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School Of Biological Sciences News, 2016, School Of Biological Sciences

School of Biological Sciences News

Alumni newsletter of Illinois State University's School of Biological Sciences.

Premedical Programs Newsletter, April 2016, University Of Dayton

Pre-Health Resource Center Campus Communications

Newsletter for students, staff, and faculty in the premedical and predental programs.

Nsu Sharks Rx-Spring, 2016, College Of Pharmacy

NSU Sharks Rx

Volume 2, Number 1

To Accommodate Or Not To Accommodate: (When) Should The State Regulate Religion To Protect The Rights Of Children And Third Parties?, Hillel Y. Levin, Allan J. Jacobs, Kavita Shah Arora

Washington and Lee Law Review

When should we accommodate religious practices? When should we demand that religious groups instead conform to social or legal norms? Who should make these decisions, and how? These questions lie at the very heart of our contemporary debates in the field of Law and Religion.

Particularly thorny issues arise where religious practices may impose health-related harm to children within a religious group or to third parties. Unfortunately, legislators, courts, scholars, ethicists, and medical practitioners have not offered a consistent way to analyze such cases, so the law is inconsistent. This Article suggests, first, that the lack of consistency is a …

Patterns Of Olfactory Neurogenesis And Immune Response In Adult Zebrafish Following Damage Of The Olfactory Bulb, Darcy M. Trimpe

Dissertations

The adult zebrafish olfactory system, with its persistent neuronal turnover and abundant regenerative capacity, is an excellent model system for studies of adult brain plasticity. Reversible deafferentation, achieved by repeated intranasal irrigation with detergent, reduces bulbar innervation and affects bulb structure and function, while cessation of treatment permits reinnervation and recovery of bulb volume. Alterations in cell genesis may account for this phenomenon. This study focuses on adult neurogenesis in the zebrafish olfactory system following reversible deafferentation and direct olfactory bulb injury.

Potential alterations in cell proliferation, differentiation, migration, and survival in the olfactory bulb following single and repeated intranasal …

Promoting Healthcare Innovation On The Demand Side, Rebecca S. Eisenberg, W. Nicholson Price

Law & Economics Working Papers

Innovation policy often focuses on the incentives of firms that sell new products. But optimal use of healthcare products also requires good information about the likely effects of products in different patients, and it is hard to provide the right incentives for producers to develop and disclose information that could limit future sales. Regulation partially fills this gap by requiring sellers to conduct clinical trials and report adverse events. But it is inherently problematic to rely on producers to supply negative information about their own products. Healthcare payers, however, can profit from avoiding inappropriate use of costly technologies. Recent technological …

A Community Hospital Antimicrobial Stewardship Program’S Assessment Of Prolonged Infusion Piperacillin-Tazobactam For Pseudomonas Aeruginosa Pneumonia, Lee Nguyen, Paul Gavaza, Amy Y. Kang, An Nguyen, Liem Hoang, Nguyen Ta

Pharmacy Faculty Articles and Research

Background: The study aim was to determine and compare the length of hospitalization, mortality, clinical stability, and time to clinical stability of a standard infusion (SI) and prolonged infusion (PI) piperacillin-tazobactam (TZP) in Pseudomonas aeruginosa ( PA) pneumonia patients.

Methods: This retrospective study evaluated length of hospitalization, mortality, clinical stability, and time to clinical stability with either SI-TZP or PI-TZP therapy in hospitalized patients diagnosed with PA pneumonia between January 01, 2008 and June 30, 2014. Patients were included in the study if they received ≥2 days of TZP, were diagnosed with PA pneumonia, and had TZP therapy …

Amp Expression In Energetic Hybrid D. Melanogaster Infected With P. Rettgeri, Cassandra K. Treu, Justin Buchanan, Kristi Montooth

UCARE: Research Products

The purpose of this experiment was to investigate immune function and energy metabolism, particularly the levels of antimicrobial peptides produced in Drosophila energetically compromised genotypes. This will provide the ability to investigate energetics of immunity without changing diet. Flies were infected with the bacteria P. rettgeri and the resulting immune response was investigated. Females did not mount as effective an immune response as males. All flies exhibited decreased survivorship from infection. Control flies survived at higher levels and showed no mitochondrial:nuclear interaction.

Solarizer, Michael Brandt, Michael Green, Shelby Pearce, Liana Soileau

Biomedical Engineering and Sciences Student Publications

In developing countries and following natural disasters, there is a need for a portable solar powered autoclave to properly sterilize surgical equipment because there is often no access to electricity or natural gas. Without proper sterilization of surgical equipment, infectious diseases may spread throughout a population.

An Analysis Of Women’S Access To Acute Opioid Detoxification Services In Maine: Identifying The Barriers To Treatment, Karen E. Conley

Muskie School Capstones and Dissertations

The lack of treatment facilities and services for opioid use disorder in Maine, combined with an increased prevalence of addiction, creates a potential for health inequity between men and women that may be intensified by barriers in access to care. This capstone study utilized detoxification screening inquiry forms and data obtained from the Milestone Foundation’s acute opioid detoxification program to assess and categorize barriers to access by gender. A barriers model was developed based on existing literature and was to identify potential associations among and between the known barriers to accessing treatment. Barriers were described as internally or externally based, …

Intimin Likely Used To Cause Disease During Competition With Commensal Escherichia Coli, Dominique J. Richburg

Senior Honors Theses

The intimin gene in the Locus of Enterocyte Effacement (LEE) island of pathogenicity is the primary attachment mechanism in Citrobacter rodentium. Intimin is a bacterial adhesin (protein) that attaches to obtain a niche/nutrient and thrive within the intestine. Intimin was deleted within C. rodentium to study colonization and pathogenesis in the murine intestine. Additionally, C. rodentium is an attaching/effacing pathogen, and a useful murine model in understanding Enterohemorrhagic Escherichia coli (EHEC) infection in humans. E. coli and C. rodentium cause gastroenteritis in humans and mice, respectively. C. rodentium is a murine pathogen commonly used to model gastrointestinal disease because …

Identification Of New Drug Candidates Against Borrelia Burgdorferi Using High-Throughput Screening, Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, David Solow-Cordero, K. M. Kim, A. V. Samineni, Mansi B. Parekh, Lobat Tayebi, Jayakumar Rajadas

School of Dentistry Faculty Research and Publications

Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of symptoms, such as muscle and joint pain, psychosocial and cognitive difficulties, and generalized fatigue. This condition is referred to as posttreatment Lyme disease syndrome. While there is no evidence for the presence of viable infectious organisms in individuals with posttreatment Lyme disease syndrome, some researchers found surviving Borrelia burgdorferi population in rodents and primates even after antibiotic treatment. …

Dissecting The Novel Roles Of Trim56 In Antiviral Innate Immunity, Baoming Liu

Theses and Dissertations (ETD)

The tripartite motif-containing (TRIM) proteins have emerged as a new class of host antiviral restriction factors, with several demonstrating roles in regulating innate antiviral responses. Of >70 known TRIMs, TRIM56 inhibits replication of bovine viral diarrhea virus, a ruminant pestivirus of the family Flaviviridae, but has no appreciable effect on VSV, a rhabdovirus. We have also shown that TRIM56 forms a complex with the Toll-like receptor-3 (TLR3) adaptor, TRIF, via its C-terminal residues 621-750, and augments TLR3-mediated interferon (IFN) induction and establishment of an antiviral state. Yet, TRIM56’s antiviral spectrum and the precise underlying mechanisms by which TRIM56 executes …

Cbct Analysis In Osteoradionecrosis Case Followed By Hyperbaric Oxygen Treatment (A Case Study), Lusi Epsilawati

Journal of Dentomaxillofacial Science

Osteoradinecrosis is an infectious disease and inflammation that occurs in the jaw after doing radio therapy. Radiographic picture of the disease is visible lesions lucent extensive radio in the jaw. In Clinical condition, seen fistula and abscess in the jaw. One therapy for the treatment of this condition is the Hyperbaric Oxygen. The purpose of this paper is to look casereport work hyperbaric oxygen therapy in treating osteoradionecrosis. Patient age55-year-old, woman, came with complaints of pain in  left and right lower jaw, since one month ago, after doing radiotherapy for 6 months. Patients diagnosed osteoradionecrosis. for the healing, selected …

Targeting Interventions To Reduce Chlamydia-Related Disparities In Kalamazoo County Using Gis And Statistical Analysis, Claudio Owusu

Masters Theses

The annual incident rates of chlamydia continue to rise within Kalamazoo County despite an increase in public health campaign, particularly for persons between the ages of 15-24. This trend in incidence rates of chlamydia by age also shows strong disparities in race/ethnicity and gender at state and county levels. With the increasing burden on the cost of treatment of chlamydia, which is one of the many sexually transmitted infections, targeting high risk populations offers a means of reducing the cost and the spread of the infection. This has shaped attention of researchers and policy makers to the complexity of the …

Wsq: Survival Editor's Note, Cynthia Chris, Matt Brim

Publications and Research

This Editor's Note introduces the WSQ issue "Survival," co-edited by Taylor Black, Elena Glasberg, and Frances Bartkowski, which explores affirmative acts of survival in the face of illness, occupation, violence, and environmental crises.

Identification And Characterization Of Ion Channel Activity Of The M2 Protein From Influenza Virus D (Dm2), Jianing Liu

School of Biological Sciences: Dissertations, Theses, and Student Research

Viral ion channels are membrane proteins of influenza viruses that play essential roles in the replication cycle, which enables them to be targeted by antiviral drugs. M2 of influenza type A virus, BM2 of influenza type B virus, and CM2 from influenza type C virus have been characterized as ion channel proteins and antiviral drug amantadine was developed to control influenza type A virus. However, few studies have been conducted to clarify the properties of the M2 protein (DM2) of influenza type D virus, a novel influenza virus genus identified in 2014. To identify the ion channel activity of DM2, …

Polymorphism Of Pfcrt K76t And Pfatpase6 S769n Genes In Malaria Patients At Teluk Bintuni Regency, Papua, Indonesia, Eka W. Suradji, Henry Ng, Ratih Finisanti, Eni Indrawati, Andreas Ciokan, Melisa I. Barliana, Rizky Abdulah

Pharmacology and Clinical Pharmacy Research

Indonesia is one of the country with the highest prevalence of malaria infections. In order to achieve malaria control as an act to support Millenium Development Goals, complete eradication of Plasmodium parasites needs to be conducted. Drugs resistance has been a hindrance in this act. This study aimed to assess Plasmodium parasite resistance towards chloroquine (CQ) and artemisinin combined therapy (ACT) through the determination of polymorphism on pfcrt K76T and pfatpase6 S769N genes, respectively. Subjects of this study were 16 adult patients positively diagnosed with malaria infection caused by P. falciparum or cross infection. DNA obtained from patient blood samples …

Sterility Status Of Reusable Intruments In Intermediate Care Rooms At Dr. Hasan Sadikin General Hospital Bandung, Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia, Hegandari S. Rahayu, Pudjiastuti Pudjiastuti

Pharmacology and Clinical Pharmacy Research

No abstract provided.

The Alteration Of Immune Cells In Elderly, Amonrat Jumnainsong, Prasert Saichua

Asian Medical Journal and Alternative Medicine

The information from National Statistic Office showed that Thailand has been in aging society since 2007 and will be completely aged society within 3-5 years (around A.D. 2019). The main characteristic of elderly is senescence including healthy. This leads to a lot of money that has to pay for medical care in elderly. One of the reasons for unhealthy in elderly is the immunosenescence. There were many publications showed that the immune system in elderly has been changed leading to susceptible infection, unresponse to vaccine, and prone to cancer and autoimmune disease. This report demonstrated the alteration of immune cells …

University Technology Transfer - Profit Centers Or Black Holes: Moving Toward A More Productive University Innovation Ecosystem Policy, Brian K. Krumm

Northwestern Journal of Technology and Intellectual Property

A great deal has been written over the years commenting on the strengths and weaknesses of the current system by which federal research funding has not produced the ideal results in terms of commercialization of inventions which are developed from such funding. The Bayh-Doyle Act was enacted in an attempt to provide a single uniform national policy which would cut through the government bureaucracy and encourage collaboration between universities and private industry to ensure that federally funded, commercially viable inventions were brought to market in an efficient manner. The question remains however, with the myriad of competing political and economic …

The Effectiveness Of California Assembly Bill 2109: Personal Belief Exemptions For Kindergarten Immunizations, Lilli Shizuka Goishi-Bessey

Doctoral Projects

The numbers of vaccine preventable diseases (VPDs) in the United States has declined with the development, administration, and effectiveness of vaccines during the 1970s and 1980s. As the eminent threat of VPDs to the public began to wane, parents started questioning the safety and necessity of vaccines. When parents were given the option of selecting personal belief exemption (PBE) waivers for state mandated immunizations for their incoming kindergarten children, an increase in PBEs and the number of VPD outbreaks began to occur. To counter the growing trend of PBEs, and to prevent outbreaks of VPDs in school settings and communities, …

Migrant Access To Healthcare: A Study Of Undocumented Migrant Access To Sexual Healthcare & Family Planning Services In Switzerland In 2016, Emily Egbert

Independent Study Project (ISP) Collection

The Swiss healthcare system has experienced a significant influx of vulnerable migrants over the past few years. This presents a challenge to providers and policy makers to account for and provide aid to these non-­‐ Swiss citizens, such as undocumented migrants (UDM), whose status and circumstances may impede their access to healthcare. Along with this, various cultural barriers may present further challenges to access to the health system. This paper explores UDM access to health through the lens of sexual healthcare and family planning. In examining sexual health, the issues of sexually transmitted infections (STIs), HIV/AIDS, and sexual violence were …

Perspectives On The Illinois Healthcare Delivery System Challenges, Structural Issues And Opportunities For Reform, Linda Baker

The Simon Review (Occasional Papers of the Paul Simon Public Policy Institute)

As fourth year students in the program, students at SIU School of Medicine have enrolled in classes at the Institute and have spent a rotation studying public policy choices that impact the delivery of health care services and the profession itself. The choices made by these public entities will have ramifications for physicians, nurses, administrative support staff and most importantly, for patients and their families. Students have studied state healthcare policy formation up-close and have learned a great deal about the forces and factors that shape their fields of study. Common to all students’ findings and much of the literature …

The Military And Infectious Disease: Rickettsial Disease, Isa Hakima

Department of Entomology: Distance Master of Science Projects

Since the founding of the United States Army on the fourteenth day of June in the year 1775, the United States Military has had millions of noncombat-related casualties due to preventable illnesses and diseases transmitted through an arthropod vector. U.S. Military operations have been affected from the effects of the smallpox and malaria outbreaks as early as the Continental Army around 1775, as well as the Civil War period in the mid-1860s. In 1898, the U.S. Military was devastated with outbreaks of typhoid fever, yellow fever, and dengue fever during the months of the Spanish-American War (Artenstein et al., 2005). …

Sinclair Lewis Society Newsletter, Vol. 24, No. 2, The Sinclair Lewis Society

Sinclair Lewis Society Newsletter

“Arrowsmith, A Synergy of Talents,” by Jan Peter Verhave, Van Raalte Institute, Hope College

“Babbitt in Paperback, 1946,” by Roger Lathbury, George Mason University

“Carl Van Vechten, Sinclair Lewis, and The Tattooed Countess,” by Sally E. Parry, Illinois State University

“What Were They Reading Then?: The Able McLaughlins by Margaret Wilson, 1923,” by Sally E. Parry, Illinois State University

“What Were They Reading Then?: In This Our Life by Ellen Glasgow, 1941,” by Sally E. Parry, Illinois State University

“What Were They Reading Then?: Moon-Calf by Floyd Dell, 1920,” by Ted G. Fleener, Waterloo Community Schools …

Experimental Demonstration Of An Allee Effect In Microbial Populations, Rajreni B. Kaul, Andrew M. Kramer, Fred C. Dobbs, John M. Drake

OES Faculty Publications

Microbial populations can be dispersal limited. However, microorganisms that successfully disperse into physiologically ideal environments are not guaranteed to establish. This observation contradicts the Baas-Becking tenet: ‘Everything is everywhere, but the environment selects’. Allee effects, which manifest in the relationship between initial population density and probability of establishment, could explain this observation. Here, we experimentally demonstrate that small populations of Vibrio fischeri are subject to an intrinsic demographic Allee effect. Populations subjected to predationby the bacterivore Cafeteria roenbergensis display both intrinsic and extrinsic demographic Allee effects. The estimated critical threshold required to escape positive densitydependence is around 5, 20 or …

Antibiotic Reimbursement In A Model Delinked From Sales: A Benchmark-Based Worldwide Approach, John H. Rex, Kevin Outterson

Faculty Scholarship

Despite the life-saving ability of antibiotics and their importance as a key enabler of all of modern health care, their effectiveness is now threatened by a rising tide of resistance. Unfortunately, the antibiotic pipeline does not match health needs because of challenges in discovery and development, as well as the poor economics of antibiotics. Discovery and development are being addressed by a range of public-private partnerships; however, correcting the poor economics of antibiotics will need an overhaul of the present business model on a worldwide scale. Discussions are now converging on delinking reward from antibiotic sales through prizes, milestone payments, …

The United Nations Sustainable Development Goals: Achieving The Vision Of Global Health With Justice, Eric A. Friedman, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

We are resolved to free the human race from the tyranny of poverty and want and to heal and secure our planet” (UN General Assembly, 2015, September 25, preamble). So pronounces the 2030 Agenda, the United Nations declaration on the Sustainable Development Goals (SDGs), adopted on September 25, 2015, succeeding the Millennium Development Goals (MDGs). If achieved, the SDGs will secure an improved level of health, development, and global justice. However, if the international community fails to live up to its commitments, an untold number of people will likely perish prematurely, people’s opportunities to thrive will be cut off, social …

Honors Research Symposium Program Spring 2016, University Honors Program, Georgia Southern University

Honors College: News & Publications (2008-2020)

No abstract provided.