Digital Commons Network^™

Examining The Effects Of Anti-Nogo A Immunotherapy On Post-Stroke Neurogenesis In The Adult Rat, Daniel Shepherd

Dissertations

Stroke is a leading cause of adult disability with no pharmacological treatments to restore lost function. Our laboratory has shown that treatment with neutralizing antibodies against the neurite growth-inhibitory protein Nogo-A improves sensorimotor and cognitive recovery after stroke in adult and aged rats. This recovery is paralleled by increased dendritic and axonal plasticity in anti-Nogo-A-treated rats. Neurogenesis, an alternate form of plasticity involving the de novo production of new neurons, may contribute to post-stroke neural repair. While previous studies have found roles for Nogo-A in adult neurogenesis, neurogenesis has not been investigated after stroke and anti-Nogo-A treatment. The goal of …

Critical Role Of C-Jun N-Terminal Kinase Signaling In Binge Alcohol-Driven Atrial Arrhythmic Remodeling, Jiajie Yan Yan

Dissertations

Holiday Heart Syndrome (HHS) is cardiac arrhythmia induced by binge alcohol consumption, a drinking pattern affects 38 million adults in our society. Atrial fibrillation (AF) is the most frequently diagnosed arrhythmia in HHS and causes significant morbidity and mortality. Despite the intensive prevention effort nationwide, the binge drinking population keeps rising. However, no effective treatment strategies are available for binge drinking induced AF due to the unknown underlying mechanisms. In this thesis, I aim to elucidate the mechanisms of binge alcohol-promoted atrial arrhythmogenicity by using a mouse model of repeated binge alcohol exposure established in the Ai Lab.

The Ai …

Effects Of Training On Intent, Ease, Self-Efficacy, Frequency, And Usefulness In Multimedia-Based Feedback For University-Level Instructors Using Canvas® Lms, Christopher Kent O'Leary

Doctoral Dissertations

The purpose of this study was to investigate how training and professional development effected university-level instructors’ perceived usefulness, perceived ease of use, behavioral intent to use, perception of self-efficacy, and frequency of use of audio-, video-, and speech-to-text-recognition-based technologies associated with the feedback and assessment process in college-level teaching. Except for usefulness, each dependent variable was divided into two based on whether the item was multimedia or not: (a) use of technology with multimedia and (b) use of technology without multimedia. The convenience sample included 52 university-level instructors who had enrolled in either the Canvas® Essentials (a basics course) or …

"Homicide," Iv. Christianity, Hille Haker

Theology: Faculty Publications and Other Works

No abstract provided.

Instructional Videos As Part Of A 'Flipped' Approach In Academic Writing, Marion Engin, Senem Donanci

All Works

This paper reports on a project in which students watched short instructional videos on aspects of academic writing as part of a 'flipped classroom' approach at an English-medium university in the United Arab Emirates. The authors present the video tutorial project in the context of the flipped classroom, and evaluate student satisfaction with the video input. The findings suggest that although most students liked watching the videos at home, and found the input easy to understand, they still felt the need for teacher explanations. One conclusion from this study is that students are not yet ready for a complete flipped …

Benefit Corporations: Providing A New Shield For Corporations With Ideals Beyond Profits, Kristin A. Neubauer

Journal of Business & Technology Law

No abstract provided.

Proposition 65 Warnings At 30 – Time For A Different Approach, David B. Fischer

Journal of Business & Technology Law

No abstract provided.

The Scientist, 2016, San Jose State University, College Of Science

The Scientist (College of Science)

No abstract provided.

Total Arsenic And Arsenic Speciation In Indigenous Food Stuffs, Bashdar Sadee

School of Geography, Earth and Environmental Sciences Theses

The properties of an element are highly dependent on its chemical form, it’s called elemental speciation. This study evaluates the arsenic species found in a range of food stuffs together with growing environments and toxicity issues. Total arsenic concentrations in fish tissue and vegetable crops were determined by ICP-MS following microwave-assisted acid digestion using nitric acid/hydrogen peroxide, trypsin and cellulase enzymatic extraction procedures. The extracted arsenic species were then quantified using HPLC-ICP-MS. A dilute nitric acid (1 % (v/v)) digestion procedure was also used to extract arsenic species from rice and the different parts (root, skin, stem, leaf and grain) …

Detection Of Poly- And Perfluoroalkyl Substances (Pfass) In U.S. Drinking Water Linked To Industrial Sites, Military Fire Training Areas, And Wastewater Treatment Plants, Xindi C. Hu, David Q. Andrews, Andrew B. Lindstrom, Thomas A. Bruton, Laurel A. Schaider, Philippe Grandjean, Rainer Lohmann, Courtney C. Carignan, Arlene Blum, Simona A. Balan, Christopher P. Higgins, Elise M. Sunderland

Graduate School of Oceanography Faculty Publications

Drinking water contamination with poly- and perfluoroalkyl substances (PFASs) poses risks to the developmental, immune, metabolic, and endocrine health of consumers. We present a spatial analysis of 2013–2015 national drinking water PFAS concentrations from the U.S. Environmental Protection Agency’s (US EPA) third Unregulated Contaminant Monitoring Rule (UCMR3) program. The number of industrial sites that manufacture or use these compounds, the number of military fire training areas, and the number of wastewater treatment plants are all significant predictors of PFAS detection frequencies and concentrations in public water supplies. Among samples with detectable PFAS levels, each additional military site within a watershed’s …

Alleviating The 'Miserable Condition': Fitzjames Stephen And The Development Of Modern Abortion Law, Kate Gleeson

The Plymouth Law and Criminal Justice Review

Contemporary English abortion law is now typically thought to be a development of the twentieth century, and little academic attention has been paid to its development before the 1938 case of R v Bourne or the Abortion Act 1967. Sir James Fitzjames Stephen's nineteenth century perspectives on pregnancy, abortion and the doctrine of necessity informing the basis of contemporary governance of abortion, child destruction, and infanticide as distinct from homicide, are often overlooked. Stephen understood abortion, child destruction and infanticide as distinct crimes with a common motivation and intention. The desperation of women to conceal or remedy the 'miserable' and …

Editorial, Kim Stevenson, Lesley Simmonds, Jason Lowther

The Plymouth Law and Criminal Justice Review

No abstract provided.

The Animals Act 1971 Places A Disproportionate Burden On The Keepers Of Animals And Is In Need Of Reform, Abigail Saunders

The Plymouth Law and Criminal Justice Review

The purpose of this paper is to determine whether the Animals Act 1971 places a disproportionate burden on the keepers of animals and whether it is in need of reform. The law prior to the Act will be considered in order to identify the problems that led to the current law. An analysis of the application of the Act and the case law follows to identify any problems with the current law. This paper will also focus specifically on damage caused by horse riding accidents due to the fact that it is a high risk sport and injuries will arise. …

Challenging Classical Legacy: Virginia Woolf' Mythical Method In To The Lighthouse, Alex Rucka

Maria Dittman Library Research Competition: Student Award Winners

No abstract provided.

Foundations In Wisconsin: A Directory [35th Ed. 2016], Mary C. Frenn, John Brick, Brittany Carloni, Jeremy Cluth, Kathryn Hendrickson, Sarah Holland, Clare Mcnamara, Katie Murray, Catherine Simmerer, Dominic Zappia

Foundations in Wisconsin: A Directory

The 2016 release of Foundations in Wisconsin marks the 35^th edition of the print directory and the 16^th edition of the online version. The directory is designed as a research tool for grantseekers interested in locating information on private, corporate, and community foundations registered in Wisconsin. Each entry in this new edition has been updated or reviewed to provide the most current information available. Most of the data was drawn from IRS 990-PF tax returns filed by the foundations. Additional information was obtained from surveys, foundation websites, and annual reports.

This edition paints a very positive picture of …

Constitutional Law And Rhetoric, Colin Starger

All Faculty Scholarship

What are the legitimate types of argument in constitutional debate? This is a perennial question in American law and every generation of constitutional scholars has the right to ask it anew. For over thirty years, Phillip Bobbitt’s taxonomy of legitimate constitutional argument types has reigned as the most influential and enduring in the scholarly discourse. In a recent article, Jamal Greene has proposed a welcome but flawed rhetorical re-conception of Bobbitt’s venerable typology. By identifying and correcting the errors in Greene’s framework, this Article provides a rigorous theoretical grounding for the entire constitutional law and rhetoric project.

When properly grounded, …

Estimating The Sustainability Of Towed Fishing-Gear Impacts On Seabed Habitats: A Simple Quantitative Risk Assessment Method Applicable To Data-Limited Fisheries, C. Roland Pitcher, Nick Ellis, Simon Jennings, Jan G. Hiddink, Tessa Mazor, Michel J. Kaiser, Mervi I. Kangas, Robert A. Mcconnaughey, Ana M. Parma, Adriaan D. Rijnsdorp, Petri Suuronen, Jeremy S. Collie, Ricardo Amoroso, Kathryn M. Hughes, Ray Hilborn

Graduate School of Oceanography Faculty Publications

Summary

1. Impacts of bottom fishing, particularly trawling and dredging, on seabed (benthic) habitats are commonly perceived to pose serious environmental risks. Quantitative ecological risk assessment can be used to evaluate actual risks and to help guide the choice of management measures needed to meet sustainability objectives.
2. We develop and apply a quantitative method for assessing the risks to benthic habitats by towed bottom-fishing gears. The method is based on a simple equation for relative benthic status (RBS), derived by solving the logistic population growth equation for the equilibrium state. Estimating RBS requires only maps of fishing intensity and …

En-Gendering Economic Inequality, Michele E. Gilman

All Faculty Scholarship

We live in an era of growing economic inequality. Luminaries ranging from the President to the Pope to economist Thomas Piketty in his bestselling book Capital in the Twenty- First Century have raised alarms about the disparity between the haves and the have-nots. Overlooked, however, in these important discussions is the reality that economic inequality is not a uniform experience; rather, its effects fall more harshly on women and minorities. With regard to gender, American women have higher rates of poverty and get paid less than comparable men, and their workplace participation rates are falling. Yet economic inequality is neither …

Using A Virtual World To Teach Joint Protection To People Living With Rheumatoid Arthritis: A Pilot Randomised Controlled Trial, Rashid Kashani

Other Faculty of Health Theses

Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting an estimated 1% of the global population. Joint protection is one intervention with some quality evidence of efficacy for RA self-management. However, joint protection education is often provided only in urban centres during Arthritis Self-Management Programs (ASMPs) in classroom sessions at designated times. These programs, therefore, may not be available to all who need them. Providing and testing more accessible methods of delivering joint protection education to people living with RA may improve accessibility. Aims: (i) To develop a virtual world (VW) intervention available via the Internet in Second …

Optimised Mammogram Displays For Improved Breast Cancer Detection, Graeme Alexander Riley

Other Faculty of Health Theses

In current mammography practice, radiologists typically view mammograms in a symmetric, side-by-side, configuration in the belief that abnormalities will be made salient because they break the perceived symmetry. The literature on the use of symmetry as an aid to signal detection is limited and this thesis has taken a psychophysical approach to investigate the radiologist’s task of detecting a small mass (a blob) in paired mammogram backgrounds. Initial experiments used Gaussian white noise and synthetic mammogram backgrounds to test observer performance for the radiologist’s task using symmetric (side-by-side) displays and animated (the two images of a pair alternated sequentially in …

Dose-Banding Studies On Oxaliplatin, Liu Xiaoqing

Other Faculty of Health Theses

Oxaliplatin is an anticancer drug widely used in cancer chemotherapy. This thesis evaluates whether a specific dose-banding scheme for oxaliplatin could replace the individual dosing method that is currently used in the oxaliplatin administration. Dose-banding was introduced into UK clinical practice in 2001, as it reduces delays in patients receiving their treatment and, through quality control and end-product testing, safeguards the infusion quality and patient safety. A range of studies were included in this thesis: an extended stability study on oxaliplatin infusions using a sequential temperature cycling design; studies on oxalate, a potential degradation product and metabolite of oxaliplatin which …

An Electrophysiological Examination Of Visuomotor Activity Elicited By Visual Object Affordances, Thomas Oliver Dixon

Other Faculty of Health Theses

A wide literature of predominantly behavioural experiments that use Stimulus Response Compatibility (SRC) have suggested that visual action information such as object affordance yields rapid and concurrent activation of visual and motor brain areas, but has rarely provided direct evidence for this proposition. This thesis examines some of the key claims from the affordance literature by applying electrophysiological measures to well established SRC procedures to determine the verities of the behavioural claims of rapid and automatic visuomotor activation evoked by viewing affording objects. The temporal sensitivity offered by the Lateralised Readiness Potential and by visual evoked potentials P1 and N1 …

The Control Of Schwann Cell Myelination During Development And After Nerve Injury, Sheridan Roberts

Other Faculty of Health Theses

Schwann cells are the principal glial cell of the peripheral nervous system and are responsible for axon maintenance, regeneration and increasing saltatory conduction of neurons. Schwann cell differentiation and myelination is mediated by a core network of transcription factors and signalling pathways, which have been divided into two groups; positive and negative regulators. Sox10, NFATc4, Oct6, Krox20 and the ERK 1/2 signalling pathway have been characterised as positive regulators of Schwann cell differentiation and myelination; with Sox10 and Krox20 also playing critical roles in myelin maintenance. On the other hand, transcription factors cJun, Pax3, Id2 and signalling pathways Notch and …

Plastic Fragmentation In The Environment, Nicolas Francis Alexandre Biber

Other Faculty of Science and Engineering Theses

Microplastics are small piece of plastic debris < 5 mm in diameter, which arise and enter the environment either as a consequence of the direct release of small pieces of plastic debris or as a consequence of the fragmentation of larger items. They are widely distributed in the marine environment, on shorelines, at the sea surface, on the seabed. They are also ingested by a variety of marine organisms, and there is some evidence that this may cause adverse effects. This thesis investigates the potential sources, distribution and fate of this contaminant. Deterioration of plastics in a variety of environments was examined as a potential source of microplastics. Plastics were exposed in light and shade, in air, fresh water and sea water. Their deterioration was monitored over six hundred days. The fastest rate of deterioration, by far, was observed in air, and this was further accelerated by natural sunlight. Degradation in water was much slower and it was therefore concluded that plastic debris only fragments slowly into microplastics while they are in the water, and much faster when they are washed ashore and/or remain exposed to air, for example on a beach. A method to assess the contamination of beaches by microplastics' likely predecessors - small items of plastic debris - was therefore developed. High spatial variability, which can impede comparison between surveys undertaken by random sampling was overcome by assessing deliberately selected debris accumulations. An attempt to utilise citizen science using this rapid survey approach returned too much variability between volunteers to obtain consistent results. Nevertheless, the survey method was successfully used to identify narrow opening towards the sea, small tidal range and several weeks of high on-beach waves as predictors for high contamination. Evidence of harmful effects of microplastics on animals is primarily from laboratory studies and could be substantiated by exposure experiments \emph{in-situ}. Cockles were exposed to fluorescent plastic particles in an intertidal mudflat. After two weeks, particles were still present in the sediment. However, the test material could not be identified in the cockles with enough certainty to validate the method. The thesis concludes that fragmentation of larger items of debris on land is an important potential source of microplastics. Therefore, preventing plastics that are prone to deteriorate from entering the environment is likely the most effective way to prevent the generation of microplastics. Measuring the success of such preventive measures in the field returns highly variable results, as small plastic debris are elusive. Measuring effects in the environment demands large amounts of data, and highly specific methods are required to detect microplastics in animals. The shift of environmental plastic contamination towards small particles demands that plastic debris research adjusts to the elusiveness of these particles. Large volumes of variable data on plastics density and precise biological essays will be required.

A Retro-Projected Robotic Head For Social Human-Robot Interaction, Frédéric C. Delaunay

Other Faculty of Science and Engineering Theses

As people respond strongly to faces and facial features, both consciously and subconsciously, faces are an essential aspect of social robots. Robotic faces and heads until recently belonged to one of the following categories: virtual, mechatronic or animatronic. As an original contribution to the field of human-robot interaction, I present the R-PAF technology (Retro-Projected Animated Faces): a novel robotic head displaying a real-time, computer-rendered face, retro-projected from within the head volume onto a mask, as well as its driving soft-ware designed with openness and portability to other hybrid robotic platforms in mind.The work constitutes the first implementation of a non-planar …

Visual Narrative: A Theory And Model For Image-Driven Digital Historiography Based On A Case Study Of China’S Boxer Uprising (C. 1900), Ellen Irene Sebring

Other Faculty of Arts, Humanities and Business Theses

Digitization that has enabled instant access to vast numbers of archival, historical images, demands a new paradigm for the use of visual imagery in historical research. This thesis proposes a new form of historiography in the digital medium, an image-based narrative mode for authoring and reading history. I propose a digital model for conveying history through the visual record, as an alternative to the printed book. Unlike the quantitative “big data” approach to digital humanities, this research explores visuality itself. In a practice-led approach, the research addresses both aspects of historiography: (1) a method of historical representation; and (2) original …

Duchamp Meets Turing: Art, Modernism, Posthuman, Gabriela Galati

Other Faculty of Arts, Humanities and Business Theses

In her book How We Became Posthuman (1999), Katherine Hayles analysed the process through which the conception of the liberal humanist subject led the way to the posthuman subject, a subject who lives in complete entwinement with the digital. This process, however, was not innocuous: it made the (fallacious) perception that information could do without material instantiation pervasive within many fields of knowledge, a process that Hayles contends originates in the Macy Conferences and the evolution of cybernetic theory. This research identifies an analogous process within the artistic realm: when Clement Greenberg delineated the concepts of opticality and colour field …

A Theoretical Model For The Design Of A Transcultural Visual Communication System In A Posthuman Condition, Haytham Nawar

Other Faculty of Arts, Humanities and Business Theses

This dissertation follows an interdisciplinary approach that weaves practice and theory in the disciplines of visual communication, semiotics, cultural studies, linguistics, and new media art. The research methodology is practice-based located within a historical and contemporary context that allows for artistic experimentation and new knowledge to be generated through reflected creative practice This research proposes a context within which society can develop a transcultural means of communication with the objective of gaining completely unambiguous forms of understanding. This research explores the possibility of an open source scaffold for pictorial language that fosters self-enhancing diversity of production models, communication paths, and …

Reciprocal Technologies: Enabling The Reciprocal Exchange Of Voice In Small-Scale Farming Communities Through The Transformation Of Information And Communications Technologies, Eugenio Tisselli

Other Faculty of Arts, Humanities and Business Theses

This dissertation claims that the reciprocal exchange of voice—an element for constructing community and strengthening political recognition—may be fostered in small-scale farming communities by (1) the appropriation and transformation of information and communications technologies, (2) artistic intervention, and (3) cross-community research. This study contributes to participatory research methodologies, particularly those that seek to tackle the diverse challenges faced by small-scale farmers from a broad, complex perspective. The main issue identified in this dissertation is as follows: The hegemony of economic behaviors, which stands as a cornerstone of neoliberal capitalism, constitutes the latest stage of a historical process in which the …

That Dark Remembered Day - A Novel, And Critical Self-Reflection On Composition And The Editorial Process, Tom Vowler

Other Faculty of Arts, Humanities and Business Theses

My aim for That Dark Remembered Day was to create a work of fiction with a strong sense of the literary, one whose themes of violence, landscape and survivor guilt shone a light on the human condition, specifically the effects of post-war trauma on one family. The novel’s structure would be crucial in achieving its emotional heft, as each of the central characters is allocated at least one section, the reader experiencing events from disparate and increasingly illuminating perspectives. Fragmenting the book’s chronology (both throughout, but particularly in Part 3) by employing a technique of temporal blurring, helped to recreate …