Digital Commons Network^™

Optimal Design Of Low-Density Snp Arrays For Genomic Prediction: Algorithm And Applications, Xiao-Lin Wu, Jiaqi Xu, Guofei Feng, George R. Wiggans, Jeremy F. Taylor, Jun He, Changsong Qian, Jiansheng Qiu, Barry Simpson, Jeremy Walker, Stewart Bauck

Department of Statistics: Faculty Publications

Low-density (LD) single nucleotide polymorphism (SNP) arrays provide a cost-effective solution for genomic prediction and selection, but algorithms and computational tools are needed for the optimal design of LD SNP chips. A multiple-objective, local optimization (MOLO) algorithm was developed for design of optimal LD SNP chips that can be imputed accurately to medium-density (MD) or high-density (HD) SNP genotypes for genomic prediction. The objective function facilitates maximization of non-gap map length and system information for the SNP chip, and the latter is computed either as locus-averaged (LASE) or haplotype-averaged Shannon entropy (HASE) and adjusted for uniformity of the SNP distribution. …

Keats, Truth, And Empathy, Peter Shum

Sophia and Philosophia

At one level, Keats’s sonnet entitled On Peace (1814) is full of philosophical certainties. The speaker believes, for example, that a nation’s people have a right to live in freedom under the rule of law, and that the rule of law should be applicable to everybody. Political and philosophical commitments of this kind do not seem to be called into question in this poem, or made the subject of an enquiry. On the contrary, it is as though we are confronted with somebody who, in certain central thematic respects at least, appears to know his own mind.

The Rhetoric Of Tyranny: Callicles The Rhetor And Nietzsche's Zarathustra, Greg Whitlock

Sophia and Philosophia

Here I will work through the rhetoric of tyranny as practiced by Callicles and as reflected in Nietzsche’s Zarathustra, in particular. In Part 2 it will be shown that Nietzsche’s account of Plato as the complex figure with a Socratic exterior but a latent alternative ego of the tyrant, arrived at an image consistent with E.R. Dodds’ later thesis. Callicles the rhetor, featured as a student of Gorgias, embodies this alter-ego. In Part 3 we find Callicles and Zarathustra shared very similar beliefs once they overcame shame and gained honesty. Indeed, Callicles expounded a number of propositions foundational to …

The Problem Of Obviousness, Benjamin Goldberg

Sophia and Philosophia

1. The Problem of Obviousness
There’s no such thing as obviousness.

This isn’t, of course, itself obvious; nor is it clear why it should be a problem. So let me start elsewhere, with the anti-vaccine movement. A friend of mine laid out the ‘obvious’ position: there are facts and rationality on one side, unenlightened ignorance and bigotry on the other. Scientists versus fools, and the fools don’t even know what game is being played.

Understanding Nitrogen Sources In The Great Bay Watershed, Michelle L. Daley

New Hampshire EPSCoR

No abstract provided.

Isu Today- September 9, 2016, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Ansc, Fall 2016, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science Newsletter

"Dedicated to the Alumni and Friends of the Animal Sciences Department, University of Arkansas."

Invisible Children: The Effectiveness Of Non-Governmental Organizations (Ngos) In Primary Education In Central America, Megan Skaggs

Mahurin Honors College Capstone Experience/Thesis Projects

what extent are non-governmental organizations (NGOs) an effective tool in primary educational development in Central America? To address this concern, this project addressed the results of several months of research in Nicaragua, Guatemala, and at the U.S. NGO headquarters, where interviews with educators, NGO workers, and citizens were conducted regarding the role of NGOs in addressing educational concerns effectively. Interviewees included: Pueblo a Pueblo, Serving Orphans Worldwide, U.S. Agency for International Development, Let Girl’s Learn Program, and varied individuals connected with education or non-profit work in that region. My research analyzed the historical and social structures of Nicaragua and Guatemala, …

The Effects Of Drought On Diets Of Apex Predators In The South African Lowveld Inferred By Fecal Hair Analysis, Shelby Wade

Mahurin Honors College Capstone Experience/Thesis Projects

To properly manage offtake quotas and conservation efforts, Balule Nature Reserve (South Africa) instituted a study in 2014 to determine prey species selection by megapredators. In 2015, Balule Nature Reserve received about 190 mm less rainfall between the months of January and June than in 2014 (116 mm less than average). This study compares the diets of lions and hyaenas between 2014 and 2015. Prey species consumed were determined by fecal analysis, and results were compared to prey availability. Sixteen, 1 km2 plots were chosen from the 400 km2 Reserve. Between June and August 2015, we walked three, 1 km …

America Abandoned: German-Jewish Visions Of American Poverty In Serialized Novels By Joseph Roth, Sholem Asch, And Michael Gold, Kerry Wallach

German Studies Faculty Publications

In 1930, Hungarian- born Jewish author Arthur Holitscher’s book Wiedersehn mit Amerika: Die Verwandlung der U.S.A. (Reunion with America: The Trans-formation of the U.S.A.) was reviewed by one J. Raphael in the German- Jewish Orthodox weekly newspaper, Der Israelit. This reviewer concluded: “Despite its good reputation, America is a strange country. And Holitscher, whose relationship to Judaism is not explicit, but direct, has determined that to be the case for American Jews as well.” The reviewer’s use of the word “strange” (komisch) offers powerful insight into the complex perceptions of America held by many …

State-Level Regulation As The Ideal Foundation For Action On Climate Change: A Localized Beginning To The Solution Of A Global Problem, Allison C.C. Hoppe

Cornell Law Review

No abstract provided.

Curriculum Subcommittee Agenda, September 1, 2016, Utah State University

Educational Policies Committee

Semester Course Approval Reviews

Program Proposals

• Changing the name from Agricultural Economics to Applied Economics
• Offering a Minor in Residential Landscape Design
• Adding a Forest Ecology Specialization to the MS and PhD programs of the Department of Wildland Resources

Other

• Approving Prerequisites
• Curriculog updates and site changes

The Connection, Fall 2016, Lindenwood University

The Connection (1989-2017)

Lindenwood University Alumni Magazine

Haworth College Of Business News (09/2016), Haworth College Of Business

Haworth College of Business News

• COLLEGE TO HONOR ALUMNI
• HOMECOMING IS OCT. 8
• FROM FBI TO FREELANCE
• PROMOTION CEREMONY

2016 Annual Accountability Report, Clemson University

Accountability Reports

Clemson University's 2015-2016 Annual Accountability Report submitted to the South Carolina Budget and Control Board.

Weather-Related Sales Of Livestock, Jc Hobbs

Rural Tax Education

There are two provisions in tax law that attempt to cushion producers from the consequences of adverse weather-related livestock sales. Under the first provision, livestock held for draft, breeding, or dairy purposes and sold due to adverse weather are provided a two-year reinvestment period. This replacement period can be extended if weather conditions persist for more than three years. The second provision, which applies to all livestock (other than poultry), allows cash basis taxpayers whose primary trade or business is farming to defer receipt from sales in excess of normal business practices due to weather-related conditions that result in a …

Book Review: Planning For Rural Resilience: Coping With Climate Change And Energy Futures, Kala Chakradhar

Contemporary Rural Social Work Journal

Book Review: Planning for rural resilience: Coping with climate change and energy futures Wayne. J. Caldwell (Ed.) 2015 Winnipeg, Canada: University of Manitoba Press 165 pages Softcover: $31.95 US ISBN-13: 978-0-88755-780-4

Design, Development And Evaluation Of A Compact Telerobotic Catheter Navigation System., Mohammad Ali Tavallaei, Daniel Gelman, Michael Konstantine Lavdas, Allan C Skanes, Douglas L Jones, Jeffrey S Bax, Maria Drangova

Medical Biophysics Publications

BACKGROUND: Remote catheter navigation systems protect interventionalists from scattered ionizing radiation. However, these systems typically require specialized catheters and extensive operator training.

METHODS: A new compact and sterilizable telerobotic system is described, which allows remote navigation of conventional tip-steerable catheters, with three degrees of freedom, using an interface that takes advantage of the interventionalist's existing dexterity skills. The performance of the system is evaluated ex vivo and in vivo for remote catheter navigation and ablation delivery.

RESULTS: The system has absolute errors of 0.1 ± 0.1 mm and 7 ± 6° over 100 mm of axial motion and 360° of …

A Quantitative Comparison Of The Hemispheric, Areal, And Laminar Origins Of Sensory And Motor Cortical Projections To The Superior Colliculus Of The Cat., Blake E Butler, Nicole Chabot, Stephen G Lomber

Brain and Mind Institute Researchers' Publications

The superior colliculus (SC) is a midbrain structure central to orienting behaviors. The organization of descending projections from sensory cortices to the SC has garnered much attention; however, rarely have projections from multiple modalities been quantified and contrasted, allowing for meaningful conclusions within a single species. Here, we examine corticotectal projections from visual, auditory, somatosensory, motor, and limbic cortices via retrograde pathway tracers injected throughout the superficial and deep layers of the cat SC. As anticipated, the majority of cortical inputs to the SC originate in the visual cortex. In fact, each field implicated in visual orienting behavior makes a …

Deaf Catholic Newsletter, Fall 2016

Deaf Catholic Newsletter

A newsletter published for Deaf Catholics in Philapelphia, PA

Deaf Catholic Newsletter Finding Aid

Legal Anarchism: Does Existence Need To Be Regulated By The State, Sirus Kashefi

PhD Dissertations

This thesis asks does existence need to be regulated by the State? The answer relies on legal anarchism, an interdisciplinary, particularly criminal law and philosophy, and unconventional research project based on multiple methodologies with a specific language. It critically analyzes and consequently rejects State law because of its unjustified and unnecessary nature founded on unlimited violence and white-collar crime (Chapters 1-4), on the one hand, and suggests some alternatives to the Governmental legal system founded on agreement and peace (Chapter 5), on the other hand. It furthermore takes into account the elements of time and space, which means the ecological, …

Nmr Analysis Of T‐Butyl‐Catalyzed Deuterium Exchange At Unactivated Arene Localities, Douglas E. Stack, Rachel Eastman

Chemistry Faculty Publications

Regioselective labelling of arene rings via electrophilic exchange is often dictated by the electronic environment caused by substituents present on the aromatic system. Previously, we observed the presence of a t‐butyl group, either covalently bond or added as an external reagent, could impart deuterium exchange to the unactivated, C1‐position of estrone. Here, we provide nuclear magnetic resonance analysis of this exchange in a solvent system composed of 50:50 trifluoroacetic acid and D2O with either 2‐t‐butylestrone or estrone in the presence of t‐butyl alcohol has shed insights into the mechanism of this t‐butyl‐catalyzed exchange. Fast exchange of the t‐butyl group concurrent …

Identification Of Pathway-Specific Serum Biomarkers Of Response To Glucocorticoid And Infliximab Treatment In Children With Inflammatory Bowel Disease, Christopher R. Heier, Alyson A. Fiorillo, Ellen Chaisson, Heather A. Gordish-Dressman, Yetrib Hathout, Jesse M. Damsker, Eric P. Hoffman, Laurie S. Conklin

Genomics and Precision Medicine Faculty Publications

Objective:

Serum biomarkers may serve to predict early response to therapy, identify relapse, and facilitate drug development in inflammatory bowel disease (IBD). Biomarkers are particularly important in children, in whom achieving early remission and minimizing procedures are especially beneficial.

Methods:

We profiled protein and micro RNA (miRNA) in serum from patients pre- and post-therapy, to identify molecular markers of pharmacodynamic effect. Serum was obtained from children with IBD before and after treatment with either corticosteroids (prednisone; n=12) or anti-tumor necrosis factor-α biologic (infliximab; n=7). Over 1,100 serum proteins were assayed using aptamer-based SOMAscan proteomics, and 22 miRNAs analyzed …

Irisin Lowers Blood Pressure By Improvement Of Endothelial Dysfunction Via Ampk‐Akt‐Enos‐No Pathway In The Spontaneously Hypertensive Rat, Jinjuan Fu, Yu Han, Jialiang Wang, Yukai Liu, Shuo Zeng, Lin Zhou, Pedro A. Jose, Chunyu Zeng

Medicine Faculty Publications

Background Exercise is a major nonpharmacological treatment for hypertension, but its underlying mechanisms are still not completely elucidated. Irisin, a polypeptide containing 112 amino acids, which is secreted mainly by skeletal muscle cells during exercise, exerts a protective role in metabolic diseases, such as diabetes mellitus and obesity. Because of the close relationship between irisin and metabolic diseases, we hypothesized that irisin may play a role in the regulation of blood pressure.

Methods and Results Blood pressures of male Wistar‐Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs) were monitored through the carotid artery. Our study found that acute intravenous injection …

Joseph Curry V. Brianne Yachera

2016 Decisions

USDC for the Eastern District of Pennsylvania

Phl 210e.01: Moral Philosophy, Bridget Clarke

University of Montana Course Syllabi

No abstract provided.

Variation In The Glucose Transporter Gene Slc2a2 Is Associated With Glycemic Response To Metformin, Kaixin Zhou, Sook-Wah Yee, Eric L. Seiser, Nienke Van Leeuwen, Roger Tavendale, Amanda J. Bennett, Christopher J. Groves, Ruth L. Coleman, Amber A. Van Der Heijden, Joline W. Beulens, Catherine E. De Keyser, Linda Zaharenko, Daniel M. Rotroff, Mattijs Out, Kathleen A. Jablonski, Ling Chen, Martin Javorský, Jozef Židzik, Albert M. Levin, Keoki L. Williams, Tanja Dujic, Sabina Semiz, Michiaki Kubo, Huan-Chieh Chien, Shiro Maeda, John S. Witte, Longyang Wu, Ivan Tkáč, Adriaan Kooy, Ron Hn Van Schaik, Coen Da Stehouwer, Lisa Logie, Calum Sutherland, Janis Klovins, Valdis Pirags, Albert Hofman, Bruno H Stricker, Alison A Motsinger-Reif, Michael J Wagner, Federico Innocenti, Leen M 'T Hart, Rury R Holman, Mark I Mccarthy, Monique M Hedderson, Colin N A Palmer, Jose C Florez, Kathleen M Giacomini, Ewan R Pearson

Internal Medicine Articles

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 × 10(-14)) greater metformin-induced reduction in hemoglobin A1c (HbA1c) in 10,577 participants of European ancestry. rs8192675 was the top cis expression quantitative trait locus (cis-eQTL) for SLC2A2 in 1,226 human liver samples, suggesting a key role …

Writers Harvest The Poetry Of Kathryn Nuernberger, Sept. 22, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

How Did The Deepwater Horizon Oil Spill Impact Deep-Sea Ecosystems?, Charles R. Fisher, Paul A. Montagna, Tracey Sutton

Marine & Environmental Sciences Faculty Articles

Approximately 90% of the volume of the Gulf of Mexico is contained in water deeper than 200 m, a region where the Deepwater Horizon (DWH) blowout had more impact on ecosystems than any previous oil spill. The remoteness and relative inaccessibility of the deep sea makes documenting even acute impacts to the animals that live in this realm difficult. This article reviews Natural Resource Damage Assessment studies and follow-up work funded as part of the Gulf of Mexico Research Initiative that targeted deepwater pelagic and benthic fauna. Oil was incorporated into the pelagic food web, and a reduction in planktonic …

Exploring Determinants Of Handwashing With Soap In Indonesia: A Quantitative Analysis, Mitsuaki Hirai, Jay P. Graham, Kay Mattson, Andrea Kelsey, Supriya Mukherji, Aidan Cronin

Environmental and Occupational Health Faculty Publications

Handwashing with soap is recognized as a cost-effective intervention to reduce morbidity and mortality associated with enteric and respiratory infections. This study analyzes rural Indonesian households’ hygiene behaviors and attitudes to examine how motivations for handwashing, locations of handwashing space in the household, and handwashing moments are associated with handwashing with soap as potential determinants of the behavior. The analysis was conducted using results from a UNICEF cross-sectional study of 1700 households in six districts across three provinces of Indonesia. A composite measure of handwashing with soap was developed that included self-reported handwashing, a handwashing demonstration, and observed handwashing materials …