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Wedding Appropriate?: A Reflection On 1 Corinthians 13:1-8, Barbara Kowalkowski Osb Jun 2026

Wedding Appropriate?: A Reflection On 1 Corinthians 13:1-8, Barbara Kowalkowski Osb

Obsculta

This piece looks at whether the passage of 1 Corinthians 13:1-8a (the wedding verses) is overused or misused as one of the most popular readings during wedding ceremonies by considering the context of the passage. It delves into whether its use leads to misunderstanding among those gathered for their wedding on what its true meaning is.


Chaotic Mooers: Rural Immersion 2025, Garrett S. "Faustino" Miller Oblsb Jun 2026

Chaotic Mooers: Rural Immersion 2025, Garrett S. "Faustino" Miller Oblsb

Obsculta

No abstract provided.


Frog Friends, Myrissa Donaldson Jun 2026

Frog Friends, Myrissa Donaldson

Obsculta

No abstract provided.


Movement Ecology And Population Dynamics Of Box-Nesting Black-Bellied Whistling-Ducks (Dendrocygna Autumnalis) In Louisiana, Katie E. Miranda Jun 2026

Movement Ecology And Population Dynamics Of Box-Nesting Black-Bellied Whistling-Ducks (Dendrocygna Autumnalis) In Louisiana, Katie E. Miranda

LSU Master's Theses

Understanding demographic and behavioral processes underlying population dynamics is essential for effective wildlife management, especially for species subject to harvest pressure or experiencing population shifts. Black-bellied Whistling-Ducks (Dendrocygna autumnalis) are currently undergoing a notable northward range expansion and are increasing in abundance across the southeastern United States, raising management concerns for both ecological and economic reasons. As a result, there is growing public support for a special Black-bellied Whistling-Duck-specific harvest season, yet little research has been conducted on this species, particularly within newly-established populations. To address this gap, I conducted this study with the goal of evaluating seasonal …


Improving Procedural Confidence: Outcomes Of A Surgical Skills Workshop For Medical Students, Mary Arden G Guillory, Jennifer Escamilla, Anika Doppalapudi, Ashlyn Holubar, Kaitlyn Ybanez, Mark Manickath, Maci Oestreich, Mckenna Stallworth, Kelsey Baker Jun 2026

Improving Procedural Confidence: Outcomes Of A Surgical Skills Workshop For Medical Students, Mary Arden G Guillory, Jennifer Escamilla, Anika Doppalapudi, Ashlyn Holubar, Kaitlyn Ybanez, Mark Manickath, Maci Oestreich, Mckenna Stallworth, Kelsey Baker

School of Medicine Publications

Introduction Introducing surgical skills early in medical training may enhance students' confidence and readiness for clinical training. Simulation-based skill workshops provide students with a comfortable learning environment, resulting in effective learning. The goal of the Surgical Skills Workshop was to provide first- and second-year medical students with hands-on exposure to essential surgical skills. The educational impact on medical students' confidence in performing the respective surgical skills and changes in surgical career interest was assessed.

Methods: First- and second-year medical students at the University of Texas Rio Grande Valley School of Medicine participated in a hands-on surgical skills workshop comprising eight …


Omnipotence And Modesty: The Still, Small Voice Of God In 1 Kings 19, Scott Cooper Jun 2026

Omnipotence And Modesty: The Still, Small Voice Of God In 1 Kings 19, Scott Cooper

Obsculta

This article examines the sovereignty of God’s self-revelation to Ezekiel in a still, small voice on Mount Horeb and considers the difficulty of reconciling competing scholarly assessments of the prophet as faithful priestly servant of YHWH or disobedient free agent. This author considers Ezekiel’s experience as a site of spiritual union with God, inspired by the exegetical work of 14th century German Dominican priest and mystic Johannes Tauler.


Passed Through Or Pushed Back? Exchange Rate Effects On Manufacturing Trade Prices In Indonesia And The Asean Plus Three, Fatikha Rizky Kurnia, Miguel Angel Esquivias, Wee-Yeap Lau, Unggul Heriqbaldi Jun 2026

Passed Through Or Pushed Back? Exchange Rate Effects On Manufacturing Trade Prices In Indonesia And The Asean Plus Three, Fatikha Rizky Kurnia, Miguel Angel Esquivias, Wee-Yeap Lau, Unggul Heriqbaldi

Bulletin of Monetary Economics and Banking

This study analyzes the Exchange Rate Pass-Through (ERPT) on export and import prices in Indonesia’s manufacturing trade with ASEAN Plus-three countries (China, Japan, and South Korea) using monthly data from 2016 to 2022. Employing the Nonlinear (NARDL) models, we examine the degree and asymmetry of ERPT across five key manufacturing sectors for each partner. The NARDL model confirms asymmetric price responses to currency appreciation and depreciation in several sectors. The findings reveal significant sectoral and country-specific variations. Some export sectors experience complete pass-through in the short term but shift to negative complete passthrough in the long run. Meanwhile, imports from …


Meeting Report From The 2025 Cure Ocular Melanoma (Cure Om) Global Science Meeting, Amsterdam, The Netherlands, October 2025, Andrew E. Aplin, Katherina Alsina, Allison S. Betof, Joseph Birkett, Marcus O. Butler, George Cole, Rizwan Haq, Florian A. Karreth, Vinit B. Mahajan, Rahul Marpadga, Prithvi Mruthyunjaya, Paul Nathan, Jonas A. Nilsson, Gary Palmer, Joseph J. Sacco, Takami Sato, Sarah Stanhope, Pang-Ning Teng, Kyleigh Lipira Jun 2026

Meeting Report From The 2025 Cure Ocular Melanoma (Cure Om) Global Science Meeting, Amsterdam, The Netherlands, October 2025, Andrew E. Aplin, Katherina Alsina, Allison S. Betof, Joseph Birkett, Marcus O. Butler, George Cole, Rizwan Haq, Florian A. Karreth, Vinit B. Mahajan, Rahul Marpadga, Prithvi Mruthyunjaya, Paul Nathan, Jonas A. Nilsson, Gary Palmer, Joseph J. Sacco, Takami Sato, Sarah Stanhope, Pang-Ning Teng, Kyleigh Lipira

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The 2025 Cure Ocular Melanoma (CURE OM) Global Science Meeting took place in Amsterdam, The Netherlands on October 25th, 2025. Several promising drug candidates are in development; however, there is still an urgent need for better prevention, detection, and treatment of uveal melanoma. The purpose of this meeting was to promote international collaboration and idea exchange between scientists, industry, and patient advocates.


Bleeding Into Human Rights Law: The Need For A Special Procedure On The Right To Menstrual Health, Hunter Tarry Jun 2026

Bleeding Into Human Rights Law: The Need For A Special Procedure On The Right To Menstrual Health, Hunter Tarry

BYU Law Review

Menstruation, a fundamental biological process experienced by nearly half of the global population, remains shrouded in stigma and silence despite its critical role in sustaining human life. Many women and girls face inadequate menstrual health management and education, undermining their ability to experience a full range of human rights. While menstruation has gained increased public visibility in recent years, the United Nations (UN)—the cornerstone of the global human rights system—has been slow to meaningfully integrate this issue into its agenda. The time is now for the UN to formally recognize menstrual health as a human right by advancing global advocacy …


Assessing The Needs Of A Church’S Older Adults To Promote Their Flourishing, Royston Terrell Booker Iii Jun 2026

Assessing The Needs Of A Church’S Older Adults To Promote Their Flourishing, Royston Terrell Booker Iii

DMin Project Theses

The purpose of this project was to lay the groundwork for creating a holistic Senior Adult Ministry to support the flourishing of older adults through the activities of God’s people, the church. This approach to help older adults’ well-being is best accomplished through holistic support to enhance well-being, but many churches have not considered a holistic approach or developed a supportive capability. To create a holistic Senior Adult Ministry, I assessed the needs of senior adults in the Brentwood Hills Church of Christ (BHCC) in Nashville, Tennessee, within the United States. The findings and conclusions of this dissertation provide a …


Knowledge, Attitudes And Dispensing Practices Regarding Antimicrobial Resistance And Stewardship: A Comparative National Assessment Among Primary Healthcare Pharmacists In Oman, Mohammed Al Ghafari, Meher Rizvi, Hana Al Ghusaini, Zaima Al Rawahi, Wafa Al Balushi, Manal Al Ghafri, Hamed Al-Qanubi, Zuhair Al Salti, Idris Al Jumaa, Muhammed Rafiq Jun 2026

Knowledge, Attitudes And Dispensing Practices Regarding Antimicrobial Resistance And Stewardship: A Comparative National Assessment Among Primary Healthcare Pharmacists In Oman, Mohammed Al Ghafari, Meher Rizvi, Hana Al Ghusaini, Zaima Al Rawahi, Wafa Al Balushi, Manal Al Ghafri, Hamed Al-Qanubi, Zuhair Al Salti, Idris Al Jumaa, Muhammed Rafiq

Sultan Qaboos University Medical Journal

Objectives: Antimicrobial resistance (AMR) is driven by inappropriate antibiotic use. This study aimed to assess the knowledge, attitudes and dispensing practices (KAP) regarding AMR and antimicrobial stewardship (AMS) among primary healthcare (PHC) pharmacists and assistant pharmacists in Oman. Furthermore, the study sought to compare these parameters across facilities with historically high versus standard antibiotic consumption to identify structural determinants of AMS.

Methods: This national cross-sectional study was conducted among PHC pharmacy staff in February 2025. KAP were assessed via a structured electronic questionnaire. Data were analysed using generalized estimating equation models to identify KAP predictors while accounting for facility-level …


Beyond Autonomy: An Actor-Network Theory Study Of A Solo Exhibition In Indonesia, Rendy Pandita Bastari, Patra Aditia, Ganesha Puspa Nabila Jun 2026

Beyond Autonomy: An Actor-Network Theory Study Of A Solo Exhibition In Indonesia, Rendy Pandita Bastari, Patra Aditia, Ganesha Puspa Nabila

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

In many exhibition artists are often perceived as singular and autonomous actors. Departing from the critique of this tendency, this study examines the solo exhibition Toyscapes, After Us by Indonesian artist Hilman Hendarsyah (November 2025) as a case study through the lens of Actor-Network Theory (ANT), in order to understand art exhibition as relational and socio-material practices. This study traces how exhibitions are produced through interaction between human and non-human actors within heterogeneous network. The analysis was conducted by following the actors and mapping processes of problematization, translation, and network stabilization. The findings elucidates that solo exhibition cannot be understood …


Self-Compassion And Meaningful Work: Examining The Role Of Personal Resources In Veterinary Medicine Student Burnout Through A Jd-R Framework, Swathi Prabhu Jun 2026

Self-Compassion And Meaningful Work: Examining The Role Of Personal Resources In Veterinary Medicine Student Burnout Through A Jd-R Framework, Swathi Prabhu

Electronic Theses and Dissertations Archive

Rates of burnout are known to be markedly high among veterinary professionals but less is known about burnout among U.S. veterinary students. The Job Demands-Resource (JD-R) Theory provides a framework through which veterinary students’ experiences can be investigated in a way that centers supportive organizational and personal resources, instead of focusing on the detrimental aspects of training that have dominated the literature. Using a sample of 469 students enrolled in U.S. colleges of veterinary medicine, the current study examined if two personal resources (self-compassion and work as meaning) mediated the relationship between two sources of support (student peer support and …


Evaluating The Reproducibility And Verifiability Of Nutrition Research: A Case Study Of Studies Assessing The Relationship Between Potatoes And Colorectal Cancer, Yasaman Jamshidi-Naeini, Colby J Vorland, Pranav Kapoor, Bailey Ortyl, Jocelyn Mineo, Luke Still, Korlu Sorsor, Shelby Rodney, Xander Tooze, Brent Flickinger, Beate Henschel, Stephanie L Dickinson, David B Allison Jun 2026

Evaluating The Reproducibility And Verifiability Of Nutrition Research: A Case Study Of Studies Assessing The Relationship Between Potatoes And Colorectal Cancer, Yasaman Jamshidi-Naeini, Colby J Vorland, Pranav Kapoor, Bailey Ortyl, Jocelyn Mineo, Luke Still, Korlu Sorsor, Shelby Rodney, Xander Tooze, Brent Flickinger, Beate Henschel, Stephanie L Dickinson, David B Allison

Faculty, Staff and Students Publications

The credibility of nutritional research is dependent on the rigor with which studies are conducted and the ability for independent assessment to be performed. Despite the importance of these, more work is needed in the field of nutrition to buttress the trustworthiness of nutrition research. To develop and apply a process for evaluating the rigor, reproducibility, and verifiability of nutritional research, using the relationship between potato consumption and Colorectal Cancer (CRC) as a case study. We updated existing systematic reviews to include studies on potatoes and CRC, assessing their design, execution, and reporting quality. We attempted to reproduce and verify …


The Mascarene Archipelago, A Data-Poor Region For Mobulid Rays: First Records, Seasonal Patterns And Conservation Implications, Joanna Harris, Estelle Crochelet, Prashant Mohesh, Guy M.W. Stevens Jun 2026

The Mascarene Archipelago, A Data-Poor Region For Mobulid Rays: First Records, Seasonal Patterns And Conservation Implications, Joanna Harris, Estelle Crochelet, Prashant Mohesh, Guy M.W. Stevens

School of Biological and Marine Sciences

The distribution and seasonal occurrence of manta and devil rays (mobulids) remain poorly understood across much of the Western Indian Ocean, particularly within remote island systems. Here, we present the first synthesis of species-level mobulid records for the Mascarene Archipelago (La Réunion, Mauritius and Rodrigues) using a combination of direct and passive citizen-science observations collected between 2014 and 2026. A total of 107 sightings were documented from 75 sighting events, comprising Mobula birostris (n = 29), M. thurstoni (n = 40), M. alfredi (n = 5), M. tarapacana (n = 2) and unidentified Mobula spp. (n = 31). One M. …


Humans Rule? Development Of Stewardship Mindsets Among Religious Undergraduates, Jamie Jensen, J Robert Nielson Jun 2026

Humans Rule? Development Of Stewardship Mindsets Among Religious Undergraduates, Jamie Jensen, J Robert Nielson

ScholarsArchive Data

Two cohorts of students enrolled in a non-major introductory biology course were surveyed in 2020 and 2025 using the Revised New Ecological Paradigm (R-NEP) instrument. Open-ended student responses concerning their definition of ‘rule’ as a human prerogative were also analyzed using qualitative coding.


Emergency Action Plan: Home, Family, Pets, And Livestock, Kristin Black, Michael Pate, Callahan K. Adams Jun 2026

Emergency Action Plan: Home, Family, Pets, And Livestock, Kristin Black, Michael Pate, Callahan K. Adams

All Current Publications

This document is an emergency family action plan designed to help your entire household prepare for emergencies. It aligns with the Youth Emergency Preparedness and Animal Project Safety Program available through Utah State University (USU). It can be taught by FFA teachers, 4-H leaders, Extension faculty/staff, and afterschool program educators. The Emergency Action Plan is intended for youth to bring home, lead their families in completing the sections, and guide them in preparing for and practicing emergency preparedness.


Engineering Small-Sized Cations With Strong Solvation For High-Voltage Supercapacitors, Tong Huo, Pan Liu, Hao Chen, Peng Zhang, Zhen-Lei Chen, Guo-Fu Sun, Zhi-Qiang Shi, Jing Wang Jun 2026

Engineering Small-Sized Cations With Strong Solvation For High-Voltage Supercapacitors, Tong Huo, Pan Liu, Hao Chen, Peng Zhang, Zhen-Lei Chen, Guo-Fu Sun, Zhi-Qiang Shi, Jing Wang

Online First

Supercapacitors (SCs) have attracted much attention in the field of energy storage due to their high power density and long cycle life. However, their relatively low energy density limits their application in a wider range of fields. Methods to increase energy density include enhancing specific capacitance and extending the operating voltage window. Herein, we report a novel electrolyte salt, tetramethylammonium bis(fluorosulfonyl)imide (TMA-FSI), the resulting electrolyte formed with propylene carbonate (PC), designated as TMF, exhibits a wide electrochemical stability window (ESW) of 5.09 V. On the one hand, we found that the small size of TMA+ enables it to enter …


Elevated Phagocytic Capacity Directs Innate Spinal Cord Repair, Dana Klatt Shaw, Vishnu Muraleedharan Saraswathy, Anthony R Mcadow, Lili Zhou, Dongkook Park, Ridim Mote, Amulya Saini, Ashley J Douthitt, Katerina Stepankova, Brittney Unverzagt, Cédric G Geoffroy, Aaron N Johnson, Mayssa H Mokalled Jun 2026

Elevated Phagocytic Capacity Directs Innate Spinal Cord Repair, Dana Klatt Shaw, Vishnu Muraleedharan Saraswathy, Anthony R Mcadow, Lili Zhou, Dongkook Park, Ridim Mote, Amulya Saini, Ashley J Douthitt, Katerina Stepankova, Brittney Unverzagt, Cédric G Geoffroy, Aaron N Johnson, Mayssa H Mokalled

2020-Current year OA Pubs

Immune cells elicit a continuum of transcriptional states after spinal cord injury (SCI). In mammals, inefficient debris clearance and chronic inflammation impede recovery and overshadow pro-regenerative immune functions. We found that zebrafish SCI elicits transient immune activation and efficient debris clearance. Transcriptomics and genetic ablation showed zebrafish macrophages are highly phagocytic and required for regeneration. Comparisons between zebrafish and mammalian macrophages identified transcription and immune response regulator (tcim) as an immune-enriched regenerative gene. Deletion of zebrafish tcim impairs phagocytosis and regeneration and activates a pro-inflammatory signature in leukocytes. Tcim expression in zebrafish and mouse macrophages establishes its conserved roles by …


The Matrix, Spring 2026, The Women's Resource Center Jun 2026

The Matrix, Spring 2026, The Women's Resource Center

The Matrix

Matrix Editor: Trinity Sue

Women's Resource Center Advisor: Marisol Ruiz

Women's Resource Center Staff (listed alphabetically):

  • Namixtu'lu' Esteva
  • Pamela Hernandez
  • Kaylee Luna
  • Izzie Rodríguez-Torres
  • Alexis Sarmiento
  • Venus Shearer
  • Trinity Sue

Authors/Illustrators in issue (listed alphabetically):

  • Megan Atherton, p. 11
  • Brenna, p. 24
  • Jess Carey, p. 17
  • Leyla Craven, p. 20
  • Annabelle Davis, p. 37
  • Erica Drew, p. 18
  • Sage Fowler, p. 11
  • Aven Gehlert, p. 30
  • Emily Hartling, p. 24
  • Riley Hemenover, p. 12
  • Pamela Hernandez, p. 14
  • Ella Humphrey, pp. 22-23, 31, 35, and throughout
  • Iran@alittlepoke, p. 13
  • Kaylee Luna, pp. 25, 29
  • Randi Maveety, p. 34
  • Xenia McLean, …


Freshwater Harmful Algal Blooms (Habs) Public Health Message Efficacy Evaluation, Alexandra Benitez Gonzalez, Heather A. Triezenberg, Diane Doberneck, Abigail Bennett, Mark Rey Jun 2026

Freshwater Harmful Algal Blooms (Habs) Public Health Message Efficacy Evaluation, Alexandra Benitez Gonzalez, Heather A. Triezenberg, Diane Doberneck, Abigail Bennett, Mark Rey

Journal of Contemporary Water Research and Education

Harmful algal blooms (HABs) can present health risks to humans, animals, or ecosystems. Communicating with the public about HABs risks can be challenging because symptoms vary in type and severity across different individuals. However, people with underlying health conditions are often particularly vulnerable to exposure, and they may experience negative health outcomes if they lack awareness of the risks that HABs pose. Literature on risk communication suggests that the way messages are framed influences the impact on risk perception and behavioral intentions. To provide insight into how agencies and practitioners can more effectively communicate health risks from HABs, we designed …


Dances With Birds, Richard F. Roadcap Dds Jun 2026

Dances With Birds, Richard F. Roadcap Dds

Virginia Dental Journal

No abstract provided.


Ooottafagvah = ???, Matthew Storm Dds Jun 2026

Ooottafagvah = ???, Matthew Storm Dds

Virginia Dental Journal

No abstract provided.


Ion Channels As Targets For Parasiticides: A Brief Review Of Past, Present, And Future Directions, Josette V. Ricker, Mallory Mendenhall Jun 2026

Ion Channels As Targets For Parasiticides: A Brief Review Of Past, Present, And Future Directions, Josette V. Ricker, Mallory Mendenhall

Georgia Journal of Science

Scientists and healthcare providers have tried for decades to find parasite treatments that balance patient safety with efficacy in eliminating the pathogen. One approach is to target specifically the parasite’s important bodily functions while sparing the host. This brief review examines the historically significant antiparasitics - pyrethrins, picrotoxin, piperazine, and avermectins – all which specifically target parasite ion channels. We discuss the history of their discovery and use, which subsequently led to the development of new generations of parasiticides, and continues to inspire the search for safe and effective treatments.


Visionarium, June 2026, Full Issue Jun 2026

Visionarium, June 2026, Full Issue

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

No abstract provided.


Differential Effects Of Amiloride And Benzamil On Salt Taste Physiology And Behavior: The Case For Phasic Responses In The Generation Of Sodium Appetite, Amyra M. Issa Jun 2026

Differential Effects Of Amiloride And Benzamil On Salt Taste Physiology And Behavior: The Case For Phasic Responses In The Generation Of Sodium Appetite, Amyra M. Issa

McNair Scholars Research Journal

The current experiment aims to investigate the relationship between the early phasic portion of salt taste transduction and sodium appetite. Prior research has identified two salt transduction pathways: a sodium-selective pathway, which is inhibited by amiloride or benzamil, and a non-selective pathway, which is insensitive to these blockers (Breslin & Spector, 2008). When presented with sodium solutions, sodium-depleted mice exhibit a behavior termed the “sodium appetite,” which results in voracious sodium consumption. The prevailing theory is that this behavior depends on neural activity of sodium-selective neurons (Breza & Contreras, 2012; Roitman & Bernstein, 1999). While previous studies have demonstrated that …


High Densities Of Large Herbivores Rapidly Disrupt Ecosystem Integrity, Jennifer A Krumins Jun 2026

High Densities Of Large Herbivores Rapidly Disrupt Ecosystem Integrity, Jennifer A Krumins

Department of Biology Faculty Scholarship and Creative Works

Human-induced high densities of large wild herbivores may pose a threat to natural ecosystems, modifying biodiversity and ecosystem functioning. Although the negative impacts on individual taxa and processes are well documented, a comprehensive understanding of how ecosystem integrity responds to high herbivore densities remains limited. This study addresses this gap through an extensive herbivore-density manipulation experiment conducted in two Mediterranean woodlands. We established two scenarios of high red deer (Cervus elaphus) density, representative of some protected areas (similar to 30 individuals.km(2)) and intensively managed hunting estates (similar to 90 individuals.km(2)). We monitored 38 metrics encompassing a broad spectrum of biodiversity …


Learning Trajectories Of Online Batch Selection Methods, Luke Green Jun 2026

Learning Trajectories Of Online Batch Selection Methods, Luke Green

Theses and Dissertations

Modern deep neural networks achieve strong performance on large-scale datasets, but often require substantial training time. Online batch selection methods seek to reduce this cost by updating models on informative subsets of each batch rather than on all available examples. Recently introduced methods leverage teacher models and report substantial speedups, particularly in noisy-label settings. However, comparisons are often based on the number of epochs required to reach a target test accuracy, a coarse metric that is sensitive to implementation details and may obscure important differences in learning dynamics. In this thesis, we implement several online batch selection methods in a …


Biologists Study Ways To Increase Food Production For Growing World, Clara Turnage Jun 2026

Biologists Study Ways To Increase Food Production For Growing World, Clara Turnage

University of Mississippi News

OXFORD, Miss. – With the world population expected to approach 10 billion by 2050, scientists are searching for ways to feed that many people with fewer resources. A new review outlines scientific advances that could help make food production more sustainable and resilient.


Microglial Swell1 Deficiency Drives Male-Specific Seizure Vulnerability But Paradoxical Neuroprotection Through Impaired Phagocytosis, Abhijeet S Barath, Aastha Dheer, Laura Montier, Mekenzie M Peshoff, Emily Dale, Flavia Goche, Thanh Thanh Le Nguyen, Mastura Akter, Fangfang Qi, Dimitrios Kleidonas, Lauren Harris, Sarah A Jewanee, Anthony D Umpierre, Dale B Bosco, Koichiro Haruwaka, Rajan Sah, Long-Jun Wu, Rongzhuo Hua, Tejaswani Datla Jun 2026

Microglial Swell1 Deficiency Drives Male-Specific Seizure Vulnerability But Paradoxical Neuroprotection Through Impaired Phagocytosis, Abhijeet S Barath, Aastha Dheer, Laura Montier, Mekenzie M Peshoff, Emily Dale, Flavia Goche, Thanh Thanh Le Nguyen, Mastura Akter, Fangfang Qi, Dimitrios Kleidonas, Lauren Harris, Sarah A Jewanee, Anthony D Umpierre, Dale B Bosco, Koichiro Haruwaka, Rajan Sah, Long-Jun Wu, Rongzhuo Hua, Tejaswani Datla

The Brown Foundation: Institute of Molecular Medicine

The discovery of genes encoding the volume-regulated anion channel (VRAC) has enabled detailed exploration of its cell type-specific roles in the brain. LRRC8A (SWELL1) is the essential VRAC subunit. We observed seizure-induced, subunit-specific changes in microglial VRAC expression and investigated its function using conditional KO (cKO) of LRRC8A in microglia. SWELL1 cKO mice exhibited a male-specific increase in kainate-induced seizure severity, yet showed paradoxical neuroprotection against seizure-associated neuronal loss. Mechanistically, SWELL1 deletion led to a cell-autonomous reduction in microglial density and decreased release of VRAC-permeable neuroactive metabolites, including taurine, GABA, and glutamate in culture. Additionally, impaired phagocytic kinetics and reduced …