Digital Commons Network^™

Building A Better Naked-Mole Rat Trap Mems 411- Senior Design Course, Alex Flammond, Lance Middleton, Andrew Chang

Mechanical Engineering Design Project Class

In this paper, we design, analyze, test, and construct an improved naked mole rat trap for Prof. Stan Braude of Washington University in St. Louis.

Compact Furniture Dolly, Gary Hu, Jieun Yim, Jason Xie, Jiayi Hou

Mechanical Engineering Design Project Class

One problem faced by people during moving is how to move large pieces of furniture, i.e. sofa, mattress, table, refrigerator, etc., conveniently without damaging them. A typical small dolly is incapable of carrying such large pieces, and a bulky dolly is inappropriate for an indoor use because it can damage the furniture and the floor. Besides, in either case, the user should lift up and put the load on the dolly. People who want to change positions of their furniture regularly to get a fresh look for the house, it is cumbersome to call a moving company every time. Our …

Contributions Of Television Use To Beliefs About Fathers And Gendered Family Roles Among First-Time Expectant Parents, Patty X. Kuo, L. Monique Ward

Department of Child, Youth, and Family Studies: Faculty Publications

TV content has been documented to portray a limited range of gender roles, and to frequently depict fathers as incompetent parents. Accordingly, this study explored whether first-time expectant parents’ beliefs about gendered family roles and the importance of fathers to child development were related to their TV use. Participants were 201 individuals (122 women, 79 men) from across the United States expecting their first biological child in a cohabiting heterosexual relationship. Participants completed an online survey assessing weekly TV exposure, exposure to TV programs featuring fathers, perceived realism of TV, use of TV to learn about the world, and beliefs …

Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity And Widespread Co-Losses Of Chromatin Regulators In Clear Cell Renal Cell Carcinoma., Wei Jiang, Essel Dulaimi, Karthik Devarajan, Theodore Parsons, Qiong Wang, Lili Liao, Eun-Ah Cho, Raymond O'Neill, Charalambos C. Solomides, Stephen C. Peiper, Joseph R Testa, Robert Uzzo, Haifeng Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Recent studies have shown that intratumoral heterogeneity (ITH) is prevalent in clear cell renal cell carcinoma (ccRCC), based on DNA sequencing and chromosome aberration analysis of multiple regions from the same tumor. VHL mutations were found to be universal throughout individual tumors when it occurred (ubiquitous), while the mutations in other tumor suppressor genes tended to be detected only in parts of the tumors (subclonal). ITH has been studied mostly by DNA sequencing in limited numbers of samples, either by whole genome sequencing or by targeted sequencing. It is not known whether immunohistochemistry (IHC) can be used as a tool …

Rabbit Control: Bait Stations, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

This factsheet provides information on using bait stations for rabbit control.

Biological control agents such as the myxoma virus (myxomatosis), and rabbit haemorraghic disease virus (RHDV) or rabbit calicivirus disease, will not provide ‘magic bullets’ for reducing the impact of rabbits on agricultural production and the environment. Biological agents are more effective when they form part of an integrated approach to rabbit control. An integrated approach should use all available control options, including biological control, the use of vertebrate pesticides, shooting, and trapping programs. Control programs are most effective when they include the greatest number of properties possible (that is, …

Developing Capabilities: A Feminist Discourse Ethics Approach, Chad Kleist

Dissertations (1934 -)

This dissertation attempts to preserve the central tenets of a global moral theory called “the capabilities approach” as defended by Martha Nussbaum, but to do so in a way that better realizes its own goals of identifying gender injustices and gaining cross-cultural support by providing an alternative defense of it. Capabilities assess an individual’s well-being based on what she is able to do (actions) and who she is able to be (states of existence). Nussbaum grounds her theory in the intuitive idea that each and every person is worthy of equal respect and dignity. The problem with grounding a theory …

Depletion Of The Rna Helicase Skiv2l2 Impedes Mitotic Progression And Histone Mrna Turnover In Murine Cell Lines, Alexis Marie Onderak

Dissertations (1934 -)

RNA surveillance via the nuclear exosome requires cofactors such as the helicase SKIV2L2 to process and degrade certain noncoding RNAs. This dissertation aimed to characterize the phenotype associated with RNAi knockdown of SKIV2L2 in two murine cancer cell lines: Neuro2A and P19. Skiv2l2 knockdown in Neuro2A and P19 cells induced changes in gene expression indicative of cell differentiation and reduced cellular proliferation. Analysis of the cell cycle revealed defective progression through mitosis following SKIV2L2 depletion. These results indicate that SKIV2L2 enhances mitotic progression, thereby maintaining cancer cell proliferation and preventing differentiation. Indeed, SKIV2L2 levels were found to be downregulated during …

Finding Meaning And Sensemaking In Hospital Nursing Teams: The Promise Of Narrative Medicine, Shelley Bobb

Dissertations (1934 -)

Purpose. Narrative medicine is an innovative field that has provided meaning and increased communication between health care providers and their patients. This study explored the significance and nature of the practice of Narrative Medicine and what impact this had with NICU nurses on their team interaction with respect to team functioning, sense-making, and vocational understanding. This study seeks to provide nursing teams another tool to find meaning in their work and strengthen their teamwork. Using Narrative Medicine and the theory of phenomenology, this is a new approach that may bring nurses to draw on fresh ways to engage their work …

Reskins: The Property Right To Racism, M. Alexander Pearl

Cardozo Law Review

Everyone has an opinion, from President Obama to Matthew McConaughey, about the Washington football team name. This Article comprehensively analyzes the legal and social issues surrounding the mascot controversy. I focus my inquiry on the interaction of trademark law and Indian law. I offer three primary contributions in this Article. First, the current mainstream conception of harm caused by the team name is subjective, and I argue that the harm caused by the team name and logo is objective, testable, and demonstrable, Psychological research shows that these images harm Native people. Second, the remedies offered by the Lanham Act are …

Rapid Evolutionary Rates And Unique Genomic Signatures Discovered In The First Reference Genome For The Southern Ocean Salp, Salpa Thompsoni (Urochordata, Thaliacea), Nathaniel K. Jue, Paola G. Batta-Lona, Sarah Trusiak, Craig Obergfell, Ann Bucklin, Michael J. O’Neill, Rachel J. O’Neill

School of Natural Sciences Faculty Publications and Presentations

A preliminary genome sequence has been assembled for the Southern Ocean salp, Salpa thompsoni (Urochordata, Thaliacea). Despite the ecological importance of this species in Antarctic pelagic food webs and its potential role as an indicator of changing Southern Ocean ecosystems in response to climate change, no genomic resources are available for S. thompsoni or any closely related urochordate species. Using a multiple-platform, multiple-individual approach, we have produced a 318,767,936-bp genome sequence, covering >50% of the estimated 602 Mb (±173 Mb) genome size for S. thompsoni. Using a nonredundant set of predicted proteins, >50% (16,823) of sequences showed significant homology …

Effects Of Nicotine On Bone During Orthodontic Tooth Movement In Male Rats: Histological And Immunohistochemical Study, Manal A. Bakathir, Amal I. Linjawi, Samia S. Omar, Ahad B. Aboqura, Ali H. Hassan

Saudi Medical Journal

Objectives: To investigate the effects of nicotine on orthodontic tooth movement and accompanying histological and immunohistochemical changes in rats. Methods: An experimental study conducted at King Abdulaziz University, Jeddah, Saudi Arabia between 2013 and 2014. Thirty-two rats randomly divided into 4 groups. Three were experimental, received daily nicotine injections: group A: 0.37 mg/kg, group B: 0.57 mg/kg, and group C: 0.93 mg/kg. The control group (group D) received a daily injection of 0.5 mL saline. All rats were subjected to 30 g of orthodontic force on the maxillary left first molars and incisors using a nickel-titanium closed-coil spring. The distance …

Philosophy And Theology: Reflections On Interests And Regret, Christopher Kaczor

Philosophy Faculty Works

The article provides an assessment of the burdens of continuing a pregnancy. Topics discussed include the burdens and costs of abortion, anecdotal evidence regarding feelings of regret after opting for abortion, reference to the book "A Defense of Abortion" by David Boonin, and the violinist argument, which must take account of the possible burdens of a crisis pregnancy.

Wrl Newsletter October 2016, Rebecca L. Seipp

WRL Newsletters

No abstract provided.

Evaluation And Management Of Sleep Disorders In The Hand Surgery Patient., Michael P. Gaspar, Patrick M. Kane, Sidney M. Jacoby, Patrick S. Gaspar, A. Lee Osterman

Department of Orthopaedic Surgery Faculty Papers

Despite posing a significant public health threat, sleep disorders remain poorly understood and often underdiagnosed and mismanaged. Although sleep disorders are seemingly unrelated, hand surgeons should be mindful of these because numerous conditions of the upper extremity have known associations with sleep disturbances that can adversely affect patient function and satisfaction. In addition, patients with sleep disorders are at significantly higher risk for severe, even life-threatening medical comorbidities, further amplifying the role of hand surgeons in the recognition of this condition.

It Could Have Been Great: An Examination Of Kandinsky's Bauhaus Paintings And The Great Synthesis Of The Arts, Deanna Brooks

Institute for the Humanities Theses

When Nazism descended upon the German art world in the late 1920s and throughout the 1930s, artists were treated as an expendable group of "political undesirables." Among them was Russian painter Wassily Kandinsky (1866-1944), who experienced firsthand the political pressure placed on his career, as he attempted to visualize a weltanschauung or "world view," that involved the marriage of different types of art, media, and practices. For Kandinsky the "Great Synthesis of the Arts" revealed the collective historical narrative, to which all artists contributed, and he strove to actualize this lifelong goal over the course of his teaching career at …

Teaching Record-Keeping Skills To 4-H Youths Through Experiential Learning Techniques, Tyanne J. Roland, Meredith Fisher

Journal of Extension

Teaching record keeping for breeding projects in a way that keeps youths engaged is a difficult task. The activity discussed in this article was used to teach 4-H participants the importance of record keeping by implementing the experiential learning model and without lecturing. A description of the activity, instructions and materials for the activity, and responses to the activity are presented.

Growing Our Own: A Longitudinal Evaluation Of A Professional Development Program For Early-Career 4-H Professionals, Gary F. Varrella, Brian P. Luckey, Jacqueline S. Baca, Curt Peters

Journal of Extension

We present the results of a longitudinal evaluation of the Western Region 4-H Institute, a 5-day training program designed to enhance the skill sets of early-career Extension professionals organized around the 4-H professional research, knowledge, and competencies model. Programs such as this often are assessed for their short-term relevance and effectiveness; we expanded the scope of our evaluation by following up with program participants 12 months after the program. Both short- and medium-term results indicated that networking and developing effective programs for youth were paramount for participants, suggesting the importance of providing professional development opportunities for early-career professionals.

Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors, Adam J. Prus, Laura E. Wise, Alan Pehrson, Scott D. Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H. Porter

Department of Psychology Faculty Scholarship and Creative Works

The atypical antipsychotic drug clozapine remains one of most effective treatments for schizophrenia, given a lack of extrapyramidal side effects, improvements in negative symptoms, cognitive impairment, and in symptoms in treatment-resistant schizophrenia. The adverse effects of clozapine, including agranulocytosis, make finding a safe clozapine-like a drug a goal for drug developers. The drug discrimination paradigm is a model of interoceptive stimulus that has been used in an effort to screen experimental drugs for clozapine-like atypical antipsychotic effects. The present study was conducted to elucidate the receptor-mediated stimulus properties that form this clozapine discriminative cue by testing selective receptor ligands in …

Decorating Behavior And Decoration Preference In The Masking Crab, Loxorhynchus Crispatus, Catherine Anne Drake

Capstone Projects and Master's Theses

Organisms adapt to responses in their environment, and over time if that adaptation is successful in increasing survival within the population, the species will evolve accordingly. An example of induced evolution is through predator-­prey interactions. As a predator hunts its prey, the prey must find ways to avoid predation in order to survive. Evolved traits or behaviors to avoid predation include escape through size refuge, various physical or chemical defensive strategies, vertical migration through a water column, inducible morphological shifts, unpalatability, mimicry, or camouflage. To camouflage oneself, organisms have been observed to use coloration or change their shape—morphological changes to …

Hutus Aiding Tutsis During The Rwandan Genocide: Motives, Meanings And Morals, Daniel Rothbart, Jessica Cooley

Genocide Studies and Prevention: An International Journal

During the Rwandan genocide of 1994, Hutu extremists who launched a propaganda campaign to demonize Rwandan Tutsis, accusing them of planning to exterminate Hutus. Embracing the propaganda, gangs of Hutus went on a killing rampage, rooming the streets and ravaging Tutsis who fell prey to their assaults. Yet, the framing of Hutus as perpetrators cannot capture the work of those Hutus who actively offered assistance to Tutsis. These Hutus provided safe haven, essential material goods and emotional support to an unknown number of Tutsis. Why did these Hutus risk their lives to save Tutsis? In addressing this question, we provide …

From Economic Inequality To Economic Freedom: Constitutional Political Economy In The New Gilded Age, K. Sabeel Rahman

Faculty Scholarship

No abstract provided.

Talin2-Mediated Traction Force Drives Matrix Degradation And Cell Invasion, Lei Qi, Naser Jafari, Xiang Li, Zaozao Chen, Liqing Li, Vesa P. Hytönen, Benjamin T. Goult, Chang-Guo Zhan, Cai Huang

Markey Cancer Center Faculty Publications

Talin binds to β-integrin tails to activate integrins, regulating cell migration, invasion and metastasis. There are two talin genes, TLN1 and TLN2, encoding talin1 and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear and, indeed, talin2 has been presumed to function redundantly with talin1. Here, we show that talin2 has a much stronger binding to β-integrin tails than talin1. Replacement of talin2 Ser339 with Cys significantly decreased its binding to β1-integrin tails to a level comparable to that of talin1. Talin2 localizes at invadopodia and is indispensable …

Stable Engraftment Of Bifidobacterium Longum Ah1206 In The Human Gut Depends On Individualized Features Of The Resident Microbiome, María X. Maldonado-Gómez, Inés Martínez, Francesca Bottacini, Amy O’Callaghan, Marco Ventura, Douwe Van Sinderen, Benjamin Hillmann, Pajau Vangay, Dan Knights, Robert W. Hutkins, Jens Walter

Department of Food Science and Technology: Faculty Publications

Live bacteria (such as probiotics) have long been used to modulate gut microbiota and human physiology, but their colonization is mostly transient. Conceptual understanding of the ecological principles as they apply to exogenously introduced microbes in gut ecosystems is lacking. We find that, when orally administered to humans, Bifidobacterium longum AH1206 stably persists in the gut of 30% of individuals for at least 6 months without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentation of specific carbohydrate utilization genes in the pre-treatment microbiome. …

Predictable Convergence In Hemoglobin Function Has Unpredictable Molecular Underpinnings, Chandrasekhar Natarajan, Federico G. Hoffmann, Roy E. Weber, Angela Fago, Christopher C. Witt, Jay F. Storz

Jay F. Storz Publications

To investigate the predictability of genetic adaptation, we examined the molecular basis of convergence in hemoglobin function in comparisons involving 56 avian taxa that have contrasting altitudinal range limits. Convergent increases in hemoglobin-oxygen affinity were pervasive among high-altitude taxa, but few such changes were attributable to parallel amino acid substitutions at key residues.Thus, predictable changes in biochemical phenotype do not have a predictable molecular basis. Experiments involving resurrected ancestral proteins revealed that historical substitutions have context-dependent effects, indicating that possible adaptive solutions are contingent on prior history. Mutations that produce an adaptive change in one species may represent precluded possibilities …

Millions Protected In Africa’S Largest-Ever Emergency Yellow Fever Vaccination Campaign

Saudi Medical Journal

No abstract provided.

Assessing The Archaeoparasitological Potential Of Quids As A Source Material For Immunodiagnostic Analyses, Johnica J. Morrow, Karl Reinhard

Karl Reinhard Publications

In the present study, quids from La Cueva de los Muertos Chiquitos (CMC) were subjected to ELISA tests for 2 protozoan parasites, Toxoplasma gondii (n=45) and Trypanosoma cruzi (n=43). The people who occupied CMC, the Loma San Gabriel, lived throughout much of present-day Durango and Zacatecas in Mexico. The known pathoecology of these people puts them into at-risk categories for the transmission of T. gondii and T. cruzi. Human antibodies created in response to these 2 parasites can be detected in modern saliva using ELISA kits intended for use with human serum. For these reasons, quids were reconstituted and …

Cardiorespiratory Fitness Is Associated With Better Executive Function In Young Women, Samuel P. Scott, Mary Jane De Souza, Karsten Koehler, Dylan L. Petkus, Laura E. Murray-Kolb

Department of Nutrition and Health Sciences: Faculty Publications

Purpose: A positive association between cardiorespiratory fitness (CRF) and cognitive function has been demonstrated mainly in children and older adults. Women attending college live in a cognitively demanding setting where optimal cognition matters but often experience declines in CRF. Our aim was to test whether CRF is associated with executive function in young adult women.

Methods: Participants in this cross-sectional study included 120 healthy women age 18–35 yr in a university setting. Each woman completed a maximal treadmill-based exercise test to determine peak oxygen uptake (V˙O_2peak), computerized tests of executive function, and questionnaires to assess motivation …

Tolkien Among The Moderns, Edited By Ralph C. Wood. Reviewed By Ryder W. Miller., Ryder W. Miller

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Fungi In The Healthy Human Gastrointestinal Tract, Heather E. Hallen-Adams, Mallory J. Suhr

Department of Food Science and Technology: Faculty Publications

Many species of fungi have been detected in the healthy human gut; however, nearly half of all taxa reported have only been found in one sample or one study. Fungi capable of growing in and colonizing the gut are limited to a small number of species, mostly Candida yeasts and yeasts in the family Dipodascaceae (Galactomyces, Geotrichum, Saprochaete). Malassezia and the filamentous fungus Cladosporium are potential colonizers; more work is needed to clarify their role. Other commonly-detected fungi come from the diet or environment but either cannot or do not colonize (Penicillium and Debaryomyces species, which are …

Ursinus Magazine, Fall 2016, Brock Blomberg, Wendy Greenberg, Ellen Labrecque, Andrew Edwards, Rebecca Evans, Richard L. Wallace

Ursinus Magazine, 1995–Present

They're here: The Class of 2020! • Out of this world • Cutting college costs • Celebrating the bard • Borough-inspired mural for Berman gallery • By the numbers: Best PA CPA pass rate • Hall of fame • Triple play: A top 100 college • Lost and found • The food network • Fulfilling a promise for our future • Welcome to the (academic) neighborhood • The Philadelphia story • "Superhero" UC ball runners • Burning question: Are there still gender gaps in political attitudes toward women as emerging political players? • Anatomy of Welcome Week • Wine and …