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2015

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An Ensemble Three-Dimensional Constrained Variational Analysis Method To Derive Large-Scale Forcing Data For Single-Column Models, Shuaiqi Tang Dec 2015

An Ensemble Three-Dimensional Constrained Variational Analysis Method To Derive Large-Scale Forcing Data For Single-Column Models, Shuaiqi Tang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Atmospheric vertical velocities and advective tendencies are essential as large-scale forcing data to drive single-column models (SCM), cloud-resolving models (CRM) and large-eddy simulations (LES). They cannot be directly measured or easily calculated with great accuracy from field measurements. In the Atmospheric Radiation Measurement (ARM) program, a constrained variational algorithm (1DCVA) has been used to derive large-scale forcing data over a sounding network domain with the aid of flux measurements at the surface and top of the atmosphere (TOA). We extend the 1DCVA algorithm into three dimensions (3DCVA) along with other improvements to calculate gridded large-scale forcing data. We also introduce …

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Modeling Platelets On Parallel Computers, Seetha Malavika Pothapragada Dec 2015

Modeling Platelets On Parallel Computers, Seetha Malavika Pothapragada

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Mechanical Heart Valves (MHV) provides life-saving solutions to patients suffering from cardiovascular diseases. But these devices are often plagued by non-physiological flow patterns resulting in increased shear stress conditions. This leads to platelet damage, a precursor of thromboembolism, thus impeding the device usability and demanding lifelong anticoagulation treatments. While the flow and stresses are in the micron level, the platelet behavior is at the nm level, thus presenting a major computational challenge for simulating this multiscale multi-physics modeling problem. This dissertation focuses on using parallel computers to develop a computational framework based on n-particle simulations, defined by Coarse Grained Molecular …

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Effects Of Processing And Medical Sterilization Techniques On 3d-Printed And Molded Polylactic Acid, Mariah Nicole Geritano Dec 2015

Effects Of Processing And Medical Sterilization Techniques On 3d-Printed And Molded Polylactic Acid, Mariah Nicole Geritano

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Manufacturing industries have evolved tremendously in the past decade with the introduction of Additive Manufacturing (AM), also known as 3D Printing. The medical device industry has been a leader in adapting this new technology into research and development. 3D printing enables medical devices and implants to become more customizable, patient specific, and allows for low production numbers. This study compares the mechanical and thermal properties of traditionally manufactured parts versus parts manufactured through 3D printing before and after sterilization, and the ability of an FDM printer to produce reliable, identical samples. It was found that molded samples and 100% infill …

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Antibacterial Block Copolymer Thin Films And Growth Characteristics Of Hela Cells, Prafulla Keskar Dec 2015

Antibacterial Block Copolymer Thin Films And Growth Characteristics Of Hela Cells, Prafulla Keskar

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The large number of devices used in medical applications have to be protected from microbial attacks as it leads to serious harm. Further, the current methods of tackling this problem involve using chemicals such as disinfectants which are harmful to us humans. This thesis aims to study the effectiveness of block copolymer thin films against microbes without using traditional harmful methods. We have attempted to prepare anti-bacterial thin films which can kill the bacteria using their surface morphology and thus eliminate the harm posed to us. In the second part of this thesis, we studied the growth characteristics of HeLa …

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Biotinylated Self-Assembled Micelles As Potential Vehicles For Targeted Anti-Cancer Drug Delivery, Weiyi Li Dec 2015

Biotinylated Self-Assembled Micelles As Potential Vehicles For Targeted Anti-Cancer Drug Delivery, Weiyi Li

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Chemotherapy is one of the most commonly used cancer treatments. However, many side effects could occur due to the non-specific bindings of extremely toxic anti-cancer drugs to healthy cells and organs. Targeted delivery has been developed to enhance the selectivity of drug delivery vehicle and minimize side effects of chemotherapy. In this study, the hydrophobically modified glycol chitosan (HGC) micelle was further modified with a biotin-avidin-biotin (B-A-B) strategy to improve the tumor-selective ability of HGC. Firstly, HGC was biotinylated either at the amine groups (NH2) or the hydroxyl groups (OH) on the chitosan main chain. Then the biotin-4-fluorescein, as a …

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Breath Biomarkers Detection By Chemical Sensors, Yan Li Dec 2015

Breath Biomarkers Detection By Chemical Sensors, Yan Li

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Our breath is a very complex mixture of chemical compositions. Usually, the majority of our exhaled breath consists of nitrogen, oxygen, carbon dioxides, water and inert gases. The remaining small fraction of breath contains thousands of components in trace amount, including inorganic gas molecules like nitric monoxide and diverse kinds of volatile organic compounds (VOCs). The concentrations of our exhaled gases are at a relatively stable level, though minor fluctuations may occur at different time of the day and they are also linked to the body status. Sometimes, if a specific breath gas of some appears to have an abnormal …

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Development Of New Generation Of Ceramics For Environmentally Focused Chemical Separations, Girish Ramakrishnan Dec 2015

Development Of New Generation Of Ceramics For Environmentally Focused Chemical Separations, Girish Ramakrishnan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This dissertation focuses on the use of composite materials for environmental applications. For the first time, applications of both fresh and aged concrete as inexpensive adsorbents for nitrogen dioxide (NO2) removal is demonstrated. Concrete is the most widely used composite material of the modern era. Cement manufacturing (a major component of concrete) is considered to be one of the leading contributors to air pollution, resulting in 7% of the global carbon dioxide emissions along with a number of other harmful pollutants such as oxides, mercury and particulates. These emissions aide in the formation of acid rain, smog, and toxic ground …

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Structurally Integrated, Damage Tolerant Thermal Spray Coatings: Processing Effects On Surface And System Functionalities, Andrew Vackel Dec 2015

Structurally Integrated, Damage Tolerant Thermal Spray Coatings: Processing Effects On Surface And System Functionalities, Andrew Vackel

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Thermal Spray (TS) coatings have seen extensive application as protective surfaces to enhance the service life of substrates prone to damage in their operating environment (wear, corrosion, heat etc.). With the advent of high velocity TS processes, the ability to deposit highly dense (>99%) metallic and cermet coatings has further enhanced the protective ability of these coatings. In addition to surface functionality, the influence of the coating application on the mechanical performance of a coated component is of great concern when such a component will experience either static or cyclic loading during service. Using a process mapping methodology, the …

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Defect Studies And Optimization Of Cvd Grown Boron Phosphide Films On Different Substrates, Xuejing Wang Dec 2015

Defect Studies And Optimization Of Cvd Grown Boron Phosphide Films On Different Substrates, Xuejing Wang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Boron phosphide (BP), a light III-V indirect semiconductor compound with medium band gap of 2.0 eV, has emerged as a promising material with its applications in solid-state neutron technology and semiconductor devices in extreme conditions. Since bulk BP is unavailable, heteroepitaxial film growth is being attempted on various substrates including silicon, silicon carbide (4H, 6H, 3C polytypes), AlN and sapphire of different orientations to determine the best substrate for growing high quality thin films. By investigating the defects (e.g. twins and grain boundaries, threading dislocations, stacking faults, inclusions) present in the BP epilayer using synchrotron white beam X-ray topography (SWBXT), …

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Stress-Assisted Grain Growth In Nanocrystalline Metals Inhibited By Grain Boundary Segregation, Yang Zhang Dec 2015

Stress-Assisted Grain Growth In Nanocrystalline Metals Inhibited By Grain Boundary Segregation, Yang Zhang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Stress-assisted grain growth in nanocrystalline metals transpires collectively with a number of competing deformation mechanisms. In this study, molecular dynamics simulations of surface nanoindentation were performed to quantify the plastic strain distribution among competing mechanisms as a function of grain size and temperature during stress-assisted grain growth in nanocrystalline Ni and a Ni-1 at. % P alloy. Under identical conditions of rate and temperature in nominally the same grain size structure, stress-assisted grain growth found to be prevalent in pure nanocrystalline Ni was virtually absent in the Ni-P alloy with P enriched grain boundaries. A reduction in the deformation temperature …

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Regularized Geometry Of The Loop Space, Cheng Hao Dec 2015

Regularized Geometry Of The Loop Space, Cheng Hao

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Interest in nonlinear sigma models with target space a symmetric space of positive curvature comes from both mathematics and physics. In this dissertation we focus on the two-dimensional nonlinear sigma model with target space the k-dimensional projective space P^k. We study the properties of a finite-dimensional approximation, which we denote by L_N(P^k), to the loop space L(P^k), and construct resolutions of singularities for these truncated loop spaces. We also look into the geometries of such spaces and propose a conjecture about the mass gap of the Schrodinger operator H on L_N(P^k) with analytic formula. | 55 pages

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$E_\Infty$-Comodules And Topological Manifolds, Anibal Medina Dec 2015

$E_\Infty$-Comodules And Topological Manifolds, Anibal Medina

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The first story begins with a question of Steenrod. He asked if the product in the cohomology of a triangulated space, which is associative and graded commutative, can be induced from a cochain level product satisfying the same two properties. He answered it in the negative after identifying homological obstructions among a collection of chain maps he constructed. Using later language, his construction could be said to endow the simplicial chains with an $E_\infty$-coalgebra structure. The second story also begins with a question: when is a space homotopy equivalent to a topological manifold? For dimensions greater than 4, an answer …

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Tritangents To Spherical Curves, Yury Arkady Sobolev Dec 2015

Tritangents To Spherical Curves, Yury Arkady Sobolev

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

A generic smooth immersed closed curve in the 2-sphere has a finite number of circles tangent to it in three points. We present a classification of these tritangent circles and study how each class changes during deformations of the curve. We relate these classes to finite type invariants of the curve and derive a relation among the numbers of tritangent circles in the classes and finite type invariants of the curve. | 39 pages

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Conical Kahler-Einstein Metrics And Its Applications, Chengjian Yao Dec 2015

Conical Kahler-Einstein Metrics And Its Applications, Chengjian Yao

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In this dissertation we prove certain deformation behaviors of Kahler-Einstein metrics with singularities. Based on smooth approximation and a priori estimates, we first give a new proof to Donaldson's Openness Theorem of deforming the cone angle of conical Kahler-Einstein metric on smooth Fano manifold, and prove a direct generalization to conical Kahler-Einstein metrics along simple normal crossing pluri-anti-canonical divisors on smooth Fano manifold. Then we use continuity method to study the deformation of weak conical Kahler-Einstein metric on Q-Fano variety. The idea of our new proof above is generalized to prove the openness part of the continuity method argument, while …

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Mutilated Bodies And Memories Of Violence: Displacements And Contestations Of Representations Of Violence, In Contemporary Video Art And Photography In Colombia, 1993-1998., Juan Carlos Guerrero Hernandez Dec 2015

Mutilated Bodies And Memories Of Violence: Displacements And Contestations Of Representations Of Violence, In Contemporary Video Art And Photography In Colombia, 1993-1998., Juan Carlos Guerrero Hernandez

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

How do contemporary artworks address and give visibility to the wounded body without reinvigorating trauma, without repeating the spectacular and homogenizing strategies used by the media? How do artworks move beyond denunciation to aesthetically and historically name and rearticulate bodily violence? And fundamentally, how do artworks offer an historical understanding of the political historicity of contemporary violence without uncritically resorting to myth and structural trauma? We intend to answer these questions within the context of art and violence in Colombia in 1990s. In this direction, we examine four artworks produced between 1993 and 1998, by artists Alberto Baraya, Clemencia Echeverri, …

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Multi-Model Validation Assessment Of Groundwater Flow Simulation Models Using Area Metric Approach, Omkar Aphale Dec 2015

Multi-Model Validation Assessment Of Groundwater Flow Simulation Models Using Area Metric Approach, Omkar Aphale

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

A model's validity, or its goodness-of-fit to the real world system, is commonly assessed by quantifying the level of agreement between the observed data and their corresponding model-simulated outputs. However, the observed data could be uncertain given inaccuracies in the observational tools and techniques while the model-simulated outputs may be incomparable since models are simplified versions, and not exact replicas, of the real world system. This limits the abilities of the traditional validation approaches. Here, an alternative approach called the area metric (Ferson et al. 2008) was adopted for multi-model validation assessment. This approach quantifies the level of agreement between …

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Designated Pages: Bradbury Thompson's Inspirations For Paper, Mi Seok Huh Dec 2015

Designated Pages: Bradbury Thompson's Inspirations For Paper, Mi Seok Huh

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

How do Bradbury Thompson’s designs in Westvaco Inspirations work as a guide for design and paper? Westvaco Inspirations was a promotional magazine first published in 1925 by the West Virginia Pulp and Paper Company. The main purpose of the magazine was to promote paper and to show an intricate relationship between print, paper and design. Bradbury Thompson was the designer for the magazine from 1939 to its final year of publication in 1962. This thesis shows how Thompson’s designs promoted the quality of each particular paper brand and its effectiveness in presenting a printed image. The thesis aims to show …

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The Role Of Pofut2 In Gastrulation And Axis Elongation Of The Mouse Embryo, Brian Benz Dec 2015

The Role Of Pofut2 In Gastrulation And Axis Elongation Of The Mouse Embryo, Brian Benz

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Protein O-fucosyltransferase 2 (POFUT2) elongates Thrombospondin Type 1 Repeats (TSR) with an O-linked fucose. Forty-nine potential proteins are modified by POFUT2 in the endoplasmic reticulum. Nearly half the POFUT2 targets belong to the A Disintegrin and Metalloprotease with ThromboSpondin type-1 motifs (ADAMTS) or ADAMTS-like family of proteins. One of POFUT2’s target proteins, ADAMTS9, contains 15 TSRs and is reported to be embryonic lethal around the same time as our Pofut2 LoxP mutants. In this study, we compared the Pofut2 and Adamts9 knockout phenotypes and used tissue specific deletion of Pofut2 to define the role of Pofut2 during gastrulation. Knockout of …

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A Targeted Crispr-Cas9 Screen In Aml Cells, Sam Blake Chiappone Dec 2015

A Targeted Crispr-Cas9 Screen In Aml Cells, Sam Blake Chiappone

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The genetic underpinnings of a cancer are key to understanding the etiology of the disease and thus to providing a cure, because any robust cure of the disease will need to target a therapeutic window, a gene or a group of genes that are different between the cancerous cells and the normal cells. The research shown in this thesis gives insight into the genetic causes of acute myelogenous leukemia in an attempt to find a therapeutic window for this disease. A genetic screen using CRISPR-Cas9 is designed and conducted in a cell line designated RN 2-5 that was determined to …

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Cyclodextrins As Lipid Exchange Mediators To Synthesize Artificial Asymmetric Model Membranes, Brad Greenstein Dec 2015

Cyclodextrins As Lipid Exchange Mediators To Synthesize Artificial Asymmetric Model Membranes, Brad Greenstein

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The use of cyclodextrins have shown promise to exchange lipids of model membranes in various conditions. Several types of cyclodextrins have been shown to exchange lipids in different conditions. In this study, we used Methyl-alpha cyclodextrin (MαCD) to facilitate lipid exchange between donor multilamellar vesicles (MLVs) containing brain SM and large unilamellar vesicle acceptors (LUVs) composed of POPE, POPS and cholesterol. This technique is just one of several exploring the use of cyclodextrins to manipulate artificial membranes in order to obtain asymmetry. Overview of other studies involving other types of cyclodextrin are also discussed to explain what is known about …

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Class Iii Phosphoinositide 3-Kinase Vps34 In Autophagy, Endocytosis, And Nutrient-Induced Signaling, Nadia Jaber Dec 2015

Class Iii Phosphoinositide 3-Kinase Vps34 In Autophagy, Endocytosis, And Nutrient-Induced Signaling, Nadia Jaber

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Vps34 is the sole member of the Class III phosphoinositide 3-kinases (PI3Ks) identified in mammals thus far. It phosphorylates phosphatidylinositol (PI) to generate PI(3)P on intracellular membranes. Previous work has suggested that Vps34 is important for the protein degradation pathways of autophagy and endocytosis, as well as nutrient-induced mTOR signaling. However, due to the pluripotent nature of available PI3K inhibitors, a clear understanding of the functions of mammalian Vps34 remains to be illustrated. To investigate the precise role of Vps34 in these processes, I have generated and characterized mice with conditional genetic ablation of Vps34. Mice with liver or heart-specific …

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The Pirna Pathway In The Somatic Stem Cells Of A Regeneration-Competent Flatworm, Macrostomum Lignano, Xin Zhou Dec 2015

The Pirna Pathway In The Somatic Stem Cells Of A Regeneration-Competent Flatworm, Macrostomum Lignano, Xin Zhou

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

piRNA pathway and its central components, PIWI proteins, are essential for transposon silencing and some aspects of gene regulation. Although they predominantly function in the animal germline, increasing evidence has pointed to their involvement in somatic cells. Some flatworms possess a unique somatic stem cell system named neoblasts. These totipotent cells are the only dividing cell population thus critical for postembryonic development, adult homeostasis and the remarkable regeneration ability. In the study led by Kaja A. Wasik and me, we identify and characterize piRNAs and PIWI proteins in the emerging regenerative flatworm model, Macrostomum lignano, combining targeted gene knockdown and …

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Structural Insights Into Mitochondrial Gene Expression And Disease, Kip Guja Dec 2015

Structural Insights Into Mitochondrial Gene Expression And Disease, Kip Guja

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Mitochondria are dual membrane-bound organelles found in the cytoplasm of all eukaryotic cells. Human mitochondria contain a 16.5 kb double-stranded DNA genome that encodes thirteen essential protein subunits of the oxidative phosphorylation system, as well as the two ribosomal RNAs and 22 transfer RNAs needed to translate the thirteen messenger RNAs. Oxidative phosphorylation produces the majority of energy needed for cells to sustain life, and this process is strictly dependent on expression of the mitochondrial genome. Defects in mitochondrial gene expression are linked to many human diseases, age-related pathologies, and the aging process itself. Obtaining a more detailed understanding of …

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The Role Of The Scribble Protein Complex In The Regulation Of Dendrite Formation, Bingru Sun Dec 2015

The Role Of The Scribble Protein Complex In The Regulation Of Dendrite Formation, Bingru Sun

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

During neuronal development, the neuronal cell polarizes to specify the structures of axons and dendrites. This polarized architecture regulates the input/output functions of the neuronal cell. In my thesis, I studied the molecular mechanisms of dendrite formation. My main hypothesis was that dendrite specification results from local elevation of the cGMP signal. Soluble guanylyl cyclase (sGC) is the major enzyme for the synthesis of cGMP in the embryonic brain. I study the molecular mechanism that activates sGC and leads to dendrite specification during neuronal polarization.Scribble is a scaffold protein, part of a polarity complex that establish apical-basal polarity in epithelial …

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Probing Dna Dynamics With Fluorescence Cross-Correlation Spectroscopy, Tomasz Bakowski Dec 2015

Probing Dna Dynamics With Fluorescence Cross-Correlation Spectroscopy, Tomasz Bakowski

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

DNA Polymer dynamics are fundamental to the function of biological systems. Examples include gene regulation, cell division, threading and transport through pores. We address the limitations of previous experimental studies of polymer dynamics by designing, building, and characterizing a novel, custom Fluorescence Cross-Correlation Spectroscopy (FCCS) system. We detail the optical considerations for quantitatively describing and shaping the confocal volume. The hardware is supplemented by a robust theoretical foundation of correlation analysis and how it applies to polymer dynamics. We carry this theory through in the design of novel fitting methods and software. We utilize our FCCS setup to quantitatively measure …

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Three-Dimensional Macroporous All-Carbon Scaffolds For Tissue Engineering Applications, Gaurav Lalwani Dec 2015

Three-Dimensional Macroporous All-Carbon Scaffolds For Tissue Engineering Applications, Gaurav Lalwani

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Assembly of carbon nanomaterials into three-dimensional (3D) architectures is necessary to harness their unique physiochemical properties for tissue engineering and regenerative medicine applications. In this dissertation, fabrication and characterization of 3D chemically crosslinked macro-sized (5-8 mm height and 4-6 mm diameter) porous carbon nanotube (CNT) scaffolds, their in vitro cytocompatibility and interactions with human mesenchymal stem cells (hMSCs) are reported. Single- or multi-walled carbon nanotubes (SWCNTs or MWCNTs) scaffolds were fabricated using a novel radical initiated thermal crosslinking and annealing method using SWCNTs or MWCNTs as nanoscale building blocks. The scaffolds possess macroscale interconnected pores, robust structural integrity, stability, and …

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Comparison Of Sustained Cognitive Training Vs. Cardiovascular Exercise On Cognitive Decline And Pathology In A Vascular Model Of Alzheimer’S Disease | Comparison Of Sustained Cognitive Training Vs. Cardiovascular Exercise On Cognitive Decline And Pathology In A Vascular Model Of Alzheimer’S Disease, Maria Elizabeth Anderson Dec 2015

Comparison Of Sustained Cognitive Training Vs. Cardiovascular Exercise On Cognitive Decline And Pathology In A Vascular Model Of Alzheimer’S Disease | Comparison Of Sustained Cognitive Training Vs. Cardiovascular Exercise On Cognitive Decline And Pathology In A Vascular Model Of Alzheimer’S Disease, Maria Elizabeth Anderson

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Despite numerous advances in our understanding of the mechanisms that underlie Alzheimer’s disease (AD), there is still no cure, and the disease continues to pose a severe public health problem. It has become clear that many factors, including certain lifestyle practices, may contribute to the development of the disease; however, much remains to be learned about how lifestyle factors may prevent or delay cognitive decline. Unlike human epidemiological studies, murine models can provide clearer inferences about causality. The present studies focus on two lifestyle factors: cognitive enrichment and cardio-vascular exercise. Specifically, the effects of lifestyle interventions on behavioral performance and …

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Modified Low-Density Lipoprotein From Mycobacterium Tuberculosis Induces Foamy Macrophage Formation, Guannan Chen Dec 2015

Modified Low-Density Lipoprotein From Mycobacterium Tuberculosis Induces Foamy Macrophage Formation, Guannan Chen

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tuberculosis (TB) is one of the major causes of mortality in the world, causing approximately 1.5 million deaths every year, among which children take a great part. However, due to the perception that children are rarely infectious or they rarely develop severe disease, children with TB have always been neglected. What is worse, diagnosis of childhood TB is difficult, making it harder to control the disease. Foamy macrophages are a key component in the pathology of TB, and the formation of foamy macrophages foresees the progression of infection to active disease. Low-density lipoprotein (LDL) is one of the major lipoproteins …

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Synthesis Of Carbon-11 Labeled Organic Molecules For Pet Studies, So Jeong Lee Dec 2015

Synthesis Of Carbon-11 Labeled Organic Molecules For Pet Studies, So Jeong Lee

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

PET has played a key role in the field of molecular imaging and nuclear medicine over the past decades. PET represents a non-invasive molecular imaging technique to study and visualize human physiology by detecting positron-emitting radiopharmaceuticals labeled with short half-live radioisotopes (i.e. | 11C, 13N, 15O, and 18F) that visualize in vivo biochemical processes and metabolic pathways (i.e. | glycolysis and protein/DNA synthesis). PET is also an emerging method for measuring body function and tailoring disease treatment in living human by detecting biochemical changes preceding anatomical changes occurring a disease. The capability of imaging quantitatively and with high sensitivity without …

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In Situ Characterization Of Promoted Rh Nanocatalysts During Co Hydrogenation, Robert Mario Palomino Dec 2015

In Situ Characterization Of Promoted Rh Nanocatalysts During Co Hydrogenation, Robert Mario Palomino

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The world’s dependence on the limited supply of fossil fuels has provided the motivation for research into alternative renewable fuel sources. Ethanol is a promising alternative due to its low toxicity, high energy density, and compatibility with the current fuel distribution system. An attractive route to ethanol production would be through the conversion of synthesis gas or ‘syngas’ (CO + H2), which is currently used to produce methanol, hydrogen, and synthetic fuels (diesel and gasoline). However, there are currently no commercially used catalysts for efficient ethanol production from syngas. In general, catalysts for syngas conversion to ethanol should promote C‒C …

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