Digital Commons Network^™

Moovy: Sensorial Communication Device, Mariana Pinheiro

Theses

Over time humans evolved and perfected their communication tools. The world today is more connected than ever, and we are able to reach people all over the world using handheld technology such as smartphones, computers, and tablets. Society is living in a digital era and many negative side effects are being identified. The excess of digital immersion can lead to physical harm, such as neck injuries caused by poor postural habits, as well as psychological and social consequences.

Inspired by the historical evolution of communication and concerned about the impacts in social behaviors, this thesis proposes a new language of …

Ecologically Inspired Metrics For Rare Earth Element Critical Material Systems, Berlyn Jo Hubler

Theses

Greenhouse gas emission reduction targets have increased demand for clean energy technologies, and the growth required for these technologies has led to concern over material availability and criticality. Critical materials are defined as having risks associated with them such as supply gaps or price volatility. Existing metrics for criticality determination are narrowly focused on physical scarcity of single materials, whereas many critical materials are byproducts of large, complex, interconnected material systems. Industrial ecology borrows methods from ecology to study complex material and energy flows, which can be used for a systems-perspective analysis. In this work, critical rare earth material systems …

Deadly Pleasure, Chunhui Bao

Theses

In this work, a girl’s father is one of the victims in the mass political persecution by Emperor Yongzheng, 18 A.D., and he is killed in front of his family. The Emperor is present during his murder and he notices the girl and her gorgeous, long hair. Because of this the girl survives the massacre of her entire family and is sent away and trained to become a concubine. It becomes the goal of the girl to work hard to become a chosen concubine by the Emperor so she can avenge the murder of her family with her gorgeous, magical …

Candelaria Hot Dog, Alexander Montoya

Theses

Candelaria Hotdog is a short animated film that attempts to show a personal perspective of a city’s landscape and culture. It’s a journey through the eyes of a person who treasures a simple memory and wants to make the best out of it by sharing it in a unique and comprehensible way.

La Candelaria is a historic neighborhood in Bogota Colombia, characterized by a constant display of a variety of street artists, musicians and beautiful locations that portray many of the local traditions and artistic styles of Colombia. The architecture from La Candelaria is primarily distinctive of the Spanish colonial …

Scent Of Geranium, Naghmeh Farzaneh

Theses

“Scent of Geranium” is an animated graduate thesis film, with a runtime of 4 minutes and 41 seconds. This film is a completion of an unfinished project from 2011, the year that I immigrated to the United States of America, called “The Whole World Is Watching”. Scent of Geranium is an autobiography about the challenges, fears, unexpected events and adaptation process that I experienced after my immigration. This film captures a series of memories and events that were significant to me and that have affected me in a certain way.

This film is a full color, hand-drawn animation that was …

Retopologizing Mri And Diffusion Tensor Tractography Datasets For Real-Time Interactivity, R. Scott Riddle

Theses

Current technology allows MRI and other patient data to be translated into voxel-based 3D models for the purpose of visualization. However, these voxel models are extremely complex and are not suitable for rapid real-time manipulation. For true “on-the-fly” interactivity, polygon-based models must be hand-built using other methods and imported into a game engine.This project develops an algorithm to translate complex datasets into optimized models for real-time interactivity without sacrificing accuracy of the original imaging modality. A working prototype, ready for integration into game engines, has been built with brain tumor data exported from OSIRIX1 and 3D Slicer2 via Mudbox3, retopologized …

Sex, Sexuality And Sexual Practice For Trans Individuals And Their Romantic Partners., Kinton Rossman

Electronic Theses and Dissertations

Transgender populations demonstrate significant sexual diversity, with over three-fourths (77%) of transgender individuals identifying as sexual minorities (Grant et al., 2011); however, a majority of research on sex, sexuality, and sexual practice has focused exclusively on cisgender and heterosexual individuals and, perhaps more importantly, addressed these issues a heteronormative and cisnormative perspective (Nichols, 2014). Such frameworks have created significant gaps in research about sex, sexuality, and sexual practice for trans individuals including understanding how gender transition influences sex and sexuality and how trans individuals and their partners engage in sexual practice. The current study addressed these omissions in the literature …

Putting Christians On The Map : Topographic Mosaics From Late Antique Jordan As Representations Of Authority And Status., Tracey Elizabeth Eckersley

Electronic Theses and Dissertations

In this dissertation, I examine nine ecclesiastic floor mosaics from Late Antique Palaestina and Arabia that contain topographic motifs ­­˗ images of cities set in realistic or stylized landscapes. Previous interpretations of the pavements have been limited by two assumptions: that artists or bishops were solely responsible for determining the compositions, and that only religious interpretations were intended for church pavements. Inscriptions indicating that patrons were generally lay people and iconography that encourages secular interpretations complicates both assumptions. This study investigates the mosaics in light of Late Antique euergetism in order to determine why donors included architectonic elements in the …

The Role Of O-Glcnacase During Heart Failure., Sujith Dassanayaka

Electronic Theses and Dissertations

Global augmentation of protein O-GlcNAcylation occurs in response to a myriad of stressors and confers a survival advantage at the cellular level. This protective phenomenon has been demonstrated to mediate cardioprotection through various in vitro and in vivo studies during ischemia-reperfusion, myocardial infarction, and oxidative stress; however, relatively little is known of the regulation of protein O-GlcNAcylation. Protein O-GlcNAcylation is regulated by two antagonistic enzymes, namely, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Ablation of cardiomyocyte OGT, the enzyme that catalyzes the addition of O-GlcNAc to proteins, exacerbates cardiac dysfunction during infarct-induced heart failure (HF). However, little is known of the …

Imagining The Nigerian Nation Through The West African Pilot 1960-1966., David Zintak

Electronic Theses and Dissertations

The independence era in Nigeria, ushered in after 1960 and ending in 1966 with the fall of the civilian-elected government in a military coup, was a pivotal juncture in the construction and imagining of the nation and the citizen. Ideas of what a citizen should act like, dress like, and what mindsets were proper to hold were discussed frequently in the media. One critically important media outlet during the independence era was the West African Pilot. The Pilot is generally considered an influential nationalist publication during and prior to this era. This thesis explores how Nigeria was imagined through the …

Care, Constraint, And Collaboration : Situating Gender And Power Among Multidisciplinary Human Service Organizations., Christa Jane Moore

Electronic Theses and Dissertations

This study incorporated a feminist approach to the use of multiple qualitative methods by conducting participant observation, focus group interviewing, and in-depth interviewing of women and men affiliated with a diverse representation of human service organizations. An applied research partnership with a multi-county human service organization provided entrée to the study population. Through analytic induction using a grounded theoretical approach the study explored perceptions of power, authority, gender, inequality, and bureaucratic constraints that emerged during organizational processes of interagency collaboration among multidisciplinary human service organizations (Charmaz 2014; Corbin and Strauss 2014). Findings indicate that establishing relationships is critical for interagency …

Murakami-Ego : Collective Culpability And Selective Retention., Yun Kweon Jeong

Electronic Theses and Dissertations

The purpose of this thesis is to argue that Murakami’s art expresses the Japanese’s psychological suffering by showing their struggle between remembering themselves as victims but forgetting themselves as aggressors. I apply the Mitscherlichs’ psychoanalisys of the Germans’s psyche to the Japanese because their people have had similar experiences. The first section examines the history of Japan surrounding WWII in order to demonstrate its effects on the Japanese people’s psyche. The second section introduces Otaku to better understand Murakami’s art. The third section examines how selective retention works on the Japanese’s psyche. The fourth section analyzes how Murakami’s art represents …

Memory And Fine Motor Skill Test Performance Among Children Living Near Coal Ash Storage Sites., Lindsay Koloff Tompkins

Electronic Theses and Dissertations

Coal ash, a byproduct of coal combustion,is reduced in 47 U.S. states andfrequently contains heavy metals, some of which are known neurotoxins. An estimated 1.5 million children live near sites where coal ash is produced andstored, yet there have been no studies assessing coal ash exposure and children’s neuro behavioral health. This study is part of a larger cross-sectional study, Coal Ash and Neuro behavioral Symptoms in Children Aged 6- 14 Years Old, and aimed to determine the relationship between children’s memory and fine motor skill test performance and the proximity of the home to coal ash storage sites, the …

Cannabinoids Suppress The Innate Immune Response To Periodontal Pathogen Porphyromonas Gingivalis In Gingival Epithelial Cells., Rajarshi Guha Niyogi

Electronic Theses and Dissertations

Marijuana is widely used in the United States for recreational and medicinal purposes. Despite the proposed beneficial effects of cannabis on certain medical conditions, there is also a concern there is also a concern over negative health consequences of marijuana smoking. Recently, cannabis use has been established as a dose related risk factor for chronic periodontitis. Although the induction / exacerbation of chronic periodontitis in marijuana users has been established epidemiologically, the mechanisms underlying such predisposition are still unknown. It has long been suggested that marijuana has anti-inflammatory properties, while human epithelial cells are known to express cannabinoid receptor type …

Cardiovascular And Hematopoietic Responses To Volatile Benzene Exposure., Wesley Tyler Abplanalp

Electronic Theses and Dissertations

The rapid and recent increase in the global epidemic of diabetes and cardiovascular disease suggests a strong component of the environment is contributing. Benzene is a ubiquitous volatile pollutant generated by cigarette smoke, automobile exhaust, wildfires and industrial activities. Consequently, it is found in almost all urban and rural air samples. Benzene is known to cause hematotoxicity and its metabolism generates oxidative stress. Although, benzene has been studied for many years, few investigations have probed what influence benzene exposure may have on other physiological processes. Here we hypothesize that benzene metabolism by hepatic-CYP450 2E1 generates oxidative stress and inflammation, which …

Developing A More Clinically-Relevant Mouse Model Of Cisplatin-Induced Nephrotoxicity., Cierra N. Sharp

Electronic Theses and Dissertations

Cisplatin is a nephrotoxic chemotherapeutic that causes acute kidney injury (AKI) in 30% of patients. Although recovery can occur after one episode of cisplatin-induced AKI, studies have indicated multiple episodes may lead to the development of chronic kidney disease (CKD), an irreversible disease with no current treatments. The standard mouse model of cisplatin-induced AKI consists of one, high dose of cisplatin (> 20 mg/kg) that is lethal to the animal three days later. This model doesn’t accurately reflect the repeated dosing regimen patients receive, and doesn’t allow for long-term outcome studies of pathologies associated with CKD. We have developed a …

Toll-Like Receptor 4 Mutation Suppresses Hyperhomocysteinemia-Mediated Hypertension., Anastasia Familtseva

Electronic Theses and Dissertations

Background: Hyperhomocysteinemia (HHcy) has been observed to promote hypertension, but the mechanisms are unclear. Toll-like receptor 4 (TLR-4) is a cellular membrane protein that is ubiquitously expressed in all cell types of the vasculature. TLR-4 activation has been shown to promote inflammation that has been associated with pathogenesis of hypertension. In this study, we hypothesize that HHcy induces hypertension by TLR-4 activation that promotes inflammatory cytokine up-regulation (IL-1β, IL-6, TNF-α) and initiation of mitochondrial dysfunction leading to cell death and chronic vascular inflammation. Methods: To test this hypothesis, we used C57BL/6J mice (WT); Cystathionine-β-synthase deficient mice (CBS+/-) with genetic mild …

Impact Of Luminance And Spatial Parameters On The Generation Of The Human Pattern Electroretinogram., Kate A. Godwin

Electronic Theses and Dissertations

The current work assessed some of the key hypotheses behind the generation of the pattern electroretinogram (PERG) response. The first of these hypotheses states that the PERG response is the result of linear cancellation of simultaneous increment and decrement retinal responses, as generated by the retinal ON- and OFF-pathways. Experiment 1 evaluated the possibility of simulating the PERG by summing the ERG responses elicited by increment and decrement flashes, and found that it was indeed possible to simulate the PERG from these responses. However, only the steady-state PERG could be modeled consistently. The second hypothesis evaluated a theory that the …

Effects Of Neonatal Capsaicin On Formalin-Induced Atf3 Expression In The Adult Rat., Sarah Krupp

Electronic Theses and Dissertations

Acute and chronic pain can be extremely debilitating conditions, and a better understanding of their underlying pathology is necessary to provide effective treatment. C-Fibers are responsible for transmission of the majority of nociceptive signals, with TRPV1+ C-Fibers being specific to noxious heat. Formalin, an inflammatory agent, acts through TRPA1+ C-Fibers, which have a high degree of co-localization with TRPV1. Using a neonatal capsaicin preparation, which irreversibly ablates the majority of TRPV1+ C-Fibers, formalin- induced inflammation and subsequent ATF3 expression was investigated. Results provide evidence that in addition to a lack of thermal nociception, animals treated with neonatal capsaicin had a …

Microfluidic Platform For Impedance Characterization Of Endothelial Cells Under Fluid Shear Stress., Vanessa Velasco

Electronic Theses and Dissertations

Endothelium dysfunction has been associated with many pathophysiological processes leading to cardiovascular diseases. Studying endothelium behavior is vital to understand the onset, prevention, and treatment of such diseases. Electrical impedance spectroscopy has been shown to provide a real-time in vitro evaluation of cell behavior including cell monolayer permeability. However, the majority of published work has been primarily with static cell culture models or macro-scale models that do not properly represent the physiological sizes, structures, and environmental conditions of human blood vessels. Within this dissertation, the design, fabrication, characterization, and application of a microfluidic impedance platform is presented for the in …

The Discovery Of A Novel, Ras-Mediated Nore1a/Pmliv Tumor Suppressor Complex., Jessica Mezzanotte Sharpe

Electronic Theses and Dissertations

Ras is the most commonly activated oncogene in human cancer. Activated Ras drives cell growth and proliferation by activating multiple mitogenic signaling pathways. However, Ras also has the paradoxical ability to promote anti-growth, pro-apoptotic, and pro-senescent signaling. The signaling pathways of many of these biological effectors remain poorly defined. One group of proteins capable of promoting Ras-induced apoptosis and cell cycle arrest is the RASSF family of tumor suppressors. Novel Ras Effector 1A, or NORE1A, was the first member of this family discovered and is a bona fide tumor suppressor that is lost or inactivated in a number of different …

In Vivo Monitoring Of Therapeutic Efficacy And Virulence Profile By Bioluminescent Klebsiella Pneumoniae., Ramy Ameen Fodah

Electronic Theses and Dissertations

Klebsiella pneumoniae causes an acute respiratory infection in human with severe outcomes and high mortality rates even with antibiotic treatment. Even with its critical clinical importance, few virulence systems have been identified for K. pneumoniae limiting the development of new therapeutic strategies. Accordingly, we performed Next Generation sequencing for the strain ATCC 43816, a virulent strain in mouse respiratory disease models, and compared its genomic data with two previously sequenced strains NTUH-K2044 and MGH 78578 for the purpose of identifying genes required for colonizing host lungs. Furthermore, the virulence potential of the three K. pneumoniae strains were tested in a …

A Systems Biology Approach Identifies A Gene Regulatory Network In Parotid Acinar Cell Differentiation., Melissa Ann Metzler

Electronic Theses and Dissertations

Objective: This project sought to understand the gene regulatory networks that drive parotid salivary gland acinar cells to terminally differentiate, and drive expression of terminal differentiation genes in dedifferentiated ParC5 cells. Methodology: Laser capture microdissection was used to isolate acinar cells at multiple time points during differentiation. This important step allowed us to measure gene expression in a single and important cell type. A systems biology approach was taken to measure global mRNA and microRNA expression across acinar cell terminal differentiation in the rat parotid salivary gland. In ParC5 cells, the ER stress activator tunicamycin was used to stimulate Xbp1 …

The Role Of The Nucleolus In Neurodegeneration., Justin Lauren Hallgren

Electronic Theses and Dissertations

The overarching goal of my studies was to determine the role of the nucleolus in neurodegenerative disease. Numerous studies suggest the impairment of ribosomal biogenesis in neurodegenerative disease and such a condition may contribute to neuronal dysfunction in two ways, loss of function and stress response. Ribosomal biogenesis has been demonstrated to play an essential role in both neuronal growth and maintenance. Therefore insufficient levels of ribosomal biogenesis would be expected to produce atrophy and synapse loss. Moreover, the fidelity of ribosomal biogenesis is monitored by nucleolar and ribosomal stress responses which induce apoptosis and/or cell cycle arrest. Therefore, I …

The Available Means Of Imagination : Personal Narrative, Public Rhetoric, And Circulation., Stephanie D. Weaver

Electronic Theses and Dissertations

This dissertation examines the digital circulation of personal narratives by non-celebrity individuals that become part of larger public and political debates. I posit the “available means of imagination” to describe the ways that narratives – cultural, fictional, and personal – influence our ability to understand the many facets of a given public debate before tracing the interactions among narrative, emotion, and circulation in a series of case studies using new materialist methods. I argue that emotion plays a key role in structures of participation of social media and in how we subsequently engage with contemporary political issues, especially with regards …

Effects Of Different Dosages Of Oxycodone And Fentanyl On The Hemodynamic Changes During Intubation, Ki-Bum Park, Junggun Ann, Haemi Lee

Saudi Medical Journal

Objectives: To investigate the effectiveness of oxycodone compared with fentanyl for attenuating the hemodynamic response during endotracheal intubation. Methods: This study was conducted from June 2014 to February 2015 on healthy adults undergoing general anesthesia at the Yeungnam University Hospital, Daegu, Republic of Korea. Ninety-five patients were randomly assigned to one of 3 groups to receive the following drugs; Group F: fentanyl 2 µg/kg; Group O/70: oxycodone 140 µg/kg; Group O/100: oxycodone 200 µg/kg. Five minutes after injection of the study drug, general anesthesia was induced with propofol 1.5 mg/kg and rocuronium 0.8 mg/kg. The mean blood pressure (MBP), heart …

Mitral Valve Repair For Ischemic Moderate Mitral Regurgitation In Patients Undergoing Coronary Artery Bypass Grafting, Faruk Toktas, Senol Yavuz, Kadir K. Ozsin, Umut S. Sanri

Saudi Medical Journal

Objectives: To investigate whether mitral valve repair (MVR) at the time of coronary artery bypass grafting (CABG) in patients with ischemic moderate mitral regurgitation (MR) and coronary artery disease could improve short- and mid-term postoperative outcomes. Methods: Between March 2013 and December 2015, 90 patients with moderate ischemic MR underwent first-time CABG in Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. Out of 90 patients, 44 (48.9%) underwent combined CABG+MVR. The remaining 46 (51.1%) underwent CABG alone. Ventricular functions and effort capacities of patients in both groups were evaluated echocardiographically and clinically in the preoperative period, and in the …

Approved For All Audiences: A Longitudinal Content Analysis Of The Portrayal Of Women In Movie Trailers, Brooke S. O’Neil

Masters Theses

Movie trailers are ever present in our society and impactful in the way society constructs views about various aspects of life. Trailers are unique in that they are specifically tailored and edited to entice audiences to buy tickets to the film. Further, prior research has indicated that in various forms of media, women are continuously underrepresented, disproportionately sexualized, stereotyped, and victimized. The present study examines the portrayal of women through a content analysis of 230 of the top grossing trailers across seven decades: 1950-2015. The research focuses on women’s representation, sexualization, gender roles, and violence. The analysis reveals that in …

Snatching Defeat From The Jaws Of Victory: The Curious Case [Study] Of California’S Proposition 37, Dave Brundage

Masters Theses

In 2012, California became the first state to qualify a ballot measure for public vote on the topic of genetically modified food labeling. Proposition 37, The California Right to Know Genetically Engineered Food Act, enjoyed overwhelming support leading up to the November elections. However, an 11th hour surge by the opposition led to its defeat. This case study examines the media messages deployed by the pro and antilabeling groups in an effort to understand how each side attempted to curry favor to their cause. Content analysis was performed on 27 television, radio, and internet advertisements broadcast during the campaign. Focused …

Experimental Assessment Of Floating Seagrass Wrack As Potential Habitat For Benthic Organisms, Joseph R. Mcginnis

Theses, Dissertations and Culminating Projects

During the summer, seagrass blades are frequently released into the water column as a method to reduce respiration demands of the plant and through physical disruption of the bed (e.g., crab foraging, boat propellers). This wrack has the potential to serve as both food and habitat for organisms dislodged or actively moving within the system. The purpose of this research was to determine how benthic organisms may use floating wrack as a food resource and shelter. Three experimental floating wrack bag treatments were assembled containing using artificial Zoster a marina (i.e., poly-ribbon), Z. marina blades, and a wrack bag control …