Digital Commons Network^™

Modulatory Action By The Serotonergic System: Behavior And Neurophysiology In Drosophila Melanogaster, Zana R Majeed, Esraa Abdeljaber, Robin Soveland, Kristin Cornwell, Aubrey Bankemper, Felicitas Koch, Robin L. Cooper

Biology Faculty Publications

Serotonin modulates various physiological processes and behaviors. This study investigates the role of 5-HT in locomotion and feeding behaviors as well as in modulation of sensory-motor circuits. The 5-HT biosynthesis was dysregulated by feeding Drosophila larvae 5-HT, a 5-HT precursor, or an inhibitor of tryptophan hydroxylase during early stages of development. The effects of feeding fluoxetine, a selective serotonin reuptake inhibitor, during early second instars were also examined. 5-HT receptor subtypes were manipulated using RNA interference mediated knockdown and 5-HT receptor insertional mutations. Moreover, synaptic transmission at 5-HT neurons was blocked or enhanced in both larvae and adult flies. The …

Evolution Of The Vertebrate Claudin Gene Family: Insights From A Basal Vertebrate, The Sea Lamprey, Christian Mukendi, Nicholas Dean, Rushil Lala, Jeramiah J. Smith, Marianne E Bronner, Natalya V. Nikitina

Biology Faculty Publications

Claudins are major constituents of tight junctions, contributing both to their intercellular sealing and selective permeability properties. While claudins and claudin-like molecules are present in some invertebrates, the association of claudins with tight junctions has been conclusively documented only in vertebrates. Here we report the sequencing, phylogenetic analysis and comprehensive spatiotemporal expression analysis of the entire claudin gene family in the basal extant vertebrate, the sea lamprey. Our results demonstrate that clear orthologues to about half of all mammalian claudins are present in the lamprey, suggesting that at least one round of whole genome duplication contributed to the diversification of …

Viral Causes Of Gastroenteritis In The Era Of Widespread Rotavirus Vaccination, Dame Idossa

Yale Medicine Thesis Digital Library

Background: It is unknown if widespread use of Rotavirus (RV) vaccine will impact the primary causative agent of viral gastroenteritis (VGE).

Objective: To identify changes in epidemiology of VGE affected by vaccination, determine factors associated with higher severity of illness, and assess agreeability between two clinical severity-grading scales; Clark and Vesikari.

Methods: We analyzed fecal samples of children, 6 months-5 years of age, evaluated at YNHH for VGE. Fecal samples were tested using a real-time PCR assay. Primer and probe sequences targeted conserved regions of the genome for RV, Norovirus GI/GII, Adenovirus, Astrovirus, and Sapovirus. Data were analyzed using SPSS. …

Emergency Medical Services Utilization And Interventions By Paramedics During A Blizzard, Shalom Sokolow

Yale Medicine Thesis Digital Library

EMERGENCY MEDICAL SERVICES UTLIZATION AND INTERVENTIONS BY PARAMEDICS DURING A BLIZZARD.

Shalom Sokolow (Sponsored by Sandy Bogucki). Department of Emergency Medicine, Yale University, School of Medicine, New Haven, CT.

On February 8th, 2013, southern Connecticut was struck by a powerful blizzard. Emergency Medical Services (EMS) crews experienced significantly increased call volume along with increased response and transport times. This study examined which types of EMS calls increased or decreased during the storm and whether paramedics performed more or fewer advanced life support (ALS) interventions.

EMS calls were differentiated by call type and analyzed to determine which types increased or decreased …

Identity-Construction And Development In The Modernist Bildungsroman, Victoria Gordon

Senior Theses

"Near the turn of the 20th century, with the advent of modernist modes of creation and thinking, there is a perceptible shift in the narrative of the Bildungsroman. This essay focuses on the shift in perception of the self and self-development in the modernist. Bildungsroman by performing a psychoanalytic reading of Oscar Wilde’s The Picture of Dorian (1890) Gray and James Joyce’s The Portrait of the Artist as a Young Man." --pages 1-2

The Truth About Parmenides' Doxa, Christopher Kurfess

Ancient Greek and Roman Studies Faculty Publications

In a recent article in this journal, Néstor-Luis Cordero has offered an interesting account of how scholars may have been misreading Parmenides' poem for centuries, as well as some provocative suggestions on how to correct that misreading. He calls into question the prevalent notion of the Doxa as Parmenides' account of the phenomenal world, and he challenges the standard arrangement of the fragments that assigns lines featuring 'physical' topics to that portion of the poem. The 'Doxa of Parmenides', if that phrase is understood to imply that Parmenides himself embraced doxai of any kind is, Cordero claims, an imaginary …

Social Media And Credibility Indicator: The Effects Of Bandwagon And Identity Cues Within Online Health And Risk Contexts, Xialing Lin

Theses and Dissertations--Communication

Three studies were conducted to investigate how social media affordances influence individuals’ source credibility perceptions in risk situations. The MAIN model (Sundar, 2008), warranting theory (Walther & Parks, 2002), and signaling theory (Donath, 1999) served as the theoretical framework to examine the effects of bandwagon cues and identity cues embedded in retweets and users’ profile pages for health and risk online information processing. Study One examines whether bandwagon heuristics triggered by retweets would influence individuals’ source credibility judgments. Study Two investigates how bandwagon heuristics interact with different identity heuristics in credibility heuristics on an individual level. Study Three explores bandwagon …

Apocynin Exerts Dose-Dependent Cardioprotective Effects By Attenuating Reactive Oxygen Species In Ischemia/Reperfusion, Qian Chen, Woodworth C. Parker, Issachar Devine, Regina Ondraskik, Tsion Habtamu, Kyle Bartol, Brendan Casey, Harsh Patel, William Chau, Tarah Kuhn

PCOM Scholarly Works

Ischemia/reperfusion results in cardiac contractile dysfunction and cell death partly due to increased reactive oxygen species and decreased endothelial-derived nitric oxide bioavailability. NADPH oxidase normally produces reactive oxygen species to facil

Metformin Represses Bladder Cancer Progression By Inhibiting Stem Cell Repopulation Via Cox2/Pge2/Stat3 Axis, Q. Liu, W. Yuan, D. Tong, G. Liu, W. Lan, Diangzheng Zhang, H. Xiao, Y. Zhang, J. Yang, J. Zhang

PCOM Scholarly Works

Cancer stem cells (CSCs) are a sub-population of tumor cells playing essential roles in initiation, differentiation, recurrence, metastasis and development of drug resistance of various cancers, including bladder cancer. Although multiple lines of evidence suggest that metformin is capable of repressing CSC repopulation in different cancers, the effect of metformin on bladder cancer CSCs remains largely unknown. Using the N-methyl-N-nitrosourea (MNU)-induced rat orthotropic bladder cancer model, we demonstrated that metformin is capable of repressing bladder cancer progression from both mild to moderate/severe dysplasia lesions and from carcinoma in situ (CIS) to invasive lesions. Metformin also can arrest bladder cancer cells …

Pharmacological Activity Of Costus Spicatus In Experimental Bothrops Atrox Envenomation, Leide Caroline Dos Santos Picanço, José Adolfo Homobono Machado Bittencourt, Shayanne Vanessa Correia Henriques, Juliane Silva Da Silva, Juliana Maria Da Silva Oliveira, José Renato Ribeiro, Antony-Babu Sanjay, José Carlos Tavares Carvalho, Didier Stien, Jocivânia Oliveira Da Silva

Department of Food Science and Technology: Faculty Publications

Context: Medicinal plants encompass a rich source of active compounds that can neutralize snake venoms or toxins. Costus spicatus (Jacq.) Sw. (Costaceae) is used by the Amazonian population to treat inflammation, pain and other pathological manifestations.

Objective: To evaluate the influence of C. spicatus aqueous extract on edema, peritonitis, nociception, coagulation, haemorrhage and indirect haemolytic activity induced by Bothrops atrox venom (BAV).

Materials and methods: Dried and pulverized leaves were extracted with distilled water. Envenoming was induced by administration of B. atrox snake venom in Swiss Webster mice. The experimental groups consisted of BAV (at the minimum dose to induce …

Leading Behavior, Positioning, And Group Spacing As Indicators Of Dominance In Hapalemur Griseus, Kimberly Foreit

Graduate Research Theses & Dissertations

Female dominance is a rarely occurring behavioral trait across mammals but a trait that is commonly observed in Malagasy lemurs. On the other hand, intersexual dominance dynamics are only known for 36% of all lemur species, being best documented in species with high rates of agonism, such as ring-tailed lemurs (Lemur catta). Other social cues such as leadership during group movements and positioning within the social group can be used to determine dominance, but few lemur studies have utilized these behaviors to test for dominance. In this study, I quantified intersexual relations in bamboo lemurs, Hapalemur griseus griseus, an herbivorous …

The Genre Of The Linguistics Article Within Studies Of Language Variation And Change : A Diachronic Perspective, 1891-2015, David Durian

Graduate Research Theses & Dissertations

I analyze the rhetorical and structural elements of the genre of the linguistics article, specifically within the subfield of studies of language variation and change, also known as "American sociolinguistics." As my analysis demonstrates, the genre of the linguistics article in studies of language variation and change can most profitably be analyzed as having been shaped by intellectual movements occurring during three distinct eras. During the first era (1891--1954), the variationist linguistics article was primarily a "discovery text." That is, many of the topics discussed are first studies of those topics or first studies of the communities in which particular …

Use Of The Green Microalga Monoraphidium Sp. Dek19 To Remediate Wastewater : Salinity Stress And Scaling To Mesocosm Cultures, Anthony Robert Kephart

Graduate Research Theses & Dissertations

The purpose of this thesis was to investigate the growth of the green microalga Monoraphidium sp. Dek19 in the context of phycoremediation under conditions representative of wastewater media of a Midwest wastewater treatment facility. Microalgae were grown in effluent collected from four different wastewater streams at the DeKalb Sanitary District (DSD), DeKalb, Illinois, USA in volumes from 1 L to 380 L. It was determined through preliminary modeling of public data that Monoraphidium sp. Dek19 will likely outcompete local heterospecifics in final effluent wastewaters at the DSD 51.8% of the year. It was also determined that neither nitrogen nor phosphorus …

Using Lidar To Measure The Urban Forest In Dekalb, Il, Dustin Bergman

Graduate Research Theses & Dissertations

Urban and metropolitan areas have grown significantly during the 21st century. With more than 50% of the global population living in cities, they are uniquely susceptible to high temperatures, poor air quality, and increases in peak storm water runoff during inclement weather; however, urban and metropolitan areas often have significant forest resources that can greatly ameliorate these factors. To maintain urban forests and maximize their benefits, tree surveys are often performed requiring extensive fieldwork. However, automatable techniques using LiDAR data and aerial orthoimagery have the potential to provide similar metrics over larger areas, more rapidly, and at lower cost. This …

Distribution And Characterization Of The Soybean Cyst Nematode, Heterodera Glycines (Hg) Types In South Dakota, Krishna Acharya

Electronic Theses and Dissertations

The soybean cyst nematode (SCN), Heterodera glycines Ichinohe, is an endoparasitic nematode and one of the major pests of soybean (Glycine max L.) in the United State and all over the world where soybean is grown. SCN is ranked first among the biological factors that cause yield loss in soybean. The estimated yield loss by this nematode is $1b annually in the United States alone. SCN is thought to have been first found in China. It was first identified in the United States in 1954 in North Carolina and in South Dakota in 1995. To date, SCN continues to spread …

Ice Concentration Linked With Extractive Stirrer (Icecles), Nujud Omar Maslamani

Electronic Theses and Dissertations

Clean water is very important for human health. Therefore, drinking water contamination is a significant research concern, especially with the increasing global population. Some contaminants, such as pesticides, can cause health effects even at low levels. Therefore, trace and ultratrace analysis of contaminants in drinking water is essential. Ultratrace analysis typically requires highly effective sample preparation methods and/or highly sensitive instruments. There are currently advanced sample preparations techniques available to analytical chemists that may allow trace analysis of certain analytes. These include liquid-liquid extraction (LLE), solid phase extraction (SPE), solid phase micro extraction (SPME), and stir bar sorpitive extraction (SBSE). …

Effects Of Visitors And Enrichments On Behavior Of Captive Red Wolves’ (Canis Rufus) At The Great Plains Zoo, Sioux Falls, South Dakota, Kylee S. Shotkoski

Electronic Theses and Dissertations

Red wolves (Canis rufus) are the first animals to maintain a wild population from captive, released individuals. A captive breeding program for red wolves was started before complete extirpation, and 4 breeding pairs were released in Alligator River National Wildlife Refuge (North Carolina) in 1987 and a small wild population still exists there. Currently, there are several captive breeding facilities for red wolves within the Species Survival Plan (SSP) program. The Great Plains Zoo in Sioux Falls, South Dakota participates in the SSP program. My study was initiated to create a natural history background and evaluate interaction between …

From Readerly To Writerly (And Back Again) : A Rhetorical Analysis Of Greentext Stories, Agustin Morado Iv

Graduate Research Theses & Dissertations

Greentext stories, a relatively new genre of short fiction, emerged from the image board site 4chan in early 2010. Although 4chan is known for its off-color, offensive humor, the popularity of greentext stories on the imageboard as well as on other websites warrants a serious rhetorical analysis. Drawing primarily on ideas from Collin Gifford Brooke, Roland Barthes, Kenneth Burke, and Carolyn Miller, greentext stories are first posted to 4chan as part of a performative dialogue, creating threads which are large writerly texts made of smaller readerly ones; this offers anonymous 4chan users, who tend to be outsiders from mainstream society, …

Analysis Of Blood Flow And Drug Concentration Distribution In Tumor-Affected Cerebral Artery Tissue Region, Sindhuja Moda

Graduate Research Theses & Dissertations

Brain tumors occur in the brain with the growth of abnormal cells. Despite the advancements in medical technologies and treatments, the complex geometry of the brain impedes the treatment of tumors in brain. A promising and efficient drug targeting to the diseased regions with the limited dosage input reduces the risk of potential damage of healthy tissue cells in the vicinity of tumor. Insertion of drug particles into the blood stream through intravenous administration is one of the efficient treatment methods which is gaining importance. Currently, extensive research is being conducted in the areas of treating brain tumors effectively with …

Encapsidation Of The Host Rnas By Broad Bean Mottle Virus (Bbmv) And Cowpea Chlorotic Mottle Virus (Ccmv), Nipin Shrestha

Graduate Research Theses & Dissertations

Encapsidation of the viral genome into capsid is a highly specific process. Despite the viral RNA specificity, evidence of the host cellular RNA co-encapsidation have been shown in some insect viruses like Flock house virus (FHV) and plant viruses like Cucumber necrotic virus (CNV). This study is dedicated to finding the similar evidence of host RNA encapsidation by the two members, BBMV and CCMV of the Bromovirus family -- model virus system. The Next Generation RNA sequencing (NGS RNA-seq) can be implemented to sequence the RNAs encapsidated by the highly purified virions. We mapped and aligned the reads obtained from …

Evidence Of Genotypic Variation, Mhc Class I Copy Number Variation And Recombination Within The Chicken Major Histocompatibility Complex-Y System, Renee T. Kopulos

Graduate Research Theses & Dissertations

The major histocompatibility complex (MHC) is a gene region found in all jawed vertebrates. These highly polymorphic, tightly linked genes are responsible for immune regulation by presenting self and non-self antigens to the immune system. The MHC is the most polymorphic vertebrate genome region because its genes face considerable selective pressure since survival depends on the capacity to respond to bacterial, viral and parasitic diseases. The MHC organization in different species has clearly evolved in separate and unique ways since the time that birds and mammals diverged from a common ancestor 310 million years ago. The size and organization of …

Copassion And Consumption: The Difference Between Cats And Cows, Miles Mcavoy

A with Honors Projects

Within the last four decades, small town family farms have given way to industrialized farming practices. Laying the foundation for a perpetually growing industry that confines and condemns livestock of all kinds to unethical atrocities unparalleled in our history while simultaneously victimizing all of humanity, ignorant and educated alike, to a future of seemingly unavoidable consequences. Our generations of many are now unjustly burdened by the actions of a few who’ve unfairly deemed the unregulated industry of confined animal feeding operations justifiable and an appropriate response to our expanding populous. Our groundwater is perpetually polluted at a rate of 1.3 …

Beauty And Loss: Tolkien's Eucatastrophe As A Mandate For The Church, Mary K. Philpott

Senior Honors Theses

In his writings, Tolkien affirms the presence of loss and longing, beauty and despair and analyzes the function they serve in both the secondary world of Middle-earth and the primary world. This thesis will explore his theories of the eucatastrophe and the dyscatastrophe, and his insistence that the joy and hope which are expressed by the eucatastrophe are dependent upon the dyscatastrophe—the presence of sorrow and despair. This thesis will also examine how Christians’ knowledge of Tolkien’s philosophy can better equip them to cope with the brokenness of a fallen world as well as provide motivation for developing and engaging …

Growth In The Midst Of Perpetual Dependency, Hannah A. Lackey

Senior Honors Theses

International aid is a powerful, beneficial tool that has been known to improve many situations in a variety of targeted communities. While aid does provide basic necessities and resources to beneficiaries, it has the potential to simultaneously hinder or slow the development and independence of the assisted people groups if not correctly implemented. Samaritan’s Purse, a Christian Non-Governmental Organization (NGO) based in Boone, North Carolina, provides a variety of domestic and international relief services that break the trend of dependency through their encouragement of local self-sufficiency and growth. Specifically, Samaritan’s Purse’s Karamoja Integrated Maternal Child Health (KIMCH) project, based in …

Social Work Ethics: Decision Making And Accountability, James J. Clark, Molly Malany Sayre

Sociology, Anthropology, and Social Work Faculty Publications

Book accompanies course that examines the interplay of social work, values, ethics, and decision-making processes. Through the use of practice scenarios, social workers will learn how to approach risk management and thorny ethical dilemmas that are common to many practice areas. The course discusses the role of laws and regulations in regard to ethics, highlights the importance of the distinction between legal and moral problems, and describes the National Association of Social Workers (NASW) Code of Ethics.

Effects Of Resveratrol On The Alterations Of Cavernosal Enos And Lox-1 Expression In The Hypercholesterolemic Condition: A Preliminary Study, Ozan Bozkurt, Aykut Kefi̇, Ömer Demi̇r, Nergi̇s Murat, Sedef Gi̇dener, Ahmet Adi̇l Esen

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to determine the effects of resveratrol on the alterations of cavernosal eNOS and LOX-1 mRNA expression in the hypercholesterolemic condition. Materials and methods: Twenty-one New Zealand white male rabbits were separated into three groups. Rabbits were fed with a normal dietary intake for the control group and a 2% cholesterol diet for the hypercholesterolemia and resveratrol groups for 6 weeks. Resveratrol 4 mg/kg daily was administered for the resveratrol group. Cavernosal LOX-1 and eNOS mRNA expressions were determined with real-time RT-PCR in all groups. The statistical analysis was performed with the Kruskal?Wallis and …

Study Of Mouse Induced Pluripotent Stem Cell Transplantation Intowistar Albino Rat Cochleae After Hair Cell Damage*, Mustafa Kürşat Gökcan, Selçuk Mülazi̇moğlu, Emre Ocak, Pinar Can, Murat Çalişkan, Ömer Beşalti, Serpi̇l Di̇zbay Sak, Gülşah Kaygusuz

Turkish Journal of Medical Sciences

Background/aim: As the regeneration capacity of hair cells is limited, inner ear stem cell therapies hold promise. Effects of mouse induced pluripotent stem cells (IPSCs) on Wistar albino rats (WARs) with hearing impairment were investigated. Materials and methods: Thirty-five adult WARs with normal hearing were divided into 4 groups. Excluding the study group (n = 15), the other three groups served as control groups for ototoxicity and IPSC injection models. IPSC injections were performed via cochleostomy after a retroauricular approach. Auditory functions were evaluated with auditory brainstem responses (ABRs) before and after the injections. After a final hearing assessment the …

Fifty/Fifty, Brianna Barron

School of Art Graduate Exhibitions, Portfolios, and Theses

No abstract provided.

Human Rights Abuses As Tort Harms: Losses In Translation, Nathan J. Miller

Seton Hall Law Review

No abstract provided.

A Small Constellation: Risk Factors Informing Police Perceptions Of Domestic Abuse, Amanda L. Robinson, Gillian M. Pinchevsky, Jennifer A. Guthrie

Criminal Justice Faculty Research

Police in the United States (US) and the United Kingdom (UK) now routinely use risk assessment tools to identify common risk factors for re-abuse and lethality when responding to domestic abuse. Nevertheless, little is known about the extent to which officers understand and perceive the importance of factors commonly included on risk assessment tools for predicting future abuse. This study attempts to shed some light into this area of research by exploring the responses of 720 British and American police officers to questions regarding how important and how essential various risk factors are for evaluating the level of risk or …