Digital Commons Network^™

Control Of The Basal Recycling And Surface Expression Of Epidermal Growth Factor Receptor By The Endocytic Recycling Regulator Ehd1 Utilizing A Pathway Shared By Rusc2, Eric Tom

Theses & Dissertations

The epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase (RTK) and oncogene aberrantly expressed or mutated in solid tumors. Its surface expression is dynamically regulated. Display of an activation-competent pool is essential for response to ligands. Internalization and degradation of EGFR following stimulation has received the most attention, fewer studies have characterized the recycling arm of EGFR transit, basal traffic and surface display are poorly understood. Thus, we evaluated the endocytic recycling of EGFR for its therapeutic potential in EGFR driven cancers. The C-Terminal Eps15 homology (EH) domain-containing proteins have emerged as regulators of surface receptor recycling …

The Role Of Tumor Suppressor Co-Chaperone Chip/Stub1 In Erbb2-Mediated Oncogenesis, Haitao Luan

Theses & Dissertations

The epidermal growth factor receptor (EGFR) family member ErbB2 (Her2) is overexpressed in 20 -30% of invasive breast cancers and this overexpression correlates with poor prognosis and shorter overall as well as disease-free survival. Aberrant expression of ErbB2 through gene amplification, transcriptional deregulation and/or altered endocytic trafficking results in overexpression of ErbB2 at the plasma membrane and biases ErbB2 from primarily ligand-driven hetero-dimerization under normal expression conditions to increased ligand-independent homo-dimer and hetero-dimer formation and consequent activation. C-terminus of HSC70-Inteeracting protein (CHIP)/STIP1-homologous U-Box containing protein 1 (STUB1) is an HSP90/HSC70 interacting negative co-chaperone known to promote ubiquitination and degradation of …

Examining Employee Knowledge Of The Jennie Edmundson Hospital Active Shooter Policy, Mallory W. Darais

Theses & Dissertations

Nationally, there has been a large increase in the number of active shooter events within healthcare facilities such as hospitals. Due to this increase, government organizations have recently released documents to guide healthcare facilities on implementing active shooter policies and updating emergency operation plans. Currently, recommendations from government entities such as the Federal Bureau of Investigation and the Department of Homeland Security suggest the “Run, Hide, Fight” approach during an active shooter incident. Jennie Edmundson Hospital, located in Council Bluffs, Iowa, and affiliated with the Methodist Health System, currently has an active shooter policy in place. Data was collected from …

Regulation Of The Transmembrane Mucin Muc4 By Wnt/Β-Catenin In Gastrointestinal Cancers, Priya Pai

Theses & Dissertations

The transmembrane mucin MUC4 is a high molecular weight glycoprotein that is expressed de novo in pancreatic ductal adenocarcinoma (PDAC). MUC4 has been shown to play a tumor-promoting role in malignancies such as PDAC, ovarian cancer and breast cancer. Unlike the normal pancreas, MUC4 is ordinarily expressed by goblet and absorptive cells in the normal colonic epithelium. However, its expression/role in colorectal cancer (CRC) is not well studied.

In this dissertation, the goal was to identify factor(s) that may differentially regulate MUC4 in these two disparate malignancies. Furthermore, in light of its pro-tumorigenic role in other malignancies, we analyzed the …

Epacs: Epigenetic Regulators That Affect Cell Survival In Cancer., Catherine Murari

Theses & Dissertations

Cyclic adenosine monophosphate (cAMP) is a second messenger responsive to many external stimuli, playing an important role in cellular gene expression, metabolism, migration, differentiation, hypertrophy, apoptosis and secretion. All of these cellular functions are important in many diseases including cancer. Most of its effects were initially attributed to the classical protein kinase A (PKA) protein, but cellular functions such as proliferation and migration were found to be PKA independent and dependent on the newly discovered exchange proteins directly activated by cAMP (EPACs). EPACs are single polypeptides that primarily function as guanine exchange factors (GEFs) for Rap proteins that allow the …

A Role For Ehd Family Endocytic Regulators In Endothelial Biology, Alexandra E. J. Moffitt

Theses & Dissertations

Endocytic trafficking is an essential process in eukaryotic cells, specifically for the transport of nutrients, membrane components, and receptors. Cargo destined for endocytic traffic is internalized at the cell surface via clathrin-dependent and clathrin-independent pathways, and brought to the early or sorting endosomes. From there, cargo is further trafficked to lysosomes for degradation, trafficked to other compartments in the cell, or recycled back to the cell surface (either directly or via the endocytic recycling compartment).

Mammalian C-terminal Eps15 homology domain-containing proteins, or EHD proteins (EHD1 to 4), are a family of highly conserved ATPases that function as key regulators of …

Morrison V. St. Luke's Regional Medical Center, Ltd Respondent's Brief 2 Dckt. 42625

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Predictability Of International Stock Returns With Sum Of The Parts And Equity Premiums Under Regime Shifts, Mahtab Athari

LSU New Orleans Theses and Dissertations

This research consists of two essays. The first essay entitled” Stock Return Forecasting with Sum-of-the-Parts Methodology: Evidence from Around the World”, examines forecasting ability of stock returns by employing the sum-of-the-parts (SOP) modeling technique introduced by Ferreira and Santa-Clara (2011).This approach decomposes return into three components of growth in price-earnings ratio, earnings growth, and dividend-price ratio. Each component is forecasted separately and fitted values are used in forecast model to predict stock return. We conduct a series of one-step ahead recursive forecasts for a wide range of developed and emerging markets over the period February 1995 through November 2014. Decomposed …

A Novel Transcription Factor In Arabidopsis Thaliana Abiotic Stress Response, Achira S. Weerathunga Arachchilage

LSU New Orleans Theses and Dissertations

Plants respond to environmental stress by altering their gene expression. Under stress conditions some genes are activated and some genes are repressed. Even though a lot of work has been done to understand mechanisms of gene activation under abiotic stress very little information is available on how stress responsive genes are kept repressed under normal growth conditions. Recent work has revealed that plants use transcriptional repression as common mechanism of gene repression. Transcriptional repression is achieved by recruitment co-repressor complexes to the target genes. Recent studies have revealed that the co-repressor LUH complexes with SLK1 and SLK2 to silence Arabidopsis …

Truth Or Consequences—Academic Physicians’ Perspective In The Management Of Commercially-Influenced Conflicts Of Interest, Melinda Lawrie Epperson

LSU New Orleans Theses and Dissertations

Since the 1990s, academic physicians have been subjected to increased requirements for disclosure in their roles as educators and researchers and for conflict of interest (COI) resolution in their financial relationships with pharmaceutical, medical device, and biotech companies, collectively referred to as industry. The requirements are the result of the convergence of federal regulations, accreditation guidelines, professional and industry codes of ethics and conduct, and institutional policies. The disclosure and COI resolution requirements are managed and resolved by a review of forms and compliance with relevant guidance documents and policies. In the context of this environmental oversight, the purpose of …

Field Study Of Electrochemical Disinfection Of Municipal Wastewater, Luis De Grau Vidal

LSU New Orleans Theses and Dissertations

Research on electrochemical disinfection of municipal wastewater has been conducted at the University of New Orleans using a continuous flow electrochemical reactor connected to a direct current (DC) power supply changing its polarity and varying the electrode distance. Bacterial inactivation and chlorine production were the main parameters that were recorded.

After months of research, it was determined that the electrochemical disinfection reactor is efficient and has a great potential for the future. There is no need to use chlorine and it has low operation costs.

The following design recommendations for an electrochemical disinfection unit were given:

• A detention time of …

Twice Displaced: Katrina And The Redevelopment Of The Magnolia, Gabriella A. Garza

LSU New Orleans Theses and Dissertations

Where and how to house the urban poor remains a controversial issue. Public housing residents are particularly vulnerable. Issues of race, class and gender intersect in their lives. Public-private partnerships in urban redevelopment projects and a focus on issues that arise from concentrated poverty gave rise to HOPE VI policy aimed at deconcentrating poverty via public housing demolition and redevelopment. In New Orleans, the effects of Hurricane Katrina further complicate this contested process. The purpose of this case study is to understand how residents experienced and framed the process of displacement brought on by disaster and the redevelopment of the …

Venereal Disease And American Policy In A Foreign War Zone: 39th Infantry Regiment In Sidi-Bel-Abbes, Algeria. May Of 1943., Thomas J. Gibbs

LSU New Orleans Theses and Dissertations

Second Lieutenant Charles Scheffel, B Company Platoon Leader, 39^th Infantry Regiment, 9^th Infantry Division modified existing methods of venereal disease control in Algeria, North Africa during Operation Torch after being ordered to reduce the venereal disease rate by his regimental commander, Colonel William Ritter. Tasked with defeating the Germans first, Scheffel learned other enemies lurked as well, and he instituted an illegal policy to solve the problem as fast and as effectively as possible. Official United States policy on the eve of World War Two prohibited the establishment and operation of a brothel. Scheffel operated this brothel as …

Fear Of Inclement Weather, Clare L. Harmon

LSU New Orleans Theses and Dissertations

No abstract provided.

Are Physically Active College Students More Successful Academically Than Their Inactive Peers?, Jared T. Meacham

LSU New Orleans Theses and Dissertations

This research project intended to explore the possible relationship between physical activity and academic achievement in college students. Using an anonymous online survey, data was collected over two semesters. Ten thousand currently-enrolled college students ages eighteen and older from all states and recognized territories of the United States participated. The survey gathered data concerning a student’s age, gender, race, body weight, height, geographic region of college attendance, cumulative GPA, and physical activity level. The FIT Index of Kasari was used to classify each student’s physical activity level. A quintile split by FIT score was conducted to determine if physically active …

The Interaction Of Parenting And The Serotonin Transporter Gene On Trajectories Of Fearfulness In Early Childhood, Moira R. Riley

LSU New Orleans Theses and Dissertations

Children who are more fearful and inhibited during early childhood are at greater risk for social problems (e.g., loneliness, social isolation) and clinically significant internalizing disorders during adolescence and adulthood (e.g., Rubin, Chen, McDougall, Bowker, & McKinnon, 1995; Williams et al., 2009). While the impact of fearful temperament on adjustment indices are regularly the focus of study, less well understood are biological and social processes that may affect the development of fearful temperament. The present study considered the role of the 5-HTTLPR polymorphism and parenting on change in fearful and inhibited temperamental characteristics during early childhood.

The s/s genotype …

From The Back Of A Bus Named Desire, Brenda D. Quant

LSU New Orleans Theses and Dissertations

N/A

Developing Inter-Professional Oral Health Education: An Evaluation Of Educational Resources, Jordan A. Jew

Master's Projects and Capstones

As healthcare continues to evolve, providers will need to uphold the quality of patient care provided to patients. Traditional healthcare holds many gaps that do not recognize the unmet needs that exist within today’s society. To maximize the abilities of healthcare services, inter-professional education introduces a collaborative approach that develops a network of shared knowledge and clinical skills beyond the primary scope of practice.

In this project, oral health learning modules developed for family practice residents were introduced to first-year dental students at the Dugoni School of Dentistry to improve their knowledge and confidence to both educate and practice with …

Phosphorus Release Potential Of Agricultural Soils Of The United States, Rebecca A. Young

School of Natural Resources: Dissertations, Theses, and Student Research

Phosphorus (P) is one of the leading causes of surface water quality decline in the United States, leading to algal blooms and hypoxia in lakes and streams. Decreasing conservation funds dictate that agencies such as the Natural Resources Conservation Service, maximizes its effectiveness and efficiency in implementing practices to address P management and runoff on agricultural lands. Additional information on P behavior in soil is needed to improve P management plans to reduce pollution risk at the watershed, farm, and field scales. This research focuses on the development of total soil P release models, to be included into assessment and …

The Gender Imbalance In U.S. Outbound Study Abroad: A Case Study Of Semester At Sea, Jessica L. Ryan

Capstone Collection

The purpose of this study is to explore the phenomenon of female college students studying abroad with Semester at Sea (SAS) at twice the rate of their male peers, in the hope of better understanding the significant gender imbalance overall in U.S. outbound study abroad. To put this issue into context, this study uses the theoretical framework of Deci and Ryan’s (1985) Self-Determination Theory of Motivation. Data was analyzed through the lens of intrinsic verses extrinsic motivation to answer the guiding research question: Is there a difference between male and female college students in their motivations to study abroad and, …

12 Cfr Part 201 – Regulation A: Extensions Of Credit By Federal Reserve Bank, Federal Reserve System: Board Of Governors

Documents

No abstract provided.

Law 18 December 2015, Luxembourg: Chamber Of Deputies

Documents

No abstract provided.

An Examination Of Voter Groups That Make Up The Emerging Democratic Majority Thesis, Jason Waguespack

LSU New Orleans Theses and Dissertations

In 2002, John Judis and Ruy Teixeira published The Emerging Democratic Majority, a book that postulated that the United States was in the beginning of a political realignment that would spell the end of the Reagan-era coalition that gave Republicans an electoral advantage on the presidency. The authors claimed an electorate that would favor the Democratic Party would emerge to take its place. Since Senator Barack Obama’s victory in the 2008 presidential election was powered by a coalition that looked much like the one Judis and Teixeira described, it appeared the authors’ thesis was being borne out by actual …

Prolongation Of The Greek Financial Support Measures (Art. 2 Law 3723/2008), European Union: European Commission, Margrethe Vestager

Documents

Margrethe VESTAGER Member of the Commission State aid SA.43825 (2015/N)

State Of Utah, Plaintiff/Appelle, Vs. Colorado Steven Irwin, Defendant/Appellant : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2007– 2019)

Appeal from a restitution order following guilty please to Theft by Receiving Stolen Property, a third degree felony, in violation of Utah Code 76-6-408, and Burglary, a third degree felony, in violation of Utah Code 76-6-202, in the Third District Court, in and for Salt Lake County, State of Utah, the Honorable Charlene Barlow presiding

An Empirical Survey Of International Commercial Arbitration Cases In The Us District Court For The Southern District Of New York, 1970-2014, Vera Korzun, Thomas H. Lee

Fordham International Law Journal

This Article identifies and organizes the circumstances in which national courts play a role in international commercial arbitrations— border crossings. It then records and analyzes empirical data of these border crossings in cases filed in a key national court for international arbitration-related litigation: the US District Court for the Southern District of New York. Data were collected from the date of entry into force for the United States of the New York Convention on the Recognition and Enforcement of Foreign Arbitral Awards (the “New York Convention”) on December 29, 1970 to September 15, 2014. Based on interpretation of these data, …

The Role Of The State, Multinational Oil Companies, International Law & The International Community: Intersection Of Human Rights & Environmental Degradation Climate Change In The 21st Century Caused By Traditional Extractive Practices, The Amazon Rainforest, Indigenous People And Universal Jurisdiction To Resolve The Accountability Issue, Marcela Cabrera Luna

Master's Theses

Local, national and international conventions that protect indigenous sovereignty and their territories, where many of the resources are extracted from by multinational corporations (MNCs) particularly oil, the number one commodity of the world and cause of climate change, continue to be jeopardized because of the lack of a clear international legal framework that can protect them and potentially hold multinationals accountable for their actions. These practices are causing not only environmental issues to the indigenous and surrounding communities, but climate change is in fact, the real human rights issue of the 21^st century and it affects everyone. By using …

Empowering Patients With Central Venous Catheters: Utilizing Evidence-Based Video-Assisted Education To Reduce Central Line-Associated Bloodstream Infections, Pritam C. Steiner

Master's Projects and Capstones

An evidence-based Central Venous Catheter (CVC) dressing change video was created to enhance patient independence, and to increase resource efficiency among nursing staff in an inpatient pediatric setting in which Central Line-Associated Bloodstream Infection (CLABSI) rates were rising. Pediatric oncology patients confer the highest risk of developing CLABSIs due to long-term CVC access, neutropenic effects of treatment regimens, and constant fluctuations between inpatient, outpatient clinic, and homecare settings. Use of video-assisted education is anticipated to standardize and improve patient care, decrease healthcare costs, and increase nurse productivity, and is widely supported by research. Qualitative data collection was conducted by surveying …

The Rhetoric Of Law And The Epistle To The Hebrews, Theodore A. Holt Iv

Electronic Theses and Dissertations

The Epistle to the Hebrews demonstrates a complex of what scholars label technical legal terms. Enlisting a series of word studies, this thesis attempts to uncover where the author learned the terminology in order to understand more about the anonymous author and the theology of the Epistle to the Hebrews. This thesis examines terms in Heb 2:2-4; 6:13-18; 7:11-19; 8:13; 9:15-18; 10:9.

Real System Features And Implications In Underwater Acoustic Networks, Lina Pu

Doctoral Dissertations

As an emerging research area, underwater acoustic network (UAN) has attracted tremendous interests from both academia and industry in recent years. However, little work has been conducted to test algorithms and protocols in real sea experiments. Due to the complexity of acoustic environments and the uncertainties in acoustic systems, it is difficult for theoretical studies or simulations to evaluate UANs in the real world. Studying real system features of UANs has become crucial in the field.

In this dissertation, I study the real system features revealed in sea tests and analyze their impact on underwater media access control (MAC), time …