Digital Commons Network^™

Impaired Immunological Synapse In Sperm Associated Antigen 6 (Spag6) Deficient Mice, Lauren Folgosa Cooley, Mohey Eldin El Shikh, Wei Li, Rebecca C. Keim, Zhengang Zhang, Jerome F. Strauss, Zhibing Zhang, Daniel H. Conrad

Microbiology and Immunology Publications

Sperm associated antigen 6 (SPAG6), a component of the central apparatus of the “9 + 2” axoneme, plays a central role in ciliary and flagellar motility; but, its contribution to adaptive immunity and immune system development is completely unknown. While immune cells lack a cilium, the immunological synapse is a surrogate cilium as it utilizes the same machinery as ciliogenesis including the nucleation of microtubules at the centrosome. This prompted our hypothesis that SPAG6 critically regulates the formation and function of immunological synapses. Using bone marrow reconstitution studies of adult WT mice, we demonstrate that SPAG6 is expressed in primary …

The Prostaglandin E2-Ep3 Receptor Axis Regulates Anaplasma Phagocytophilum-Mediated Nlrc4 Inflammasome Activation, Xiaowei Wang, Dana K. Shaw, Holly L. Hammond, Fayyaz S. Sutterwala, Manira Rayamajhi, Kari Ann Shirey, Darren J. Perkins, Joseph V. Bonventre, Thangam S. Velayutham, Sean M. Evans, Kyle G. Rodino, Lauren Viebrock, Karen M. Scanlon, Nicholas H. Carbonetti, Jason A. Carlyon, Edward A. Miao, Jere W. Mcbride, Michail Kotsyfakis, Joao H. F. Pedra

Microbiology and Immunology Publications

Rickettsial agents are sensed by pattern recognition receptors but lack pathogen-associated molecular patterns commonly observed in facultative intracellular bacteria. Due to these molecular features, the order Rickettsiales can be used to uncover broader principles of bacterial immunity. Here, we used the bacterium Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis, to reveal a novel microbial surveillance system. Mechanistically, we discovered that upon A. phagocytophilum infection, cytosolic phospholipase A2 cleaves arachidonic acid from phospholipids, which is converted to the eicosanoid prostaglandin E2 (PGE2) via cyclooxygenase 2 (COX2) and the membrane associated prostaglandin E synthase-1 (mPGES-1). PGE2-EP3 receptor signaling leads …

Can Empowered Nurses Decrease Catheter Associated Urinary Tract Infection (Cauti) Rates?, Judith Peters

Regis University Student Publications (comprehensive collection)

Nurses lack knowledge about the use and importance of a nurse-driven urinary catheter removal protocol, an evidence-based tool empowering them to remove urinary catheters that are no longer needed or are inappropriate based on set criteria, without calling a physician. (Health Care Infection Control Practice Advisory Committee (HIPAC), 2009) Despite this autonomy, catheter-associated urinary tract infections (CAUTI) are one of the leading hospital-acquired infections in many institutions (Centers for Disease Control and Prevention [CDC], 2015).
A quasi-experimental pre post intervention in a medical-surgical telemetry floor of an acute hospital in North Carolina showed a statistically significant increase in knowledge among …

Evaluation Of A Temporary, Immersive Learning Community Based On Worldschooling, Aimee Ferraro

Walden Faculty and Staff Publications

Learning communities are a proven method for engaging groups of people who share common goals for personal growth and knowledge acquisition (Gabelnick, MacGregor, Matthews, & Smith, 1990; Taylor, Moore, MacGregor, & Lindblad, 2003). However, little is known about the usefulness of this approach in the context of alternative education. This article describes the evaluation of a temporary, immersive learning community for self-directed teen learners, Project World School (PWS), which was based on a new, pedagogical approach to learning called worldschooling. Findings indicate that regardless of demographic characteristics and personal interests, PWS attendees experienced learning and progress in three main areas: …

Doctor Of Philosophy In Health Science Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

2016 Annual Report, Center For Applied Research On Substance Use And Health Disparities

Center for Applied Research on Substance Use and Health Disparities Annual Reports

No abstract provided.

2015-2016 Pediatric Subspecialty Trainees, Children's Mercy Hospital

Residents and Fellows Portraits

Photo composite of the graduate pediatric trainees in allergy/immunology, child abuse pediatrics, child neurology, clinical child psychology, clinical cytogenetics, clinical pharmacology, developmental-behavioral pediatrics, neonatal-perinatal medicine, pediatric adolescent gynecology, pediatric & congenital cardiac perfusion, pediatric cardiology, pediatric critical care, pediatric dentistry, pediatric dermatology, pediatric emergency medicine, pediatric endocrinology, pediatric gastroenterology, pediatric hematology/oncology, pediatric hospital medicine, pediatric infectious diseases, pediatric nephrology, pediatric ophthalmology, pediatric optometry, pediatric otolaryngology, pediatric ophthalmology/optometry, pediatric otolaryngology, pediatric radiology, pediatric rehabilitation, pediatric surgery, pediatric residency and med/peds residency

Ecology, Livelihoods And Rift Valley Fever Disease In Ijara Division, Garissa County, North Eastern Kenya, Geoffrey O Muga

All PhD Dissertations

Although scholars have advocated for a multi-disciplinary approach to the study of human and animal health, available evidence suggests that such studies are still limited. This thesis attempts to bridge this gap by focusing on the anthropology of Rift Valley Fever. It explores the interactions of ecology, livelihoods and Rift Valley Fever in Ijara division, North Eastern Kenya. Specifically, the thesis examines the adaptive strategies of pastoralist system as a livelihood practice and their influence on Rift Valley Fever occurrence as well as the socio-cultural, economic and political drivers of vulnerability to Rift Valley Fever. The indigenous knowledge base pertaining …

Development And Implementation Of A Pharmacist-Managed Outpatient Parenteral Antimicrobial Therapy Program, Eun Kyoung Chung, Cole B. Beeler, Eva W. Muloma, Danielle Osterholzer, Kendra M. Damer, Sharon M. Erdman

Scholarship and Professional Work – COPHS

Purpose The development and implementation of a pharmacist-managed outpatient parenteral antimicrobial therapy (OPAT) program in a county teaching hospital are described.

Summary A pharmacist-managed OPAT program was developed and implemented at a county teaching hospital to provide consistent evaluation, approval, and monitoring of patients requiring OPAT for the treatment of infection. The developmental and implementation stages of the OPAT program included (1) a needs assessment, (2) the identification of resources necessary for program operation, (3) delineation of general OPAT program operations and activities of individual OPAT clinicians, (4) the development of patient selection criteria, including a plan of care algorithm, …

Awareness Of Antibiotic Resistance In The General Population As Related To Education Level, Rachel M. Cantlon, Emma Wilson

All Electronic Theses and Dissertations

An antibiotic is a drug, also known as an antimicrobial, which is used to treat infectious diseases caused by bacteria (National Institute of Allergy and Infectious Diseases (NIAID), 2012). The effect of antibiotic overuse and mistreatment with these drugs has led to infectious bacteria developing antibiotic resistance (Centers for Disease Control and Prevention (CDC), 2014). Antibiotic resistance results in at least 23,000 deaths each year in the United States alone (CDC, 2014). The purpose of this study was to evaluate the general population’s awareness of antibiotic resistance in regard to education level, and proper use of antibiotics as measured by …

Pregnancy With Psoriasis: What New Parents Need To Know, Debra Henline Sullivan, Deborah Weatherspoon, Christopher Weatherspoon

Walden Faculty and Staff Publications

Psoriasis is a common, chronic, autoimmune inflammatory disease that affects a substantial number of women annually during pregnancy and childbirth. Some of these women will need and seek guidance before or during their pregnancies and during lactation. The childbirth educator needs a basic knowledge base and ability to answer questions that may arise regarding psoriasis during the childbirth experience. This article will define psoriasis and its effects on pregnancy and childbirth, consider genetic concerns, and explore treatment options.

Smallpox And Dracunculiasis: The Scientific Value Of Infectious Diseases That Have Been Eradicated Or Targeted For Eradication. Is Schistosomiasis Next?, Michael H. Hsieh, Margaret M. Mentink-Kane

Urology Faculty Publications

No abstract provided.

Graduate Medical Education 2015-2016 Annual Report, Children's Mercy Hospital

GME Annual Reports

Annual report of the Children's Mercy Hospital Graduate Medical Education department, including pediatric residency, internal medicine/pediatrics residency, fellowship programs, medical students, continuing medical education, and library services.

Doctor Of Osteopathic Medicine Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Nsu Translational Research And Economic Development Fy 2016 Annual Report, Nova Southeastern University

Annual Reports

No abstract provided.

Lineage-Specific Differences In The Gp120 Inner Domain Layer 3 Of Human And Simian Immunodeficiency Viruses, Shilei Ding, Halima Medjahed, Jérémie Prévost, Mathieu Coutu, Shi-Hua Xiang, Andrés Finzi

Nebraska Center for Virology: Faculty Publications

Binding of HIV-1 and SIV gp120 exterior envelope glycoprotein to CD4 triggers conformational changes in gp120 that promote its interaction with one of the chemokine receptors, usually CCR5, ultimately leading to gp41-mediated virus-cell membrane fusion and entry. We previously described that topological Layers (Layer 1, Layer 2 and Layer 3) in the gp120 inner domain contribute to gp120-trimer association in the unliganded state but also help secure CD4 binding. Relative to Layer 1 of HIV-1 gp120, the SIVmac239 gp120 Layer 1 plays a more prominent role in maintaining gp120-trimer association but is minimally involved in promoting CD4 binding, which could …

Jet Lag And The Biological Clock, Shayna Melool

The Science Journal of the Lander College of Arts and Sciences

Jet lag is a resulting disorder of flight travel across several time zones. Circadian rhythms, the approximately 24 hour system that our bodies follow, become distorted following such a trip, as the body’s internal biological clock has not yet caught up to the current local time zone. Time cues and other external factors are necessary to adjust the clocks and reverse the negative effects of jet lag.

Is There A Link Between Zika Virus And Microcephaly In Neonates?, Yuliya Salanovich

The Science Journal of the Lander College of Arts and Sciences

With Zika virus spreading worldwide, a lot of attention is drawn to researching its pathogenesis and etiology. It has also been noticed by various research groups and such health agencies such as CDC and WHO that there might be a connection between ZIKV and microcephaly, due to the spiking number of cases of microcephaly reported in areas with affected patients. Temporal and geographical data from the affected ZIKV areas, including Brazil and French Polynesia, suggests a connection between microcephaly and the virus. Tests of amniotic fluids of pregnant women with reported Zika virus infection and microcephalic fetuses revealed the presence …

Community Rates Of Igg4 Antibodies To Ascaris Haemoglobin Reflect Changes In Community Egg Loads Following Mass Drug Administration, Johnny Vlaminck, Taniawati Supali, Peter Geldhof, Cornelis H. Hokke, Peter U. Fischer, Gary J. Weil

Open Access Publications

No abstract provided.

Genseed-Hmm: A Tool For Progressive Assembly Using Profile Hmms As Seeds And Its Application In Alpavirinae Viral Discovery From Metagenomic Data, João M.P. Alves, Andre L. De Oliveira, Tatiana O.M. Sandberg, Jaime L. Moreno-Gallego, Marcelo A.F. De Toledo, Elisabeth M.M. De Moura, Liliane S. Oliveira, Alan M. Durham, Dolores U. Mehnert, Paolo M. De A. Zanotto, Alejandro Reyes, Arthur Gruber

Open Access Publications

No abstract provided.

Case Report: Severe Cutaneous Leishmaniasis In A Human Immunodeficiency Virus Patient Coinfected With Leishmania Braziliensis And Its Endosymbiotic Virus, Laurent Parmentier, Alexia Cusini, Norbert Müller, Haroun Zangger, Mary-Anne Hartley, Chantal Desponds, Patrik Castiglioni, Patrick Dubach, Catherine Ronet, Stephen M. Beverley, Nicolas Fasel

Open Access Publications

No abstract provided.

Rna-Seq Of The Caribbean Reef-Building Coral Orbicella Faveolata (Scleractinia-Merulinidae) Under Bleaching And Disease Stress Expands Models Of Coral Innate Immunity, David A. Anderson, Marcus E. Walz, Ernesto Weil, Peter Tonellato, Matthew C. Smith

Open Access Publications

No abstract provided.

The Yersiniabactin-Associated Atp Binding Cassette Proteins Ybtp And Ybtq Enhance Escherichia Coli Fitness During High-Titer Cystitis, Eun-Ik Koh, Chia S. Hung, Jeffrey P. Henderson

Open Access Publications

No abstract provided.

Previous Antibiotic Exposure Increases Risk Of Infection With Extended-Spectrum-Β-Lactamase- And Ampc-Producing Escherichia Coli And Klebsiella Pneumoniae In Pediatric Patients, Danielle M. Zerr, Arianna Miles-Jay, Matthew P. Kronman, Chuan Zhou, Amanda L. Adler, Wren Haaland, Scott J. Wessman, Alexis Elward, Jason G. Newland, Theoklis Zaoutis, Xuan Qin

Open Access Publications

No abstract provided.

Evolutionary Inactivation Of A Sialidase In Group B Streptococcus, Masaya Yamaguchi, Yujiro Hirose, Masanobu Nakata, Satoshi Uchiyama, Yuka Yamaguchi, Kana Goto, Tomoko Sumitomo, Amanda L. Lewis, Shigetada Kawabata, Victor Nizet

Open Access Publications

No abstract provided.

A Cohort Study Of Bacteremic Pneumonia: The Importance Of Antibiotic Resistance And Appropriate Initial Therapy?, Cristina Vazquez Guillamet, Rodrigo Vazquez, Jonas Noe, Scott T. Micek, Marin H. Kollef

Open Access Publications

No abstract provided.

Role Of Metal-Dependent Regulation Of Esx-3 Secretion In Intracellular Survival Of Mycobacterium Tuberculosis, Emir Tinaztepe, Jun-Rong Wei, Jenelle Raynowska, Cynthia Portal-Celhay, Victor Thompson, Jennifer A. Philips

Open Access Publications

No abstract provided.

Evaluation Of An Immunochromatographic Assay For Rapid Detection Of Penicillin-Binding Protein 2a In Human And Animal Staphylococcus Intermedius Group, Staphylococcus Lugdunensis, And Staphylococcus Schleiferi Clinical Isolate, A. R. Arnold, Carey-Ann Burnham, B. A. Ford, S. D. Lawhon, S. K. Mcallister, D Lonsway, V. Albrecht, R. C. Jerris, J. K. Rasheed, B. Limbago, E. M. Burd, L. F. Westblade

Open Access Publications

No abstract provided.

Adhesive Pili In Uti Pathogenesis And Drug Development, Caitlin N. Spaulding, Scott J. Hultgren

Open Access Publications

No abstract provided.

An Update On Mortality Of Fledged Whooping Cranes In The Aransas/Wood Buffalo Population, Thomas V. Stehn, Carey L. Haralson-Strobel

Proceedings of the North American Crane Workshop

From winter 1950 through spring 2011, 6,364 whooping cranes (Grus americana) overwintered at Aransas National Wildlife Refuge, or rarely, elsewhere. Documented winter losses amounted to 105 birds dead or disappeared. About 20% of total losses occurred in the wintering area, where birds spend 5 to 6 months of the year including a few birds that over-summer. Losses of white-plumaged whooping cranes on the summering area in Canada appear to be low with only 3 instances documented. The most significant losses seem to occur in migration and may comprise over 80% of the annual mortality. Migration involves only 17-20% of the …