Digital Commons Network^™

Cell Therapy Must Be Regulated As Medicine, Zihai Li, Delong Liu

NYMC Faculty Publications

Background

The current standard of care for relapsed and refractory acute lymphoblastic leukemia (ALL) is combination chemotherapy.

Case presentation

We report a case of highly refractory ALL who was treated with blinatumomab. The ALL in this patient relapsed within a month after completion of hyperCVAD regimen and was refractory to high dose mitoxantrone/cytarabine and CLAG regimens.

Conclusion This highly refractory pre-B Ph− ALL was induced to complete remission after one course of single agent blinatumomab.

When Are Puppies At Their Cutest?, Harold Herzog

'Animals and Us' Blog Posts

A new study helps explain why puppies are most adorable at weaning time.

Using World Café Methodology For Affective Change, Stephen Rynearson

Doctor of Ministry Major Applied Project

Rynearson, Stephen P. “Using World Café Methodology for Affective Change” D.MIN MAP., Concordia Seminary, 2016. pp.142.

The purpose of this MAP is to evaluate the usefulness of using the “World Café” methodology in changing attitudes. In particular, the participants went through a World Café to see if any change was made from the previous apathetic service to the Lord into a joyful service. Also tested was the usefulness of the World Café methodology for congregational decision making.

Among the topics discussed are: what constitutes joyful service in the Scriptures; what other means are often used in making decisions; and how …

Vitamin B12 Deficiency Among Adult Diabetic Patients In Uganda: Relation To Glycaemic Control And Haemoglobin Concentration, Martha Sajatovic

Faculty Scholarship

Background: Vitamin B12 deficiency is highly prevalent among adult individuals with diabetes yet screening is infrequent in Uganda. There are currently no published data regarding the prevalence of vitamin B12 deficiency and its associated factors among adult individuals with diabetes in sub-Saharan Africa. This study aimed at describing the prevalence and factors associated with vitamin B12 deficiency among this patient population in a resource constrained setting in sub-Saharan Africa. Methods: In this cross-sectional study, 280 eligible study participants attending the outpatient diabetic clinic at Mulago national referral and teaching hospital in Kampala, Uganda were enrolled. Their socio-demographic, clinical and laboratory …

Can Skeletal Morphology Support New Molecular Phylogenies Of Antedonidae (Crinoidea: Comatulida)?, Brenna Hays

HCNSO Student Theses and Dissertations

Antedonidae (Crinoidea: Comatulida) is the largest of extant crinoid families; it currently includes ~155 accepted species in 50 genera and accounts for ~23% of extant crinoid species (~29% of feather stars) and 27% of genera. Molecular phylogenies have returned the family as polyphyletic, with several clades scattered among non-antedonid sister groups (Hemery 2011, Hemery et al. 2013, Rouse et al. in prep.). Traditional morphological characteristics are thus inadequate for reconstructing relationships among taxa. SEM imaging was used in an effort to discover new diagnostic features that will support the molecular data, focusing on skeletal ossicles within the calyx, specifically the …

Leaf Protein And Mineral Concentrations Across The “Miracle Tree” Genus Moringa, Mark E. Olson, Renuka P. Sankaran, Jed W. Fahey, Michael A. Grusak, David Odee, Wasif Nouman

Publications and Research

The moringa tree Moringa oleifera is a fast-growing, drought-resistant tree cultivated across the lowland dry tropics worldwide for its nutritious leaves. Despite its nutritious reputation, there has been no systematic survey of the variation in leaf nutritional quality across M. oleifera grown worldwide, or of the other species of the genus. To guide informed use of moringa, we surveyed protein, macro-, and micro- nutrients across 67 common garden samples of 12 Moringa taxa, including 23 samples of M. oleifera. Moringa oleifera, M. concanensis, M. stenopetala, an M. concanensis X oleifera hybrid, and M. longituba were highest in protein, with M. …

Emu Today, July 26, 2016, Eastern Michigan University

EMU Today

No abstract provided.

Haloarchaeal Species Genesis: Diversity, Recombination, And Evolution, Nikhil Ram Mohan

Doctoral Dissertations

This dissertation discusses a working model for species genesis in Haloarchaea based on evidence obtained from multiscale analyses of Haloarchaeal communities and populations. First, a spatial distribution analysis of the haloarchaeal communities using both PCR amplified environmental gene marker as well as metagenomic comparisons reveal unique haloarchaeal communities in geographically distant hypersaline environments. Similar to eukaryotes, endemism is apparent in haloarchaea. However, unlike the eukaryotes, there is neither a distance-decay relationship nor is there a similarity in haloarchaeal communities based on whether they are from lakes or salterns. Second, temporal analysis on one haloarchaeal community reveals stability in the community …

Polyphenol Proteasome Inhibitors, Synthesis, And Methods Of Use, Ping Q. Dou, Tak-Hang Chan, David M. Smith

USF Patents

The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.

Inhibitors Of The Fkbp51 Protein From A High-Throughput Drug Screen And Methods Of Use, Jonathan J. Sabbagh, Chad Dickey

USF Patents

The subject invention concerns materials and methods for treating depression, stress disorders, such as PTSD, anxiety disorders, and/or a neurodegenerative disease or condition in a person or animal. In one embodiment, a person or animal in need of treatment is administered one or more compounds or drugs, or a composition comprising the one or more compounds or drugs, that inhibit FKBP51 activity or function. The subject invention also concerns a method for inhibiting activity of the FKBP51 protein in a cell. The subject invention also concerns methods of screening for compounds or drugs that inhibit the FKBP51 protein.

Phenotypes Associated With Knockouts Of Eight Dense Granule Gene Loci (Gra2-9) In Virulent Toxoplasma Gondii, Leah M. Rommereim, Valeria Bellini, Barbara A. Fox, Graciane Pètre, Camille Rak, Bastien Touquet, Delphine Aldebert, Jean-François Dubremetz, Marie-France Cesbron-Delauw, Corinne Mercier, David J. Bzik

Dartmouth Scholarship

Toxoplasma gondii actively invades host cells and establishes a parasitophorous vacuole (PV) that accumulates many proteins secreted by the dense granules (GRA proteins). To date, at least 23 GRA proteins have been reported, though the function(s) of most of these proteins still remains unknown. We targeted gene knockouts at ten GRA gene loci (GRA1-10) to investigate the cellular roles and essentiality of these classical GRA proteins during acute infection in the virulent type I RH strain. While eight of these genes (GRA2-9) were successfully knocked out, targeted knockouts at the GRA1 and GRA10 loci were not …

Mousensor: A Versatile Genetic Platform To Create Super Sniffer Mice For Studying Human Odor Coding, Charlotte D'Hulst, Raena B. Mina, Zachary Gershon, Sophie Jamet, Antonio Cerullo, Delia Tomoiaga, Li Bai, Leonardo Belluscio, Matthew E. Rogers, Yevgeniy Sirotin, Paul Feinstein

Publications and Research

Typically, 0.1% of the total number of olfactory sensory neurons (OSNs) in the main olfactory epithelium express the same odorant receptor (OR) in a singular fashion and their axons coalesce into homotypic glomeruli in the olfactory bulb. Here, we have dramatically increased the total number of OSNs expressing specific cloned OR coding sequences by multimerizing a 21-bp sequence encompassing the predicted homeodomain binding site sequence, TAATGA, known to be essential in OR gene choice. Singular gene choice is maintained in these ‘‘MouSensors.’’ In vivo synaptopHluorin imaging of odor-induced responses by known M71 ligands shows functional glomerular activation in an M71 …

Minimizing The Dynamic Load Of High Contact Ratio Spur Gear Using Profile Modification, Srijana Shah

Electronic Theses and Dissertations Archive

One of the major concern in the design of power transmission gear is the reduction of gear dynamic load. Research on gear noise and vibration has revealed that the basic mechanics of noise generated from gearing is gear box vibration excited by the dynamic load. This thesis studies the effect of tooth spacing errors on the dynamic load of high contact ratio spur gear subjected to unideal loading conditions. Spur gear is the simplest kind gear available. Spur gears have their teeth parallel to the axis of rotation and are used for transmitting power between two parallel shafts. Three types …

Do Forest Commons Contribute To International Environmental Initiatives? A Socio-Ecological Analysis Of Nepalese Forest Commons In View Of Redd+, Harisharan Luintel

Dissertations and Theses

Forests in developing countries have the potential to contribute to global efforts to mitigate climate change, promote biodiversity and support the livelihoods of rural, local people. Approximately one-fourth of such forests are under the control of local communities, which primarily manage forests for subsistence and to meet their livelihood needs. The trend of bottom-up community control is increasing through the adoption of decentralization reforms over the last 40 years. In contrast, the United Nations has introduced the top-down program, Reducing Emissions from Deforestation and Forest Degradation (REDD+) for the conservation and enhancement of forest carbon and the sustainable management of …

Why Are Vacations So Exhausting?, Howard Schaap

Faculty Work Comprehensive List

"What do we mean by 'vacation'? Is vacation about relaxation or adventure? What do we even mean by those terms? Does vacation really give you a break?"

Posting about retreating from every day activities­­­­­­­­ from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.

http://inallthings.org/why-are-vacations-so-exhausting/

Racing To The Top: Who’S Accounting For The Children?, Celia Genishi, Anne Haas Dyson

Occasional Paper Series

The authors argue that teachers are accountable not to some narrow “top” but to the rhythms and rhymes of their developing students.

Introduction: Diving Into The Wreckage: Our Schools, Education Reform, And The Future Society, William Ayers

Occasional Paper Series

"In this special issue of the Bank Street Occasional Papers, we will dive into the wreckage, engage the fight, and hope to reclaim the ground of education in and for democracy." --Author.

A Portrait Of Raymond Brutinel As A Young Man (Part I): The Future Machine Gun Commander In Edmonton, Alberta, 1905-1914, Cameron Pulsifer

Canadian Military History

Raymond Brutinel remains one of the Canadian Corps’ most intriguing and little understood senior officers. A fair amount has been written about his service with the Canadian Corps, which generally portrays him as a significant commander and military innovator. But his life before he joined the Canadian military largely remains a mystery, which Brutinel himself did little to clear up. He had emigrated from France to Edmonton, Alberta in 1905 and lived there until the outbreak of war. Yet little is known in detail about this formative period of his life. Based largely upon Edmonton-based sources, the following aims to …

Growth Performance Of Adult Florida Pompano, Trachinotus Carolinus, Fed Semi-Purified Diets With Graded Levels Of Methionine, Christina M. Belfranin

Open Access Theses

Replacement of fishmeal with soy-based protein alternatives has produced the need to determine nutritional requirements of aquaculture species to appropriately formulate and supplement aquafeeds. Compared to fishmeal, soybean meal is deficient in methionine, an essential amino acid. Thus, the methionine requirement of a high-value and soy-tolerant species, the Florida pompano (Trachinotus carolinus) at a near harvestable size (>200 g) was evaluated. Six semi-purified, isonitrogenous and isocaloric, experimental diets were formulated based on the whole-body amino acid (AA) profile of the Florida pompano with incremental inclusions of methionine (0.5, 0.7, 0.9, 1.1, 1.3, and 1.5 g 100 g …

Opn-A Induces Muscle Inflammation By Increasing Recruitment And Activation Of Pro-Inflammatory Macrophages., Gina M Many, Yasuyuki Yokosaki, Kitipong Uaesoontrachoon, Peter P Nghiem, Luca Bello, Sherry Dadgar, Ying Yin, Jesse M Damsker, Heather B Cohen, Joe N Kornegay, Marcas M Bamman, David M Mosser, Kanneboyina Nagaraju, Eric P Hoffman

Genomics and Precision Medicine Faculty Publications

New Findings

• What is the central question of this study? What is the functional relevance of OPN isoform expression in muscle pathology?
• What is the main finding and its importance? The full‐length human OPN‐a isoform is the most pro‐inflammatory isoform in the muscle microenvironment, acting on macrophages and myoblasts in an RGD‐integrin‐dependent manner. OPN‐a upregulates expression of tenascin‐C (TNC), a known Toll‐like receptor 4 (TLR4) agonist. Blocking TLR4 signalling inhibits the pro‐inflammatory effects of OPN‐a, suggesting that a potential mechanism of OPN action is by promoting TNC–TLR4 signalling.

Although osteopontin (OPN) is an important mediator of muscle remodelling in health …

Diabetes Self-Management Education In The Home, Diane Lavelle, Joanah Zeitoun, Marianne Stern, Elise Butkiewicz, Elfie Wegner, Courtney Reinisch

School of Nursing Faculty Scholarship and Creative Works

Purpose: Diabetes self-management education and home visits have been found to improve clinical outcomes in individuals living with diabetes. The purpose of this pilot project was to evaluate the feasibility and effectiveness of conducting self-management education in patients' homes.

Methods: Baseline biometric data was collected from a cohort of adult patients with diabetes. Home visits to 19 patients were conducted by doctoral students from Rutgers University School of Nursing. The visits included knowledge assessment, review of foods in the home, diabetes self-management education, and teaching the proper use of monitoring tools such as the glucometer and blood pressure monitor. Biomarkers …

Reproductive Ecology Of Dragonfishes (Family: Stomiidae) In The Gulf Of Mexico, Alex D. Marks

HCNSO Student Theses and Dissertations

The most speciose group of fishes in the Gulf of Mexico is the dragonfishes (Family: Stomiidae). These fishes are dominant mesopelagic predators occurring throughout the world’s oceans, including the Antarctic seas. Little is known regarding their reproductive ecology, a consequence attributed to insufficient sample sizes of mature adults due to inadequacies of sampling gear; larger, sexually mature stomiid adults are more adept at net avoidance, thereby obfuscating synoptic reproductive biology studies. Between 2010-2011, the Offshore Nekton Sampling and Analysis Program was initiated in the northern Gulf of Mexico over all four seasons using a discrete-depth sampling system (MOCNESS) and a …

Emu Today, July 25, 2016, Eastern Michigan University

EMU Today

No abstract provided.

Ruminating On Garbage: Exemplified By Kunal Vohra's Film The Plastic Cow, Chang Chia-Ju

Theoretical Studies in Literature and Art

This paper examines the way in which non-human animals are constructed as unwanted object through human language, culture and economic system, and how such construction in return affects the lives of the animals. The paper aims to think through the entangled interconnected relationship among animals, humans and environment on both the conceptual and material levels. It argues that animals are deeply enmeshed in capitalist system while the animal-garbage connection can be traced in etymological, cultural, and economic and ecological systems. In order to reflect on our culture, globalization, and modernity, an Indian documentary film, The Plastic Cow, by Kunal Vohra, …

First Record Of The Non-Native Suckermouth Armored Catfish Hypostomus Cf. Niceforoi (Fowler 1943) (Siluriformes: Loricariidae) From Central America, Wilfredo A. Matamoros, Caleb D. Mcmahan, Carlos R. Mejia, Parker H. House, Jonathan W. Armbruster, Prosanta Chakrabarty

Occasional Papers of the Museum of Natural Science, Louisiana State University

We document the first record of Hypostomus cf. niceforoi in Central America. Two specimens of these suckermouth armored catfishes were collected in Lake Nicaragua (Nicaragua) and identified as H. cf. niceforoi. Hypostomus niceforoi is endemic to Andean streams of Colombia, Venezuela, Ecuador, and Peru. We hypothesize that its introduction in Central America is related to the aquarium trade, as is the case of other armored catfish species introductions.

Unh Launches Silvopasture Project At Organic Dairy Research Farm, Lori Tyler Gula

UNH Today Archive

No abstract provided.

New Unh Research Explores New Practice That Brings Cows Into The Woods, Lori Wright

Media Relations

No abstract provided.

How Does Composting At School Change The Way Middle School Students Perceive Their Ability To Positively Impact The Earth?, Katie Lynn Pangborn

School of Education and Leadership Student Capstone Theses and Dissertations

The research question addressed in this project is: how does composting at school change the way middle school students perceive their ability to positively impact the earth? The motivating factor for this capstone was the lack of awareness middle school students seem to have in regards to the waste they create and how to handle their waste. This capstone delves into the impacts of service learning combined with environmentalism. Since service learning is most impactful when it is student-led, students brainstormed ideas around waste management at their school and concluded that composting should be part of the plan. Students designed, …

Alma Link Resolver Subject Report 2015-2016, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2015-2016 on the number of OpenURL requests by Library of Congress classification code made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries.

Information provided includes Classification Code, Classifications, Number of Requests, Number of Clicked Requests, and % Clicks from Requests.

Alma Link Resolver Title & Issn Report (Top 500) 2015-2016, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2015-2016 on the total number of OpenURL requests by journal title and ISSN made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries. Includes only the top 500 journals.

Information provided includes journal Title, ISSN, EISSN, Number of Requests, Number of Clicked Requests, % Clicks from Requests.