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2016

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Proceedings Of The Thirteenth North American Crane Workshop, Abstracts, David A. Aborn, Richard P. Urbanek Jan 2016

Proceedings Of The Thirteenth North American Crane Workshop, Abstracts, David A. Aborn, Richard P. Urbanek

Proceedings of the North American Crane Workshop

AGE-SPECIFIC SURVIVAL OF GREATER SANDHILL CRANE COLTS IN NEVADA. Chad August, Jim Sedinger, and Chris Nicolai 111

WHOOPING CRANE DISTRIBUTION AND HABITAT USE: PAST, PRESENT, AND FUTURE? Jane Austin, Matthew Hayes, and Jeb Barzen 111

BEHAVIORAL MOVEMENTS OF ARANSAS-WOOD BUFFALO WHOOPING CRANES: ANOMALIES OR INDICATIONS OF WAYS TO FURTHER ENHANCE SPECIES RECOVERY. David Baasch, Mark Bidwell, Wade Harrell, Kris Metzger, Aaron Pearse, and Mary Harner 112

INFLUENCES ON NEST SUCCESS IN A REINTRODUCED POPULATION OF WHOOPING CRANES. Jeb Barzen, Sarah Converse, Peter Adler, Elmer Gray, Anne Lacy, Eva Szyszkoski, and Andrew Gossens 113

DETERMINING DIET COMPOSITION AND INGESTION RATE OF …


Suppression Of Pulmonary Innate Immunity By Pneumoviruses, Jayeeta Dhar Jan 2016

Suppression Of Pulmonary Innate Immunity By Pneumoviruses, Jayeeta Dhar

ETD Archive

Pneumonia Virus of Mice (PVM) and Respiratory Syncytial Virus (RSV) are negative sense, single-stranded, enveloped RNA viruses from Pneumovirus genus, Paramyxoviridae family. RSV is the leading cause of respiratory diseases in infants. PVM causes similar respiratory illness in mice. PVM is used as an animal model to study RSV pathogenesis because of its similarity with RSV infection. Viral infection induces type I interferon (IFN) response as an antiviral strategy. PVM and RSV both have two non-structural (NS) proteins that are known to be IFN antagonists. While RSV can target different signaling components of IFN pathway, the mechanism of IFN suppression …


Coastal Development And Precipitation Drive Pathogen Flow From Land To Sea: Evidence From A Toxoplasma Gondii And Felid Host System, Elizabeth Vanwormer, Tim E. Carpenter, Purnendu Singh, Karen Shapiro, Wesley W. Wallender, Patricia A. Conrad, John L. Largier, Marco P. Maneta, Jonna A. K. Mazet Jan 2016

Coastal Development And Precipitation Drive Pathogen Flow From Land To Sea: Evidence From A Toxoplasma Gondii And Felid Host System, Elizabeth Vanwormer, Tim E. Carpenter, Purnendu Singh, Karen Shapiro, Wesley W. Wallender, Patricia A. Conrad, John L. Largier, Marco P. Maneta, Jonna A. K. Mazet

School of Natural Resources: Faculty Publications

Rapidly developing coastal regions face consequences of land use and climate change including flooding and increased sediment, nutrient, and chemical runoff, but these forces may also enhance pathogen runoff, which threatens human, animal, and ecosystem health. Using the zoonotic parasite Toxoplasma gondii in California, USA as a model for coastal pathogen pollution, we examine the spatial distribution of parasite runoff and the impacts of precipitation and development on projected pathogen delivery to the ocean. Oocysts, the extremely hardy free-living environmental stage of T. gondii shed in faeces of domestic and wild felids, are carried to the ocean by freshwater runoff. …


Synthesis Of Apramycin And Paromomycin Derivatives As Potential Next Generation Aminoglycoside Antibiotics And Chemistry Of Isothiocyanato Sialyl Donors, Appi Reddy Mandhapati Jan 2016

Synthesis Of Apramycin And Paromomycin Derivatives As Potential Next Generation Aminoglycoside Antibiotics And Chemistry Of Isothiocyanato Sialyl Donors, Appi Reddy Mandhapati

Wayne State University Dissertations

AGAs are clinically important antibacterials for human therapy and have long been used as highly potent antibiotics for treating several bacterial infections. The fidelity of protein synthesis is affected by AGAs in the course of binding to specific sites of the bacterial rRNA. The clinical use of AGAs and their applications as therapeutics is restricted by toxicity (irreversible ototoxicity and reversible nephrotoxicity) and by the resistance of pathogens. The objective of this research was the development of proficient AGAs that are less toxic (i.e., more selective) and that evade resistance. The first three chapters of this thesis are aimed towards …


Ampicillin In Combination With Ceftaroline, Cefepime, Or Ceftriaxone Demonstrates Equivalent Activities In A High-Inoculum Enterococcus Faecalis Infection Model, Megan K. Luther, B. Rice, Kerry L. Laplante Jan 2016

Ampicillin In Combination With Ceftaroline, Cefepime, Or Ceftriaxone Demonstrates Equivalent Activities In A High-Inoculum Enterococcus Faecalis Infection Model, Megan K. Luther, B. Rice, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Ampicillin-ceftriaxone combination therapy has become a predominant treatment for serious Enterococcus faecalis infections, such as endocarditis. Unfortunately, ceftriaxone use is associated with future vancomycin-resistant enterococcus colonization. We evaluated E. faecalis in an in vitro pharmacodynamic model against simulated human concentration-time profiles of ampicillin plus ceftaroline, cefepime, ceftriaxone, or gentamicin. Ampicillin-cefepime and ampicillin-ceftaroline demonstrated activities similar to those of ampicillin-ceftriaxone against E. faecalis.


Predictors Of Mortality Among U.S. Veterans With Streptococcus Pneumoniae Infections, Jacob B. Morton, J. Morrill, Kerry L. Laplante, Aisling R. Caffrey Jan 2016

Predictors Of Mortality Among U.S. Veterans With Streptococcus Pneumoniae Infections, Jacob B. Morton, J. Morrill, Kerry L. Laplante, Aisling R. Caffrey

Pharmacy Practice and Clinical Research Faculty Publications

Introduction

Serious Streptococcus pneumoniae infections, encompassing pneumonia, bacteremia, and meningitis, are a major cause of mortality. However, literature regarding mortality is often limited to invasive pneumococcal disease, excluding pneumonia. This study sought to identify predictors of mortality among adults with serious pneumococcal disease, including pneumonia and invasive pneumococcal disease.

Methods

This was a nested case-control study of unvaccinated older Veterans with positive S. pneumoniae cultures (blood, cerebrospinal fluid, respiratory) admitted to Veterans Affairs medical centers nationally between 2002 and 2011. Patients vaccinated against pneumococcal disease were excluded. Using multivariable logistic regression, predictors of 30-day mortality were identified, including patient demographics, …


Blastocystis Sp. Infection Mimicking Clostridium Difficile Colitis, Gaby S. Gil, Shobhana A. Chaudhari, Ahmed Shady, Ana Caballes, Joe Hong Jan 2016

Blastocystis Sp. Infection Mimicking Clostridium Difficile Colitis, Gaby S. Gil, Shobhana A. Chaudhari, Ahmed Shady, Ana Caballes, Joe Hong

NYMC Faculty Publications

We report an unusual case of severe diarrhea related to Blastocystis sp. infection in a patient with end stage renal disease on hemodialysis. The patient was admitted due to profuse diarrhea associated with fever and leukocytosis. Pertinent stool work-up such as leukocytes in stool, stool culture, clostridium difficile toxin B PCR, and serology for hepatitis A, hepatitis B, and hepatitis C and cytomegalovirus screening were all negative. Ova and parasite stool examination revealed Blastocystis sp. The patient was given intravenous metronidazole with clinical improvement by day three and total resolution of symptoms by day ten.


Unm Pathology Pathfinder Winter 2016, Unm Department Of Pathology Jan 2016

Unm Pathology Pathfinder Winter 2016, Unm Department Of Pathology

Newsletters

No abstract provided.


Unm Health Sciences Center Data Book 2015-16, University Of New Mexico - Health Sciences Center Jan 2016

Unm Health Sciences Center Data Book 2015-16, University Of New Mexico - Health Sciences Center

Health Sciences Center Databook (1990-ongoing)

No abstract provided.


Unm Health Sciences Center Research Annual Report 2016, Michael Haederle, Sara Mota, Furhana Afrid, John Arnold, Cindy Foster, Luke Frank, Parl Noskin, Kelko Ohnuma, Jennifer Ruden, Michele Sequeira, Rebecca Gustaf Jan 2016

Unm Health Sciences Center Research Annual Report 2016, Michael Haederle, Sara Mota, Furhana Afrid, John Arnold, Cindy Foster, Luke Frank, Parl Noskin, Kelko Ohnuma, Jennifer Ruden, Michele Sequeira, Rebecca Gustaf

Research Annual Reports

No abstract provided.


Live, Attenuated Vaccines And Methods Of Making And Using, Jiantao Guo, Qingsheng Li, Wei Niu, Yue Li, Nanxi Wang Jan 2016

Live, Attenuated Vaccines And Methods Of Making And Using, Jiantao Guo, Qingsheng Li, Wei Niu, Yue Li, Nanxi Wang

Department of Chemistry: Faculty Publications

A live, attenuated HIV vaccine is provided, and methods of making a atenuated HIV vaccine are provided.


Children's Mercy Hospital Annual Report 2015, Children's Mercy Hospital Jan 2016

Children's Mercy Hospital Annual Report 2015, Children's Mercy Hospital

Children's Mercy Annual Reports

Annual report for The Children's Mercy Hospital in Kansas City MO, a pediatric medical center.


Reimagining Long-Term Antibiotics In Persons Who Inject Drugs: Time To Shift The Status Quo?, Jesse Theisen-Toupal, Elana S. Rosenthal, Christopher F. Rowley Jan 2016

Reimagining Long-Term Antibiotics In Persons Who Inject Drugs: Time To Shift The Status Quo?, Jesse Theisen-Toupal, Elana S. Rosenthal, Christopher F. Rowley

Uniformed Services University of the Health Sciences

In the United States, there are an estimated 744,000 individuals who have engaged in recent injection drug use (IDU) and 6.6 million individuals who have ever injected a drug.1 The practice of IDU predisposes individuals to serious bacterial and fungal infections that often require long-term intravenous antibiotics. In individuals without IDU, these serious infections are often treated with outpatient parenteral antibiotic therapy (OPAT). However, a different standard exists for many persons who inject drugs (PWID)—the mandated completion of antibiotics in an inpatient setting.

Though mandating inpatient antibiotic therapy for PWID is a widely adopted standard, this practice is not evidence …


A Urinary Metabolic Signature For Multiple Sclerosis And Neuromyelitis Optica, Teklab Gebregiworgis, Helle H. Nielsen, Chandirasegara Massilamany, Arunakumar Gangaplara, Jay Reddy, Zsolt Illes, Robert Powers Jan 2016

A Urinary Metabolic Signature For Multiple Sclerosis And Neuromyelitis Optica, Teklab Gebregiworgis, Helle H. Nielsen, Chandirasegara Massilamany, Arunakumar Gangaplara, Jay Reddy, Zsolt Illes, Robert Powers

Jay Reddy Publications

Urine is a metabolite-rich biofluid that reflects the body’s effort to maintain chemical and osmotic homeostasis. Clinical diagnosis routinely relies on urine samples because the collection process is easy and noninvasive. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). Nuclear magnetic resonance spectroscopy (NMR) has become a common approach for analyzing urinary metabolites for disease diagnosis and biomarker discovery. For illustration of the potential of urinary metabolites for diagnosing and treating MS patients, and for differentiating between MS and other illnesses, 38 urine samples were collected from healthy controls, MS patients, and neuromyelitis optica-spectrum …


Paying The Pipers: Mitigating The Impact Of Anticoagulant Rodenticides On Predators And Scavengers, John E. Elliott, Barnett A. Rattner, Richard F. Shore, Nico W. Van Den Brink Jan 2016

Paying The Pipers: Mitigating The Impact Of Anticoagulant Rodenticides On Predators And Scavengers, John E. Elliott, Barnett A. Rattner, Richard F. Shore, Nico W. Van Den Brink

United States Geological Survey: Staff Publications

Anticoagulant rodenticides, mainly second-generation forms, or SGARs, dominate the global market for rodent control. Introduced in the 1970s to counter genetic resistance in rodent populations to first-generation compounds such as warfarin, SGARs are extremely toxic and highly effective killers. However, their tendency to persist and accumulate in the body has led to the widespread contamination of terrestrial predators and scavengers. Commercial chemicals that are classified by regulators as persistent, bio-accumulative, and toxic (PBT) chemicals and that are widely used with potential environmental release, such as dichloro-diphenyl-trichloroethane (DDT) or polychlorinated biphenyls (PCBs), have been removed from commerce. However, despite consistently failing …


Immunoglobulin Detection Inwild Birds: Effectiveness Of Three Secondary Anti-Avian Igy Antibodies In Direct Elisas In 41 Avian Species, Carol A. Fassbinder-Orth, Travis E. Wilcoxen, Tiffany Tran, Raoul K. Boughton, Jeanne M. Fair, Erik K. Hofmeister, Jennifer L. Grindstaff, Jen C. Owen Jan 2016

Immunoglobulin Detection Inwild Birds: Effectiveness Of Three Secondary Anti-Avian Igy Antibodies In Direct Elisas In 41 Avian Species, Carol A. Fassbinder-Orth, Travis E. Wilcoxen, Tiffany Tran, Raoul K. Boughton, Jeanne M. Fair, Erik K. Hofmeister, Jennifer L. Grindstaff, Jen C. Owen

United States Geological Survey: Staff Publications

1.Immunological reagents for wild, non-model species are limited or often non-existent for many species.

2. In this study, we compare the reactivity of a newanti-passerine IgY secondary antibody with existing secondary antibodies developed for use with birds. Samples from 41 species from the following six avian orders were analysed: Anseriformes (1 family, 1 species), Columbiformes (1 family, 2 species), Galliformes (1 family, 1 species), Passeriformes (16 families, 34 species), Piciformes (1 family, 2 species) and Suliformes (1 family, 1 species). Direct ELISAs were performed to detect total IgY using goat anti-passerine IgY, goat anti-chicken IgY or goat anti-bird IgY secondary …


State Prescription Drug Purchases. Pricing Standards. Initiative Statute. Jan 2016

State Prescription Drug Purchases. Pricing Standards. Initiative Statute.

Propositions

Prohibits state agencies from buying any prescription drug from a drug manufacturer at any price over the lowest price paid for the same drug by the United States Department of Veterans Affairs, except as may be required by federal law. • Applies to any program where the state agency is the ultimate payer for a prescription drug, even if the state agency does not itself buy the drug. • Exempts purchases of prescription drugs under managed care programs funded through Medi-Cal. • Potential for state savings of an unknown amount depending on (1) how the measure’s implementation challenges are addressed …


Bait Flavor Preference And Immunogenicity Of Onrab Baits In Domestic Dogs On The Navajo Nation, Arizona, Are R. Berentsen, Scott Bender, Peggy Bender, David Bergman, Amy T. Gilbert, Hannah M. Rowland, Kurt C. Vercauteren Jan 2016

Bait Flavor Preference And Immunogenicity Of Onrab Baits In Domestic Dogs On The Navajo Nation, Arizona, Are R. Berentsen, Scott Bender, Peggy Bender, David Bergman, Amy T. Gilbert, Hannah M. Rowland, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Rabies is responsible for an estimated 59,000 human deaths worldwide, and domestic dogs are the primary reservoir and vector of the disease. Among some nations, widespread vaccination has led to elimination of rabies in domestic dogs, yet dogs are still susceptible to rabies infection from interactions with wildlife reservoirs. On Tribal lands in the United States, less than 20% of domestic dogs are vaccinated for rabies, and parenteral vaccination is often unfeasible. Oral rabies vaccination may provide a solution, but a suitable bait flavor and vaccine must be identified. We evaluated 5 bait flavors (bacon, cheese, egg, fish, and sweet) …


Faculty Spotlight Journal 2016, Fordham Law Communications Jan 2016

Faculty Spotlight Journal 2016, Fordham Law Communications

Faculty Spotlight Journal

Excerpts of articles from: Deborah W. Denno; Sean J. Griffith; Chi Adanna Mgbako; John Pfaff; Jed Handelsman Shugerman; faculty bibliography


Office Of The Vice Provost For Research Annual Report - 2016, Office Of The Vice Provost For Research, East Tennessee State University Jan 2016

Office Of The Vice Provost For Research Annual Report - 2016, Office Of The Vice Provost For Research, East Tennessee State University

Annual Reports

No abstract provided.


Health Profiles Of Foreigners Attending Primary Care Clinics In Malaysia, N. Ab Rahman, S. Sivasampu, K. Mohamad Noh, E.M. Khoo Jan 2016

Health Profiles Of Foreigners Attending Primary Care Clinics In Malaysia, N. Ab Rahman, S. Sivasampu, K. Mohamad Noh, E.M. Khoo

Research Publications (2016 to 2020)

Background: The world population has become more globalised with increasing number of people residing in another country for work or other reasons. Little is known about the health profiles of foreign population in Malaysia. The aim of this study was to provide a detailed description of the health problems presented by foreigners attending primary care clinics in Malaysia. Methods: Data were derived from the 2012 National Medical Care Survey (NMCS), a cross sectional survey of primary care encounters from public and private primary care clinics sampled from five regions in Malaysia. Patients with foreign nationality were identified and analysed for …


Chronic Leptomeningitis And Spinal Intradural Mass Secondary To Alternaria Infection In A Patient With Ventriculoperitoneal Shunt, Sanjeet S. Dadwal, Russell Thompson, Rahul Jandial, Bernard Tegtmeier, Mike Yue Chen Jan 2016

Chronic Leptomeningitis And Spinal Intradural Mass Secondary To Alternaria Infection In A Patient With Ventriculoperitoneal Shunt, Sanjeet S. Dadwal, Russell Thompson, Rahul Jandial, Bernard Tegtmeier, Mike Yue Chen

Open Access Publications

No abstract provided.


Attitudes Towards Tax Evasion In Turkey And Australia: A Comparative Study, Robert W. Mcgee, Ken Devos, Serkan Benk Jan 2016

Attitudes Towards Tax Evasion In Turkey And Australia: A Comparative Study, Robert W. Mcgee, Ken Devos, Serkan Benk

College of Business and Economics

The authors conducted a survey of 502 Turkish and Australian undergraduate and graduate business and economic students to determine their views regarding the ethics of tax evasion. These two groups were selected on the premise that their views represented the perceptions of two very different cultures, which has not been investigated in previous studies. The survey instrument required students to indicate their level of agreeableness to 18 general statements representing various scenarios in the socio-economic environment. The statements in the survey reflected the three main viewpoints regarding the ethics of tax evasion which have emerged from the literature to date. …


2016 Intersession Catalog, Illinois Mathematics And Science Academy Jan 2016

2016 Intersession Catalog, Illinois Mathematics And Science Academy

Intersession Catalogs

No abstract provided.


The Respiratory Protection Effectiveness Clinical Trial (Respect): A Cluster-Randomized Comparison Of Respirator And Medical Mask Effectiveness Against Respiratory Infections In Healthcare Personnel., Lewis J. Radonovich, Mary T. Bessesen, Derek A.T. Cummings, Aaron Eagan, Charlotte A. Gaydos, Cynthia Gibert, Geoffrey J. Gorse, +8 Additional Authors Jan 2016

The Respiratory Protection Effectiveness Clinical Trial (Respect): A Cluster-Randomized Comparison Of Respirator And Medical Mask Effectiveness Against Respiratory Infections In Healthcare Personnel., Lewis J. Radonovich, Mary T. Bessesen, Derek A.T. Cummings, Aaron Eagan, Charlotte A. Gaydos, Cynthia Gibert, Geoffrey J. Gorse, +8 Additional Authors

Medicine Faculty Publications

BACKGROUND: Although N95 filtering facepiece respirators and medical masks are commonly used for protection against respiratory infections in healthcare settings, more clinical evidence is needed to understand the optimal settings and exposure circumstances for healthcare personnel to use these devices. A lack of clinically germane research has led to equivocal, and occasionally conflicting, healthcare respiratory protection recommendations from public health organizations, professional societies, and experts.

METHODS: The Respiratory Protection Effectiveness Clinical Trial (ResPECT) is a prospective comparison of respiratory protective equipment to be conducted at multiple U.S. study sites. Healthcare personnel who work in outpatient settings will be cluster-randomized to …


Disseminated Cryptococcosis With Endobronchial Lesions, Kusha Davar, Arun Jose, Anne Cramer, Alexander Aldrich, Jillian S. Catalanotti Jan 2016

Disseminated Cryptococcosis With Endobronchial Lesions, Kusha Davar, Arun Jose, Anne Cramer, Alexander Aldrich, Jillian S. Catalanotti

Medicine Faculty Posters and Presentations

No abstract provided.


Metataxonomic And Metagenomic Approaches Vs. Culture-Based Techniques For Clinical Pathology., Sarah K. Hilton, Eduardo Castro-Nallar, Marcos Pérez-Losada, Ian Toma, Timothy A. Mccaffrey, Eric P. Hoffman, Marc O. Siegel, Gary L. Simon, W. Evan Johnson, Keith Crandall Jan 2016

Metataxonomic And Metagenomic Approaches Vs. Culture-Based Techniques For Clinical Pathology., Sarah K. Hilton, Eduardo Castro-Nallar, Marcos Pérez-Losada, Ian Toma, Timothy A. Mccaffrey, Eric P. Hoffman, Marc O. Siegel, Gary L. Simon, W. Evan Johnson, Keith Crandall

Genomics and Precision Medicine Faculty Publications

Diagnoses that are both timely and accurate are critically important for patients with life-threatening or drug resistant infections. Technological improvements in High-Throughput Sequencing (HTS) have led to its use in pathogen detection and its application in clinical diagnoses of infectious diseases. The present study compares two HTS methods, 16S rRNA marker gene sequencing (metataxonomics) and whole metagenomic shotgun sequencing (metagenomics), in their respective abilities to match the same diagnosis as traditional culture methods (culture inference) for patients with ventilator associated pneumonia (VAP). The metagenomic analysis was able to produce the same diagnosis as culture methods at the species-level for five …


Improving Hiv Surveillance Data For Public Health Action In Washington, Dc: A Novel Multiorganizational Data-Sharing Method, Joanne Ocampo, J. C. Smart, Adam Allston, Reshma Bhattacharjee, Sahithi Boggavarapu, Amanda D. Castel, +13 More Jan 2016

Improving Hiv Surveillance Data For Public Health Action In Washington, Dc: A Novel Multiorganizational Data-Sharing Method, Joanne Ocampo, J. C. Smart, Adam Allston, Reshma Bhattacharjee, Sahithi Boggavarapu, Amanda D. Castel, +13 More

GW Biostatistics Center

Background: The National HIV/AIDS Strategy calls for active surveillance programs for human immunodeficiency virus (HIV) to more accurately measure access to and retention in care across the HIV care continuum for persons living with HIV within their jurisdictions and to identify persons who may need public health services. However, traditional public health surveillance methods face substantial technological and privacy-related barriers to data sharing.

Objective: This study developed a novel data-sharing approach to improve the timeliness and quality of HIV surveillance data in three jurisdictions where persons may often travel across the borders of the District of Columbia, Maryland, and Virginia. …


D-Dimer Levels Before Hiv Seroconversion Remain Elevated Even After Viral Suppression And Are Associated With An Increased Risk Of Non-Aids Events, Matthew S Freiberg, Ionut Bebu, Russell Tracy, Kaku So-Armah, Jason Okulicz, Anuradha Ganesan, Adam Armstrong, Thomas O'Bryan, David Rimland, Amy C Justice, Brian K Agan Jan 2016

D-Dimer Levels Before Hiv Seroconversion Remain Elevated Even After Viral Suppression And Are Associated With An Increased Risk Of Non-Aids Events, Matthew S Freiberg, Ionut Bebu, Russell Tracy, Kaku So-Armah, Jason Okulicz, Anuradha Ganesan, Adam Armstrong, Thomas O'Bryan, David Rimland, Amy C Justice, Brian K Agan

GW Biostatistics Center

The mechanism underlying the excess risk of non-AIDS diseases among HIV infected people is unclear. HIV associated inflammation/hypercoagulability likely plays a role. While antiretroviral therapy (ART) may return this process to pre-HIV levels, this has not been directly demonstrated. We analyzed data/specimens on 249 HIV+ participants from the US Military HIV Natural History Study, a prospective, multicenter observational cohort of >5600 active duty military personnel and beneficiaries living with HIV. We used stored blood specimens to measure D-dimer and Interleukin-6 (IL-6) at three time points: pre-HIV seroconversion, ≥6 months post-HIV seroconversion but prior to ART initiation, and ≥6 months post-ART …


Generalized Confidence Intervals And Fiducial Intervals For Some Epidemiological Measures., Ionut Bebu, G. Luta, T. Mathew, B. K. Agan Jan 2016

Generalized Confidence Intervals And Fiducial Intervals For Some Epidemiological Measures., Ionut Bebu, G. Luta, T. Mathew, B. K. Agan

GW Biostatistics Center

For binary outcome data from epidemiological studies, this article investigates the interval estimation of several measures of interest in the absence or presence of categorical covariates. When covariates are present, the logistic regression model as well as the log-binomial model are investigated. The measures considered include the common odds ratio (OR) from several studies, the number needed to treat (NNT), and the prevalence ratio. For each parameter, confidence intervals are constructed using the concepts of generalized pivotal quantities and fiducial quantities. Numerical results show that the confidence intervals so obtained exhibit satisfactory performance in terms of maintaining the coverage probabilities …