Digital Commons Network^™

Novel Approaches For Ungual And Trans-Ungual Delivery Of Drugs, Avadhesh Singh Kushwaha

Electronic Theses and Dissertations

Topical therapy is commonly used for the treatment of nail diseases such as onychomycosis and nail psoriasis due to less severe side effects, non-invasiveness, direct drug delivery at the site of infection, patient compliance and lower cost of treatment. However, topical treatment is limited due to poor permeability and hard nature of nail plate. The main objective of first project was to investigate the penetrability of apremilast into and across the nail plate, folloby the preparation of a novel nail lacquer formulation to improve its ungual and trans-ungual permeation for the treatment of nail psoriasis. Dexpanthenol and salicylic acid were …

Ureaplasma Diversum Genome Provides New Insights About The Interaction Of The Surface Molecules Of This Bacterium With The Host, Lucas M. Marques, Izadora S. Rezende, Maysa S. Barbosa, Ana M. Guimarães, Hellen B. Martins, Guilherme B. Campos, Naila C. Do Nascimento, Andrea P. Dos Santos, Aline T. Amorim, Verena M. Santos, Sávio T. Farias, Fernanda A C Carrence, Lauro M. De Souza, Melissa Buzinhani, Victor E. Arana-Chavez, Maria E. Zenteno, Gustavo P. Amarante-Mendes, Joanne Messick, Jorge Timenetsky

Department of Comparative Pathobiology Faculty Publications

Whole genome sequencing and analyses of Ureaplasma diversum ATCC 49782 was undertaken as a step towards understanding U. diversum biology and pathogenicity. The complete genome showed 973,501 bp in a single circular chromosome, with 28.2% of G+C content. A total of 782 coding DNA sequences (CDSs), and 6 rRNA and 32 tRNA genes were predicted and annotated. The metabolic pathways are identical to other human ureaplasmas, including the production of ATP via hydrolysis of the urea. Genes related to pathogenicity, such as urease, phospholipase, hemolysin, and a Mycoplasma Ig binding protein (MIB)—Mycoplasma Ig protease (MIP) system were identified. More …

An Investigation Of The Adsorption Behavior Between Silver Nanoparticles (Agnps) And Corundum (Α-Al2O3) At Environmental Ph Values Using Inductively-Coupled Plasma Optical Emission Spectroscopy (Icp-Oes) And Raman Spectroscopy, Kevin Andrew O'Neil

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With the increased use of silver nanoparticles (AgNPs) in consumer products, the need to monitor their release into environmental soils has become critical. Although minerals make up a large component of soils, research on their interactions with AgNPs is still limited. Furthermore, the majority of the existing research focused on silica-based minerals rather than metal oxides, which is the second most abundant mineral type in the earth's crust. This study examined for the first time the aqueous interaction between the widely used, spherical Creighton AgNPs and a-corundum (a-Al2O3), a representative non-silica-based mineral, at environmentally relevant pH values (6-11). Samples were …

Mining And Analyzing Subjective Experiences In User Generated Content, Lu Chen

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Web 2.0 and social media enable people to create, share and discover information instantly anywhere, anytime. A great amount of this information is subjective information -- the information about people's subjective experiences, ranging from feelings of what is happening in our daily lives to opinions on a wide variety of topics. Subjective information is useful to individuals, businesses, and government agencies to support decision making in areas such as product purchase, marketing strategy, and policy making. However, much useful subjective information is buried in ever-growing user generated data on social media platforms, it is still difficult to extract high quality …

An Unrelenting Past: Historical Memory In Japan And South Korea, Hannah Elisabeth Collins

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Every population maintains collective memories which provide meaning and identity for members (Langenbache, 2003). Elites have exerted influence on what is being remembered and the interpretation of the remembrances for specific objects, through the concept of historical memory. Wang (2012) has shown that authoritarian governments leverage historical memory to increase legitimacy. Similarly, Bernhard and Kubik (2014) have demonstrated that transitioning democracies also benefit from elite use of historical memory for consolidation. The lack of studies concerning consolidated democracies' use of historical memory raises many questions, including whether consolidated democracies manipulate historical memory for the purpose of legitimacy? I contend that, …

The Development And Validation Of A One Tier Diagnostic Assessment To Test Premedical Students' Misconceptions About Traumatic Brain Injury, Md Hasan Iqbal

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Since brain injury is common in the United States, it is important for health professionals and the public to have accurate knowledge about traumatic brain injury (TBI). Understanding misconceptions is important for health educators, nurses, and physicians, who work with TBI patients. While previous studies on misconceptions about TBI have been undertaken, these have not focused on pre-medical students, nor utilized validated assessments. The purpose of this study was to develop and validate a one tier diagnostic test with a confidence index to determine premedical students' misconceptions about TBI. Using the theoretical framework suggested by Treagust (1986, 1988, and 1995), …

Missing Gene Identification Using Functional Coherence Scores, Meghana Chitale, Ishita K. Khan, Daisuke Kihara

Department of Biological Sciences Faculty Publications

Reconstructing metabolic and signaling pathways is an effective way of interpreting a genome sequence. A challenge in a pathway reconstruction is that often genes in a pathway cannot be easily found, reflecting current imperfect information of the target organism. In this work, we developed a new method for finding missing genes, which integrates multiple features, including gene expression, phylogenetic profile, and function association scores. Particularly, for considering function association between candidate genes and neighboring proteins to the target missing gene in the network, we used Co-occurrence Association Score (CAS) and PubMed Association Score (PAS), which are designed for capturing functional …

A Review Of The Evidence Supporting The Taste Of Non‐Esterified Fatty Acids In Humans, Cordelia Running, Richard D. Mattes

Department of Food Science Faculty Publications

Dietary fats contribute to the flavor of foods by multiple mechanisms. A role for their taste has only recently gained credence. Current evidence indicates non‐esterified fatty acids (NEFA) are the effective stimuli for the taste component. CD36 and GPR120 are putative receptors, but may not fully account for the totality of the range of sensations elicited by fatty acids. The sensory quality of long‐chain NEFA is not adequately characterized by commonly accepted taste primary qualities and has been termed oleogustus. There is marked individual variability in sensitivity to the taste of NEFA prompting hypotheses of genetic and environmental determinants. Though …

Identified Research Directions For Using Manufacturing Knowledge Earlier In The Product Lifecycle, Thomas D. Hedberg Jr, Nathan W. Hartman, Phil Rosche, Kevin Fischer

Computer Graphics Technology Faculty Publications

Design for manufacturing (DFM), especially the use of manufacturing knowledge to support design decisions, has received attention in the academic domain. However, industry practice has not been studied enough to provide solutions that are mature for industry. The current state of the art for DFM is often rule-based functionality within computer-aided design (CAD) systems that enforce specific design requirements. That rule-based functionality may or may not dynamically affect geometry definition. And, if rule-based functionality exists in the CAD system, it is typically a customisation on a case-by-case basis. Manufacturing knowledge is a phrase with vast meanings, which may include knowledge …

Collaboration Between French Speaking University Libraries Of Belgium And University Libraries Of Developing Countries Since 2004, Frédéric Brodkom

Proceedings of the IATUL Conferences

No abstract provided.

Woodstock Scholarship: An Interdisciplinary Annotated Bibliography, Jeffrey Gatten

Librarian Publications & Presentations

Since August 1969, the Woodstock Music and Art Fair looms large when recounting the history and impact of the baby boom generation and the societal upheavals of the Sixties. Scholars study the sociological, political, musical, and artistic impact of the event and use it as a cultural touchstone when exploring alternative perspectives or seeking clarity. This interdisciplinary annotated bibliography records the details of over 400 English-language resources on the Festival, including books, chapters, articles, websites, transcriptions and videos. Divided into six main subsections―Culture & Society, History, Biography, Music, Film, Arts & Literature―for ease of consultation Woodstock Scholarship sheds light on …

Inclusion Of Students With High Need Autism: General Education Teachers’ Attitudes And Beliefs Versus Practice, Joanna Davis

Graduate Theses & Dissertations

Given the simultaneous rise in rates of autism and the expectations for school-based inclusion of students with disabilities, research targeting inclusive practices continues to be a priority. Researchers have examined the attitudes and perspectives of general education teachers and best practice for including individuals with high functioning autism spectrum disorders. However, there is little research exploring the relationship between attitudes and practice with regard to the inclusion of individuals on the low functioning end of the spectrum. The purpose of this study was to explore the self-reported attitudes and perspectives of general education teachers in relation to what was observed …

Application Of Geographical Information Systems To Determine Human Population Impact On Water Resources Of Yellow Springs, Ohio, And The Use Of Lidar Intensities In Land Use Classification, Gregory Geise

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The purposes of the following studies were to investigate natural and human influences on several spatial and temporal aspects of a local and regional environment. The decreasing discharge rate of the ground water supplied Yellow Spring may be caused by the increase in population of the nearby Village of Yellow Springs, Ohio. Periodic measurements of Yellow Spring's discharge rate compared to changes in the town's population showed an inverse relationship, where spring discharge declined as population grew. A sharp decrease in discharge occurred during a period when the spring's facade was modified and an airport was built partially overlying the …

Hiv/Aids Health Policy, Feminism, Backlash, And Anti-Lgbt Attitudes In Uganda, Michael Andrew Wilson

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As LGBT (lesbian, gay, bisexual, and transgender) community organizing becomes increasingly common internationally, backlash also increased in frequency. This research examines the observed increase in violence against the Ugandan LGBT people from 2006-2014 as well as how this violence was exacerbated by international pressures in response to HIV/AIDS and local actors. This research also focuses on how those pressures from international agents affected the successes of the Ugandan feminist movement.

Theoretical Estimation Of PkA'S Of Pyrimidines And Related Heterocycles, Rachael Ann Wessner

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Pyrimidines and related heterocycles are an important class of compounds with a wide variety of applications. As a result, there is great interest in the chemical properties of these compounds, specifically their pKa's. Despite the importance of these compounds their reported pKa's are often only approximations or are completely absent from literature. Experimentally measuring pKa's can be challenging, especially if the pKa is below zero. Alternatively, pKa's can be estimated computationally using a Quantitative Structure-Activity Relationship (QSAR). However, most of the compounds included in this study exist as two or more forms that arise from tautomerism. Tautomerism complicates the estimation …

To Honor Our Past: Historical Research, Library History And The Historiographical Imperative: Conceptual Reflections And Exploratory Observations, Jean-Pierre V. M. Hérubel

Libraries Faculty and Staff Scholarship and Research

This exploratory discussion considers history of libraries, in its broadest context; moreover, it frames the entire enterprise of pursuing history as it relates to LIS in the context of doing history and of doing history vis-à-vis LIS. Is it valuable intellectually for LIS professionals to consider their own history, writing historically oriented research, and what is the nature of this research within the professionalization of LIS itself as both practice and discipline? Necessarily conceptual and offering theoretical insight, this discussion perforce tenders the idea that historiographical innovations and other disciplinary approaches and perspectives can invigorate library history beyond its current …

Crossing Literacy And Informed Learning Boundaries With Manga, Kathleen Smeaton, Clarence Maybee, Christine Susan Bruce, Hilary Hughes

Libraries Faculty and Staff Scholarship and Research

This research investigated high school students’ experiences of informed learning in a literacy development workshop. It was conducted in the library of an Australian high school with a low socio-economic population. Building upon students’ fascination with Manga fi ction and artwork, the workshop was part of a larger university– community engagement project, Crossing Boundaries with Reading, which aimed to address widespread literacy challenges at the school.

Research Data Management, Part Two: Data Reuse, Jane Kinkus Yatcilla

Libraries Faculty and Staff Scholarship and Research

No abstract provided.

Cultivar Identification And Genetic Relatedness Among 25 Black Walnut (Juglans Nigra) Clones Based On Microsatellite Markers, Kejia Pang, Keith E. Woeste, Charles Michler

Department of Forestry & Natural Resources Faculty Publications

A set of eight microsatellite markers was used to genotype 25 black walnut (Juglans nigra L.) clones within the Purdue University germplasm repository. The identities of 212 ramets were verified using the same eight microsatellite markers. Some trees were mislabeled and corrected as to clone using analysis of microsatellite markers. A genetic dendrogram was constructed to show the degree of genetic relatedness between clones. Two additional dendrograms, one based on crown architecture traits and the other on tree size and form traits, were also built and compared with the genetic dendrogram. The genetic dendrogram showed that these eight molecular markers …

Effect Of Cooling Pad Installation On Indoor Airflow Distribution In A Tunnel-Ventilated Laying-Hen House, Hui Xue, Zhu Qiang, Ji-Qin Ni, Li Baoming, Shi Zhengxiang, Zhao Shumei, Wang Yu

School of Agricultural & Biological Engineering Faculty Publications

Extra cooling pads on the sidewalls are needed for larger poultry houses using tunnel ventilation system. Preliminary study showed that the airflow velocity going through different aisles varies greatly when the extra pads are installed at the end of sidewalls, making a “[”-shape air inlet. Combined with field tests, the CFD (computational fluid dynamics) technology was used to study the uniformity of airflow distribution in a tunnel-ventilated laying-hen house. The air distribution was first monitored in a layer house to find the main reason resulting in the variations of airflows in different aisles. Then CFD simulations were carried out with …

Use Of Nanoparticles In Refrigeration Systems: A Literature Review Paper, Amey Majgaonkar

International Refrigeration and Air Conditioning Conference

The monetary savings from energy efficient systems & responsibility felt to contribute to save environment are encouraging researchers to use different technologies & advancements in science to make their equipments & systems more & more energy efficient. Refrigeration systems are no exceptions. The advances in nanotechnology have lead to emerging of new generation heat transfer fluids called nanofluids. Researchers are trying to use these nanofluids to improve energy efficiency of refrigeration systems. This paper presents a literature review of the research in this field. This paper briefs about basics, historical developments, nanoparticle production techniques, nanofluids & its preparation method and …

Nano Roughness, Tamara J. Moore

School of Engineering Education Working Papers

No abstract provided.

Under-Reactive But Easily Distracted: An Fmri Investigation Of Attentional Capture In Autism Spectrum Disorder, Brandon Keehn, Aarti K N Nair, Alan J. Lincoln, Jeanne Townsend, Ralph Axel Müller

Department of Speech, Language, and Hearing Sciences Faculty Publications

For individuals with autism spectrum disorder (ASD), salient behaviorally-relevant information often fails to capture attention, while subtle behaviorally-irrelevant details commonly induce a state of distraction. The present study used functional magnetic resonance imaging (fMRI) to investigate the neurocognitive networks underlying attentional capture in sixteen high-functioning children and adolescents with ASD and twenty-one typically developing (TD) individuals. Participants completed a rapid serial visual presentation paradigm designed to investigate activation of attentional networks to behaviorally-relevant targets and contingent attention capture by task-irrelevant distractors. In individuals with ASD, target stimuli failed to trigger bottom-up activation of the ventral attentional network and the cerebellum. …

Expectation, Expectoration And Disgust: Information Manipulation Alters Spitting Efficiency, A Proxy For Salivary Flow, Cordelia Running, John E. Hayes

Department of Nutrition Science Faculty Publications

Saliva is becoming an increasingly useful research material across multiple fields of inquiry, including biomedical, dental, psychological, nutritional, and food choice research. However, both the flow rate and protein composition of stimulated saliva differ as a function of the collection method. We hypothesized that the context in which a salivary stimulus is presented to participants may alter salivation via behavioral (i.e., spitting efficiency) or top down cognitive effects. We presented participants with a constant stimulus (commercially available green tea) in two distinct contexts, once where the tea was described as a food item (“tea”) and once where it was described …

Reference Ranges And Association Of Age And Lifestyle Characteristics With Testosterone, Sex Hormone Binding Globulin, And Luteinizing Hormone Among 1166 Western Chinese Men, Xubo Shen, Ruifeng Wang, Na Yu, Yongjun Shi, Honggang Li, Chengliang Xiong, Yan Li, Ellen M. Wells, Yuanzhong Zhou

School of Health Sciences Faculty Publications

Decreased total testosterone (TT) is the recommended metric to identify age-related hypogonadism. However, average TT and the extent to which it varies by age, can vary substantially among different populations. Population-specific reference ranges are needed to understand normal versus abnormal TT levels. Therefore, the goal for this study was to describe androgen concentrations and their correlates among Western Chinese men. We completed a population-based, cross-sectional study including 227 young adults (YA) (20–39 years) and 939 older adults (OA) (40–89 years). We measured TT, sex-hormone binding globulin (SHBG), luteinizing hormone (LH), testosterone secreting index (TSI), and calculated free testosterone (cFT). Reference …

Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia, John Timothy Caldwell

Wayne State University Dissertations

Acute myeloid leukemia (AML) is a potentially devastating disease that can affect people of all ages. While there are certain patient groups that typically have favorable outcomes, in the pediatric population, overall survival (OS) is approximately 70%, leaving much progress to be made. Children with Down syndrome (DS) have a substantially elevated risk for developing AML, especially of the megakaryocytic phenotype (AMKL).

Patients with DS AMKL almost universally harbor a mutation in the gene encoding the GATA1 transcription factor, resulting in the translation of a short-form protein GATA1s, which has been shown to contribute to chemotherapy sensitivity. In contrast, in …

Critical Literacy: An Innovative Approach To Learning Among Students With Reading Disabilities, Karyn Marie Chiapella

Wayne State University Dissertations

ABSTRACT

CRITICAL LITERACY: AN INNOVATIVE APPROACH TO LEARNING AMONG STUDENTS WITH READING DISABILITIES

by

KARYN M. CHIAPELLA

DECEMBER 2015

Co-Advisors: Dr. Marshall Zumberg; Dr. Gerald Oglan

Major: Special Education

Degree: Doctor of Philosophy

Many students, particularly those with learning disabilities do not read and/ or write at levels sufficient for meeting the demands of the 21st century. Successfully reading to learn requires the ability to analyze, synthesize, and evaluate information from multiple texts. Critical literacy provides a framework for students to engage in dialogue with texts to become more aware of the relationships of power communicated within texts. This study …

Systems Biology Approaches For The Analysis Of High-Throughput Biological Data, Michele Donato

Wayne State University Dissertations

The identification of biological processes involved with a certain phenotype, such as a disease or drug treatment, is the goal of the majority of life sciences experiments.

Pathway analysis methods are used to interpret high-throughput biological data to identify such processes by incorporating information on biological systems to translate data into biological knowledge.

Although widely used, current methods share a number of limitations.

First, they do not take into account the individual contribution of each gene to the phenotype in analysis.

Second, most of the methods include parameters of difficult interpretation, often arbitrarily set.

Third, the results of all methods …

Public Subjects: Wayne State, Institutional Texts, And Public Rhetoric, Michael Mcginnis

Wayne State University Dissertations

Applying a public sphere approach to Wayne State, I argue that the university has defined itself as a public subject within public debates about race, educational access, and economic development in the city of Detroit, even when such commitments to its local urban public sphere have existed uneasily alongside its ambition to function as a research university with a primary research mission within a wider public sphere of peer research universities. I focus on Wayne State University’s urban mission and open for consideration the ways the university has both expanded and contracted its relationships to its local and academic public …

The Effects Of Individual-Level Income And Contextual-Level Income Inequality On Health, Beth Simmert

Wayne State University Dissertations

The relationship between income inequality and health is often studied at either the individual-level or contextual-level. The purpose of this research is to assess both of these levels, by simultaneously examining the individual and contextual contributions of income inequality on health. To address this research objective, I use data for 14,126 respondents from the 2006 wave of the Health and Retirement Study (HRS), a nationally representative sample of Americans over 50. For this analysis, I use multi-level modeling with fixed and random intercepts to assess the relationship between income inequality and three measures of health. This study has two main …