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The Role Of Drak2 In T Cell Function And Autoimmunity, Tarsha L. Harris

Theses and Dissertations (ETD)

The immune system utilizes many regulatory mechanisms to limit immune responses and ensure that immune cells target foreign pathogens and not healthy cells of the body. However, some immune cells can escape these checkpoints and attack the body’s healthy cells, leading to tissue destruction and devastating autoimmune disorders. For example, multiple sclerosis (MS) occurs when immune cells attack the myelin sheath surrounding neurons of the central nervous system (CNS). Likewise, the destruction of pancreatic islet cells by dysregulated immune cells leads to type 1 diabetes (T1D). Remarkably, there are more than 80 types of autoimmune diseases. An estimated 50 million …

Painless Hematophagy: The Functional Role Of Novel Tick Metalloproteases In Pain Suppression, Joseph W. Jelinski

Honors Theses

Ticks secrete a plethora of pharmacologically active molecules in their saliva while feeding. These allow the tick to feed upon a host over prolonged periods of time in an itch free and painless attachment. The exact mechanism of pain suppression by the tick has barely been investigated. In this study, two angiotensin converting enzymes (ACEs), members of the metalloprotease family, are identified as potentially responsible for the degradation of pro-inflammatory peptides. It is hypothesized that these tick ACEs block the function of bradykinin through degradation of the peptide, contributing to the tick’s ability to conduct a pain and itch-free host …

Translating Ecology, Physiology, Biochemistry And Population Genetics Research To Meet The Challenge Of Tick And Tick-Borne Diseases In North America, Maria Dolores Esteve-Gassent, Ivan Castro-Arellano, Teresa Patricia Feria-Arroyo, Ramiro Patino, Andrew Y. Li, Raul F. Medina, Adalberto A. Pérez De León, Roger Iván Rodríguez-Vivas

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Emerging and re-emerging tick-borne diseases threaten public health and the wellbeing of domestic animals and wildlife globally. The adoption of an evolutionary ecology framework aimed to diminish the impact of tick-borne diseases needs to be part of strategies to protect human and animal populations. We present a review of current knowledge on the adaptation of ticks to their environment, and the impact that global change could have on their geographic distribution in North America. Environmental pressures will affect tick population genetics by selecting genotypes able to withstand new and changing environments and by altering the connectivity and isolation of several …

A One Health Message About Bats Increases Intentions To Follow Public Health Guidance On Bat Rabies, Hang Lu, Katherine A. Mccomas, Danielle E. Buttke, Sungjong Roh, Margaret A. Wild

Research Collection Lee Kong Chian School Of Business

Since 1960, bat rabies variants have become the greatest source of human rabies deaths in the United States. Improving rabies awareness and preventing human exposure to rabid bats remains a national public health priority today. Concurrently, conservation of bats and the ecosystem benefits they provide is of increasing importance due to declining populations of many bat species. This study used a visitor-intercept experiment (N = 521) in two U.S. national parks where human and bat interactions occur on an occasional basis to examine the relative persuasiveness of four messages differing in the provision of benefit and uncertainty information on intentions …

Invasive Mucormycosis In Chronic Granulomatous Disease, Abdulnasir M. Al-Otaibi, Dayel A. Al-Shahrani, Eman M. Al-Idrissi, Hail M. Al-Abdely

Saudi Medical Journal

Mucormycosis is a rare opportunistic fungal infection that occurs in certain immunocompromised patients. We present 2 cases of invasive mucormycosis due to Rhizopus spp. in patients with chronic granulomatous disease (CGD) and discuss their clinical presentation, management challenges, and outcomes.

Yellow Fever Vaccination Essential For Angola, Who Reminds Travellers

Saudi Medical Journal

No abstract provided.

Herpes Zoster In Patients With Bullous Pemphigoid: A Population-Based Case-Control And Cohort Study, Benjamin Barrick, Joshua Barrick, Chad Weaver, Christine Lohse, Carilyn Wieland, Amer Kalaaji, Julia Lehman

Student Publications

No abstract provided.

A Qualitative Study Of Barriers To Accessing Water, Sanitation And Hygiene For Disabled People In Malawi., Sian White, Hannah Kuper, Ambumulire Itimu-Phiri, Rochelle Holm, Adam Biran

Faculty and Staff Scholarship

Globally, millions of people lack access to improved water, sanitation and hygiene (WASH). Disabled people, disadvantaged both physically and socially, are likely to be among those facing the greatest inequities in WASH access. This study explores the WASH priorities of disabled people and uses the social model of disability and the World Health Organization's International Classification of Functioning, Disability and Health (ICF) framework to look at the relationships between impairments, contextual factors and barriers to WASH access. 36 disabled people and 15 carers from urban and rural Malawi were purposively selected through key informants. The study employed a range of …

Reducing Potentially Inappropriate Prescribing In Geriatrics Using The Stopp/Start Tool, Samantha Radel

Nursing Capstones

No abstract provided.

The Perils Of “Contact”, Warren Thompson, Obed Garcia

Tipití: Journal of the Society for the Anthropology of Lowland South America

No abstract provided.

The Intangible Legacy Of The Indonesian Bajo, Chandra Nuraini

Wacana, Journal of the Humanities of Indonesia

The Sama-Bajau, or Bajo diaspora, extends from the southern Philippines and Sabah (Malaysian Borneo) to the eastern part of Indonesia. The Indonesian Bajo, now scattered along the coasts of Sulawesi (Celebes) and East Kalimantan, the Eastern Lesser Sunda Islands and Maluku, were once mostly nomadic fishermen of the sea or ocean freight carriers. Today, the Bajo are almost all fishermen and settled. Their former and present ways of life made them favour intangible forms of culture: it is impossible to transport bulky artefacts when moving frequently by boat, or when living in stilt houses, very close to the sea or …

Enhancing Interest And Knowledge Of How To Start A Nurse Practitioner-Led Clinic, Kami S. Campbell

Doctor of Nursing Practice Scholarly Projects

Theoretical and methodological contributions of nursing entrepreneurship and starting an independent practice within the Nurse Practitioner arena are sparse in American clinical prospectuses. The American health care system is in need of enhancement to better serve the healthcare needs of all people so there has never been a greater opportunity for NP entrepreneurial thinking and implementation of new initiatives (Marshall, 2011). Information regarding NP-led clinics is limited and NPs need to be educated on elements of successful independent healthcare ventures. The purpose of this project was to enhance interest and knowledge of starting a NP-led clinic.

A review of the …

Honoring Others By Accompaniment, Merrilee Brown

Theses and Graduate Projects

Nurses recognize that access to healthcare for marginalized individuals prevents some from utilizing western medicine basic health services. People living in the margins can experience difficult encounters to healthcare as a system and a culture. Providers in Scott County that offer access to the marginalized are referred to as safety net services, lack individual choice, resource coordination, or a health partnership with individuals struggling in their daily lives. public Health Nurses recognize the need for intentional collaboration among providers. This project began with a Hispanic individual who had accessed all safety net providers in Scott County and still was not …

The Sustainable Anthropocentrism, Sebastian L. Brana

Departmental Honors & Graduate Capstone Projects

A paper focusing on sustainability and remedying the problem presented by climate change through the unusual approach of Enlightened Anthropocentrism.

“Un Pueblo Tan Dulce”: Diabetes, Depression, And Obesity Syndemics In Puerto Rico, Shir Lerman

Doctoral Dissertations

Diabetes, depression, and obesity are global health crises that disproportionately affect people with low socioeconomic status and other marginalized identities. These diseases have high incidence and prevalence rates in Puerto Rico due to high poverty and unemployment rates, changing dietary patterns, and Puerto Rico’s political status as a U.S. commonwealth. The myriad problems on the island contribute to the flight of Puerto Ricans to the mainland in search of better education and employment; there are currently more Puerto Ricans living on the mainland than there are in Puerto Rico. Puerto Rico’s political status is of particular importance, as it simultaneously …

Trips Article 31(B) And The Hiv/Aids Epidemic, Johanna Kehl

Journal of Intellectual Property Law

No abstract provided.

The Effect Of Antibiotics On Gastrointestinal Motility And Gut Microbiota, Catherine Chen

IMSAloquium Student Investigation Showcase

Antibiotics are widely used to treat infectious diseases caused by pathogenic bacteria in many disease states. While eliminating pathogens, antibiotics also affect gut commensal bacteria composition, leading to long-lasting gastrointestinal (GI) symptoms associated with GI motility problems. In this study, the mechanism by which the broad-spectrum antibiotic cefoperazone, gram-positive specific antibiotic vancomycin, and gram-negative specific antibiotic neomycin affect GI motility and gut microbial composition was examined. To assess alterations in the host after antibiotic treatment, whole gut transit time was measured by gavaging and tracing charcoal dye. Significantly delayed GI transit time in antibiotic-treated mice was observed, especially in the …

The Divine Viscera: Medicine And Religion In The Islamic Golden Age, Isabella A. Pua

Young Historians Conference

Islamic medicine is largely ignored in Western tradition, but in an era when Western European medical practice relied more on mysticism than science and had lost the advances made by Classical Greece, the Islamic Empire entered a golden age of scientific thought. The impetus for the Golden Age medicine that developed can be partially attributed to the Islamic religion itself. This paper explores the role of Islam as both a unifying force and a set of broad cultural values in creating that atmosphere that allowed for the study of medicine, within the context of the scientific-religious duality that characterized discovery …

Genetic Diversity Of Coronaviruses In Miniopterus Fuliginosus Bats, Jiang Du, Xianwen Ren, Junpeng Zhang

KIP Articles

Coronaviruses, such as severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, pose significant public health threats. Bats have been suggested to act as natural reservoirs for both these viruses, and periodic monitoring of coronaviruses in bats may thus provide important clues about emergent infectious viruses. The Eastern bent-wing bat Miniopterus fuliginosus is distributed extensively throughout China. We therefore analyzed the genetic diversity of coronaviruses in samples of M. fuliginosus collected from nine Chinese provinces during 2011–2013. The only coronavirus genus found was Alphacoronavirus. We established six complete and five partial genomic sequences of alphacoronaviruses, which revealed that …

Infinite Color Urn Models., Debleena Thacker Dr.

Doctoral Theses

In recent years, there has been a wide variety of work on random reinforcement models of various kinds. Urn models form an important class of random reinforcement models, with numerous applications in engineering and informatics and bioscience. In recent years there have been several works on different kinds of urn models and their generalizations. For occupancy urn models, where one considers recursive addition of balls into finite or infinite number of boxes, there are some works which introduce models with infinitely many colors, typically represented by the boxes.As observed in [51], the earliest mentions of urn models are in the …

Genotoxic And Cytotoxic Potential Of Smoke Crack Cocaine On The Epithelium Of The Human Oral Mucosa, Raphaela Cássia De Lima, Priscila Ferraz, Cassiano Lima Chaiben, Ângela Fernandes, Ana Maria Trindade Grégio, Maria Ângela Naval Machado, Luciana Reis Azevedo-Alanis, Antonio Adilson Soares De Lima

Journal of Dentistry Indonesia

Crack cocaine is an illicit drug derived from cocaine. It can produce some damages to the lungs and oral cavity. Objective: The aim of this study was to analyze the frequency of micronuclei and some nuclear alterations in epithelial cells of crack cocaine users. Methods: Oral smears were collected from clinically normal-appearing buccal mucosa exfoliative cytology of 30 individuals (15 crack cocaine users and 15 controls). Results: Crack cocaine users consumed about 3.8 grams per day and the time consumption of the drug was of 6.4 (+3.3) years. The prevalence of micronuclei, binucleated cells, broken egg cells, budding cells, picnosis, …

The Routes Of Migration In The Mediterranean Sea And Training Opportunities For Naval Units On Migration At Nmiotc, Ioannis Argyriou

WMU Symposium on Migration by Sea, Malmö, Sweden, 26-27 April 2016

No abstract provided.

Safety Management Analysis For Construction Industry: Statistical Process Control (Spc) Approach, Zhenpeng Liu

Morehead State Theses and Dissertations

A Thesis Presented to the Faculty of the College of Business and Technology Morehead State University in Partial Fulfillment of the Requirements for the Degree Master of Science by Zhenpeng Liu on April 26, 2016.

Assessment Of Red Blood Cell Distribution Width As A Prognostic Marker In Chronic Lymphocytic Leukemia, Monika Podhorecka, Dorota Halicka, Agnieszka Szymczyk, Arkadiusz Macheta, Sylwia Chocholska, Zbigniew Darzynkiewicz

NYMC Faculty Publications

Red blood cell distribution width (RDW) is a quantitative measure of the variability in size of circulating erythrocytes. It was recently reported that RDW is a prognostic factor for infection diseases, cardiovascular and pulmonary diseases, as well as some neoplasms. Moreover, RDW is remarkably strong predictor of longevity, including all causes of death, for adults aged 45 years and older. To explain this occurrence it was proposed that persistent IGFs/mTOR signaling is one of the factors that play a role in affecting the RDW and mortality.The above observations induced us to analyze the prognostic role of RDW in chronic lymphocytic …

Internships Help Alumni Progress To Pharmacy Schools, Sarah Gardner, Dave Albee

Press Releases

Dominican alumni Brandi Tacdol ’15 and Scott Grigsby ’14 are different in age and come from different backgrounds, yet they have the same purpose as they attend pharmacy schools.

Are Scientific Data Repositories Coping With Research Data Publishing?, Massimiliano Assante, Leonardo Candela, Donatella Castelli, Alice Tani

Copyright, Fair Use, Scholarly Communication, etc.

Research data publishing is intended as the release of research data to make it possible for practitioners to (re)use them according to “open science” dynamics. There are three main actors called to deal with research data publishing practices: researchers, publishers, and data repositories. This study analyses the solutions offered by generalist scientific data repositories, i.e., repositories supporting the deposition of any type of research data. These repositories cannot make any assumption on the application domain. They are actually called to face with the almost open ended typologies of data used in science. The current practices promoted by such repositories are …

Did Garin And Bujadoux Actually Report A Case Of Lyme Radiculoneuritis?, Gary P. Wormser, Vanessa Wormser

NYMC Faculty Publications

A 1922 report by Garin and Bujadoux is widely regarded as describing the first case of neurologic Lyme borreliosis. Although the patient reported had a tick bite followed by the development of a rash and radiculoneuritis, there were a number of highly atypical features, raising the question of whether the patient, in fact, had neurologic Lyme borreliosis. The paper may not deserve the historic recognition that it has received.

Summary Of Results From The 2016 National Health Security Preparedness Index, Glen P. Mays, Michael T. Childress, Pierre Martin Dominique Zephyr, Anna Goodman Hoover

Health Management and Policy Reports

The National Health Security Preparedness Index tracks the nation’s progress in preparing for, responding to, and recovering from disasters and other large-scale emergencies that pose risks to health and well-being in the United States. Because health security is a responsibility shared by many different stakeholders in government and society, the Index combines measures from multiple sources and perspectives to offer a broad view of the health protections in place for nation as a whole and for each U.S. state. The Index identifies strengths as well as gaps in the protections needed to keep people safe and healthy in the face …

The Emergence Of The Zika, Chikungunya, And Dengue Viruses In Brazil, The Dominican Republic, And Puerto Rico, Nelson Xavier Del Pilar

Honors Scholar Theses

The Zika, Chikungunya, and Dengue viruses are three emerging viral infections of the 21st century. Outbreaks have occurred in twenty countries, including areas of South America, and territories in the Caribbean. These viral diseases are mosquito-borne infections transmitted primarily by Aedes aegypti and Aedes albopictus mosquitoes. The origins of the diseases, viral morphology, and vector transmission will be described in this review as well as symptoms that humans experience, medical testing procedures, and preventative measures. This study will focus on three locations: Brazil, the Dominican Republic, and Puerto Rico. There are many similarities between the three viruses to emphasize, but …

Citation Mapping Of Advances In Anthropology, Sanjukta Sahoo 2976942

Library Philosophy and Practice (e-journal)

Abstract: The study is based on the articles published in the open access journal, Advances in Anthropology during the year 2013-2014 covering 59 articles in 8 issues having 1750 citations. Data has been collected from Advances in Anthropology from the Directory of Open Access Journals. Data has been analyzed by using excel sheet by year, types of document, trend of research, author productivity, journal productivity etc. The citation study has been carried out to find out the various sources of literature used by the researchers in the field of Anthropology. A rank list of journals is also prepared …