Digital Commons Network^™

Duchamp Meets Turing: Art, Modernism, Posthuman, Gabriela Galati

Other Faculty of Arts, Humanities and Business Theses

In her book How We Became Posthuman (1999), Katherine Hayles analysed the process through which the conception of the liberal humanist subject led the way to the posthuman subject, a subject who lives in complete entwinement with the digital. This process, however, was not innocuous: it made the (fallacious) perception that information could do without material instantiation pervasive within many fields of knowledge, a process that Hayles contends originates in the Macy Conferences and the evolution of cybernetic theory. This research identifies an analogous process within the artistic realm: when Clement Greenberg delineated the concepts of opticality and colour field …

A Theoretical Model For The Design Of A Transcultural Visual Communication System In A Posthuman Condition, Haytham Nawar

Other Faculty of Arts, Humanities and Business Theses

This dissertation follows an interdisciplinary approach that weaves practice and theory in the disciplines of visual communication, semiotics, cultural studies, linguistics, and new media art. The research methodology is practice-based located within a historical and contemporary context that allows for artistic experimentation and new knowledge to be generated through reflected creative practice This research proposes a context within which society can develop a transcultural means of communication with the objective of gaining completely unambiguous forms of understanding. This research explores the possibility of an open source scaffold for pictorial language that fosters self-enhancing diversity of production models, communication paths, and …

Reciprocal Technologies: Enabling The Reciprocal Exchange Of Voice In Small-Scale Farming Communities Through The Transformation Of Information And Communications Technologies, Eugenio Tisselli

Other Faculty of Arts, Humanities and Business Theses

This dissertation claims that the reciprocal exchange of voice—an element for constructing community and strengthening political recognition—may be fostered in small-scale farming communities by (1) the appropriation and transformation of information and communications technologies, (2) artistic intervention, and (3) cross-community research. This study contributes to participatory research methodologies, particularly those that seek to tackle the diverse challenges faced by small-scale farmers from a broad, complex perspective. The main issue identified in this dissertation is as follows: The hegemony of economic behaviors, which stands as a cornerstone of neoliberal capitalism, constitutes the latest stage of a historical process in which the …

That Dark Remembered Day - A Novel, And Critical Self-Reflection On Composition And The Editorial Process, Tom Vowler

Other Faculty of Arts, Humanities and Business Theses

My aim for That Dark Remembered Day was to create a work of fiction with a strong sense of the literary, one whose themes of violence, landscape and survivor guilt shone a light on the human condition, specifically the effects of post-war trauma on one family. The novel’s structure would be crucial in achieving its emotional heft, as each of the central characters is allocated at least one section, the reader experiencing events from disparate and increasingly illuminating perspectives. Fragmenting the book’s chronology (both throughout, but particularly in Part 3) by employing a technique of temporal blurring, helped to recreate …

Opportunities And Risks In Online Gaming Environments, Benjamin George Sanders

Other Faculty of Science and Engineering Theses

Massively Multiplayer Online Role Playing Games (MMORPGs) have evolved from traditional video games in that they embrace both the technology of the Internet and video games. The massive “exodus” from the physical offline world to online gaming communities brings with it not only a number of unique and exciting opportunities, but also a number of emerging and serious risks. This research set out to examine the unique opportunities and risks to vulnerable individuals, namely, young adults, teenagers and young children; all of whom are considered by many to be priority groups in the protection from harm. The purpose was to …

Improving Our Understanding Of Evolutionary Persistence In An Increasingly High Co2 World: Insight From Marine Polychaetes At A Low Ph Vent System, Noelle Marie Lucey

Other Faculty of Science and Engineering Theses

The main aim of this thesis was to determine how marine metazoans might persist as ocean acidification (OA) conditions intensify. This was done using a combination of field surveys, field transplants and laboratory experiments with polychaetes from a site where volcanically-derived CO2 gas bubbles through the seafloor and drives the seawater pH down, resulting in a marine ecosystem representative of global OA projections for, or before, the year 2100. My first objective was to identify phenotypes, or traits, associated with OA tolerance (Chapter 2 and 5). To do this, I characterized the distribution of dominant calcifying polychaetes along natural pH …

Defining New Knowledge Produced By Collaborative Art-Science Research, Juanita Schlaepfer-Miller

Other Faculty of Arts, Humanities and Business Theses

This thesis takes a theoretical framework constructed for transdisciplinary research within different natural science disciplines and investigates what kind of new knowledge is produced when this framework is applied to projects at the interface of art and natural science. The main case study is “Sauti ya Wakulima – The Voice of the Farmers”, which involves collaboration with another intervention artist, and with natural scientists and farmers. This is a collaborative knowledge project with small-scale urban as well as rural farmers in Tanzania who have created an online community archive of their farming practices by using mobile phones to upload images …

Embodying Topeng: Gender, Training And Intercultural Encounters, Tiffany Strawson

Other Faculty of Arts, Humanities and Business Theses

This research centres on the Balinese performance tradition known as topeng which translates as Balinese masked dance-drama. In Bali this genre is performed traditionally in spaces reserved for religious ceremonies. The research questions the extent to which, and how, it may be possible for a non-Balinese person to embody a culturally coded, sacred object (the mask) and how a woman is able to make meaning and express herself within a genre which is traditionally the preserve of men. The research has therefore sought to develop an individual and intercultural approach to both the design of new masks and their performance. …

Development Of Protein-Polymer Core-Shell Nanoparticles (Ppcs-Nps) As Efficient Vehicles To Deliver Therapeutic Agents Across Blood Brain Barrier (Bbb), Napat Tandikul

Theses and Dissertations

Blood Brain Barrier (BBB) plays a main role as selective barrier which controls and limits access of chemicals, molecules and therapeutic agents from blood to brain. The BBB endothelial cells are connected by Tight Junctions (TJs) which close intracellular spaces between the endothelial cells and block the free diffusion of substances, therefore many potential drugs for treating human brain diseases cannot reach the brain in sufficient concentration. Recently, many studies have thrown an interest in development of nanoparticles for delivering drugs and imaging agents across BBB. Our research group has developed protein-polymer core-shell nanoparticles (PPCS-NPs) which demonstrate great potential for …

Influence Of Built Environment On Physical Activity Outcomes Among African Americans In Community-Based Obesity Intervention Studies, Amanda Sue Thomas

Theses and Dissertations

More than sixty-five percent of people in the U.S. are considered overweight or obese. African-Americans in the U.S. have a higher risk of obesity than any other racial group. One way to reduce this statistic is physical activity. Recreational green spaces (parks) can serve as an avenue to complete the 150 min/wk of recommended physical activity for adults by the ACSM. Data from SISTAS and HEALS interventions, that recruited overweight/obese African-Americans from Columbia and Florence, SC, was used to assess the association of recreational green space (parks) around a residence and physical activity. Physical activity measures of RAPA questionnaire (self-report), …

Iv Prenatal Nicotine Exposure Modulates Α6, Α7, And Α4Β2 Nicotinic Acetylcholinergic Receptor Subunit Expression In Male And Female Neonatal And Adolescent Rat Offspring: An Autoradiographical Analysis, Amanda Morgan

Theses and Dissertations

Maternal smoke exposure produces long-term adverse cognitive and behavioral outcomes in offspring, including an increased likelihood of attention problems (e.g., attention deficit hyperactivity disorder; ADHD) and drug abuse. Preclinical research shows that gestational exposure to nicotine, the primary psychoactive compound in tobacco smoke, influences the neurodevelopment of attention and reward neuronal circuits. This study investigated hypotheses about five brain regions, to determine if prenatal nicotine (PN) exposure altered expression of nicotinic acetylcholine receptors (nAChRs). A low dose, intravenous nicotine (IV) exposure method was used to administer nicotine (0.05 mg/kg/injection) or saline, 3x/day on gestational days 8–21 (Treatment). Brain tissue was …

A Mechanical Approach To The Characterization Of Material Failure Of Atherosclerotic Lesions, Lindsey A. Davis

Theses and Dissertations

Failure of atherosclerotic plaques can lead to potentially life threatening clinical events such as myocardial infarction (MI), stroke, or transient ischemic attack (TIA). The most frequently described plaque failure mechanism is tensile rupture of the fibrous cap; however, often during angioplasty another plaque failure mechanism occurs in which the atherosclerotic plaque separates from the internal elastic lamina (IEL). This study aims assess the material strength of atherosclerotic lesions using mechanical concepts.

To assess likelihood of plaque dissection at the vessel wall, adhesion strength was assessed in both mouse and human specimens using plaque delamination experiments. Measuring plaque adhesion in transgenic …

Frailty Probit Models For Clustered Interval-Censored Failure Time Data, Haifeng Wu

Theses and Dissertations

Survival analysis is an important branch of statistics that deals with time to event data or survival data. An important feature of such data is that the survival time of interest is usually not completely known but is censored due to the design of the study or an early dropout. In this dissertation we focus on studying clustered interval-censored data, a special type of survival data. Interval-censored data arise in many epidemiological, social science, and medical studies, in which subjects are examined at periodical follow-up visits. The survival (or failure) time of interest is never exactly observed but is known …

Gulf South Summit On Service Learning Program [2016], Gulf South Summit On Service-Learning

Gulf South Summit on Service-Learning (Archived)

N/A

Adams As Potential Regulators Of Stem Cell Quiescence In The Olfactory Epithelium, Elaine Elizabeth Orendorff

Master's Theses

I demonstrate that a member of the protein family A Disintegrin and Metalloprotease (ADAM), ADAM23, is expressed in the olfactory epithelium (OE) and may inhibit neural progenitor cell (NPC) proliferation. I generated a list of ten gene candidates and selected ADAM23 for further study, based on its conserved protein structure and accumulating evidence for its role in cell cycle progression of proliferative cells. I next determined ADAM23 protein localization using immunohistochemistry and measured both mRNA and protein expression post-lesion with RT-qPCR and Western blot. ADAM23 is expressed in multiple cell types of the OE, including glial Sustentacular (Sus) cells and …

Prevalence And Diversity Of The Haemosporidian Blood Parasite Leucocytozoon In Sub-Saharan African Birds, Heather Skeen

Master's Theses

Our knowledge of avian Haemosporidian parasites has increased dramatically with the advent and increased used of molecular technologies. Yet Leucocytozoon, a common avian parasite, remains relatively understudied. Haemosporidian parasite diversity and prevalence has been shown to be dependent on several factors, including host family and habitat, on a microecological scale. In this study I screened 3,375 birds from sub-Saharan Africa for the presence of Leucocytozoon and demonstrate that the patterns of prevalence and diversity continue at a macroecological scale. Using molecular data, I found that the prevalence of Leucocytozoon varied between sampling areas from 3.9% to 62.64% and the diversity …

Lactobacillus Crispatus Produces A Bacteridical Molecule That Kills Uropathogenic E. Coli, Katherine Diebel

Master's Theses

As many as 1 in 2 women will have at least one urinary tract infection (UTI) in their lifetime. UTIs can cause complications in pregnancy and decrease quality of life, and their treatment and prevention are expensive. Uropathogenic E. coli (UPEC) is the primary cause of UTI. The probiotic and bactericidal capacities of gut and vaginal Lactobacillus isolates have been studied, but the same attention has not been paid to urinary strains. These urinary isolates of L. crispatus appear to have a greater killing capacity against UPEC and this bactericidal activity does not depend on the cells themselves, consistent with …

The Role Of C-Abl Kinase In Hcc Development, Lennox Chitsike

Master's Theses

Hepatocellular Carcinoma is the second most lethal cancer after pancreatic cancer. Unresectable HCC tumors carry a poor prognosis and few treatment options are available. The dismal prognosis is mainly due to limited therapy options and molecularly targeted therapy is deemed as solution. Here, we report a novel role of c-Abl in HCC development. We provide evidence of c-Abl activation in human HCC samples compared to normal liver. Using genetic and pharmacological tools, we show that c-Abl plays a vital role in HCC progression in vitro and in vivo. We have identified Axl as an effector in processes mediated by c-Abl. …

Influence Of Metaphoric Language On Juror Decision Making, Melissa Michelle David

Master's Theses

This paper examines the effects of metaphoric language on judgment, assessment and juror verdict decision making. It further examines potential interactions between the use of figurative language and defendant race on juror verdict decisions. Research has potential implications on how the recent cultural climate has changed racial biases within the realm of juror decision making.

Cellular Consequences Of Lysosomal Rupture Induced By Alpha Synuclein, Zachary Carpenter Green

Master's Theses

Misfolded, toxic forms of amyloid alpha synuclein (α-syn) have been implicated in Parkinson’s disease (PD) pathology and have been shown to spread throughout the brain in a prion-like manner, explaining the progressive loss of neurons in PD. The mechanisms of spread and cell death are unknown, however, evidence from previous studies suggests that neurons may undergo apoptosis due to the uptake of exogenous α-syn aggregate through the endocytic pathway and subsequent lysosomal rupture.

This study aimed to corroborate previous evidence of α-syn induced lysosomal rupture and investigate the cellular repercussions of rupture with respect to cell death and α-syn transfer. …

Estrogen Regulation Of Mir-181a Stability In Neurons, Chun Kim

Master's Theses

Estrogens are an important class of steroid hormones involved in many cellular signaling processes. Levels of estrogens fluctuate across the lifespan suggesting that they target intracellular mediators, such as microRNAs, to fine-tune homeostatic cellular processes. Previous work in our lab demonstrated that 17β-estradiol (E2), the predominant circulating estrogen, stabilized miR-181a in a neuronal cell line derived from rat hypothalamus. These results lead to the hypothesis that E2 regulated miR-181a stability by altering the pool of endogenous RNA and by recruiting PNRC2 away from the miRNA degradation machinery. By utilizing miRNA degradation assays and immunostaining techniques, it was determined that the …

Interfering In A Non-Interference Policy: Defining Star Trek's Prime Directive, Andrew Steele

Master's Theses

The aim of this thesis is to provide a comprehensive definition of the Prime Directive, a concept that was developed in Star Trek: The Original Series, as well as provide a non-fictionalized version of the edict.

The Prime Directive is an edict that governs Starfleet not to interfere with a society’s development.

The first main section will discuss in further detail why The Original Series account of the Prime Directive was selected. Furthermore, it will discuss how members of academia interpret the Prime Directive.

The second main section will be an episode-by-episode analysis of each Prime Directive centered episode to …

Early Round Goby (Neogobius Melanostomus) Invasion Into Lake Michigan Tributaries And Competitive Interactions With Two Native Benthic Fishes., Margaret Ann Malone

Master's Theses

The round goby is a prolific invasive species and is currently spreading into Great Lake tributary streams. There is a high potential for negative impacts on native benthic fishes in these stream habitats and the aim of this study is to assess the impacts of the round goby on two native darter species in particular (johnny darter and blackside darter). I review the history of round goby invasion in the Great Lakes and summarize hypotheses of the invasive characters of the round goby. Using game theory, I provide a G-function approach to understanding the outcomes of the round goby invasion …

Phosphodiesterase Inhibition As A Mechanism Of Ion Channel Modulation By Celecoxib, Christina Jean Robakowski

Master's Theses

The overall objective of this thesis work is to determine the mechanism by which celecoxib modulates Kv7 potassium channels in vascular smooth muscle cells. The central hypothesis of the project is that celecoxib modulates Kv7 potassium channels in vascular smooth muscle cells through inhibition of phosphodiesterase 4 (PDE4, which catalyzes the breakdown of cyclic adenosine monophosphate (cAMP)), thereby activating a cAMP/protein kinase A (PKA) signaling pathway. The aims of this thesis targeted different points in the cAMP/PKA pathway with pharmacological interventions using whole cell perforated patch clamp electrophysiology and biochemical methods.

The data suggest multiple mechanisms by which celecoxib could …

A Bioluminescence Sensor Of Nlrp3 Inflammasome Activation, Michael Alexander Winek

Master's Theses

The innate immune system is many organisms first line of defense against pathogenic insult or tissue damage. This defense strategy is intent on restoring homeostasis upon perturbation. Upon activation of the innate immune system in humans, an oligomeric protein complex termed the “Inflammasome” forms in myeloid cells. The canonical output of activation of any subset of inflammasome is Caspase-1-mediated secretion of pro-inflammatory cytokines IL1β and IL18. Chronic or uncontrolled inflammasome activation is at the core of myriad economically burdening diseases. In many of these diseases, endogenous factors chronically engage the innate immune system. To study these diseases in in vivo, …

The Great Portion Of The Scum Of Society'? Representations Of Execution Crowds In The Lancashire Press, 1830-1868, John Walliss

SOLON Law, Crime and History (previously SOLON Crimes and Misdemeanours: Deviance and the Law in Historical Perspective)

From 1830 to the abolition of public executions in 1868, there was a growing critique of the execution crowd among elite commentators. To date, however, most, if not all, discussion of this critique has focused on the metropolis, elite groups and decision makers and on national newspapers such as The Times. The aim of this article is to shift the focus away from the metropolis towards the provinces, by exploring how the execution crowd was represented in the provincial press. While there have been several analyses of how executions were represented in the provincial press during the period, there has …

In Black And White: The Sociopolitical Rhetoric Surrounding Anti-Miscegenation Attitudes In Ohio, Sarah Mccrea

Senior Independent Study Theses

In this study, I argue that the appearance of anti-miscegenation writings in Ohio spiked during periods that saw massive threats to the notion of white male supremacy, such as the months just prior to the onset of the Civil War, several especially tense points during the Civil War and the Reconstruction period, and the early to middle years of the 1880s. During these times, Ohioans used at least one of three major rhetorical strategies—each of which coincided with a major trend in national events and politics—to justify and explain their anti-miscegenation attitudes.

When the Ohio State Legislature first debated the …

The Problematical, The Cave, And The Maya: A Theoretical Discussion And Ethnoarchaeological Investigation, Haley N. Austin

Senior Independent Study Theses

This project concerns itself with the theoretical framework and application of ethnoarchaeological research methods in the Maya region. Following an in-depth discussion of ethnoarchaeology and its theoretical locus within archaeology as well as the transformations it has seen in recent year, the current work focuses on the following source- and subject-side cultural groups and phenomena: cave use at La Ventana and La Ventana Campana by Maya peoples from the Suchitepéquez and Sololá Department of Guatemala in comparison with Problematical Deposit 21 at Tikal, Petén, Guatemala. The purpose of this work is not only to investigate the case study mentioned above …

Attempted Identification Of The Calcium-Dependent Sodium Channel Gene In Paramecium Tetraurelia Using Rnai, Gwendolyn Kuzmishin

Senior Independent Study Theses

Ion channels play an important role in the swimming behavior of Paramecium tetraurelia. Electrophysiological experiments indicate that a calcium-dependent sodium channel exists in Paramecium, but a gene has not been identified for this channel. It is hypothesized that this channel evolved from a voltage-dependent sodium channel after a whole genome duplication event. In this paper, 13 candidate genes were identified from the Paramecium genome based on their similarity to a reference human voltage-dependent sodium channel. Bioinformatics analysis of the selectivity filter of these putative ion channel genes suggested that at least 8 of the candidate genes were sodium channels …

When Do Black Lives Matter?: An Experimental Analysis Of White American Support For Black Social Movements, Latrice M. Burks

Senior Independent Study Theses

The BlackLivesMatter Movement has caught the media’s eye as it addresses racism in our criminal justice system. However, there seems to be a racial divide in support for this race-based movement, namely, black Americans tend to be supportive of the cause, and white Americans appear to be less so. Previous literature suggests that an emotional reaction to injustice, specifically moral shock, may trigger cross-racial support for race-based movements. In addition, racial attitudes can also be influential on cross-racial social movement support. This experimental analysis explores under what conditions white Americans will support a black social movement, one that does not …