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New Techniques To Characterise The Vaginal Microbiome In Pregnancy, G Mendz, N Kaakoush, J Quinlivan

Medical Papers and Journal Articles

Understanding of the vaginal microbiome in health and disease is essential to screen, detect and manage complications in pregnancy. One of the major complications of pregnancy is preterm birth, which is the leading world-wide cause of death and disability in children under five years of age. The aetiology of preterm birth is multifactorial, but a causal link has been established with infection. Despite the importance of understanding the vaginal microbiome in pregnancy in order to evaluate strategies to prevent and manage PTB, currently used culture based techniques provide limited information as not all pathogens are able to be cultured.

The …

Employment May Protect Fathers In The Setting Of Maternal Teenage Pregnancy From Anxiety And Depression: Findings From The Australian Father's Study, A Atkinson, R Petersen, J Quinlivan

Medical Papers and Journal Articles

Objective: There is limited research on fathers in the setting of maternal teenage pregnancy. Most studies report data from regions of social disadvantage and low education. We report on the levels of anxiety, depression and quality of life of fathers in the setting of maternal teenage pregnancy in an area where the unemployment rate is low.

Methods: Observational study of 50 fathers in the setting of maternal teenage pregnancy and 100 fathers whose partners were not teenagers (control), living within the same metropolitan healthcare region with high employment rates. Fathers were enrolled within the larger Australian Father’s Study and were …

Circadian Rhythmicity In Emerging Mood Disorders: State Or Trait Marker?, A Grierson, I Hickie, S Naismith, D Hermans, E Scott, J Scott

Medical Papers and Journal Articles

Background: Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders.

Methods: Actigraphy was undertaken for about 14 days in 63 post-pubertal individuals aged 13–25 years with a recent onset of a mood disorder meeting recognised diagnostic criteria. We examined associations between three easily interpretable markers of circadian rhythm activity (amplitude, acrophase and rhythmicity index) and demography and clinical characteristics. Then, circadian markers were compared between diagnostic groups, …

An Integrated General Practice And Pharmacy-Based Intervention To Promote The Use Of Appropriate Preventive Medications Among Individuals At High Cardiovascular Disease Risk: Protocol For A Cluster Randomized Controlled Trial, A Hayek, R Joshi, T Usherwood, R Webster, B Kaur, B Saini, C Armour, I Krass, T Laba, C Reid, L Shiel, C Hespe, F Hersch, S Jan, S Lo, D Peiris, A Rodgers, A Patel

Medical Papers and Journal Articles

Background: Cardiovascular diseases (CVD) are responsible for significant morbidity, premature mortality, and economic burden. Despite established evidence that supports the use of preventive medications among patients at high CVD risk, treatment gaps remain. Building on prior evidence and a theoretical framework, a complex intervention has been designed to address these gaps among high-risk, under-treated patients in the Australian primary care setting. This intervention comprises a general practice quality improvement tool incorporating clinical decision support and audit/feedback capabilities; availability of a range of CVD polypills (fixed-dose combinations of two blood pressure lowering agents, a statin ± aspirin) for prescription when appropriate; …

A Patient Preference Study That Evaluated Fluticasone Furoate And Mometasone Furoate Nasal Sprays For Allergic Rhinitis, A Yanez, A Dimitroff, P Bremner, C Rhee, G Luscombe, B Prillaman, N Johnson

Medical Papers and Journal Articles

Background: Corticosteroid nasal sprays are the mainstay of treatment for allergic rhinitis. These sprays have sensory attributes such as scent and/or odor, taste and aftertaste, and run down the throat and/or the nose, which, when unpleasant, can affect patient preference for, and compliance with, treatment.

Objective: This study examined patient preference for fluticasone furoate nasal spray (FFNS) or mometasone furoate nasal spray (MFNS) based on their sensory attributes after administration in patients with allergic rhinitis.

Methods: This was a multicenter, randomized, double-blind, cross-over study. Patient preferences were determined by using three questionnaires (Overall Preference, Immediate Attributes, and Delayed Attributes).

Results: …

Changing The Antibiotic Prescribing Of General Practice Registrars: The Chap Study Protocol For A Prospective Controlled Study Of A Multimodal Educational Intervention, Mieke L. Van Driel, Simon Morgan, Amanda Tapley, Lawrie Mcarthur, Patrick Mcelduff, Lucy Yardley, Anthea Dallas, Laura Deckx, Katie Mulquiney, Joshua S. Davis, Andrew Davey, Kim Henderson, Paul Little, Parker J. Magin

Medical Papers and Journal Articles

Background: Australian General Practitioners (GPs) are generous prescribers of antibiotics, prompting concerns including increasing antimicrobial resistance in the community. Recent data show that GPs in vocational training have prescribing patterns comparable with the high prescribing rate of their established GP supervisors. Evidence-based guidelines consistently advise that antibiotics are not indicated for uncomplicated upper respiratory tract infections (URTI) and are rarely indicated for acute bronchitis. A number of interventions have been trialled to promote rational antibiotic prescribing by established GPs (with variable effectiveness), but the impact of such interventions in a training setting is unclear. We hypothesise that intervening while early-career …

The Illegality Defence In Corporate Law Claims Against Directors And Officers, Wai Yee Wan

Research Collection Yong Pung How School Of Law

If a company incurs substantial fines or other pecuniary losses as a result of its unlawful conduct, can the company obtain an indemnity from its director/officer for having caused the company to incur such fines and losses? In particular, can the director/officer utilise the defence of illegality, notwithstanding that he has breached his duties owed to the company? The illegality defence, which raises the twin issues of the relationship between the unlawful act to the corporate claim and the attribution of the unlawful act to the company, has been the subject of detailed analysis recently in England, Singapore and Hong …

Differences Between Multimedia And Text-Based Assessments Of Emotion Management: An Exploration With The Multimedia Emotion Management Assessment (Mema), Carolyn Maccann, Filip Lievens, Nele Libbrecht, Richard D. Roberts

Research Collection Lee Kong Chian School Of Business

People process emotional information using visual, vocal, and verbal cues. However, emotion management is typically assessed with text based rather than multimedia stimuli. This study (N=427) presents the new multimedia emotion management assessment (MEMA) and compares it to the text-based assessment of emotion management used in the MSCEIT. The text-based and multimedia assessment showed similar levels of cognitive saturation and similar prediction of relevant criteria. Results demonstrate that the MEMA scores have equivalent evidence of validity to the text-based MSCEIT test scores, demonstrating that multimedia assessment of emotion management is viable. Furthermore, our results inform the debate as to whether …

Are Primetime Diets Congruent With Dietary Recommendations? Content Analyses Of Food Advertisements In The United States, China, And Singapore, Su Lin Yeo, Wonsun Shin, May O. Lwin, Jerome Williams, Ying-Yi Hong

Research Collection Lee Kong Chian School Of Business

Despite public programs to promote healthy eating among populations in developed and developing countries, the increase in obesity as a result of poor dietary patterns continues to persist. As food advertising has been implicated for contributing to this global health challenge, this study aims to provide empirical evidence on food advertising in a broader global context, across economically and culturally different nations. We conducted a large scale content analysis of the types of food advertised on primetime television in the United States, China, and Singapore, which resulted in the collection of 1,008 television hours. Using the dietary blue2376s proposed by …

Impact Of Technology On Learning And Scholarship, And The New Learning Paradigm, Arnoud Cyriel Leo De Meyer

Research Collection Lee Kong Chian School Of Business

Recently I took on the challenge of teaching a course to Undergraduate students at Singapore Management University. It had been more than 20 years since I had taught any Undergraduates, having spent most of my career at Graduate Business Schools. I did it partially because many of my younger colleagues had told me that teaching had changed tremendously. Deep down I may have felt that I was perhaps a little out of touch with what happened inside and, as I would soon discover, outside our classrooms. I was indeed intrigued by the experience. When I entered the classroom for my …

From Qasc To Qascip: Successful Australian Translational Scale-Up And Spread Of A Proven Intervention In Acute Stroke Using A Prospective Pre-Test/Post-Test Study Design, S Middleton, A Lydtin, D Comerford, D Cadilhac, P Mcelduff, S Dale, K Hill, M Longworth, J Ward, N Cheung, C D'Este

Health Sciences Papers and Journal Articles

Objectives: To embed an evidence-based intervention to manage FEver, hyperglycaemia (Sugar) and Swallowing (the FeSS protocols) in stroke, previously demonstrated in the Quality in Acute Stroke Care (QASC) trial to decrease 90-day death and dependency, into all stroke services in New South Wales (NSW), Australia’s most populous state.

Design: Pre-test/post-test prospective study.

Setting: 36 NSW stroke services.

Methods: Our clinical translational initiative, the QASC Implementation Project (QASCIP), targeted stroke services to embed 3 nurse-led clinical protocols (the FeSS protocols) into routine practice. Clinical champions attended a 1-day multidisciplinary training workshop and received standardised educational resources and ongoing support. Using the …

An Examination Of The Correlation Amongst Trunk Flexibility, X-Factor And Clubhead Speed In Skilled Golfers, Christopher Joyce

Health Sciences Papers and Journal Articles

Skilled golfers are reported to be more flexible than lesser able golfers, which may assist in increased x-factor (shoulder – pelvis separation) at the top of the backswing. However, it is unknown if increased flexibility produces faster clubhead speed. The aim of this study was to investigate the correlations amongst trunk flexibility and x-factor, as well as the association between flexibility and clubhead speed in low handicap golfers. Fifteen low handicap male golfers who displayed a modern swing, had their trunk static anatomical end-range of motion (ROM) (flexibility) and driver swing kinematics were measured. Although Pearson correlations revealed trunk extension …

Relationship Between Pre-Season Testing Performance And Playing Time Among Ncaa Dii Basketball Players, Jay J. Dawes, Marshall M, Tania Spiteri

Health Sciences Papers and Journal Articles

Purpose: The purpose of this study was to investigate the relationships between pre-season testing performance and playing time within a men’s Division II basketball team.

Methods: Archival data from pre-season athletic performance testing for ten (n=10) male NCAA Division II basketball players was collected and analyzed to determine if there was a relationship between anthropometric data (height, weight, wingspan), physical performance tests (vertical jump height, lane agility test, 5 and 20 m sprint time, National Basketball League (NBA) line drill and 20 m multi-stage fitness test (MSFT)), and playing time in the subsequent collegiate season.

Results: Pearson’s product …

Predicting Academic Success Of Health Science Students For First Year Anatomy And Physiology, R Anderton, P Chivers

Health Sciences Papers and Journal Articles

Students commencing tertiary education enter through a number of traditional and alternative academic pathways. As a result, tertiary institutions encounter a broad range of students, varying in demographic, previous education, characteristics and academic achievement. In recent years, the relatively constant increase in tertiary applications in Australia has not translated to an increase in student retention or graduate numbers. The Health Sciences discipline typically falls within this paradigm, prompting various approaches to promote academic success and overall student retention. In this study, the demographic and previous education of health science students at an Australian University, were analysed along with first year …

Triage, Treatment And Transfer Of Patients With Stroke In Emergency Department Trial (The T3 Trial): A Cluster Randomised Trial Protocol, Sandy Middleton, Chris Levi, Simeon Dale, N. Wah Cheung, Elizabeth Mcinnes, Julie Considine, Catherine D'Este, Dominique A. Cadilhac, Jeremy Grimshaw, Richard Gerraty, Louise E. Craig, Verena Schadewaldt, Patrick Mcelduff, Mark Fitzgerald, Clare Quinn, Greg Cadigan, Sonia Denisenko, Mark Longworth, Jeanette Ward, T3 Trialist Collaborators

Health Sciences Papers and Journal Articles

Background: Internationally recognised evidence-based guidelines recommend appropriate triage of patients with stroke in emergency departments (EDs), administration of tissue plasminogen activator (tPA), and proactive management of fever, hyperglycaemia and swallowing before prompt transfer to a stroke unit to maximise outcomes. We aim to evaluate the effectiveness in EDs of a theory-informed, nurse-initiated, intervention to improve multidisciplinary triage, treatment and transfer (T3) of patients with acute stroke to improve 90-day death and dependency. Organisational and contextual factors associated with intervention uptake also will be evaluated.

Methods: This prospective, multicentre, parallel group, cluster randomised trial with blinded outcome assessment will be conducted …

Perceived Emotional Demands-Abilities Fit, James M. Diefendorff, Gary J. Greguras, John Fleenor

Research Collection Lee Kong Chian School Of Business

The purposes of this paper are to introduce the concept of perceived emotional demands-abilities (ED-A) fit and develop theory about how it relates to other fit perceptions as well as employee well-being and performance outcomes. ED-A fit is defined as the perceived congruence or match between the emotional demands of the job and one's abilities to meet those demands. In two studies using occupationally diverse samples from Western and Eastern cultures, we empirically distinguished perceived ED-A fit from other fit perceptions (i.e. person-organisation, demands-abilities, needs-supplies, person-group, person-supervisor). In addition, across the two studies, we found that perceived ED-A fit accounted …

Wildebeest-Associated Malignant Catarrhal Fever: Perspectives For Integrated Control Of A Lymphoproliferative Disease Of Cattle In Sub-Saharan Africa, Lillian Wambua, Peninah Nduku Wambua, Allan Maurice Ramogo, Domnic Mijele, Moses Yongo Otiende

All Peer-Reviewed Publications

Wildebeest-associated malignant catarrhal fever (WA-MCF), an acute lymphoproliferative disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), remains a significant constraint to cattle production in nomadic pastoralist systems in eastern and southern Africa. The transmission of WA-MCF is dependent on the presence of the wildlife reservoir, i.e. wildebeest, belonging to the species Connochaetes taurinus and Connochaetes gnou; hence, the distribution of WA-MCF is largely restricted to Kenya, Tanzania and the Republic of South Africa, where wildebeest are present. WA-MCF is analogous to sheep-associated MCF (SA-MCF) in many aspects, with the latter having sheep as its reservoir host and a more …

Chemical Ecology Of African Tephritid Fruit Flies, Ayuka T. Fombong, Donald L. Kachigamba, Baldwyn Torto

All Peer-Reviewed Publications

African Tephritid fruit flies are distributed in three main genera, Bactrocera, Ceratitis and Dacus constituting both indigenous and invasive species. They use a diverse and complex range of semiochemicals for host location and reproduction. This chapter reviews the identification of these semiochemicals and includes examples of lures developed from some of these chemicals for the management of economically important fruit fly species.

Analyses Of Mitochondrial Genes Reveal Two Sympatric But Genetically Divergent Lineages Of Rhipicephalus Appendiculatus In Kenya, Esther G. Kanduma, Joram M. Mwacharo, Naftaly W. Githaka, Peter W. Kinyanjui, Joyce N. Njuguna, Lucy M. Kamau, Edward Kariuki, Stephen Mwaura, Robert A. Skilton, Richard P. Bishop

All Peer-Reviewed Publications

Background: The ixodid tick Rhipicephalus appendiculatus transmits the apicomplexan protozoan parasite Theileria parva, which causes East coast fever (ECF), the most economically important cattle disease in eastern and southern Africa. Recent analysis of micro- and minisatellite markers showed an absence of geographical and host-associated genetic sub-structuring amongst field populations of R. appendiculatus in Kenya. To assess further the phylogenetic relationships between field and laboratory R. appendiculatus tick isolates, this study examined sequence variations at two mitochondrial genes, cytochrome c oxidase subunit I (COI) and 12S ribosomal RNA (rRNA), and the nuclear encoded ribosomal internal transcribed spacer 2 (ITS2) of the …

Revision Of Dvivarnus (Scelionidae, Teleasinae), Elijah J. Talamas, István Mikó, Robert S. Copeland

All Peer-Reviewed Publications

Two new species, Dvivarnus elektrolythron Talamas & Mikó, sp. n. and D. mikuki Talamas & Mikó, sp. n. are described. The genus is redescribed and a key is provided to separate Dvivarnus from other groups in Teleasinae with mesoscutellar spines.

Cme/Cne Article: A Framework Of Care In Multiple Sclerosis, Part 1, Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones

Faculty, Staff and Student Publications

Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org.

TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS).

LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) …

Fruit Fly Species Composition, Distribution And Host Plants With Emphasis On Mango- Infesting Species, Ivan Rwomushana, Chrysantus M. Tanga

All Peer-Reviewed Publications

Mango is the most widely cultivated fruit tree in tropical and sub-tropical Africa. However, the sustainability of this lucrative business is threatened by infestations of fruit flies (Diptera: Tephritidae) that annually inflict heavy economic losses on the industry. The nutritional quality of different fruit species can influence the survival and fecundity of adult fruit flies. This host-insect interaction determines the species composition, distribution and abundance of the major frugivorous tephritids. The economic impact of fruit fly pest species includes direct yield losses and the loss of export markets due to quarantine restrictions implemented to prevent the entry and establishment of …

Role Of Microsatellite Markers In Molecular Population Genetics Of Fruit Flies With Emphasis On The Bactrocera Dorsalis Invasion Of Africa, Fathiya M. Khamis, Anna R. Malacrida

All Peer-Reviewed Publications

Microsatellites, also referred to as short tandem repeats (STRs) or simple sequence repeats (SSRs) are short sequences of tandem repeats of 1-6 bp in length in clusters of less than 150 bp flanked by sections of non-repetitive unique sequences that are scattered throughout the nuclear genome. These markers are co-dominant and hypervariable, revealing many alleles per locus; they are inherited in Mendelian fashion making them useful for detecting genetic variability within species. Once isolated and characterized, microsatellites can also be used in closely related taxa. Microsatellites can be amplified, even from highly degraded DNA, and are very simple to score. …

Fruit Fly Nutrition, Rearing And Quality Control, Samira A. Mohamed, Fathiya M. Khamis, Chrysantus M. Tanga

All Peer-Reviewed Publications

Tephritid fruit flies are recognized worldwide as an important threat to the horticultural industry. Most of the species belonging to this group are highly polyphagous attacking several important fruits and vegetables. They cause direct damage through larval feeding and indirect losses are associated with quarantine restrictions. The increasing awareness of the damage caused by these fruit flies to the horticultural industry has created a demand for the development of control measures based on integrated pest management (IPM) strategies and the sterile insect technique (SIT). However, success of the majority of these control methods largely depends on the ability to establish …

Maize Landraces Are Less Affected By Striga Hermonthica Relative To Hybrids In Western Kenya, Charles A.O. Midega, John Pickett, Antony Hooper, Jimmy Pittchar, Zeyaur R. Khan

All Peer-Reviewed Publications

Production of maize in western Kenya is severely constrained by the parasitic weed striga. Although productivity of maize can be improved through adoption of improved varieties, adoption of such varieties remains low in the region, as the majority of smallholder farmers still grow unimproved open-pollinated varieties (landraces). The performance of two improved hybrid varieties was evaluated against six landraces in striga-infested soils in western Kenya. The varieties were planted in plots under natural striga infestation and were supplemented with pot experiments under artificial infestation. Striga emergence was lower in landraces than in the hybrid varieties in both field and pot …

Spatial Separation Of Semiochemical Lurem-Tr And Entomopathogenic Fungi To Enhance Their Compatibility And Infectivity In An Autoinoculation System For Thrips Management, David K. Mfuti, Sevgan Subramanian, Rob Whm Van Tol, Gerrie L. Wiegers, Willem J. De Kogel, Saliou Niassy, Hannalene Du Plessis, Sunday Ekesi, Nguya K. Maniania

All Peer-Reviewed Publications

BACKGROUND: The effect of spatial separation of the semiochemical Lurem-TR, which has been found to inhibit conidia of entomopathogenic fungi when put together, on the persistence of conidia of Metarhizium brunneum and M. anisopliae was evaluated in the greenhouse and field in order to develop an autodissemination strategy for the management of Megalurothrips sjostedti on cowpea crop. Influence of spatial separation of the semiochemical on thrips attraction and conidial acquisition by thrips from the autoinoculation device was also investigated in the field. RESULTS: Persistence of conidia of M. brunneum and M. anisopliae increased with distance of separation of Lurem-TR. Direct …

Ratcheting And Energetic Aspects Of Synchronization In Coupled Bursting Neurons, E. Marius Yamakou, E. Maeva Inack, F. M. Moukam Kakmeni

All Peer-Reviewed Publications

In this paper, we investigate the dynamics of two coupled bursting neurons. The Hindmarsh–Rose mathematical model of the neuron subjected to an external periodic stimulus is considered. We transform this model into that of the one-dimensional problem of a particle driven by a periodic external force under the influence of a double-well potential. We study the bifurcation structures, chaotic behavior, and the synchronization dynamics of the transformed model. Numerical simulations reveal the existence of some bifurcation structures including saddle-node, symmetry-breaking, and period-doubling route to chaos. By varying the system’s parameters, we also find thresholds for which the system remains periodic. …

A "Clarion" Call For Embracing Ipe As The Status Quo For Preparing Health Professionals To Engage In Interprofessional Health Research, Kimberly Adams Tufts

Ellmer School of Nursing Faculty Publications

Complex health conditions and the social-economic determinants that contribute to disease and injury incidence, prevalence, and health inequalities require multifaceted evidence-based interventions that only interprofessional research teams who collaborate across traditional disciplinary lines can generate. Interprofessionally driven and derived research evidence is the method of du jour. Nonetheless as a whole, health professionals who are often members of interprofessional health research teams are products of educational systems wherein they were educated in disciplinary silos. Health professionals that learn about, with, from, each other during their foundational education will be better prepared to function as interprofessional research team members. With the …

The Effectiveness Of An Anesthesia Handoff Tool: An Electronic Health Record Application To Enhance Patient Safety, Karen Gillikin, Nathaniel Apatov

Ellmer School of Nursing Faculty Publications

Perioperative patient care handoffs are complex and multidimensional and require accurate attention to detail. Communication failures among healthcare providers increase the risk of morbidity and mortality. Utilizing a standardized handoff tool located within the electronic anesthesia record formalizes the handoff process and improves patient safety. Prior to the introduction of the Electronic Anesthesia Handoff Tool, 82 patient care transfer observations were conducted; subsequent to the launch of the tool, 75 patient care transfer observations were conducted, and then before and after comparisons were made. Descriptive statistics, a two-tailed t-test, and Spearman’s correlations were conducted. Alpha level was set at p < 0.05. There were significantly (p< .05) fewer errors made in all categories of patient information following the introduction of the Electronic Anesthesia Handoff Tool. Though there were trends towards more omissions occurring after 3:00 p.m., the difference in most patient information categories was not significant (p< .05). In addition, there were no differences in omissions related to the severity of patient co-morbidities based on patients’ American Society of Anesthesiologists physical status classification. This study provided information regarding the incidence of patient information inaccuracies and omissions during patient care transfer before and after implementation of an electronic patient care transfer tool.

Assent Described: Exploring Perspectives From The Inside, Rebecca D. Poston

Ellmer School of Nursing Faculty Publications

Purpose- The purpose of this study was to describe the informed consent and assent experience for oncology research from the perspective of the participants: adolescents, their parents, and their physician providers.

Design & Methods- This descriptive mixed-methods study included the pilot use of the Quality of Informed Consent Questionnaire (QuIC) with an adolescent population and semi-structured interviews with adolescents, their parents, and their physician providers within 48-72 hours of the informed consent and assent discussion for a pediatric oncology clinical trial and again 6-9 weeks later. Results: Adolescents and their parents scored considerably lower on part A of the QuIC …