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Articles 17581 - 17610 of 732892
Full-Text Articles in Entire DC Network
(((Qpie))) Advancing Phase Synchrony Detection Part 2 - Defining Nsrf, Teddy Burroughs
(((Qpie))) Advancing Phase Synchrony Detection Part 2 - Defining Nsrf, Teddy Burroughs
Defensive Publications Series
The Grand Unified Theory (QPIE)
Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters
Advancing Phase Synchrony Detection Part 2
Advancing Phase Synchrony Detection — Continuation and Defining of the Non-local Substrate Resonance Field (NSRF)
(CREDIT: Quantum Perspective is Everything GUT and Frameworks; #Avision4change #Vision2Funding #Charity2Roi #TedFunding) (((QPIE))) Created by Teddy Burroughs with significant contributions or Honorable mentions: Google Collab, IBM Cloud and Open AI ChatGpt 3 4 5 for technical support. Also Special Inspirational Acknowledgment to: Kaiya Burroughs, Aleah Burroughs, April Saunders and Perry Mason TECHNICAL CONTACT: [email protected] SOCIAL CONTACT: [email protected] Please Support (((QPIE))) …
The Antelope, University Of Nebraska At Kearney
Scalable Biosynthesis And Recovery Of Poly-3-Hydroxybutyrate Produced From Cotton-Derived Glucose By Cupriavidus Necator, Ashley M. Clark, Lucia E. Gargano, Gabriella M. Fioravanti, Hannah M. Schapiro, Ron G. Kander
Scalable Biosynthesis And Recovery Of Poly-3-Hydroxybutyrate Produced From Cotton-Derived Glucose By Cupriavidus Necator, Ashley M. Clark, Lucia E. Gargano, Gabriella M. Fioravanti, Hannah M. Schapiro, Ron G. Kander
School of Design and Engineering Papers
To combat the growing issue of petroleum plastic waste, alternative bio-based polymers are being developed. Many of these biopolymers are made from bio-derived materials, or are biodegradable, but the most promising polymers fall in both categories. Polyhydroxyalkanoates (PHAs) are one such class of polymers, and poly-3-hydroxybutyrate (P3HB), the most popular PHA, has shown great potential. This study utilized two types of cotton-derived glucose, alongside commercial glucose, as a feedstock for the biosynthesis of P3HB by Cupriavidus necator (also known as Ralstonia eutropha). The fermentation took place in a 2-L bioreactor, showing potential for scale-up. A single-solvent extraction method was …
Bette Eakin V. Adams County Board Of Elections
Bette Eakin V. Adams County Board Of Elections
2025 Decisions
USDC for the Western District of Pennsylvania
Cytotoxicity And Osteogenic Potentials Of Mesenchymal Stem Cells Via A Novel Formulation Of Mineral Trioxide Aggregate: An In Vitro Study, Ahmed Elgendi, Ehab Hassanien, Mohamed Nagy, Iman Fathy, Ashraf Abu Seida, Elhassan Hassanein
Cytotoxicity And Osteogenic Potentials Of Mesenchymal Stem Cells Via A Novel Formulation Of Mineral Trioxide Aggregate: An In Vitro Study, Ahmed Elgendi, Ehab Hassanien, Mohamed Nagy, Iman Fathy, Ashraf Abu Seida, Elhassan Hassanein
International Arab Journal of Dentistry
Objectives: Root perforations can lead to periodontitis and alveolar bone loss. This study compared cytotoxicity and osteogenic potential of zirconia-containing mineral trioxide aggregate (MTA) Matreva (MAT group) to MTA Angelus (ANG group) as root perforation repair materials.
Methods: Bone marrow mesenchymal stem cells (BM-MSCs) were extracted from two albino rats and cultivated. The cytotoxicity of the studied materials was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay at three time points: 3, 7, and 14 days. The evaluated materials were employed to guide the osteogenic differentiation of BM-MSCs into osteoblasts. The osteogenic impact was evaluated by assessing calcium …
Allergy In Dentistry: Mechanisms Of Development And Effective Treatment Methods, Maria Zofia Lisiecka
Allergy In Dentistry: Mechanisms Of Development And Effective Treatment Methods, Maria Zofia Lisiecka
International Arab Journal of Dentistry
Objectives: This study is conducted to analyse the mechanisms of allergic reaction development in dentistry and the effectiveness of their treatment methods.
Methods: During it, a review of current scientific sources on allergology, immunology, dentistry, pharmacology, and materials science is conducted, mechanisms for the development of allergies of various types are established, the effectiveness of treatment methods is evaluated, and clinical recommendations for allergy therapy in dentistry are formed.
Results: The results show that the development of allergic reactions occurs by two mechanisms. Immediate-type immunoglobulin E-mediated (IgE-mediated) responses are triggered by the release of histamine, serotonin, and …
Sickle Cell Anemia And Its Impact On The Oral Cavity: Integrative Review, Fernanda Leal, Maria Inês Guimarães, Ambre Natbeth, Inês Lopes Cardoso
Sickle Cell Anemia And Its Impact On The Oral Cavity: Integrative Review, Fernanda Leal, Maria Inês Guimarães, Ambre Natbeth, Inês Lopes Cardoso
International Arab Journal of Dentistry
Introduction: Sickle cell anemia, a hereditary disease, results from a mutation in the β-globin coding gene that makes up hemoglobin, leading to the deformation of erythrocytes. Numerous oral manifestations result from this disease; however, some may not be specific.
Objectives: This study’s objective is to recognize these clinical manifestations of the disease to be able to manage oral health in sickle cell anemia patients.
Methods: this integrative review analyzes scientific literature on the impact of sickle cell anemia on oral cavity. A bibliographic search was performed in PubMed, ScienceDirect, CINAHL Plus (via EBSCO host), Web of Science …
The Adjacent Possible, Marcus O’Donnell Prof
The Adjacent Possible, Marcus O’Donnell Prof
Staff Scholarship - Australia & Dubai
My hybrid traditional-digital prints explore pattern, chaos and complexity at the intersection of bodies, sexuality, and landscape. The ‘Strange appearance’ series overprints photogravure key plates, (developed through layering several original images of urban gardens) onto multiple colour pigment prints of close focus details of flowers or foliage. This process creates micro landscapes and variants which change in colour and form as layers intersect. This exhibition uses three different key plates over a repeated sequence of the same twenty colour underprints. These different approaches to variation, multiplicity and adjacency speak to both possibility and mutation: the open and the determined aspects …
Modeling Neurodegeneration In The Retina And Strategies For Developing Pan-Neurodegenerative Therapies, Emily L Ward, Aaron Diantonio, Et Al.
Modeling Neurodegeneration In The Retina And Strategies For Developing Pan-Neurodegenerative Therapies, Emily L Ward, Aaron Diantonio, Et Al.
2020-Current year OA Pubs
BACKGROUND: Glaucoma Research Foundation's third Catalyst for a Cure team (CFC3) was established in 2019 to uncover new therapies for glaucoma, a leading cause of blindness. In the 2021 meeting "Solving Neurodegeneration," (detailed in Mol Neurodegeneration 17(1), 2022) the team examined the failures of investigational monotherapies, issues with translatability, and other significant challenges faced when working with neurodegenerative disease models. They emphasized the need for novel, humanized models and proposed identifying commonalities across neurodegenerative diseases to support the creation of pan-neurodegenerative disease therapies. Since then, the fourth Catalyst for a Cure team (CFC4) was formed to explore commonalities between glaucoma …
Antibiotic Treatment Limits Survival Of Peripheral And Bone Marrow B-Cell Populations, Lila S Sanning, Forrest C Walker, Arushana A Maknojia, Leran Wang, Haina Jin, Gowri Kalugotla, Crystal Lovato, Katherine Y King, Megan T Baldridge
Antibiotic Treatment Limits Survival Of Peripheral And Bone Marrow B-Cell Populations, Lila S Sanning, Forrest C Walker, Arushana A Maknojia, Leran Wang, Haina Jin, Gowri Kalugotla, Crystal Lovato, Katherine Y King, Megan T Baldridge
2020-Current year OA Pubs
Prolonged or broad-spectrum antibiotic courses are associated with intestinal dysbiosis and cytopenias, and depletion of hematopoietic progenitor populations after antibiotics is associated with loss of peripheral immune cells, leading to increased susceptibility to systemic infections. We evaluated the bone marrow hematopoietic compartment in a murine model of antibiotic exposure. Single-cell RNA sequencing revealed a substantial and previously unrecognized depletion of bone marrow B cells at all stages of development in antibiotic-treated mice, further confirmed by flow cytometric analysis. Depletion of the microbiota was associated with rapid changes in the peripheral B-cell compartment, yet fecal microbiota transfer did not rescue either …
Spartan Daily, October 14, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, October 14, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, 2025
Volume 165, Issue 22
Quantifying Interest In And Sentiment Of Online Media About Greenhouse Gas Emissions From Cattle Production In The United States, Michael L. Smith, Jinho Jung, Nicole Olynk Widmar, Danielle J. Ufer, Maria Berikou, Jayson Lusk
Quantifying Interest In And Sentiment Of Online Media About Greenhouse Gas Emissions From Cattle Production In The United States, Michael L. Smith, Jinho Jung, Nicole Olynk Widmar, Danielle J. Ufer, Maria Berikou, Jayson Lusk
Department of Agricultural Economics Faculty Publications
The public is paying increased attention to the environmental impacts associated with cattle production systems in the US. Thus, cattle producers are increasingly exploring ways to communicate their efforts to reduce those environmental and climate impacts. This study uses online and social media data from 2018 to 2022 to examine public interest in and sentiment about beef and dairy cattle production when discussed within the context of greenhouse gas (GHG) emissions. Variation in mentions and net sentiment over the reporting period is quantified and analyzed. Over the period of data collection, which was interrupted by the COVID-19 pandemic, we find …
Yx0798 Is A Highly Potent, Selective, And Orally Effective Cdk9 Inhibitor For Treating Aggressive Lymphoma, Vivian Jiang, Yu Xue, Hong Kim, Qingsong Cai, Tianci Zhang, Lei Nie, Joseph Mcintosh, Yang Liu, Haiying Chen, Jia Zhou, Michael Wang
Yx0798 Is A Highly Potent, Selective, And Orally Effective Cdk9 Inhibitor For Treating Aggressive Lymphoma, Vivian Jiang, Yu Xue, Hong Kim, Qingsong Cai, Tianci Zhang, Lei Nie, Joseph Mcintosh, Yang Liu, Haiying Chen, Jia Zhou, Michael Wang
Faculty, Staff and Student Publications
Nongenetic transcription evolution has been increasingly explored and recognized to drive tumor cell progression and therapeutic resistance. As the regulation hub of transcription machinery, cyclin-dependent kinase 9 (CDK9) is the gatekeeper of RNA polymerase II transcription, and CDK9 dysfunction results in transcriptomic reprogramming and tumor cell progression. We recently reported that the heat shock protein 90 (HSP90)-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma (MCL) through transcriptomic reprogramming. We also showed that targeting CDK9 by AZD4573 and enitociclib is a safe and effective treatment in preclinical Mantle Cell Lymphoma (MCL) models, supporting CDK9 as a valid therapeutic target for …
Hesperidin Efficacy Of Epidural Fibrosis In A Post Laminectomy Rat Model: An Experimental Study, Emrah Keski̇n, Mehmet Seli̇m Gel
Hesperidin Efficacy Of Epidural Fibrosis In A Post Laminectomy Rat Model: An Experimental Study, Emrah Keski̇n, Mehmet Seli̇m Gel
Turkish Journal of Medical Sciences
Background/aim: Epidural fibrosis (EF) plays a significant role in the development of failed back surgery syndrome (FBSS). This study evaluates the antifibrotic effect of hesperidin, a citrus-derived bioflavonoid, within a rat laminectomy model.
Materials and methods: Thirty-two female Wistar albino rats were randomized into four groups (n = 8 each). Group 1 received laminectomy alone (control); Group 2 received a gelatin sponge; Groups 3 and 4 intraperitoneally received 50 mg/kg and 100 mg/kg of hesperidin, respectively, for 7 days post-laminectomy. After 6 weeks, epidural tissues were assessed histopathologically, and hydroxyproline levels were measured.
Results: Group 4 showed significantly lower EF …
Ai Performance In Emergency Medicine Fellowship Examination: Comparative Analysis Of Chatgpt-4o, Gemini 2.0, Claude 3.5, And Deepseek R1 Models, İshak Şan, Medi̇ne Akkan Öz, Mehmet Yortanli, Murat Genç, Bensu Bulut, Ayşenur Gür, Rami̇z Yazici, Hüseyi̇n Mutlu, Mustafa Önder Gönen
Ai Performance In Emergency Medicine Fellowship Examination: Comparative Analysis Of Chatgpt-4o, Gemini 2.0, Claude 3.5, And Deepseek R1 Models, İshak Şan, Medi̇ne Akkan Öz, Mehmet Yortanli, Murat Genç, Bensu Bulut, Ayşenur Gür, Rami̇z Yazici, Hüseyi̇n Mutlu, Mustafa Önder Gönen
Turkish Journal of Medical Sciences
Background/aim: This study evaluated the accuracy rates and response consistency of four different large language models (ChatGPT- 4o, Gemini 2.0, Claude 3.5, and DeepSeek R1) in answering questions from the Emergency Medicine Fellowship Examination (YDUS), which was administered for the first time in Türkiye.
Materials and methods: In this observational study, 60 multiple-choice questions from the Emergency Medicine YDUS administered on 15 December 2024, were classified as knowledge-based (n = 26), visual content (n = 2), and case-based (n = 32). Each question was presented three times to the four large language models. The models’ accuracy rates were evaluated according …
The Effect Of Beverages And Cleansers On The Color Stability And Surface Roughness Of Conventional And Digital Denture Base Resins , Zeynep Şahi̇n, Nazi̇re Esra Özer, Mehmet Ali̇ Kiliçarslan
The Effect Of Beverages And Cleansers On The Color Stability And Surface Roughness Of Conventional And Digital Denture Base Resins , Zeynep Şahi̇n, Nazi̇re Esra Özer, Mehmet Ali̇ Kiliçarslan
Turkish Journal of Medical Sciences
Background/aim: Research on the optical and surface properties of 3D-printed denture base materials is limited. This study investigated the effects of different beverages and denture cleansers on the color stability and surface roughness of conventional and digital denture bases.
Materials and methods: A total of 240 specimens were prepared using two digital (CAD/CAM milling and 3D printing) and two conventional (cold- and heat-polymerized) materials. The specimens were immersed in tea, coffee, and artificial saliva for 12 days. After immersion, specimens were cleaned with either sodium hypochlorite or a Corega effervescent tablet. Color changes and surface roughness were measured with a …
Corrected Amicus Brief Filed By Amici Curiae Law Professors In 25-11612 & 25-11821, William Snape, Delicianna Winders, Patrick Parenteau, Christopher Courchesne, Hope Babcock, Holly Doremus, Paul Boudreaux, Oliver A. Houck, Zygmunt J.B. Plater, Michelle Benedict Nowlin, Daniel Rohlf
Corrected Amicus Brief Filed By Amici Curiae Law Professors In 25-11612 & 25-11821, William Snape, Delicianna Winders, Patrick Parenteau, Christopher Courchesne, Hope Babcock, Holly Doremus, Paul Boudreaux, Oliver A. Houck, Zygmunt J.B. Plater, Michelle Benedict Nowlin, Daniel Rohlf
Amicus Briefs & Court Filings
STATEMENT OF THE ISSUES: Whether the district court's injunction requiring FDEP to cease Endangered Species Act-violating conduct, obtain an incidental take permit before it continues with the conduct, and implement reasonable protective measures violates principles of cooperative federalism, the Tenth Amendment, or the anti-commandeering doctrine.
Eutrophication, Hope Northagen, Sarah Erwin, Ethan Gilliam
Eutrophication, Hope Northagen, Sarah Erwin, Ethan Gilliam
All Current Publications
Eutrophication refers to the ecological state of a water body after excessive nutrient pollution. The external introduction of nutrients (primarily nitrogen and phosphorus) accelerates the growth and reproduction of plants, algae, and microbes. This fact sheet explains where eutrophication comes from, its impacts, how it is treated, and what you can do to help restore and protect our lakes, rivers, and oceans.
Differential Patterns Of Gut And Oral Microbiomes In Hispanic Individuals With Cognitive Impairment, Yannick N. Wadop, Erin L. Vasquez, Julia J. Mathews, Jazmyn A. S. Muhammad, Rosa P. Mavarez, Claudia Satizabal, Mitzi M. Gonzales, Jeremy A. Tanner, Gladys E. Maestre, Bernard Fongang
Differential Patterns Of Gut And Oral Microbiomes In Hispanic Individuals With Cognitive Impairment, Yannick N. Wadop, Erin L. Vasquez, Julia J. Mathews, Jazmyn A. S. Muhammad, Rosa P. Mavarez, Claudia Satizabal, Mitzi M. Gonzales, Jeremy A. Tanner, Gladys E. Maestre, Bernard Fongang
School of Medicine Publications
Alterations in both oral and gut microbiomes have been associated with Alzheimer's disease and related dementia (ADRD). While extensive research has focused on the role of gut dysbiosis in ADRD, the contribution of the oral microbiome remains relatively understudied. This study aims to evaluate distinct patterns and potential synergistic effects of oral and gut microbiomes in a cohort of predominantly Hispanic individuals with cognitive impairment (CI) and without cognitive impairment (NC). We conducted 16S rRNA gene sequencing on stool and saliva samples from 32 participants (17 CI, 15 NC; 62.5% female, mean age = 70.4 ± 6.2 years) recruited in …
Needs Analysis Of Interactive Learning Media For Teachingheat Transfer In Physics: Students’ And Teachers’Perspectives, Rizki Eka Shintya, Ika Mustika Sari, Ida Kaniawati
Needs Analysis Of Interactive Learning Media For Teachingheat Transfer In Physics: Students’ And Teachers’Perspectives, Rizki Eka Shintya, Ika Mustika Sari, Ida Kaniawati
Jurnal Pendidikan Sains
Heat transfer material in physics is known to be abstract. This study specifically analyzes the conceptual difficulties, and visualization needs specific to this material, which is different from the analysis of physics needs in general. This analysis does not only look for the need for traditional media but explicitly looks for the need for interactive media (simulation, animation, virtual laboratory). Therefore, this study aims to identify the need for interactive learning media in physics education, specifically in the teaching of heat transfer, from the perspective of students and teachers in West Java, Indonesia. Using a quantitative descriptive survey, data were …
A Comprehensive Approach Addressing The Most Chronic And Emerging Contaminants Along The Egyptian Mediterranean Coast, Tarek O. Said
A Comprehensive Approach Addressing The Most Chronic And Emerging Contaminants Along The Egyptian Mediterranean Coast, Tarek O. Said
Blue Economy
Newly identified substances known as emerging contaminants (ECs) are harmful to the environment and public health, frequently because limited regulation and incomplete understanding of their impacts. They comprise a broad variety of materials, such as insecticides, industrial wastes, personal care items, and medications. Persistent pollutants (POPs) are organic compounds that have remained in the environment for an extended period of time. They tend to move through the atmosphere over enormous distances making them a chronic contaminant and may harm ecology and humanity over time. In Egypt, particularly within its Mediterranean Exclusive Economic Zone (EEZ), heavy metal (HM) contamination is increasingly …
Incorporating An Innovative Kennel In A Guide Dog Program Based On The Health And Welfare Of Dogs And Humans, Naoko Koda, Miwa Murata, Sakura Mizuta
Incorporating An Innovative Kennel In A Guide Dog Program Based On The Health And Welfare Of Dogs And Humans, Naoko Koda, Miwa Murata, Sakura Mizuta
People and Animals: The International Journal of Research and Practice
During guide dog training, dogs live in kennels and lack house training. The demand for guide dogs that can live easily with their users who are visually impaired is increasing. The Kansai Guide Dogs for the Blind Association (KGBDA) in Japan built an innovative wooden kennel (Mokka Terrace) that is more similar to homes than general kennels and that efficiently controlled dogs and reviewed their operations. This study conducted a literature survey, participant observations, and semi-structured interviews with staff to clarify the background and consensus-building process involved in creating the Mokka Terrace, corresponding efforts, and its strengths, issues, and prospects. …
2024 American Field Ornithologist (Afo) And Western Bird Banding Association (Wbba) Joint Annual Meeting Scientific Abstracts, Walter H. Sakai
2024 American Field Ornithologist (Afo) And Western Bird Banding Association (Wbba) Joint Annual Meeting Scientific Abstracts, Walter H. Sakai
North American Bird Bander
No abstract provided.
Utilitarianism, Dune, And The Moral Problem Of Genetic Engineering, Mathias W. Alling
Utilitarianism, Dune, And The Moral Problem Of Genetic Engineering, Mathias W. Alling
Quest
Moral Philosophy Essay
Research in progress for PHIL 2306: Introduction to Ethics (Honors)
Faculty Mentor: John Macready, PhD
This article began as a research essay during the Fall 2024 semester for my honors- level course, Introduction to Ethics (PHIL 2306). In this course, students are asked to research a moral issue and offer an argument for whether the issue is morally required, morally permitted, morally permissible, or morally impermissible. Mathias Alling’s philosophically ambitious article “Utilitarianism, Dune, and the Moral Problem of Genetic Engineering” examines the moral permissibility of genetic engineering through the fictional universe of Frank Herbert’s novel Dune …
Skin Cancer Image Classification Using Deep Learning With Data Segmentation Technique, Akhilesh Kumar Shrivas, Hema Vastrakar
Skin Cancer Image Classification Using Deep Learning With Data Segmentation Technique, Akhilesh Kumar Shrivas, Hema Vastrakar
Karbala International Journal of Modern Science
The human skin is an impressive organ and structural element often impacted by a diverse range of recognized and unknown diseases. Diagnosing disorders that affect the outermost layer of the body is the most uncertain and difficult component in the scientific field. Dermatological diseases are one of the most significant health concerns in the 21st century since their identification is challenging and costly, plagued with challenges and the subjectivity that comes with human interpretation. The main objective of this piece of research work is to develop a robust model for the classification of skin cancer diseases using deep convolution neural …
A Recent Insight On Prevalence Of Atopic Diseases In Children With Type 1 Diabetes, Randa Mohamed Darwish, Ayat Ibrahim Ghanem
A Recent Insight On Prevalence Of Atopic Diseases In Children With Type 1 Diabetes, Randa Mohamed Darwish, Ayat Ibrahim Ghanem
Journal of Medicine in Scientific Research
Background Type 1 diabetes mellitus (T1DM) and atopic diseases are both prevalent immunemediated conditions in children. Although traditionally viewed as immunologically opposing disorders—T1DM being Th1-mediated and atopy Th2-mediated—recent studies suggest possible overlap in genetic susceptibility and environmental triggers. This study aimed to evaluate the prevalence and association of various atopic conditions in pediatric T1DM patients. Aim of the study To investigate the prevalence of atopic diseases—including atopic dermatitis, allergic rhinitis, allergic conjunctivitis, bronchial asthma, food allergy, and anaphylaxis—among children with T1DM compared to healthy age- and sex-matched controls, and to analyze contributing risk factors. Methods A retrospective cohort study was …
The Daily Gamecock: October 2025, University Of South Carolina, Office Of Student Media
The Daily Gamecock: October 2025, University Of South Carolina, Office Of Student Media
2025
No abstract provided.
The Cardioprotective Effects Of Adiponectin In Diabetes., Tara Kazemi, Yuanjie Mao, Tina Zhang
The Cardioprotective Effects Of Adiponectin In Diabetes., Tara Kazemi, Yuanjie Mao, Tina Zhang
Ambulatory and Primary Care Articles
PURPOSE OF REVIEW: Adiponectin, a hormone secreted by adipocytes, plays a crucial role in maintaining metabolic balance and supporting cardiovascular health. Although it is known for its protective effects, such as improving insulin sensitivity, reducing inflammation, and maintaining endothelial function, there are paradoxical associations between high adiponectin levels and increased cardiovascular mortality-referred to as the "adiponectin paradox"-which complicates its clinical interpretation. This review explores the cardioprotective effects of adiponectin in both type 1 and type 2 diabetes, focusing on its potential to regulate glucose metabolism and prevent cardiovascular complications.
RECENT FINDINGS: By reviewing key studies, the article evaluates adiponectin's diverse …
Chimes: October 13, 2025, Calvin University
Chimes: October 13, 2025, Calvin University
Chimes
Creation care on Calvin's campus by Maya Oeverman
Breaking new ground: Calvin's ecosystem preserve adds a rock garden by Ian Tjoelker
Break-in News: Deer in Boer Bennink Kitchen by Maya Oeverman
A story worth seeing: Calvin's The Glass Menagerie by Ellery Johnson
Donald Trump vs. John Calvin by Joe Toly
Ode to the fallen deer by Marcail Schuurmann
Organism-Specific Sequence Motifs Link Ribosomal Rnas To Brain Disorders, Isidore Rigoutsos, Stepan Nersisyan, Eric Londin, Iliza Nazeraj, Bonnie Dong, Anastasios Vourekas, Phillipe Loher
Organism-Specific Sequence Motifs Link Ribosomal Rnas To Brain Disorders, Isidore Rigoutsos, Stepan Nersisyan, Eric Londin, Iliza Nazeraj, Bonnie Dong, Anastasios Vourekas, Phillipe Loher
Computational Medicine Center Faculty Papers
We report that in humans, mice, fruit flies, and worms, the ribosomal RNAs and the transcribed spacers of 45S are densely packed with organism-specific sequence motifs that are primarily shared with nervous system genes. The human ribosomal RNAs and 45S spacers contain 1,723 such motifs. Specific combinations of these motifs are predominantly found in 3,430 human nervous system genes, of which 1,046 are genes associated with brain disorders, including autism spectrum disorder and schizophrenia. The sequences of the 1,723 motifs and their locations in the introns and exons of nervous system genes are unique to primates. Experimental evidence indicates that …