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Clay Nanotube Composites For Antibacterial Nanostructured Coatings, Christen J. Boyer

Doctoral Dissertations

A surging demand for the development of new antimicrobial nanomaterials exists due to the frequency of medical device-associated infections and the transfer of pathogens from highly touched objects. Naturally occurring halloysite clay nanotubes (HNTs) have shown to be ideal particles for polymer reinforcement, time-release drug delivery, nano-reactor synthesis, and as substrate material for nanostructured coatings.

This research demonstrates the feasibility of a novel method for coating HNTs with metals for antibacterial applications. The first ever ability to coat HNTs through electrolysis was developed for customizable and multi-functional antibacterial nanoparticle platforms. HNTs were investigated as substrate for the deposition of copper …

Planning For Climate Change: The Need For Mechanistic Systems-Based Approaches To Study Climate Change Impacts On Diarrheal Diseases, Jonathan E. Mellor, Karen Levy, Julie Zimmerman, Mark Elliott, Jamie Bartram, Elizabeth Carlton, Thomas Clasen, Rebecca Dilingham, Joseph Eisenberg, Richard Guerrant, Daniele Lantagne, James Mihelcic, Kara Nelson

Civil and Environmental Engineering Faculty Publications

Increased precipitation and temperature variability as well as extreme events related to climate change are predicted to affect the availability and quality of water globally. Already heavily burdened with diarrheal diseases due to poor access to water, sanitation and hygiene facilities, communities throughout the developing world lack the adaptive capacity to sufficiently respond to the additional adversity caused by climate change. Studies suggest that diarrhea rates are positively correlated with increased temperature, and show a complex relationship with precipitation. Although climate change will likely increase rates of diarrheal diseases on average, there is a poor mechanistic understanding of the underlying …

Twenty-Fourth Annual Scientific Congress

Journal of the Hong Kong College of Cardiology

No abstract provided.

Arrhythmia In Severe Fever With Thrombocytopenia Syndrome, Viroj Wiwanitkit

Journal of the Hong Kong College of Cardiology

There are many new emerging infectious diseases in the present day. In cardiology, the important concern is on the cardiac presentation of any new disease. Severe fever with thrombocytopenia syndrome is a new disease firstly reported from China and becomes the important emerging infection in East Asia at present. The disease is proved to be due to the new severe fever with thrombocytopenia syndrome virus, a newly identified pathogenic Bunyavirus, infection. This disease usually presents with high fever and thrombocytopenia. Focusing on cardiac presentation, it is evidenced that the cardiac arrhythmia can be observed in this new disease. Here, the …

Hunting, Food Subsidies, And Mesopredator Release: The Dynamics Of Crop-Raiding Baboons In A Managed Landscape, Rachel A. Taylor, Sadie J. Ryan, Justin S. Brashares, Leah R. Johnson

Integrative Biology Faculty and Staff Publications

The establishment of protected areas or parks has become an important tool for wildlife conservation. However, frequent occurrences of human-wildlife conflict at the edges of these parks can undermine their conservation goals. Many African protected areas have experienced concurrent declines of apex predators alongside increases in both baboon abundance and the density of humans living near the park boundary. Baboons then take excursions outside of the park to raid crops for food, conflicting with the human population. We model the interactions of mesopredators (baboons), apex predators, and shared prey in the park to analyze how four components affect the proportion …

Alignment Of Epidemiology Practice And Academic Competencies Through Effective Collaboration, Kimberly R. Glenn, Paula R. Masters, Megan Quinn

ETSU Faculty Works

Background: Online learning has recently garnered increased attention as technology use in the classroom grows. However, most of the published approaches regarding this topic in postgraduate education centers on clinical environments. Models of partnerships between applied public health agencies and academic centers to produce mutually beneficial online learning opportunities for graduate-level public health courses have not been explored in the literature.

Methods: East Tennessee State University (ETSU) and the Tennessee Department of Health (TDH) partnered to build three online, asynchronous epidemiology modules for an interdisciplinary audience of graduate students. The goals of the modules were to (1) introduce students to …

Fish & Wildlife News: Spring 2016, Matt Trott

Fish and Wildlife News

No abstract provided.

Alaska Justice Forum ; Vol. 32, No. 4 (Winter 2016), Brad A. Myrstol, Barbara Armstrong

Vols 31-36 (2014-2019)

The Winter 2016 issue of the Alaska Justice Forum features articles on approaches to evidence-based criminal justice reform and recidivism reduction in Alaska, and an initiatve to make Alaska and national public health data available online.

A Retrospective Analysis Of Trends In Central Ohio Wildlife Health Using Records From A Wildlife Rehabilitation Facility, Rachel B. Dalton

Undergraduate Honors Thesis Projects

The analysis of records from wildlife rehabilitation facilities has shown great potential as a technique for monitoring health trends in local wildlife populations. We examined 45,668 records of animals admitted to a wildlife rehabilitation facility located in Ohio over a 10 year period (2005-2014). The objective was to examine how causes of admission for commonly admitted species may change over time and co-vary with seasonal patterns, with the goal of using fluctuations in wildlife admissions as a monitoring technique for population and ecosystem health. We assigned causes of admission to broad categories, such as “Collision with Non-Moving Object”, and a …

Proceedings Of The 94th Annual Virginia Academy Of Science Meeting, 2016

Virginia Journal of Science

Full proceedings of the 94th Annual Virginia Academy of Science Meeting, May 18-20, 2016, at University of Mary Washington, Fredericksburg, VA.

94th Annual Meeting Best Student Presentation Awards

Virginia Journal of Science

List of award winning student papers by section from the 94th Annual Meeting of the Virginia Academy of Science, 2016

Mythbusting The Common Cold And Flu, Matthew Dillon

McNair Scholars Research Journal

As we have created vaccines for many contagious pathogens in the last 100 years, the flu and cold still lack a “cure.” There are many things people do to try to get over the cold and flu from homeopathic remedies to the flu vaccine. While nothing can prevent the cold or flu, there are ways we can mitigate our chances of getting these viruses. By doing what we can to avoid getting these illnesses, we are also helping prevent the spread of the viruses to others. In the end, this is our best course of action until a vaccine that …

Undergraduate And Graduate Course Descriptions, 2016 Spring, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Spring 2016.

Mechanistic Binding Insights For 1-Deoxy-D-Xylulose-5-Phosphatesynthase, The Enzyme Catalyzing The First Reaction Of Isoprenoid Biosynthesis In The Malaria-Causing Protists, Plasmodium Falciparum And Plasmodium Vivax, Matthew R. Battistini, Christopher Shoji, Sumit Handa, Leonid Breydo, David J. Merkler

Chemistry Faculty Publications

We have successfully truncated and recombinantly-expressed 1-deoxy-D-xylulose-5-phosphate synthase (DXS) from both Plasmodium vivax and Plasmodium falciparum. We elucidated the order of substrate binding for both of these ThDP-dependent enzymes using steady-state kinetic analyses, dead-end inhibition, and intrinsic tryptophan fluorescence titrations. Both enzymes adhere to a random sequential mechanism with respect to binding of both substrates: pyruvate and D-glyceraldehyde-3-phosphate. These findings are in contrast to other ThDP-dependent enzymes, which exhibit classical ordered and/or ping-pong kinetic mechanisms. A better understanding of the kinetic mechanism for these two Plasmodial enzymes could aid in the development of novel DXS-specific inhibitors that might prove useful …

Helminthr: An R Interface To The London Natural History Museum's Host-Parasite Database, Tad Dallas

Faculty Publications

© 2016 Nordic Society Oikos. The understanding of the diversity and distribution of helminth parasites is currently constrained by the limited number of host-parasite interaction databases, and the difficulty in accessing existing data. The London Natural History Museum's Host-Parasite Database represents one such underutilized database, containing over a quarter million helminth parasite occurrence records, accessible through a web interface. To enable users to programmatically search and manipulate data from this database, I developed an R package called helminthR. Here, I introduce the core functions of the package, and detail how helminthR can be used to obtain host-parasite interaction records, citations …

Treatment And Prevention Of Human Rotavirus (Hrv) In Developing Countries: The Potential Of Avian Immunoglobulin Y, Christa Brown

Senior Honors Theses

Rotavirus gastroenteritis is a leading cause of childhood mortality, killing ~1400 children younger than five daily, primarily through severe diarrheal dehydration. Eighty-five percent of this mortality occurs in developing countries where rotavirus vaccines are not widely implemented and are only partially effective. In those countries, it has proven difficult to implement the recommended supportive therapies like oral rehydration therapy (ORT) on a wide scale due to lack of both medical infrastructure and private economic investment combined with cultural bias against ORT. IgY targeting human rotavirus (anti-HRV IgY) shows potential as a passive immunotherapy that reduces rotavirus-associated morbidity and mortality, augments …

Depolarizing Science: The Effects Of Local Crises On Partisan Science Policy, Christopher R. Handy

Honors Capstones

No abstract provided.

Pharmacy Newsletter : April 2016, Pharmacy Department

Department of Pharmacy Archives

Content:

• Medication Management in Geriatrics | Overview of Beers Criteria 2015
• Zika Virus Disease (ZVD) – An Emerging Culprit
• Emerging Avenues for Botulinium Toxin Therapy
• Novel Treatment Approach of Pancreatic Cancer
• FDA Podcast 2015
• Extra Care is Needed Because Warfarin is High - Alert Medicine
• Reporting of ADR
• ADR Trends of 2015 at AKUH

Unl Emeriti And Retirees Association Newsletter, Spring 2016

UNL Emeriti and Retirees Association: Newsletters and Other Materials

University of Nebraska-Lincoln Emeriti and Retirees Association Newsletter, Spring 2016

The Casualty Transportation Of Ebola Outbreak In Liberia: A Simulation Study, Hyejin Cho

Open Access Theses

In this paper, we have solved the unique problem of casualty transportation problem under Ebola by developing dynamic policies for vehicle routing in order to provide practical decision support. The objective of the proposed model is to minimize the total transmission risk. We describe the problem with real- constraints and parameters based on the empirical data of the 2014 Ebola outbreak in Liberia. The casualty transportation problem is a variant of Dynamic Pick-up and Delivery Problems (DPDP), in which a vehicle is dispatched to demand location in real time and it then transports the demands to the aimed area (destination). …

Evaluation Of Negative Energy And Mineral Balance In Periparturient Holstein-Friesian Cattle, Ameer Ahmed Abdelhameed

Open Access Dissertations

Most cows experience a state of negative energy and mineral balance during the periparturient period. This imbalance is a major problem in the dairy industry and it is more frequently seen in multiparous cattle due to their high milk production. A large amount of fat and protein is mobilized in order to address the energy deficit during the periparturient period. The ability to accurately monitor energetics and electrolytes status using accurate, rapid, and low cost point-of-care instruments will assist in optimizing animal health and productivity.

This dissertation contains three studies that evaluated point-of-care instruments for measuring blood and plasma glucose, …

The Things They Carried: The Biological Residue Of Childhood Misfortune, Patricia M. Morton

Open Access Dissertations

There is a well-established relationship between childhood misfortune and adult health, but how these early-life experiences “get under the skin” to later manifest as poor health is less clear. To elucidate this process, this dissertation investigates (1) how childhood conditions influence immune functioning and (2) whether these physiological consequences of early misfortune lead to poor health, indicated by ischemic heart disease (IHD) onset. Guided by cumulative inequality theory and biological embedding, this dissertation also examines adult health lifestyles and socioeconomic status (SES) as possible mechanisms linking childhood misfortune to inflammation and IHD in later life. Data come from six waves …

Vol. 41, No. 1: Spring 2016, School Of Medicine & Health Sciences

North Dakota Medicine Archive

No abstract provided.

Litigating From The Prison Of The Mind: A Cognitive Right To Post-Conviction Counsel, Ken Strutin

Cardozo Public Law, Policy & Ethics Journal

No abstract provided.

Pharmdigest Volume 2, Issue 3, Philadelphia College Of Osteopathic Medicine, School Of Pharmacy

PharmDigest

This issue of the Pharmacy Student Council newsletter includes the following articles:

• A Year in Review
• Impacting Patient Care
• Getting Your Voice Heard
• 10 Reasons to Counsel
• The Daily Dose: Residency
• AMCP Out West
• Dinner with a Pharmacist
• Introducing... [2016-2017 Pharmacy Student Council]

Informed Alaskans Initiative: Public Health Data In Alaska, Barbara Armstrong

Vols 31-36 (2014-2019)

This article describes the national and state public health data made available online through the Alaska Division of Public Health's Informed Alaskans Initiative.

Use Of Culturally Tailored Media To Increase Hiv Screening Among African Americans, Leda Evans

Doctoral Projects

Over one million people in the United States have HIV with a substantial portion of these individuals being African American. Innovative approaches to improving the HIV disparity among African Americans have been encouraged by the federal government. Culturally tailored HIV risk reduction interventions have been noted as effective in several studies in reducing risk behavior. The purpose of the intervention was to determine if the use of culturally tailored HIV risk reduction media would result in an increase in HIV screening among African Americans. A one-time community based-intervention with no control group was utilized to determine impact of media. Screening …

Studies Of Debaryomyces Hansenii Killer Toxin And Its Effect On Pathogenic Bloodstream Candida Isolates, Rhaisa A. Crespo Ramírez

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Candida species are normal commensal organisms found in the skin, mouth, and gastrointestinal and genitourinary tracts of humans. Candida albicans is a normal component of the gut flora, and the oral and genital cavities. However, this organism is an opportunistic pathogen and it is one of the most frequently isolated species from patients with nosocomial fungal infections. Candida infections have grown in recent years due to antimycotics resistance and the extensive use of antibiotics. This has pushed scientists to look for alternative therapeutic agents to treat fungal infections.

Yeasts can produce toxic proteins called “mycocins” or “killer toxins” that can …

The Plant Phenology Monitoring Design For The National Ecological Observatory Network, Sarah Elmendorf, Katherine D. Jones, Benjamin I. Cook, Jeffrey M. Diez, Carolyn A. F. Enquist, Rebecca A. Hufft, Matthew O. Jones, Susan J. Mazer, Abraham J. Miller-Rushing, David J. P. Moore, Mark D. Schwartz, Jake F. Weltzin

Numerical Terradynamic Simulation Group Publications

Phenology is an integrative science that comprises the study of recurring biological activities or events. In an era of rapidly changing climate, the relationship between the timing of those events and environmental cues such as temperature, snowmelt, water availability, or day length are of particular interest. This article provides an overview of the observer-based plant phenology sampling conducted by the U.S. National Ecological Observatory Network (NEON), the resulting data, and the rationale behind the design. Trained technicians will conduct regular in situ observations of plant phenology at all terrestrial NEON sites for the 30-yr life of the observatory. Standardized and …

Prediction Of Fluoroquinolone Resistance In Gram-Negative Bacteria Causing Bloodstream Infections, Seejil Dan, Ansal Shah, Julie Ann Justo, P Brandon Bookstaver, Joseph Kohn, Helmut Albrecht, Majdi N. Al-Hasan

Faculty Publications

Increasing rates of fluoroquinolone resistance (FQ-R) have limited empirical treatment options for Gram-negative infections, particularly in patients with severe beta-lactam allergy. This case-control study aims to develop a clinical risk score to predict the probability of FQ-R in Gram-negative bloodstream isolates. Adult patients with Gram-negative bloodstream infections (BSI) hospitalized at Palmetto Health System in Columbia, South Carolina, from 2010 to 2013 were identified. Multivariate logistic regression was used to identify independent risk factors for FQ-R. Point allocation in the fluoroquinolone resistance score (FQRS) was based on regression coefficients. Model discrimination was assessed by the area under receiver operating characteristic curve …