Digital Commons Network^™

Translocation And Phosphorylation Of Ampa Receptors Following Transcranial Direct Current Stimulation In Vivo, Justin Andrew Stafford

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Transcranial direct current stimulation (tDCS) is the current technique used clinically to attenuate the effects of various neurological related deficits and augment functions such as memory and learning. The cellular and molecular mechanisms behind tDCS remain largely unknown and this study provides some of the first insights into the mechanisms behind tDCS. Direct current stimulation has been used to increase levels of long term potentiation (LTP) ex vivo suggesting that this stimulation has an effect on the LTP mechanisms of action. Subcellular protein extraction and fractionation methods were used to isolate synaptoneurosomes from various brain regions to assess the effects …

The Expression Of Dopamine-Related Genes And Behavioral Performance In Mice, Victoria Lynne Dershem

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While the neurotransmitter dopamine has been well-studied for its role in mood regulation and activation of the intrinsic reward pathway, several psychiatric disorders linked to dopamine are also known to cause memory impairment, a phenomenon which has attracted much less attention. In the current study, whole-transcriptome RNA sequencing was performed, and transcript levels of several dopamine-related genes were compared to results of behavioral assays designed to test spatial and emotional memory, as well as anxiety. The results suggest a positive relationship between expression level of Nurr1, a nuclear receptor known to initiate transcription of genes necessary for dopaminergic signaling, …

The University Of Akron Human Powered Vehicle Team, Maria E. Rizzo, Andrew J. Derhammer, Christopher M. Trowbridge, Timothy M. Nutt, Joseph R. Boyd, Jeremy W. Marcum, Jonathan E. Adams, Donald G. Haiss, Julia Wood, Brian D. Goshia, Scott T. Fagan, Joshua D. Everhard, Rebecca L. Slivka

Williams Honors College, Honors Research Projects

The University of Akron Human Powered Vehicle Team’s 2016 vehicle, Klokan, was designed, manufactured and tested with safety, reliability, performance and ease of use in mind. The vehicle is a fully faired tadpole trike with a lightweight aluminum frame constructed from 6061-T6 tubing having a total weight of 8.9 lbs. To complement the lightweight frame, the fairing is constructed from polycarbonate, PETG and carbon fiber strips which combine into a lightweight, easy to manufacture weather barrier and aerodynamic structure. Klokan was designed to be a safe and efficient mode of everyday transportation which ensures that riders are sufficiently protected by …

Difference In Knowledge Of Mrsa Regarding Sophomore And Senior Baccalaureate Nursing Students, Payton T. Lloyd, Daniel B. Whited, Lori N. Crimaldi

Williams Honors College, Honors Research Projects

Abstract

Background

The risk of infection by antibiotic resistant organisms is a common problem in hospital settings. Methicillin-resistant Staphylococcus Aureus (MRSA) is the most common type of resistant bacteria that can have serious consequences or even lead to death. Nurses' knowledge of how to prevent and treat this problem is essential for patient safety. The purpose of this study is to determine the differences in level of knowledge of MRSA in sophomore and senior level baccalaureate nursing students.

Methods

This descriptive, comparative study will examine differences in knowledge of MRSA between sophomore and senior baccalaureate nursing students and determine if …

The Changes In Woodlot Land Cover From 1988 To 2006 Within Private/Farmland In Hancock County, Ohio, Louis C. Birchall

Williams Honors College, Honors Research Projects

The amount of woodlots in Ohio have dramatically decreased since the introduction of settlers into the State. The removal of forest for open space, urban areas, fuel and resources was key to this change. Since the development of the economy to a more service based industry in recent years, woodlots have begun to return in certain areas. This research shows the change in woodlot patterns in Hancock County, Ohio from 1988 to 2006.

The analysis was done by classifying the data into 'woodlot' and 'other land use' by using image segmentation and manual editing processes. Accuracy checks were conducted on …

Assessing The Effectiveness Of The New Senior Ed Program At Summa Akron City Hospital, Ahmed F. Ozgur

Williams Honors College, Honors Research Projects

Objectives: To compare the outcomes of patients seen during a pilot Senior Emergency Department (ED) program to a historical cohort of geriatric patients receiving usual ED care.

Methods: We performed a retrospective cohort analysis of quality assurance data obtained to evaluate the implementation of a pilot Senior ED program at a 78,000 visit hospital ED. The historical cohort covered 1/23/2012 to 12/31/2012. The pilot Senior ED program was implemented from 1/1/2013 to 12/31/2013. Patients 65 years and older arriving between 8:30 am and 8:30 pm were triaged to a 15 bed Senior ED. Interventions included assessment by a nurse transitional …

Golden Rice: Effectiveness And Safety, A Literature Review, Janel M. Albaugh

Williams Honors College, Honors Research Projects

This literature review begins by introducing GMOs, then moving on to golden rice and its background and development, including The Golden Rice Project. The literature review portion discusses the effectiveness and health and safety issues surrounding golden rice. Methodology for this paper includes agriculture and food science databases in addition to keyword searches.

Criminogenic Of The Older Adult With Addiction: Case Study, Maria A. Dixon

Williams Honors College, Honors Research Projects

Throughout history of America’s criminal justice system as it relates to drug use has been utilize as a reactive solution to crime and addiction. In current times, this framework has become ineffective in addressing the criminogenic of the older adult with substance abuse. There needs to be alternatives to the incarceration of this population. The implication for social work is advocacy for policy change, and alternative programs.

What Makes A Man?: An Alpha Male’S Fight For Masculinity Against The Media’S Muscular Ideals, Julie A. Yockey

Williams Honors College, Honors Research Projects

Previous studies have focused heavily on media effects on women however growing trends in male ideals are finding that men are no longer static observers. The media constructs the ideal male body as lean, strong and muscular and men exposed to these idealized images may experience body dissatisfaction. Therefore, this project explores the effects of media ideals on men and the possible relationship between the media depictions of the muscular ideals and masculinity. Current research analysis shows that exposure to media ideals not only causes body dissatisfaction among men; trying to achieve the perfect body may result in unhealthy behaviors. …

Understanding The Stigma Of Hearing Loss And How If Affects The Patient And Treatment Process, Carolyn M. Zaitzew

Williams Honors College, Honors Research Projects

This project is a literature review on the topic of hearing loss related stigma and the effects it has on persons with hearing loss. There has not been very much research conducted on this topic, which limited the paper’s content. Through researching and analyzing previous studies, it was found that a stigma related to hearing loss still exists today and has multiple effects on persons with hearing loss. The stigma can put negative stress on patients with hearing loss, both psychologically and socially, and may even cause them to not seek or accept treatment when needed. Younger adults are more …

Development And Validation Of Virus And Ebola Misconceptions Assessment (Viremia): Ebola Virus Misconceptions In College Students, Michele Miller

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In this study an assessment (VirEMiA) on college students' knowledge and misconceptions of the Ebola virus was created and validated. VirEMiA was then used to determine what misconceptions college students have about Ebola, if there is a difference in misconceptions between students with and without a strong science background, and if Just-in-Time Teaching (JiTT) increases students' knowledge of Ebola and decreases their misconceptions. VirEMiA was shown to be a valid and reliable assessment whether confidence was integrated (seprel=0.97) or not (seprel=0.98), and for measuring misconceptions (seprel=0.97). If psychology and nursing majors were considered to have a strong background in science, …

Improving Anomaly Detection Through Identification Of Physiological Signatures Of Unconscious Awareness, Alyssa Marie Piasecki

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Missed anomalies have the potential to cause detrimental effects in the Intelligence, Surveillance, and Reconnaissance (ISR) domain. One possible cause of these missed anomalies is that cognitive processing may not reach conscious awareness and may only be perceived by the unconscious mind. Identification of correlates of these unconscious processes could provide an insight into potential missed targets. The present study explored missed anomalies in a visual search task and the possibility of unconscious awareness. Eye metrics were recorded and a "Detection Threshold Model" was created and validated with a nominal logistic regression model, in order to characterize the search patterns …

Private Record Linkage: A Comparison Of Selected Techniques For Name Matching, Pawel B. Grzebala

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The rise of Big Data Analytics has shown the utility of analyzing all aspects of a problem by bringing together disparate data sets. Efficient and accurate private record linkage algorithms are necessary to achieve this. However, records are often linked based on personally identifiable information, and protecting the privacy of individuals is critical. This work contributes to this field by studying an important component of the private record linkage problem: linking based on names while keeping those names encrypted, both on disk and in memory. We explore the applicability, accuracy, speed and security of three different primary approaches to this …

The Timing Of Fluoxetine, Simvastatin And Ascorbic Acid Administration In A Post-Ischemic Stroke Environment Affects Infarct Volume And Hemorrhagic Transformation Frequency, Neal R. Verma

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Previous animal experiments have indicated that administration of fluoxetine and simvastatin at 20-26 hours post-stroke decreases the volume of ischemic infarcts. This experiment expanded on previous experiments by adding ascorbic acid to the post-stroke regimen, initiating simvastatin pre-stroke, and adding a third initiation time frame (48-54 hours). Male retired breeder Sprague-Dawley rats were on simvastatin for 7 days prior to stroke induction. Combined medications of 5 milligrams/kilogram of fluoxetine, 1 milligram/kilogram of simvastatin and 20 milligrams/kilogram of ascorbic acid were orally administered at 6-12 hours, 20-26 hours, or 48-54 hours, respectively, following stroke induction. Adult rats that were treated 20-26 …

Glacial Deposits, Vol. 41, 2016, Department Of Geography-Geology

Glacial Deposits

Newsletter of the Department of Geography-Geology

Gender And The American State, E. Mcdonagh, Carol Nackenoff

Political Science Faculty Works

The study of gender in American political development (APD) challenges the efficacy for advancing women’s political inclusion of a liberal tradition valorizing principles of individual equality and positing a separation of the family and the state. Masked are ways in which gender roles and the family are integral to governance and state-building. Gender is both a dependent and an independent variable in APD. Shaped by institutions and policies of the state, it also shapes institutions and policies that promote women’s political citizenship and expand the state’s capacity for social provision—by asserting not only liberal claims of women’s equality with men, …

Making A Rainbow Military: Parliamentary Skill And The Repeal Of "Don't Ask, Don't Tell", Richard M. Valelly , '75

Political Science Faculty Works

No abstract provided.

China's Population Policy In Historical Context, Tyrene White

Political Science Faculty Works

The year 2014 marked the de facto end to China’s “one-child policy,” the most extreme example of state intrusion into the realm of reproduction. Deng Xiaoping’s 1979 initiative built on earlier, short-lived “birth planning” campaigns. The 1979 policy set an absolute population limit of 1.2 billion and tied this number to the goal of achieving modernization by 2000. A 1980 “Open Letter” defined the “one-child policy” as an absolute priority, and the government’s strict reinforcement of the policy in the early 1990s finally reduced rates of reproduction. This chapter chronicles the stages of policy implementation between 1979 and 2014 and …

Type One Protein Phosphatase 1 And Its Regulatory Protein Inhibitor 2 Negatively Regulate Aba Signaling, Hou Yueju, Yingfang Zhu, Pengcheng Wang, Yang Zhao, Shaojun Xie, Giorgia Batelli, Bangshing Wang, Chengguo Duan, Xingang Wang, Lu Xing, Mingguang Lei, Jun Yan, Xiaohong Zhu, Jian-Kang Zhu

Department of Horticulture & Landscape Architecture Faculty Publications

The phytohormone abscisic acid (ABA) regulates plant growth, development and responses to biotic and abiotic stresses. The core ABA signaling pathway consists of three major components: ABA receptor (PYR1/PYLs), type 2C Protein Phosphatase (PP2C) and SNF1-related protein kinase 2 (SnRK2). Nevertheless, the complexity of ABA signaling remains to be explored. To uncover new components of ABA signal transduction pathways, we performed a yeast two-hybrid screen for SnRK2-interacting proteins. We found that Type One Protein Phosphatase 1 (TOPP1) and its regulatory protein, At Inhibitor-2 (AtI-2), physically interact with SnRK2s and also with PYLs. TOPP1 inhibited the kinase activity of SnRK2.6, and …

De Novo Genome Assembly Of Geosmithia Morbida, The Causal Agent Of Thousand Cankers Disease, Taruna A. Schuelke, Anthony Westbrook, Kirk Broders, Keith E. Woeste, Matthew D. Macmanes

Department of Forestry & Natural Resources Faculty Publications

Geosmithia morbida is a filamentous ascomycete that causes thousand cankers disease in the eastern black walnut tree. This pathogen is commonly found in the western U.S.; however, recently the disease was also detected in several eastern states where the black walnut lumber industry is concentrated. G. morbida is one of two known phytopathogens within the genus Geosmithia, and it is vectored into the host tree via the walnut twig beetle. We present the first de novo draft genome of G. morbida. It is 26.5 Mbp in length and contains less than 1% repetitive elements. The genome possesses an …

Chloroplast Rna-Binding Protein Rbd1 Promotes Chilling Tolerance Through 23s Rrna Processing In Arabidopsis, Shuai Wang, Ge Bai, Shu Wang, Leiyun Yang, Fen Yang, Yi Wang, Jiankang Zhu, Jian Hua

Department of Horticulture & Landscape Architecture Faculty Publications

Plants have varying abilities to tolerate chilling (low but not freezing temperatures), and it is largely unknown how plants such as Arabidopsis thaliana achieve chilling tolerance. Here, we describe a genome-wide screen for genes important for chilling tolerance by their putative knockout mutants in Arabidopsis thaliana. Out of 11,000 T-DNA insertion mutant lines representing half of the genome, 54 lines associated with disruption of 49 genes had a drastic chilling sensitive phenotype. Sixteen of these genes encode proteins with chloroplast localization, suggesting a critical role of chloroplast function in chilling tolerance. Study of one of these proteins RBD1 with an …

Changes In The Proteome Of Langat-Infected Ixodes Scapularis Ise6 Cells: Metabolic Pathways Associated With Flavivirus Infection, Jeffrey M. Grabowski, Rushika Perera, Ali M. Roumani, Victoria E. Hedrick, Halina Dorota Inerowicz, Catherine A. Hill, Richard Kuhn

Department of Entomology Faculty Publications

Background: Ticks (Family Ixodidae) transmit a variety of disease causing agents to humans and animals. The tick-borne flaviviruses (TBFs; family Flaviviridae) are a complex of viruses, many of which cause encephalitis and hemorrhagic fever, and represent global threats to human health and biosecurity. Pathogenesis has been well studied in human and animal disease models. Equivalent analyses of tick-flavivirus interactions are limited and represent an area of study that could reveal novel approaches for TBF control. Methodology/Principal Findings: High resolution LC-MS/MS was used to analyze the proteome of Ixodes scapularis (Lyme disease tick) embryonic ISE6 cells following infection with Langat virus …

A Methodology For Measuring The Air Infiltration Rates Into Refrigerated Compartments, Paula Do Vale Pereira, André Sgrott, Lucas F. Back, Débora T. Kohara, Claudio Melo

International Refrigeration and Air Conditioning Conference

This work focuses on the development of a methodology for measuring the air infiltration rates into refrigerated compartments based on the tracer gas technique. To this end an experimental apparatus was designed and constructed. The apparatus is comprised of a device to supply the tracer gas uniformly into the zone, a device to ensure a uniform concentration both in the vertical and horizontal directions, a device to collect the air samples and a gas analyzer to measure the gas concentration according to the infrared photoacoustic spectroscopy technique. Tests were carried out with three distinct refrigerators, with the compressor on and …

Regulation Of Brown And White Adipocyte Transcriptome By The Transcriptional Coactivator Nt-Pgc-1Α, Jihyun Kim, Vivian E. Fernand, Tara M. Henagan, Jeho Shin, Peter Huypens, Susan Newman, Thomas W. Gettys, Ji Suk Chang

Department of Nutrition Science Faculty Publications

The β3-adrenergic receptor (AR) signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β3-AR signaling highly induces the expression of transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, which in turn activate the transcription program of adaptive thermogenesis by co-activating a number of transcription factors. We previously reported that NT-PGC-1α is able to increase mitochondrial number and activity in cultured brown adipocytes by promoting the expression of mitochondrial and thermogenic genes. In the present study, we performed genome-wide profiling of NT-PGC-1α-responsive genes in brown adipocytes to identify genes potentially …

Β-Aminopropionitrile-Induced Reduction In Enzymatic Crosslinking Causes In Vitro Changes In Collagen Morphology And Molecular Composition, Silvia P. Canelón, Joseph M. Wallace

Weldon School of Biomedical Engineering Graduate Student Publications

Type I collagen morphology can be characterized using fibril D-spacing, a metric which describes the periodicity of repeating bands of gap and overlap regions of collagen molecules arranged into collagen fibrils. This fibrillar structure is stabilized by enzymatic crosslinks initiated by lysyl oxidase (LOX), a step which can be disrupted using β-aminopropionitrile (BAPN). Murine in vivo studies have confirmed effects of BAPN on collagen nanostructure and the objective of this study was to evaluate the mechanism of these effects in vitro by measuring D-spacing, evaluating the ratio of mature to immature crosslinks, and quantifying gene expression of type I collagen …

Life Is Good No Matter What, Daniel J. Wyrock, Emily Kosuda, Brian Raglow

Williams Honors College, Honors Research Projects

As part of our Leadership Experience Project through the Institute of Leadership Advancement, our goal was to create an alternative revenue stream for an Akron cancer charity, Life Is Good No Matter What. As a team of three, we had to plan, development and implement our strategy over the course of a year. We researched charities and trends in the charity space which led us to the development of a product. After much time, we developed the idea of an ice cream line that not only fit the message of Life Is Good No Matter What, bus also helped define …

Relationship Among Motivation, Emotion Regulation, And Psychological Well-Being Of Sophomore And Senior Level Nursing Students, Aryene Delgado, Douglas Garner, Nicole Langhals

Williams Honors College, Honors Research Projects

Nursing education and professional work involve stressful circumstances that may lead to attrition, which can further contribute to the projected nursing shortage. This study examines the relationships between motivation, emotional regulation, psychological well-being and academic performance in baccalaureate sophomore and senior level nursing students at a Midwest urban university in the United States. The non-experimental, correlational study is guided by Deci and Ryan’s self-determination theory and uses an online survey data collection and convenience sampling. Measures include: motivation, emotional regulation, psychological well-being (burnout; inauthenticity), and academic performance (GPA), and will be measured using Deci and Ryan’s scale, the Emotion Regulation …

Stress And Exercise In Undergraduate Health Professions Students, Kristin R. Weismantel, Meghan G. Brickner, Leah N. Rosler

Williams Honors College, Honors Research Projects

Background: Stress is prevalent among undergraduate students, especially students in health professions majors. Exercise as a health promoting behavior decreases stress. At the same time, increased stress may decrease exercise. This study described exercise and stress among undergraduate health professions students. More specifically this study described the intensity and duration of each exercise and the frequency of exercise during a typical week of the semester for students in health professions majors.

Theoretical framework: Pender’s Health Promotion Model guided this study.

Design: Cross-sectional, descriptive survey.

Methods: A convenience sample of 437 undergraduate students in a college of health professions (N =2,700) …

A Systematic Review: Effects Of Breastfeeding On Early And Late Childhood, Kara Campbell, Samantha Fritz

Williams Honors College, Honors Research Projects

Abstract

The topic of the long-term impact of breast milk and formula milk composition on the health status of children continues to be a focus of discussion and research. The aim of this systematic review is to describe and critically appraise current evidence regarding the lasting effects of breastfeeding on health outcomes in children throughout early and late childhood. Twenty-one studies focusing on infant feeding were identified using PubMed, CINAHL, and Medline databases. These studies were then categorized according to health outcomes such as: weight, developmental, and immune system effects. Through a critical appraisal of this evidence, it was found …

Effect Of Case Management On Frequency Of Emergency Department Visits By Persons With Mental Illness: A Systematic Review, Allison M. Stanton, Kayla C. Osoteo

Williams Honors College, Honors Research Projects

A problem in healthcare is the increasing number of emergency department visits by repeat users with a comorbid mental illness. These visits increase costs, patient wait times, demand for service, overcrowding, and fragmented care; they may decrease quality of care and effective treatment. The purpose of this study is to identify, review, and critically appraise the evidence about the effect of case management on repeat emergency department (ED) use in those with comorbid mental illness. A systematic review of 21 studies was performed. All explored mental illness, frequent visits to the ED, and interventions. These twenty-one studies were reviewed and …