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Macrophage Migration Inhibitory Factor Polymorphisms And Tuberculosis Disease Susceptibility In Kwazulu-Natal, South Africa, Max Mu Wang

Public Health Theses

Background: TB is a leading cause of mortality, infecting over one-third of the world’s population. Difficulties combating the disease are compounded by the fact that a majority of TB infections remain in an asymptomatic latent state. Macrophage migration inhibitory factor (MIF) is an innate cytokine that is encoded in a functionally polymorphic genetic locus with characterized allelic variants that correlate to TB progression. Understanding the genetic factors that regulate host immune responses to TB will help to identify individuals who are at higher risk of severe infection.

Methods: A case-control study of HIV+ active pulmonary TB cases and HIV+ controls …

The Effect Of Spatiotemporally-Dependent Air Pollution Exposure On Birthweight In The Lanzhou Birth Cohort, Dennis Wang

Public Health Theses

Introduction: Low birthweight serves as a proxy risk factor for a number of conditions later in development. Of China’s urban centers, Lanzhou has long been considered one of the worst-affected cities by air pollution.

Objectives: This study uses spatial heterogeneity in air pollution exposure across addresses in Lanzhou and temporal heterogeneity resulting from the differential timing of pregnancy in the Lanzhou Birth Cohort to investigate the association between PM10 exposure and birthweight.

Methods: The study population consisted of 4,865 mother-child pairs from the Gansu Provincial Maternity and Child Care Hospital. Participants completed an epidemiological questionnaire and patient data were collected …

Whole-Genome Sequencing And Phylogenetic Analysis Of Novel Paramyxoviruses Discovered In Bats From Brazil, Heather Louise Wells

Public Health Theses

Wildlife disease surveillance has been increasing in recent years in an effort to identify and characterize novel emerging zoonoses. In particular, bats have been targets of active surveillance because of their recent associations with diseases of global public health importance, such as Ebola virus, SARS-like coronaviruses, and Nipah and Hendra virus. The high species richness, large population sizes, and frequent inter- and intra-species interactions of bats make them ideal reservoirs of infectious diseases. For this molecular epidemiological study, novel paramyxoviruses discovered through surveillance of bats in Brazil were fully sequenced to allow for a range of genetic analyses, including the …

The Role Of Folate In The Association Between Perinatal Air Pollution Exposure And Birth Outcomes In Lanzhou, China, Rebecca Ann Wong

Public Health Theses

Background: China’s rapid economic and industrial development over the past few decades has been accompanied by tremendous increases in air pollutant emissions and come at a serious cost to the environment and public health. Recent research has revealed an increased risk of adverse birth outcomes associated with perinatal air pollution exposure. Although the mechanisms by which air pollutants contribute to adverse birth outcomes have not yet been established, folate intake has been shown to counteract several of the hypothesized biological pathways.

Hypothesis: Dietary folate intake and folic acid supplementation modify the association between perinatal air pollution exposure (PM10, NO2, SO2) …

All-Source Exposures To Arsenic For Residents Living Near Historic Gold Mine Areas In Northwest Romania, Zhen Zhang

Public Health Theses

Background: Roşia Montană gold mine is the site of historic mining operations since Roman times. Contamination of nearby communitiesby historic mining activities is of serious concern.

Objective: The study objective is to investigate whether living in the vicinity of historic gold mining increases risk of arsenic exposure from the surrounding environment, and if dietary intake from home gardens is associated with reduced risk of arsenic exposure.

Methods: We performed assessments in 64 participants from 57 households within the target communities. All study participants gave written informed consent. The study was approved by the institutional review boards of the regional public …

Property Rights And Governance Strategies: How Best To Deal With Land, Water, Intellectual Property, And Spectrum, Richard A. Epstein

Colorado Technology Law Journal

No abstract provided.

Aldehyde Dehydrogenase 1 (Aldh1) Genes In Cancer Clinical Prognosis Outcomes, Mengyi Ding

Public Health Theses

ABSTRACT

Background & Hypothesis

It has become clear that ALDH1 genes are involved in the pathobiology of various human cancers. Several lines of evidence indicated that ALDH1 gene expression in tumors may be associated with clinical prognosis outcomes. This hypothesis of our study is that ALDH1 genes may be used to predict human cancer prognosis. In order to test this hypothesis, a systematic review of published articles, a meta-analysis using Random-Effects model was conducted to assess the association between ALDH1 genes and clinicopathological features as well as survival outcomes.

Methods

Using PubMed, EMBASE and Web of Science, this study identified …

Neighborhood-Level Socioeconomic Status And County Fairs And The Risk Of Shiga Toxin-Producing Escherichia Coli Incidence In Connecticut, 2012 To 2014, Gili Hrusa

Public Health Theses

Abstract

Background: Shiga toxin-producing E. coli (STEC) is a reportable illness. It is associated with a spectrum of clinical manifestations that range from watery and/or bloody diarrhea to hemolytic uremic syndrome (HUS), a life threatening condition which causes acute renal failure in both children and adults. A study in Connecticut (CT) by Whitney et al. (2015) found a strong association between higher socioeconomic status (SES) and Shiga toxin-producing E. coli incidence. In the same study, there was a weaker association demonstrated between rurality and STEC incidence as well. The primary aim of this study is to investigate the relationship between …

Vitamin D Status And Age Of Menarche:, Alexandra Hua

Public Health Theses

Early age of menarche (AOM) increases risk for chronic disorders, including cardiovascular disease and related mortality, type 2 diabetes, and breast cancer. Vitamin D deficiency may be linked to earlier onset of menstruation, but there is limited research examining vitamin D and its association with AOM. The objective of this study was to examine the association between vitamin D levels and AOM by analyzing the National Health and Nutrition Examination Survey (NHANES) data from 2001-2010. We hypothesized that that vitamin D deficiency is associated with earlier age of menarche in adolescent and early adult females in the United States. Cross-sectional …

Lifetime Residential Water Source And Thyroid Cancer Risk: A Connecticut Based Case-Control Study, Hannah Grace Kaneck

Public Health Theses

While incident thyroid cancer diagnoses continue to increase at a rate faster than any other cancer in the US, questions about environmental exposures’ link to small malignancy increases persist. Nitrate consumption as a predictor for thyroid cancer has become a topic of interest due to their ubiquitous contamination of water and food supplies. No epidemiological studies have looked at the correlation of residential water source over an entire lifetime and its relation to thyroid cancer. A Connecticut based case-control study conducted in 2010-2011, including 462 histologically confirmed incident thyroid cancer cases and 498 Connecticut based controls used multivariate unconditional logistic …

E-Cigarette Use Among Urban Adolescents: A Longitudinal Study Of Prevalence And Predictors Of Use, Melody Kingsley

Public Health Theses

Purpose: In a study of middle school students, the objectives were to (1) document prevalence of early e-cigarette use and characteristics of users, and (2) identify psychosocial and behavioral factors that predict susceptibility and uptake.

Methods: Students in 12 randomly selected public schools in New Haven, Connecticut, completed health and behavior surveys in grades 7 and 8 (N=490). Descriptive statistics were calculated to assess the prevalence of e-cigarette susceptibility (considering e-cigarette use) and e-cigarette uptake among students at grade 7 and grade 8. Multivariate logistic regression analyses were used to assess associations between psychosocial and behavioral characteristics measured at grade …

A Healthy Herd: Addressing The Justifications For Vaccine Denial And Applying The Health Belief Model To The Current Anti-Vaccination Movement, Sarah L. Mchugh

Honors Program Theses

The purpose of this thesis is to explore and analyze the existing literature regarding the refusal to receive vaccinations designed specifically to prevent Measles-Mumps-Rubella (MMR), which has spurred a serious public health issue that puts every unvaccinated person at risk. It will investigate the reasons people refuse to get vaccinations for themselves or their children. The analysis of the current situation and the application of the Health Belief Model to the related factors will provide potential explanations regarding how the decision-making process may strengthen efforts towards increasing vaccination rates.

Impact Of Alcohol On Households And Families In Trinidad And Tobago, Rebecca Lakew

Public Health Theses

Objective: To characterize the lived experience of women in Trinidad and Tobago who have at least one family member with chronic alcohol use.

Method: In-person, semi-structured qualitative interviews.

Results: 1) The cultural context in which women with alcohol dependent relatives live shapes their understanding of their roles; 2) a tension emerged between the participants’ idealized role in their family and the reality; 3) participants employed a range of coping mechanisms to deal with their alcohol dependent relative; and 4) the experiences of the participants can be better understood in the larger context of systems of support and enablement in Trinidad …

Spermatogenesis Drives Rapid Gene Creation And Masculinization Of The X Chromosome In Stalk-Eyed Flies (Diopsidae), Richard H. Baker, Apurva Narechania, Rob Desalle, Philip M. Johns, Josephiine A. Reinhardt, Gerald S. Wilkinson

Biology

Throughout their evolutionary history, genomes acquire new genetic material that facilitates phenotypic innovation and diversification. Developmental processes associated with reproduction are particularly likely to involve novel genes. Abundant gene creation impacts the evolution of chromosomal gene content and general regulatory mechanisms such as dosage compensation. Numerous studies in model organisms have found complex and, at times contradictory, relationships among these genomic attributes highlighting the need to examine these patterns in other systems characterized by abundant sexual selection. Therefore, we examined the association among novel gene creation, tissue-specific gene expression, and chromosomal gene content within stalk-eyed flies. Flies in this family …

Fire Severity Controlled Susceptibility To A 1940s Spruce Beetle Outbreak In Colorado, Usa, Dominik Kulakowski, Thomas T. Veblen, Peter Beb

Geography

The frequency, magnitude, and size of forest disturbances are increasing globally. Much recent research has focused on how the occurrence of one disturbance may affect susceptibility to subsequent disturbances. While much has been learned about such linked disturbances, the strength of the interactions is likely to be contingent on the severity of disturbances as well as climatic conditions, both of which can affect disturbance intensity and tree resistance to disturbances. Subalpine forests in western Colorado were affected by extensive and severe wildfires in the late 19th century and an extensive and severe outbreak of spruce beetle (Dendroctonus rufipennis) in the …

Socioeconomic Rights Adjudication In Canada: Can The Minimum Core Help In Adjudicating The Rights To Life And Security Of The Person Under The Canadian Charter Of Rights And Freedoms?, Ania Kwadrans

Journal of Law and Social Policy

Violations of the minimum core economic and social rights (ESR) deprive society’s most vulnerable individuals and groups of the very resources that are essential to life and basic well-being. States have an obligation to ensure that meaningful remedies are available for such infringements. Though articulating a minimum core for ESR poses challenges, and critics of the concept find it beyond the institutional competence of courts, it remains an important tool for adjudication. The minimum core focuses the inquiry on the underlying goals of human rights: the protection of vulnerable and marginalized groups from the most serious forms of deprivation and …

Music And The Child, Natalie Sarrazin

Milne Open Textbooks

Children are inherently musical. They respond to music and learn through music. Music expresses children’s identity and heritage, teaches them to belong to a culture, and develops their cognitive well-being and inner self worth. As professional instructors, childcare workers, or students looking forward to a career working with children, we should continuously search for ways to tap into children’s natural reservoir of enthusiasm for singing, moving and experimenting with instruments. But how, you might ask? What music is appropriate for the children I’m working with? How can music help inspire a well-rounded child? How do I reach and teach children …

Good Corporation, Bad Corporation: Corporate Social Responsibility In The Global Economy, Guillermo C. Jimenez, Elizabeth Pulos

Milne Open Textbooks

This textbook provides an innovative, internationally oriented approach to the teaching of corporate social responsibility (CSR) and business ethics. Drawing on case studies involving companies and countries around the world, the textbook explores the social, ethical, and business dynamics underlying CSR in such areas as global warming, genetically modified organisms (GMO) in food production, free trade and fair trade, anti-sweatshop and living-wage movements, organic foods and textiles, ethical marketing practices and codes, corporate speech and lobbying, and social enterprise. The book is designed to encourage students and instructors to challenge their own assumptions and prejudices by stimulating a class debate …

Meaningful Science: A Look At Elementary Science Education Practices, Avery Shelton

Senior Honors Theses and Projects

This honors project examines best practices in elementary science education. It focuses on how arts integration, technology, children's literature, discussion, group work, and hands-on activities all maintain engagement in elementary students.

Hunting Down The Meaning Of The Second Amendment: An American Right To Pursue Game, Ryan Notarangelo

South Dakota Law Review

No abstract provided.

Volume 28 — Religions Of Africa And The Ecology: Strategizing For Environmental Protection, The Ecumencial Association Of Nigerian Theologians

Bulletin of Ecumenical Theology

No abstract provided.

A Bill Of Goods: How Advertisers Sold The Great War, And Created The Lost Generation, Adam Poltrack

Dissertations and Theses

No abstract provided.

"The Diaries Of The Backpacking Puppies: An Adventure Series", Estefania Di Bua

Dissertations and Theses

No abstract provided.

Food And Slave Communities In The Antebellum South, Jessica Rose

Dissertations and Theses

No abstract provided.

Adsorption Of Antibiotics By Vermiculite, Mosa J. Ferdous

Dissertations and Theses

The occurrence of residual antibiotics in the environment has been a worldwide issue and warrants the development of inexpensive yet effective methods for antibiotics removal from contaminated water. In this thesis work, the adsorption of four antibiotics, namely chlorotetracycline (CTC), oxytetracycline (OTC), ofloxacin (OFL), and enrofloxacin (ENR), onto natural vermiculite has been studied using batch (static) and column (dynamic) adsorption techniques. The Langmuir and Freundlich isotherm models were initially used to explain the adsorption processes. The separation factor (RL) values derived from the Langmuir model and the 1/n values derived from Freundlich model in the present investigation were less than …

Expression And Function Of A Putative Cox-Like Gene In D. Melanogaster, Michelle S. Batchu

Dissertations and Theses

Cyclooxygenases (COX) are the enzymes that catalyze the conversion of arachidonic acid into prostaglandins. In mammals, isoform COX-1 is constitutively expressed, whereas the isoform COX-2 gene expression is induced, primarily at sites of inflammation. While eicosanoids play a major role in inflammation in insects, their existence in fruit flies has not been reported. Recent computational analyses by Qi and Singh (2014) have identified putative COX-like enzymes in the fruit fly Drosophila melanogaster. Here we compare the expression patterns of these enzymes and the effects of their knockdown in immune cells of D. melanogaster third instar larvae. Because of high genetic …

"Molecular Analysis Of Virulence Factors Unique To Leptopilina Heterotoma-A Parasitic Wasp Of Drosophila Spp.", Noelle Dziedzic

Dissertations and Theses

Endoparasitioid wasps of Drosophila spp. frequently avoid or overcome the immune defense mechanisms of their fly hosts. Leptopilina heterotoma (Lh) is a generalist wasp species, successful on many Drosophila spp. world-wide. During oviposition, the female wasp introduces venom proteins and virus-like particles (VLPs) into developing fly larvae. VLPs are endocytosed by plasmatocytes, a macrophage-like blood cell that is the most abundant hemocyte present in the circulating hemolymph. Once internalized, VLPs destroy plasmatocytes by programmed cell death. To understand the contributions of VLP proteins in VLP trafficking within host cells, we took advantage of proteomic data from purified Lh VLPs. Two …

What Accounts For The Success Of New Ethnically Based Parties In Latin America And The Rise Of Ethnopopulism: – A Comparative Study Between Ecuador, Bolivia And Peru, Monica M. Orellana

Dissertations and Theses

No abstract provided.

Assessing The Utility Of Imaging Radar For Identifying White Sand Vegetation Structure, Jessica Rosenqvist

Dissertations and Theses

White sand vegetation communities are wide spread across South America; found in Peru, Venezuela, Brazilian Amazon and Guyana. They are distributed in patches ranging from <1 km2 to greater than tens of square kilometers and their origins and locations are still not well understood. The communities are related to a variety of factors (soil type, flooding, nutrient content and fire); hence a precise definition for the ecosystem is still not fully defined. Nevertheless, the result of these variations creates a unique environment for endemic plant and animal species to thrive. Furthermore, analysis of these areas has been very scattered and identification of local white sand areas (<1 km2) have not been accomplished. In addition, identification of these locations has currently only used optical satellite imagery (Landsat, MODIS). Hence, in this project, we have attempted to use synthetic aperture radar to create a classification system to locate the white sand vegetation systems. The goal is to be able to apply this method to identify white sand vegetation distribution across South America. The region of focus for this thesis has been in Aracá, a large white sand area located in Brazil in the State of Amazonas. Due to the lack of ground reference data, a classified map by Capurucho et al. (2013), generated using Landsat data, was used as a comparison and reference. JAXA’s ALOS-1 PALSAR (L-band), ESA’s Sentinel-1A (C-band) and NASA’s SRTM sensors were used for land classification. As microwave signals penetrate clouds and haze, the advantage of using sensors with this wavelength allows for an unobstructed coverage of the landscape all year round. Different combinations of polarizations and wavelengths were used during the analysis to try and separate the white sand vegetation from water and terra firme forest. The resulting classification images showed a 30% agreement with the classification map by Capurucho et al. It is important to note, that this number is in fact an agreement percentage as the map used was a classification image and coarse in resolution (due to the lack of reference data). Therefore, this value does not imply a bad classification. Future work will include time-series data, precise ground reference points and data from other sensors such as ALOS-2 PALSAR, to improve the classification accuracy.

Discrete Model For Cancer Tumor Growth And Effect Of Chemotherapy, Karim Virani

Dissertations and Theses

Many mathematical models have focused on growth of a single tumor with their spreading rate with some have included its metastasis. Some of the earlier models focus on exponential growth and its shift with time on to a linear model. The Gompertzian model involves a quadratic terms and that limit growth. We looked into Iwata et al paper it discusses a different model and takes into account the growth and metastasis of a tumor population but does not look into tumor shrinking or chemotherapy. Our new model focuses on the extending Iwata et al model to take into account tumor …