kathleen Blaney, Jing Cheng, Qian Hong, Hongbo Zhang, Jing Chai, Gregory Szekeres, Jerome T. Galea, Thomas J. Coates

Social Work Faculty Publications

Background: China is experiencing growing epidemics of HIV and sexually transmitted infections (STIs). Programmes to train physicians in China on HIV and STI knowledge, diagnosis, treatment, and risk reduction counselling can potentially reduce HIV and STI risk among high-risk patients. We aimed to assess a knowledge-based and skills-based programme for physicians in China to reduce patients' STI risk.

Methods: In this cluster randomised trial, we block randomised counties in two provinces in eastern China to intervention or control groups. In the intervention group, physicians from county general hospitals participated in a structured HIV and STI training programme and received …

Cross-Sectional Analysis Of Salivary Cortisol And Cyathostome Infestation In Horses, Danielle L. Keating

Undergraduate Honors Thesis Projects

With an increase in anthelmintic resistance and decreased efficacy of many commercial dewormers, understanding factors that contribute to parasite infestations in horses is integral to their management. The goal of this study was to look at the potential relationship between parasites and stress response by evaluating salivary cortisol levels and cyathostome egg shedding levels. Using a sample size of n = 200 horses from the state of Ohio, fecal and saliva samples were collected from each horse. Fecal egg counts were performed for each horse with a modified Stoll method, and saliva samples were tested with an enzyme-linked immunosorbent assay …

3: "The Current Extinction: Defaunation & Ecosystem Disruption", Sarah O'Leary-Driscoll, Crystal Randall

Ecosystem Disruption & Climate Change

Information taken from: Dirzo, R. et al (2014). Defaunation in the Anthropocene. Science, 345(401).

Scientists estimate, conservatively, that there are 5 to 9 million different animal species on the planet. But that number is continually changing, and unfortunately, dropping, as we are likely losing 11,000- 58,000 species annually, and evidence suggests that on average, there has been a decline of about 28% in terms of numbers of individuals within a species over the last four decades. Both of these statistics are vitally important. The critical nature of the first is perhaps more obvious, as total loss of a species is …

A Study Of The Media's Portrayal Of The Measles Outbreak, Ashley K. Lawrence

Honors College Theses

This thesis project examines how social media was used during the measles outbreak in the United States from February 1, 2015-April 30, 2015. This content analysis research project will examine social media, specifically Twitter and Facebook, on the basis of the Center for Disease Control and Prevention (CDC) and the World Health Organization (WHO). The media outlets will be observed in order to determine the context of the measles outbreak, and the responses from the public (positive and negative) about how they felt or reacted to the information. In order to examine the social media outlets, research from the CDC …

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2015-2016), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2015/2016 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Message from the President
• PCOM Updates
• Inauguration of the eighth President, Jay S. Feldstein, DO '81
• Trained for Trauma Care: PCOM Alumni Were Well Prepared to Treat the Mass Casualties of May's Amtrak Derailment
• Remembering Camille DiLullo, PhD, Professor of Anatomy
• Class Notes
• My Turn

Rapid And High Throughput Molecular Identification Of Diverse Mosquito Species By High Resolution Melting Analysis., Yvonne Ukamaka Ajamma, Enock Mararo, David Omondi, Thomas Onchuru, Anne W.T. Muigai, Daniel Masiga, Jandouwe Villinger

All Peer-Reviewed Publications

Mosquitoes are a diverse group of invertebrates, with members that are among the most important vectors of diseases. The correct identification of mosquitoes is paramount to the control of the diseases that they transmit. However, morphological techniques depend on the quality of the specimen and often unavailable taxonomic expertise, which may still not be able to distinguish mosquitoes among species complexes (sibling and cryptic species). High resolution melting (HRM) analyses, a closed-tube, post-polymerase chain reaction (PCR) method used to identify variations in nucleic acid sequences, has been used to differentiate species within the Anopheles gambiae and Culex pipiens complexes. We …

Phylogenetic Analysis Of Bunyamwera And Ngari Viruses (Family Bunyaviridae, Genus Orthobunyavirus) Isolated In Kenya, C. Odhiambo, M. Venter, O. Lwande, R. Swanepoel, R. Sang

All Peer-Reviewed Publications

Orthobunyaviruses, tri-segmented, negative-sense RNA viruses, have long been associated with mild to severe human disease in Africa, but not haemorrhagic fever. However, during a Rift Valley fever outbreak in East Africa in 1997-1998, Ngari virus was isolated from two patients and antibody detected in several others with haemorrhagic fever. The isolates were used to identify Ngari virus as a natural Orthobunyavirus reassortant. Despite their potential to reassort and cause severe human disease, characterization of orthobunyaviruses is hampered by paucity of genetic sequences. Our objective was to obtain complete gene sequences of two Bunyamwera virus and three Ngari virus isolates from …

The Adoption Of Mandatory Gunshot Wound Reporting Legislation In Canada: A Decade Of Tension In Lawmaking At The Intersection Of Law Enforcement And Public Health, Andrew Flavelle Martin

Articles, Book Chapters, & Popular Press

In 2005, Ontario adopted the Mandatory Gunshot Wounds Reporting Act. Over the following decade, seven other provinces and one territory adopted largely identical legislation. While these statutes require health facilities to report gunshot wounds to the police, they are mostly silent on what purpose this reporting is intended to achieve and how police are to use the reports to achieve it. This paper analyzes the legislative history across these nine jurisdictions to identify these features. It demonstrates that the statutes embody an unresolved tension between the purposes of public health and safety, on the one hand, and law enforcement on …

Who Will Be The First To Buy Autonomous Vehicles? An Application Of Everett Rogers’ Diffusion Of Innovations Theory, Reilly Jackson Umberger

CMC Senior Theses

Autonomous, otherwise known as self-driving, vehicles represent the future of transportation. Vehicles that drive themselves offer far reaching benefits from increased leisure and productivity for individuals to significant improvements in congestion and infrastructure for governments. The autonomous car will radically change the way we look at transportation, and they are right around the corner. However, the question remains: are we ready? Are we, as a society, ready to hand over the steering the wheel and trust autonomous vehicles with our safety? This paper predicts how the autonomous car will spread through society by analyzing and applying the product qualities and …

The Psychotherapist-Patient Privilege In Prison Litigation: How Can You Claim "Garden Variety" Emotional Distress When The Flowers Are Made Out Of Steel, Michael D'Ambrosio

Fordham Urban Law Journal

No abstract provided.

Will Meaningful Use (Mu) Improve Cancer Data Reporting?, Curtisha Manire

Applied Research Projects

The American Recover and Reinvestment Act directives supply the healthcare community with the improvement of technology across the nation through the Health Information Technology Economic and Clinical Health (HITECH) Act passed in 2009 by promoting healthcare technology. In order to reach the goal of an interoperability that supports reliable communication systems, certain individual technological objectives need to be addressed in particular, Meaningful Use (MU). Meaningful Use objectives contribute to interoperability, with potential outcomes that may increase accuracy and reduce time for reporting. This study will describe how cancer data reporting methods impacts data accuracy and turnaround time evolving around transitions …

University Of Texas At Tyler Catalog, 2016 - 2017, University Of Texas At Tyler

Catalogs

No abstract provided.

The Expression Of Aryl Hydrocarbon Receptor In Raw 264.7 Macrophages In The Presence Of Socs1 Peptide And Socs3 Peptide Mimetic And Cells Infected With Hsv-1, Maher Salem Alwethaynani

Browse all Theses and Dissertations

Macrophages play a crucial role for our immune system and protect our body from infection. Suppressor of cytokine signaling (SOCS) proteins negatively regulate cytokine receptor and TLRs. The aryl hydrocarbon receptor (AhR) also performs an important role in immunity. This study investigated the changes in expression of AhR in RAW 264.7 macrophage cells after the addition of SOCS1 and SOCS3 peptide mimetics and also examined AhR expression in RAW 264.7 macrophage cells before and after the addition of HSV-1 RAW 264.7 murine macrophage cell lines which are from male BALB/c mice were used in this study. The addition of the …

The Evolution Of The Intersection Of Hiv And Breastfeeding In Global Policy, Kristin M. Sinning

Master of Public Health Program Student Publications

Increasing breastfeeding rates and reducing HIV/AIDS are two important global health priorities, and their intersection has led to policies that meet mutual goals of supporting, protecting and promoting breastfeeding and reducing the risk of HIV/AIDS. The World Health Organization has developed and released recommendations, policies, and guidance on infant feeding and the risk of transmission through breastfeeding. This analysis provides a historical, chronological perspective on the global policies for infant feeding in the case of an HIV-positive mother, an analysis of changes, and recommendations for the future. The policies evaluated demonstrate the evolution in knowledge and recommendations for infant feeding …

Sustainable Improvement In Immunization Rates For Seniors: A Local And Community-Wide Effort, Linda C. Lopez

Master of Public Health Program Student Publications

Objective: Overall: To improve influenza and pneumococcal immunization rates in patients age ≥65 years by developing relationships with community organizations that would provide opportunities for community member education about adult vaccines. Pre/post Surveys: To assess potential changes in influenza and pneumococcal immunization knowledge and opinions in community members exposed to an educational presentation.

Methods: Using personal and university resources, contact was made with several organizations serving the senior, underserved population in West Dayton, Ohio. An educational presentation about adult immunizations was developed and used at ten community events. The presentation included oral and written communication, and was based on the …

Strengths And Challenges Of A Rural Ohio Public Health Department: Considerations For Effective Service Delivery And Emergency Preparedness, Cindy L. Harris Graessle

Master of Public Health Program Student Publications

The local public health department is the main entity in cities and counties established to ensure the safety, health, and well-being of its community members. In many cases, particularly in rural areas, the health department may be the community’s closest access to health care, providing not only clinical care, but preventive services as well. These rural health departments have additional challenges that may not be experienced in the larger, more populated metropolitan areas. These challenges include lack of resources and funding that impact daily operations, expanded registered sanitarian responsibilities, and emergency preparedness difficulties with resource allocation and communication. Despite these …

Comparison Of The Difference In Nephrotoxicity Between Nafcillin And Piperacillin-Tazobactam, Sonali Kishor Patel

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objective

To evaluate whether nephrotoxicity differs between nafcillin and piperacillin-tazobactam in adult hospitalized patients.

Introduction

Acute kidney injury (AKI) is a significant cause of morbidity and mortality in the inpatient setting, with antibiotics being a significant contributor. There is evidence of an increased risk of nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam compared to vancomycin and cefepime or vancomycin alone. It is unknown whether this effect is exclusive for piperacillin-tazobactam. Therefore, in order to promote optimal medication therapy for inpatient bacterial infections, there is a need to assess the persistence of this difference in other beta-lactam antibiotics.

Methods

A …

Rainbow Trout (Oncorhynchus Mykiss) Threaten Andean Amphibians, Laura Martín-Torrijos, Jose Vladimir Sandoval-Sierra, Jesús Muñoz, Javier Diéguez-Uribeondo, Jaime Bosch, Juan M. Guayasamin

Neotropical Biodiversity

Amphibian populations are declining due to a myriad of abiotic and biotic factors, including invasive species and pathogens. In temperate freshwater ecosystems, for example, amphibian populations are threatened by the predation of introduced salmonids. Salmonids not only directly predate upon amphibian eggs and larvae but may also transport deadly pathogens into freshwater systems. Though most research has focused on temperate systems, much less is known about the effects of introduced species in Neotropical streams. We conducted two experiments to investigate the impacts of rainbow trout (Oncorhynchus mykiss) in two Neotropical anurans. First, we assessed the effect of the rainbow trout …

Artificial Nutrition And Hydration And The Patient In Persistent Vegetative State: Roman Catholic Magisterial Teaching On The Right To Refuse Medical Treatment Versus The Obligation To Provide Ordinary Care, Donald H.J. Hermann

University of Dayton Law Review

No abstract provided.

Modeling Nosocomial Disease Outbreaks Using A Combined Differential Equations And Agent Based-Modeling Approach, Cody Eion Fitzgerald

Honors Theses and Capstones

A nosocomial infection is an infection that a patient develops while in a hospital or healthcare related setting, also known as a hospital acquired infection (HAI).This project has two foci: firstly to model a HAI within an individual, then secondly to understand community-level propagation effects of a nosocomial infection within a hospital ward. An analysis of a novel system of coupled nonlinear ordinary differential equations (representing the HAI attack and immune response within an individual) was first completed. More specifically the model includes an s parameter that allows frailty to be patient specific. After the dynamic behaviors of the model …

A Dietary Approach To Cardiovascular Disease And Cancer: Does A Plant Based Diet Help Prevent And Reverse Cardiovascular Disease And Cancer?, Chana Wircberg

The Science Journal of the Lander College of Arts and Sciences

Modern Western societies seem to suffer from a veritable epidemic of serious diseases, two of the most serious of which are cardiovascular disease and cancer. In contrast, hunter and gatherer groups have a very low incidence of such diseases. Despite the diversity of hunter and gather diets, they all share the same characteristic: the absence of a Western diet. This suggests that there is something uniquely inflammatory about a Western diet, which is high in both fats and carbohydrates. Departures from a Western diet appear to result in better health. Experimental studies have shown that heart disease can be reversed …

How Compatible Is Cow’S Milk With The Human Immune System?, Mindy Knopfler

The Science Journal of the Lander College of Arts and Sciences

Cow’s milk has been part of the human diet for at least 8,000 years and provides a rich source of proteins, lipids, vitamins, and minerals. Despite its longstanding importance in human nutrition, questions remain about how compatible cow’s milk is with our immune system. Cow’s milk allergy (CMA) is the most common form of food allergy in infants and children and cow’s milk has been implicated in a number of immune-mediated disorders. Reviewing current research obtained through Google Scholar and Touro’s library database on CMA and the potential role of cow’s milk in systemic inflammation and autoimmunity reveals a tangle …

Full Issue: Volume 9, Number 2

The Science Journal of the Lander College of Arts and Sciences

No abstract provided.

The Effect Of Doctors Without Borders On Low- And Middle-Income Countries In Sub-Saharan Africa, Nathan Hayenga

Honors College Theses

This research studies the relationship between the activity of medical disaster-response humanitarian aid and the rate of growth in developing economies. Data of total annual GDP and Doctors without Borders (MSF) activity in 23 countries was analyzed over the years 2000-2014 with correlation and regression analysis. Under this analysis results are inconclusive, with a correlation of zero between MSF activity’s within a country and change in that country’s rate of GDP growth. A conclusive response was found on the comparison between GDP growth in countries MSF was active in compared to countries with no MSF activity, showing that countries in …

Putting Prep Into Practice: Lessons Learned From Early-Adopting U.S. Providers’ Firsthand Experiences Providing Hiv Pre-Exposure Prophylaxis And Associated Care, Sarah K. Calabrese, Manya Magnus, Kenneth H. Mayer, Douglas S. Krakower, Adam I. Eldahan, Lauren A. Gaston Hawkins, Nathan B. Hansen, Trace S. Kershaw, Kristen Underhill, Joseph R. Betancourt, John F. Dovidio

Faculty Scholarship

Optimizing access to HIV pre-exposure prophylaxis (PrEP), an evidence-based HIV prevention resource, requires expanding healthcare providers’ adoption of PrEP into clinical practice. This qualitative study explored PrEP providers’ firsthand experiences relative to six commonly-cited barriers to prescription – financial coverage, implementation logistics, eligibility determination, adherence concerns, side effects, and anticipated behavior change (risk compensation) – as well as their recommendations for training PrEP-inexperienced providers. U.S.-based PrEP providers were recruited via direct outreach and referral from colleagues and other participants (2014-2015). One-on-one interviews were conducted in person or by phone, transcribed, and analyzed. The sample (n = 18) primarily practiced …

Genomic Insights Into The Ixodes Scapularis Tick Vector Of Lyme Disease, Monika Gulia-Nuss, Andrew B. Nuss, Jason M. Meyer, Daniel E. Sonenshine, R. Michael Roe, Robert M. Waterhouse, David B. Sattelle, Jose De La Fuente, Jose M. Ribeiro, Karine Megy

Biological Sciences Faculty Publications

Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ~57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle …

Invasion Of Two Tick-Borne Diseases Across New England: Harnessing Human Surveillance Data To Capture Underlying Ecological Invasion Processes, Katharine S. Walter, Kim M. Pepin, Colleen T. Webb, Holly D. Gaff, Peter J. Krause, Virginia E. Pitzer, Maria A. Diuk-Wasser

Biological Sciences Faculty Publications

Modelling the spatial spread of vector-borne zoonotic pathogens maintained in enzootic transmission cycles remains a major challenge. The best available spatio-temporal data on pathogen spread often take the form of human disease surveillance data. By applying a classic ecological approach-occupancy modelling-to an epidemiological question of disease spread, we used surveillance data to examine the latent ecological invasion of tick-borne pathogens. Over the last half-century, previously undescribed tick-borne pathogens including the agents of Lyme disease and human babesiosis have rapidly spread across the northeast United States. Despite their epidemiological importance, the mechanisms of tick-borne pathogen invasion and drivers underlying the distinct …

We Have The Tools To End Hiv: Benefits, Barriers, And Solutions To Expanded Utilization Of Pre-Exposure Prophylaxis (Prep) In The Us Deep South, Jason Ervin, Allison Weller Tikare, Carolyn Mcallaster

Faculty Scholarship

No abstract provided.

The Effect Of Rna2 Mutation Dr7 On Recombination Of Brome Mosaic Virus Rna3, Matthew K. Schnizlein

Honors Capstones

Brome mosaic virus (BMV) is a positive-sense, single-stranded RNA virus that infects plants throughout the world, including barley, tobacco, and wheat. Although this virus is not known for its ability to cause widespread crop damage, researchers frequently utilize BMV to understand more about other RNA viruses, such as human immunodeficiency virus. RNA2 of BMV’s tripartite genome contains a sequence that is thought to be responsible for regulating recombination of RNA3. Currently, there are no studies investigating this function in the Nicotiana benthamiana plant model. Thus, determining how the RNA-dependent RNA polymerase of RNA2 influences recombination in this model will increase …