Digital Commons Network^™

Identification Of Early Gene Expression Changes In Primary Cultured Neurons Treated With Topoisomerase I Poisons., Sharyn L. Rossi, Casey J. Lumpkin, Ashlee W. Harris, Jennifer Holbrook, Cinsley Gentillon, Suzanne M. Mccahan, Wenlan Wang, Matthew E.R. Butchbach

Department of Pediatrics Faculty Papers

Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits. To understand the molecular basis for the enhanced sensitivity of neurons to CPT, we examined the effects of compounds that inhibit TOP1-CPT, actinomycin D (ActD) and β-lapachone (β-Lap)-on primary cultured rat motor (MN) and cortical (CN) neurons as well as fibroblasts. Neuronal cells expressed higher levels of Top1 mRNA than fibroblasts but transcript levels are reduced in all cell types after treatment with CPT. Microarray analysis was performed to identify …

A Contrastive Analysis Of Dar ‘Give’ In English And Brazilian Portuguese: Semantic-Syntactic Relationships And Implications For L2 Instruction, Katherine Christoffersen

Writing and Language Studies Faculty Publications

In recent years, research on multiword lexical units has influenced second language acquisition research, but little work has been done on light verbs, especially comparing the use of light verbs in English and Brazilian Portuguese. This paper presents a comparative analysis of the syntactic and semantic aspects of dar and ‘give’ through the semantic continuum, event type, denominal verbs and incorporation. This study finds that distinct and varied semantic uses of light verbs present a unique challenge to second language learners in terms of both their understanding and their production. Furthermore, this study analyzes the semantic-syntactic interrelationships and suggests implications …

Neuromodulation, Stephen Silberstein

Department of Neurology Faculty Papers

Neuromodulation is a new promising treatment for headache disorders. It consists of peripheral nerve neurostimulation and central neurostimulation. © 2016, Touch Briefings. All rights reserved.

Fluorescent Materials Design At Nanoscale For Biomedical Photonics In Near Infrared Window, Kohei Soga, Masao Kamimura

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.

Learning To Survive Ecological Risks Among The Sidama Of Southwestern Ethiopia, Samuel J. Dira, Barry S. Hewlett

Journal of Ecological Anthropology

Sidama farmers rely on rain-fed agriculture and experience a highly variable natural environment. Recurrent drought, erratic rainfall, and crop and livestock loss are common in mid and lowland areas, but local people are not passive victims of the changing environment: they use accumulated knowledge and skills to respond to and buffer ecological changes. Based on freelists and in-depth interviews with 70 adults and 50 adolescents, this paper describes how the Sidama conceive of ecological risks, survive difficult times, and learn to be resilient. The results indicate that food shortage and drought are salient risk factors. While local people think the …

Central Research Forum Program - 2016, Office Of Research Affairs, Boonshoft School Of Medicine

Central Research Forum

The 22-page program includes a schedule, speaker biographies, and presentation titles from the 2016 Central Research Forum held by the Boonshoft School of Medicine's Office of Research Affairs.

Chanticleer | October 13, 2016, Jacksonville State University

Chanticleer

No abstract provided.

The Pacifican October 13, 2016, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

Otter Realm, October 13, 2016, California State University, Monterey Bay

The Otter Realm

New Students, New Programs -- Sustainability and You -- College and Politics: The Same Lesson -- What You Otter Be Doing October 13-26 -- Otter Open House: New students and new developments -- New Signs Open Door to Gender Inclusivity -- Ocean's Forum Seeks Questions: Regional candidates to discuss issues before public at World Theater -- Lighting the Way: Campus event helps fight the stigma of mental illness -- Mindful Madness Eases Student Stress Halfway Through Semester -- Otters Come Up Short Against Cougars: Women's Soccer team loses to CSU San Marcos, 3-1 -- Monterey Loses Hard Battle Against San …

The Misunderstood Right To Be Forgotten: The Future Of Free Expression And Privacy In The Online World, University Of Michigan Law School

Event Materials

Program for the 26th Annual University of Michigan Senate's Davis, Markert, Nickerson Lecture on Academic and Intellectual Freedom.

Judgement Bias In Goats (Capra Hircus): Investigating The Effects Of Human Grooming, Luigi Baciadonna, Christian Nawroth, Alan G. Mcelligott

Emotion Collection

Animal emotional states can be investigated by evaluating their impact on cognitive processes. In this study, we used a judgement bias paradigm to determine if shortterm positive human-animal interaction (grooming) induced a positive affective state in goats. We tested two groups of goats and trained them to discriminate between a rewarded and a non-rewarded location over nine training days. During training, the experimental group (nD9) was gently groomed by brushing their heads and backs for five min over 11 days (nine training days, plus two testing days, total time 55 min). During training, the control group (nD10) did not experience …

Ua12/2/1 College Heights Herald, Vol. 92, No. 14 [15], Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Keltner, Bryson. Major Redz Leave Section Due to Safety Concerns – Protests
• Miller, Callie. University to Change Internet Network
• Kast, Monica. Professor Gary Houchens Joins Kentucky Board of Education
• Carlson, Kylie. Retired Officer Joins Police Department – Lee McKinney
• Collins, Emma. New Bus Route to Service Downtown Garage – Parking & Transportation
• King, Jennifer. Editorial Cartoon re: Donald Trump
• Repulsive Rhetoric: Donald Trump’s Comments Contribute to Rape Culture
• Johnson, Kayln. Black Hair Styles in the Professional Sphere
• Fall Festival
• Austin, Emma. Conference to Raise Human …

Il-10 Plays An Important Role In The Control Of Inflammation But Not In The Bacterial Burden In S. Epidermidis Cns Catheter Infection., Yenis M. Gutierrez-Murgas, Gwenn Skar, Danielle Ramirez, Matthew Beaver, Jessica N. Snowden

Journal Articles: Pathology and Microbiology

BACKGROUND: Shunt infection is a frequent and serious complication in the surgical treatment in hydrocephalus. Previous studies have shown an attenuated immune response to these biofilm-mediated infections. We proposed that IL-10 reduces the inflammatory response to Staphylococcus epidermidis (S. epidermidis) CNS catheter infection.

METHODS: In this study, a murine model of catheter-associated S. epidermidis biofilm infection in the CNS was generated based on a well-established similar model for S. aureus. The catheters were pre-coated with a clinically derived biofilm-forming strain of S. epidermidis (strain 1457) which were then stereotactically implanted into the lateral left ventricle of 8-week-old C57BL/6 and IL-10 …

How Do You Know A Labor Shortage When You See One?, Burt Barnow

Health Workforce Speaker Series

No abstract provided.

Fighting Pain Through Knowledge About Sensory Organs In The Fingertips, Jeff Hansen

Browse All News

No abstract provided.

The Missouri Miner, October 13, 2016

The Missouri Miner Newspaper

No abstract provided.

Fumarate Modulates The Immune/Inflammatory Response And Rescues Nerve Cells And Neurological Function After Stroke In Rats., Ruihe Lin, Jingli Cai, Eric W Kostuk, Robert H. Rosenwasswer Md, Lorraine Iacovitti

Farber Institute for Neuroscience Faculty Papers

BACKGROUND: Dimethyl fumarate (DMF), working via its metabolite monomethylfumarate (MMF), acts as a potent antioxidant and immunomodulator in animal models of neurologic disease and in patients with multiple sclerosis. These properties and their translational potential led us to investigate whether DMF/MMF could also protect at-risk and/or dying neurons in models of ischemic stroke in vitro and in vivo. Although the antioxidant effects have been partially addressed, the benefits of DMF immunomodulation after ischemic stroke still need to be explored.

METHODS: In vitro neuronal culture with oxygen-glucose deprivation and rats with middle cerebral artery occlusion were subjected to DMF/MMF treatment. Live/dead …

Daily Eastern News: October 13, 2016, Eastern Illinois University

October

No abstract provided.

The East Texan, 2016-10-13, Texas A&M University-Commerce

All Issues

A color copy of The East Texan, a student newspaper published at Texas A&M University-Commerce.

The Rising Conflict On The Nile Waters: Understand Its Legal, Environmental, And Public Health Consequences, Edna Udobong

Liberty University Law Review

No abstract provided.

An Inconvenient Trial: Using The Nuremberg Trials As A Mock Judicial Framework To Force Human-Caused Climate-Change Proponents To Plead And Prove Their Best Case With Proposed Remedies Under The Burden Of Proof Of Their Choosing, Tory L. Lucas

Liberty University Law Review

No abstract provided.

Humility And Environmental Law, John Copeland Nagle

Liberty University Law Review

No abstract provided.

Deciphering Daubert's Dilemma: Using Probability And Statistics To Assign Liability Where A Defendant Has Not More Than Doubled The Likelihood Of A Plaintiff's Harm, Christopher Collins

Liberty University Law Review

No abstract provided.

The Price Is Wrong: A Biblical Approach To Punitive Damages, Zachary Hurt

Liberty University Law Review

No abstract provided.

Introduction To Undergraduate Research Evs 295x, Michael Cerbo

Library Impact Statements

No abstract provided.

The Lumberjack, October 12, 2016, The Lumberjack Staff

2016

The student newspaper of Humboldt State University

Think Twice Before Giving Medical Marijuana To Your Pet, Harold Herzog

'Animals and Us' Blog Posts

There are problems with the use of cannabis in veterinary medicine.

African Inter-City Railway Connection System, Ntende Edward K.

Young African Leaders Journal of Development

African countries are limited in unifying themselves due to the boundaries and various requirements which hinder their free and perfect mobility, manifested in visa requirement, multi-currencies, different leadership, insecurity, unemployment, poor resource utilisation and poor production. Leadership, perfect mobility and industrialisation are the major sectors to Africa’s unification and prosperity. There is always the thinking that perhaps the means used by the imperialists to exploit Africa’s minerals and partitioning, that in return led to Europe’s industrialisation, could be the very means to Africa’s unification, industrialisation and becoming a first world continent. The effort to find a possible means of providing …

Campus Chronicle, Caleb Bredlinger, Bailey Brooker, Ryan Burger, Emily Kuebler, Samantha Watsabaugh, Andy Langager

Campus Chronicle

No abstract provided.

Fighting Pain Through Knowledge About Sensory Organs In The Fingertips, Jeff Hansen

Browse All News

No abstract provided.