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Neoplastic Therapy : On Violence And Aesthetics, Mengyu Chen

Masters Theses

The goal of this thesis is to create a new theoretical framework to examine and understand the meaning of an art object and its relational social existence. This thesis serves as a critique on contemporary media culture and hierarchical social oppression. At the same time, it adopts a pseudoscientific way to introduce notions of art’s autonomy and its opposition to social functionality. By merging political theories on individualism, capitalism, and metaphysics with foundational structures of art creation, I am attempting to construct a new system of thinking that challenges traditional ways of understanding mediums, functions and the viewer’s relationship with …

Mandatory Hiv Status Disclosure For Students In Illinois: A Deterrent To Testing And A Violation Of The Americans With Disabilities Act, Anthony Todd

Northwestern Journal of Law & Social Policy

No abstract provided.

Commencement Of The Class Of 2015, José M. Torres

Keynotes, Speeches, and Lectures

Thank you, Mr. Lawrence. It is a privilege to be here with you this morning. IMSA Board of Trustees, faculty, staff, parents, family members, IMSA Fund Board Members, significant others, and—the Class of 2015! Welcome to all! It is a pleasure and an honor to accept you, the Class of 2015. Congratulations to the Seniors, who today become IMSA alumni!

Commencement Of The Class Of 2015, Priya Triedi '15, Vinesh Kannan '15, Sheila Mb Griffin, Jamie N. Jones, Branson D. Lawrence, José M. Torres

Ceremony

"Let me conclude my remarks this morning with a quote from Countee Cullen, a poet of the Harlem Renaissance who graduated from NYU, then Harvard University. He said, “For we must be one thing or the other, an asset or a liability, the sinew in your wing to help you soar, or the chain to bind you to earth” (Countee Cullen).

Class of 2015, I ask: Will you be an asset or a liability? Class of 2015, will you give back and pay it forward? Class of 2015, will you invest in this world? Will you advance the human condition? …

Identification Of Novel Genes That Regulate Androgen Receptor Signaling And Growth Of Androgen-Deprived Prostate Cancer Cells, Elina Levina, Hao Ji, Mengqiang Chen, Mirza Baig, David Oliver, Patrice Ohouo, Chang-Uk Lim, Garry Schools, Steven Carmack, Ye Ding, Eugenia Broude, Igor Roninson, Ralph Buttyan, Michael Shtutman

Faculty Publications

Prostate cancer progression to castration refractory disease is associated with anomalous transcriptional activity of the androgen receptor (AR) in an androgen-depleted milieu. To identify novel gene products whose downregulation transactivates AR in prostate cancer cells, we performed a screen of enzymatically-generated shRNA lenti-libraries selecting for transduced LNCaP cells with elevated expression of a fluorescent reporter gene under the control of an AR-responsive promoter. The shRNAs present in selected populations were analyzed using high-throughput sequencing to identify target genes. Highly enriched gene targets were then validated with siRNAs against selected genes, testing first for increased expression of luciferase from an AR-responsive …

Comparison Of Cardiovascular Risk Profiles Amongst Newly Diagnosed Cancer Patients And Non-Cancer Patients At The Aga Khan University Hospital Nairobi, Majid Lingani-Ncube Sikosana

Master of Medicine in Internal Medicine

Background: Non-Communicable Diseases (NCDs) are fast becoming the leading causes of morbidity and mortality in Low and Middle-income countries (LMIC) with cancers and cardiovascular diseases (CVDs) becoming the most prominent. CVD can be prevented if appropriate measures of screening and treatment of modifiable risk factors are addressed. This may translate to reduced risk of CVDs and some cancers in the long term. Increasing evidence exhibits common risk factors for both CVDs and cancer and that CVDs and their risk factors when present in cancer patients may worsen the overall outcome. Objectives: The primary objective was to determine and compare the …

Selective Impairment Of Spatial Cognition Caused By Autoantibodies To The N-Methyl-D-Aspartate Receptor, Eric H. Chang, Bruce T. Volpe, Meggan Mackay, Cynthia Aranow, Philip Watson, Czeslawa Kowal, Justin Storbeck, Paul Mattis, Roseann Berlin, Huiyi Chen, Simone Mader, Tomás S. Huerta, Patricio T. Huerta, Betty Diamond

Publications and Research

Patients with systemic lupus erythematosus (SLE) experience cognitive abnormalities in multiple domains including processing speed, executive function, and memory. Here we show that SLE patients carrying antibodies that bind DNA and the GluN2A and GluN2B subunits of the N-methyl-d-aspartate receptor (NMDAR), termed DNRAbs, displayed a selective impairment in spatial recall. Neural recordings in a mouse model of SLE, in which circulating DNRAbs penetrate the hippocampus, revealed that CA1 place cells exhibited a significant expansion in place field size. Structural analysis showed that hippocampal pyramidal cells had substantial reductions in their dendritic processes and spines. Strikingly, these abnormalities became evident at …

The Void, The Mystery, The Vast Array, The Infinity Of Unities, The Otherworld, The Absolute, The Hidden Order, The Randomness, The Infraworld, The Nothing, The Zone Of Immaterial Sensibility, The Silence, The Hollow Of Space, The Ineffable, The Emptiness, The Wild, Drew Ludwig

Masters Theses

This thesis presents the culmination of two years of excursions into and longing for the void: the sense of absolute presence and connectivity that I have always found in the desert of the Colorado Plateau. Away from the desert, I use my artistic practice as a means of approaching this kinship with the wild, the void.

My work may be understood as a series of experiments, striving to locate and access the void through different language, logic and media. My process speaks to a deep respect for the external wild of landscape (the desert), and a growing recognition of the …

Make Every Day Count: Longing, Vision, & Painting, Sarah R. Pater

Masters Theses

Images are non-verbal holders of narrative and meaning in Western culture. Historically, painting served this function—a job that we now generally give to digital photography and cinema. One task for contemporary painting, then, might simply be as a self-reflective metaphor for the experience of vision that is mostly lost in photographic technologies: seeing as looking plus touching. Paintings are simultaneously objects and images—corporeal material constructions and visceral illusionary fields. Given the current state of rapid image production, consumption, and instrumentalization, painting’s insistence on singularity and a more ‘composed gaze’—one that asks the viewer to re-read—stands out as significant and potentially …

The Investigation Of The Low Temperature Combustion Of Mesitylene And Tert-Amyl Methyl Ether By Synchrotron Photoionization Mass Spectrometry, Martin Yu-Hin Ng

Master's Theses

This thesis describes the combustion experiments performed at the Chemical Dynamics Beamline of the Advanced Light Source (ALS) located at the Lawrence Berkeley National Laboratories (LBNL). The need for renewable fuel sources, the need for the study of their combustion in the contexts of homogenous charge combustion ignition (HCCI) engines can be found in Chapter 1. The components of the experimental set-up used throughout this thesis—time-of-flight mass spectrometer, Excimer laser, vacuum pumps and other components—and the components of ALS responsible in synchrotron radiation generation and processing—the linear accelerator, the booster ring, insertion devices, gas filters and monochromator are explained in …

Group Retesting To Promote Learning Self-Awareness And Individual Accountability, Robbin Eppinga, Kayt E. Frisch, Jeff Ploegstra

Faculty Work Comprehensive List

Allowing students to retake tests in groups provides them with the immediate opportunity to learn from their mistakes while improving their perceptions of a course. We explore Group Review Advancing Content/Concept Essentials (aka GRACE), a variation on group retesting, which creates a peer learning environment and emphasizes individual metacognition, concept articulation, and accountability. Through an interactive demonstration, we introduce the process, relate some of the literature-reported benefits of group retesting, and share our experiences using GRACE in a variety of disciplines at different course levels.

Incorporating Instant Student Feedback In A Large Psychology Course, Paige Fisher

Emerging Learning Design Conference

Concurrent Session B

The Why And Where Of Big History: Building A Program, Mojgan Behmand

Office of Academic Affairs

The goals of our First Year Experience program are aligned with our institutional mission, our core values, and the goals of our General Education program. The program is designed to promote:

1. recognition of the personal, communal, and political implications of the Big History story;
2. critical and creative thinking in a manner that awakens curiosity and enhances openness to multiple perspectives; and,
3. development of reading, thinking, and research skills to enhance one’s ability to evaluate and articulate understanding of one’s place in the unfolding universe.

Paper Abstracts (2015), Association Of Christians In The Mathematical Sciences

ACMS Conference Proceedings 2015

Twentieth Conference of the Association of Christians in the Mathematical Sciences

Jane Eyre's Masculine Crisis, Samantha Hilton

Senior Theses

Charlotte Bronte’s famed novel Jane Eyre was among the first novels celebrated by early feminist theorists in the 1960s for its portrayal of an independent and enviable female protagonist; both Charlotte Bronte and Jane have since been heralded as examples of the modern Western woman. Feminist theorists have taken to Jane Eyre because of the text’s rebellion against Victorian ideals: rather than passively follow orders, governess Jane instead follows her own code of morality. Jane is an appropriate early feminist heroine, and that, perhaps, is Bronte’s greatest achievement and Jane Eyre’s most lasting success. Feminist interpretations of the novel …

A Model For The Force Exerted On A Primary Cilium By An Optical Trap And The Resulting Deformation, Ian Lofgren, Andrew Resnick

Physics Faculty Publications

Cilia are slender flexible structures extending from the cell body; genetically similar to flagella. Although their existence has been long known, the mechanical and functional properties of non-motile (“primary”) cilia are largely unknown. Optical traps are a non-contact method of applying a localized force to microscopic objects and an ideal tool for the study of ciliary mechanics. We present a method to measure the mechanical properties of a cilium using an analytic model of a flexible, anchored cylinder held within an optical trap. The force density is found using the discrete-dipole approximation. Utilizing Euler-Bernoulli beam theory, we then integrate this …

Limits On Use Of Facilities In Government Buildings And Businesses. Initiative Statute.

Initiatives

Prohibits individuals from using facilities in government buildings except in accordance with their sex as determined at birth, through medical examination, or court judgment recognizing a change of gender. Creates legal damages claim of at least $4,000 against a government entity or person that violates the provision. Allows businesses to prohibit employees or patrons, including transgender people, from using facilities except in accordance with their sex as determined at birth, through medical examination, or court judgment. Exempts businesses from criminal and civil liability for implementing such a prohibition. Summary of estimate by Legislative Analyst and Director of Finance of fiscal …

Correction: A Novel Approach For Detection And Quantification Of Magnetic Nanomarkers Using A Spin Valve Gmr-Integrated Microfluidic Sensor, J. Devkota, G. Kokkinis, T. Berris, M. Jamalieh, S. Cardoso, F. Cardoso, Hariharan Srikanth, Manh-Huong Phan, I. Giouroudi

Physics Faculty Publications

We demonstrate the application of a spin valve giant magneto-resistance (GMR) integrated microfluidic sensor for the detection and quantification of superparamagnetic nanomarkers. A microfluidic channel containing the magnetic fluid, micro-conductors (MCs) for collection of magnetic markers and a spin valve GMR sensor for detecting the presence of magnetic stray field were integrated into a single chip and employed for detection of various concentrations of Nanomag-D beads of 250 nm diameter. The results show that the sensor is capable of detecting concentrations as low as 500 pg μl⁻¹ of Nanomag-D beads and quantifying them in a linear scale over a …

Deletion Of The Proposed Iron Chaperones Isca/Sufa Results In Accumulation Of A Red Intermediate Cysteine Desulfurase Iscs In Escherichia Coli, Jing Yang, Guoqiang Tan, Ting Zhang, Robert H. White, Jianxin Lu, Huangen Ding

Faculty Publications

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. In Escherichia coli, sulfur in iron-sulfur clusters is primarily derived from L-cysteine via the cysteine desulfurase IscS. However, the iron donor for iron-sulfur cluster assembly remains elusive. Previous studies have shown that, among the iron-sulfur cluster assembly proteins in E. coli, IscA has a unique and strong iron-binding activity and that the iron-bound IscA can efficiently provide iron for iron-sulfur cluster assembly in proteins in vitro, indicating that IscA may act as an iron chaperone for iron-sulfur cluster biogenesis. Here we report that deletion of IscA and its …

Living With, Managing And Minimising Treatment Burden In Long Term Conditions: A Systematic Review Of Qualitative Research, S Demain, A-C Gonçalves, C Areia, R Oliveira, Aj Marcos, A Marques, R Parmar, K Hunt

School of Health Professions

No abstract provided.

Disruption Of Columnar And Laminar Cognitive Processing In Primate Prefrontal Cortex Following Cocaine Exposure, Ioan Opris, Greg A. Gerhardt, Robert E. Hampson, Sam A. Deadwyler

Neuroscience Faculty Publications

Prefrontal cortical activity in primate brain plays a critical role in cognitive processes involving working memory and the executive control of behavior. Groups of prefrontal cortical neurons within specified cortical layers along cortical minicolumns differentially generate inter- and intra-laminar firing to process relevant information for goal oriented behavior. However, it is not yet understood how cocaine modulates such differential firing in prefrontal cortical layers. Rhesus macaque nonhuman primates (NHPs) were trained in a visual delayed match-to-sample (DMS) task while the activity of prefrontal cortical neurons (areas 46, 8 and 6) was recorded simultaneously with a custom multielectrode array in cell …

The Biosynthesis Of Capuramycin-Type Antibiotics: Identification Of The A-102395 Biosynthetic Gene Cluster, Mechanism Of Self-Resistence, And Formation Of Uridine-5'-Carboxamide, Wenlong Cai, Anwesha Goswami, Zhaoyong Yang, Xiaodong Liu, Keith D. Green, Sandra Barnard-Britson, Satoshi Baba, Masanori Funabashi, Koichi Nonaka, Manjula Sunkara, Andrew J. Morris, Anatol P. Spork, Christian Ducho, Sylvie Garneau-Tsodikova, Jon S. Thorson, Steven Van Lanen

Pharmaceutical Sciences Faculty Publications

A-500359s, A-503083s, and A-102395 are capuramycin-type nucleoside antibiotics that were discovered using a screen to identify inhibitors of bacterial translocase I, an essential enzyme in peptidoglycan cell wall biosynthesis. Like the parent capuramycin, A-500359s and A-503083s consist of three structural components: a uridine-5'-carboxamide (CarU), a rare unsaturated hexuronic acid, and an aminocaprolactam, the last of which is substituted by an unusual arylamine-containing polyamide in A-102395. The biosynthetic gene clusters for A-500359s and A-503083s have been reported, and two genes encoding a putative non-heme Fe(II)-dependent α-ketoglutarate:UMP dioxygenase and an l-Thr:uridine-5'-aldehyde transaldolase were uncovered, suggesting that C-C bond formation during assembly of …

Prenatal Predictors Of Infant Self-Regulation: The Contributions Of Placental Dna Methylation Of Nr3c1 And Neuroendocrine Activity, Elisabeth Conradt, Mary Fei, Linda Lagasse, Edward Tronick, Dylan Guerin, Daniel Gorman, Carmen J. Marsit, Barry M. Lester

Dartmouth Scholarship

We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128) participated in the still-face paradigm when infants were 5 months old. Infant self-regulation following the still-face episode was coded and pre-stress cortisol and cortisol reactivity was assessed in response to the still-face paradigm. A factor analysis of NR3C1 CpG sites revealed two factors: one for CpG sites 1-4 and the other for sites 5-13. DNA methylation of the factor comprising NR3C1 …

From Tea To Trompe L’Oeil, May Term Offers Immersive Experiences, University Communications, Illinois Wesleyan University

News and Events (Discontinued Series)

No abstract provided.

Volume Cxxxii, Number 25, May 29, 2015, Lawrence University

The Lawrentian

No abstract provided.

Intramembranous Bone Healing Process Subsequent To Tooth Extraction In Mice: Micro-Computed Tomography, Histomorphometric And Molecular Characterization, Andreia Espindola Vieira, Carlos Eduardo Repeke, Samuel De Barros Ferreira Junior, Priscila Maria Colavite, Cláudia Cristina Biguetti, Rodrigo Cardoso Oliveira, Gerson Francisco Assis, Rumio Taga, Ana Paula Favaro Trombone, Gustavo P. Garlet

School of Podiatric Medicine Publications

Bone tissue has a significant potential for healing, which involves a significant the interplay between bone and immune cells. While fracture healing represents a useful model to investigate endochondral bone healing, intramembranous bone healing models are yet to be developed and characterized. In this study, a micro-computed tomography, histomorphometric and molecular (RealTimePCRarray) characterization of post tooth-extraction alveolar bone healing was performed on C57Bl/6 WT mice. After the initial clot dominance (0 h), the development of a provisional immature granulation tissue is evident (7 d), characterized by marked cell proliferation, angiogenesis and inflammatory cells infiltration; associated with peaks of growth factors …

Precision Of Hard Structures Used To Estimate Age Of Mountain Whitefish (Prosopium Williamsoni), Carson J. Watkins, Tyler J. Ross, Ryan S. Hardy, Michael C. Quist

Western North American Naturalist

The mountain whitefish (Prosopium williamsoni) is a widely distributed salmonid in western North America that has decreased in abundance over portions of its distribution due to anthropogenic disturbances. In this investigation, we examined precision of age estimates derived from scales, pectoral fin rays, and sagittal otoliths from 167 mountain whitefish. Otoliths and pectoral fin rays were mounted in epoxy and cross-sectioned before examination. Scales were pressed onto acetate slides and resulting impressions were examined. Between-reader precision (i.e., between 2 readers), between-reader variability, and reader confidence ratings were compared among hard structures. Coefficient of variation (CV) in age estimates …

Northern Range Extension Of The Figeater Beetle, Cotinis Mutabilis (Scarabaeidae: Cetoniinae), Into Nevada, Utah, And Colorado, Frank-Thorsten Krell, Jeff B. Knight, Robert Hammon, Pamela Wheeler, Jeffrey Johns Roberts, Jason R. Eckberg

Western North American Naturalist

The native Figeater Beetle, Cotinis mutabilis (Coleoptera: Scarabaeidae: Cetoniinae), is known to occur from Texas, New Mexico, Arizona, and California to northern South America. Here we present records from Nevada, where it became established in the late 1960s; from Utah, where it has been found since the late 2000s; and from Colorado, where it was found in 2012. These records indicate a recent northward range extension of the species, which circumvents the Colorado Plateau. The range extension of C. mutabilis has potential positive effects, namely the addition of a new pollinator to those areas, but also potential negative implications if …

Tolerance Values And Effects Of Selected Environmental Determinants On Diatom Distribution In Northwest And North Central Washington, Usa, Dean W. Blinn

Western North American Naturalist

Diatoms were collected at 165 stream, river, wall seep, and pond/lake sites in 9 counties in northwest and north central Washington, including the Olympic Pennsisula, over a 5-year period. Four hundred and fifteen species in 77 genera were identified. Species assemblages were compared to altitude, physicochemical factors, aquatic habitats, and land use on west and east sides of the North Cascade Range. Species richness averaged 30.5 per site on the west side and 43 on the east side. Diatom species richness showed significant positive correlations to total nitrogen, total phosphorus, pH, specific conductance, channel embeddedness, and water temperature, and a …

Molecular Systematics Of Nyctinomops (Chiroptera: Molossidae), Richard W. Dolman, Loren K. Ammerman

Western North American Naturalist

The genus Nyctinomops comprises 4 species of bats in the free-tailed family Molossidae: Nyctinomops macrotis, Nyctinomops femorosaccus, Nyctinomops aurispinosus, and Nyctinomops laticaudatus. The objective of this study was to use mitochondrial sequence data to test hypotheses of relationship within Nyctinomops. A total of 460 bases of cytochrome b and 686 bases of NADH dehydrogenase were sequenced and analyzed from 22 individuals by use of parsimony, maximum likelihood, and Bayesian methods. Sequences from other molossid genera (Tadarida, Cynomops,and Otomops) were used as outgroups. In addition, a series of Nyctinomops specimens from Peru was re-assessed using …